Snail Cancer Research Results

Snail, SNAI1, Snail Family Transcriptional Repressor 1: Click to Expand ⟱
Source:
Type:
Scientific Papers found: Click to Expand⟱
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
80- QC,    Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway
- in-vitro, Pca, PC3
Vim↓, ERK↓, Snail↓, Slug↓, Twist↓, EGFR↓, p‑Akt↓, EGFR↓, N-cadherin↓, TumMeta↓, EMT↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
101- RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑, TumCI↓, TumMeta↓,
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
PD-L1↑, Snail↑, E-cadherin↓, N-cadherin↑, Fibronectin↑, Vim↑, Axin2↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2/PTGS2↓, cMyc↓,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp/ABCB1↓, ATP↓,
7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
- in-vitro, Oral, NA
*antiOx↑, *AntiBio↑, TGF-β↓, p‑SMAD3↓, p‑SMAD2↓, p‑SMAD4↓, SMAD3↓, Snail↓, ERCC1↓, ERCC4/XPF↓, Ku70/XRCC6↓, PCNA↓, cycD1/CCND1↓, Hif1a↓, IL6↓, Mcl-1↓, BAX↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, PARP↑, DNArepair↓, TumCP↓, TumCI↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
1134- SANG,    Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
Hif1a↓, EMT↓, Snail↓, PI3K↓, Akt↓, SMAD2↓, SMAD3↓,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2/KDR/Flk1↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, Synergy↑,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1136- SFN,    Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells
- in-vitro, Lung, NA - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Snail↓, ERK5↑, EMT↓,
1462- SFN,    Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2/PTGS2↝, MMP2↝, MMP9↝,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
1137- Taur,    Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
- in-vitro, Pca, NA
N-cadherin↓, Twist↓, Zeb1↓, Snail↓, Vim↓, E-cadherin↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4844- Uro,    Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,

Showing Research Papers: 101 to 129 of 129
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 129

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 6,   NRF2↑, 6,   p‑NRF2↓, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 42,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 4,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 3,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 2,   mtDam↑, 5,   OCR↓, 3,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 8,   GSK‐3β↑, 3,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 5,   lactateProd↓, 2,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 3,   PFK↓, 1,   PFK1↓, 1,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 3,   SIRT1↓, 3,   SIRT1↑, 2,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 39,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 2,   BAX↑, 22,   Bax:Bcl2↑, 1,   Bcl-2↓, 32,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 6,   BNIP3↑, 1,   Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 37,   Casp3∅, 1,   cl‑Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 9,   Casp8↑, 14,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 24,   cl‑Casp9↑, 3,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 24,   Diablo↑, 5,   DR5↑, 8,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   HEY1↓, 2,   iNOS↓, 6,   Mcl-1↓, 12,   MDM2↓, 3,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 4,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 22,   TNFR 1↑, 2,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 7,   XIAP↓, 16,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   p‑Akt↓, 18,   AKT1↓, 2,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   ERK↓, 9,   p‑ERK↓, 7,   ERK5↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 5,   IKKα↑, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 3,   MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 34,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 8,   RAS↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 20,   p‑STAT3↓, 7,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 2,   p‑ATF4↝, 1,   cJun↓, 2,   cMyc↓, 14,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-126↑, 1,   miR-127-5p↑, 2,   miR-139-5p↑, 1,   miR-140↑, 1,   miR-182-5p↓, 1,   miR-200c↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-29b↓, 1,   miR-339-5p↝, 1,   miR-375↑, 1,   miR-592↑, 1,   Myc↓, 4,   OCT4↓, 12,   other↓, 2,   other↑, 1,   other↝, 1,   SOX2↓, 6,   SOX4↓, 1,   SOX9↓, 1,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 10,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 9,   Erlin1↑, 1,   GRP78/BiP↑, 3,   HSP27↓, 3,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 2,   PDI↑, 1,   PERK↑, 2,   p‑PERK↝, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 4,   PARK2↑, 2,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 2,   DNAdam↓, 1,   DNAdam↑, 10,   DNAdam⇅, 1,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 17,   p‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↑, 9,   cl‑PARP↑, 15,   PARP1↑, 1,   PCNA↓, 9,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,   UHRF1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1/2/5/9↓, 1,   CDK2↓, 15,   CDK2↑, 2,   CDK4↓, 11,   CDK4/6↓, 1,   CDK6↓, 9,   CDK8↓, 2,   CHK1↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 5,   E2Fs↓, 2,   Ki-67↓, 6,   MAD↓, 1,   P21↑, 15,   p27/CDKN1B↑, 6,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 27,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   CD133↓, 4,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 24,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 9,   HH↓, 9,   IGF-1↓, 2,   JAG1↓, 1,   Ki-67↓, 6,   LRP6↓, 3,   p‑LRP6↓, 2,   Nanog↓, 10,   NOTCH↓, 10,   NOTCH1↓, 7,   NOTCH1↑, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 2,   PTCH2↓, 1,   Shh↓, 8,   Smo↓, 6,   TumCG?, 1,   TumCG↓, 18,   TumCP↓, 33,   TumCP↑, 2,   Wnt↓, 20,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 3,   AXL↓, 2,   Ca+2↑, 10,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   Cdc42↓, 1,   CDH1↑, 2,   Cofilin↓, 1,   COL1↓, 3,   COL1A1↓, 3,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 68,   EM↑, 1,   EMT↓, 84,   EpCAM↓, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 8,   Fibronectin↑, 1,   GLI2↓, 5,   ITGA5↓, 1,   ITGA5↑, 3,   ITGB1↓, 2,   ITGB1↑, 3,   ITGB3↓, 1,   LAMA5↑, 3,   LEF1↓, 3,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP2↓, 45,   MMP2↝, 1,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 45,   MMP9↝, 1,   MMPs↓, 9,   N-cadherin↓, 50,   N-cadherin↑, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 3,   Sharpin↓, 2,   Slug?, 1,   Slug↓, 42,   Smad1↓, 3,   SMAD2↓, 3,   p‑SMAD2↓, 4,   SMAD3↓, 5,   p‑SMAD3↓, 3,   p‑SMAD4↓, 1,   Snail?, 2,   Snail↓, 119,   Snail↑, 6,   TET1↑, 1,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 48,   TumCI↑, 1,   TumCMig↓, 42,   TumMeta↓, 31,   Twist↓, 27,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 8,   Vim?, 1,   Vim↓, 71,   Vim↑, 3,   vinculin↓, 1,   Zeb1↓, 25,   Zeb1↑, 4,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 35,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   NO↓, 1,   NO↝, 1,   VCAM-1↓, 3,   VEGF↓, 27,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   GLUT1↓, 2,   MMP↓, 27,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 10,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 4,   IL2↑, 2,   IL4↓, 1,   IL6↓, 17,   IL8↓, 4,   Imm↑, 2,   Inflam↓, 7,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 33,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 1,   p50↓, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 5,   RAGE↓, 1,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α∅, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 3,   AR↑, 1,   ER-α36↓, 1,   PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 30,   CompStab↑, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose↝, 11,   Dose∅, 3,   eff↓, 6,   eff↑, 15,   eff↝, 1,   Half-Life↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 10,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 28,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 3,   AR↑, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 17,   LDH↓, 2,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cachexia↓, 2,   cardioP↑, 3,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 3,   Risk↓, 5,   Symptoms∅, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 4,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Catalase↑, 5,   DPPH↓, 1,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 4,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 6,   Prx↑, 1,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 4,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   DGAT1↓, 1,   FASN↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Casp3?, 1,   Casp3↓, 3,   Cyt‑c↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   mTOR↑, 2,   PI3K↑, 2,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   RUNX2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   F-actin↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   Snail↑, 1,   TregCell↑, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↓, 1,   Vim↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   NeuroI↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 1,   CYP2E1↓, 1,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   creat↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 3,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 6,   Obesity↓, 1,   PDE4↓, 1,   toxicity↓, 7,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiViral↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 108

Scientific Paper Hit Count for: Snail, SNAI1, Snail Family Transcriptional Repressor 1
9 Sulforaphane (mainly Broccoli)
7 Resveratrol
7 Quercetin
6 EGCG (Epigallocatechin Gallate)
6 Honokiol
5 Apigenin (mainly Parsley)
4 Ellagic acid
4 Luteolin
3 Boron
3 Curcumin
3 Cyclopamine
3 Eugenol
3 Fisetin
3 HydroxyTyrosol
3 Matrine
3 Urolithin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Benzyl isothiocyanate
2 Chrysin
2 Ginkgetin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Kaempferol
2 Piperine
2 Pterostilbene
1 1,8-Cineole
1 Astragalus
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cisplatin
1 Artemisinin
1 Baicalin
1 Betulinic acid
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Chlorogenic acid
1 Citric Acid
1 Diindolylmethane
1 Genistein (soy isoflavone)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 Isorhamnetin
1 Allyl isothiocyanate
1 Juglone
1 L-Theanine
1 Magnolol
1 5-fluorouracil
1 mebendazole
1 Metformin
1 Melatonin
1 Morin
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Propranolol
1 isoflavones
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Taurine
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:376  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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