Snail Cancer Research Results

Snail, Snail: Click to Expand ⟱
Source:
Type:
Snail gene may show a role in recurrence of breast cancer by downregulating E-cadherin and inducing an epithelial to mesenchymal transition. Snail promotes metastasis of breast cancer cells and overexpression of Snail is a biomarker of poor clinical outcome for patients with breast cancer.
Snail, a repressor of E-cadherin and an inducer of EMT.
Snail (SNAI1):
A transcription factor that plays a key role in the regulation of the epithelial-to-mesenchymal transition (EMT).
It suppresses the expression of epithelial markers (such as E-cadherin) and upregulates mesenchymal markers, facilitating changes in cell adhesion and motility.
EMT Induction:
Snail actively represses genes such as E-cadherin, a protein critical for cell–cell adhesion. Its upregulation leads to a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype, enhancing migratory potential.
Invasion and Metastasis:
Through EMT induction, Snail facilitates tumor cell dissemination and invasion into surrounding tissues, thereby playing a central role in metastasis.

Elevated levels of Snail have been observed in a variety of cancers, including breast, colorectal, pancreatic, and head and neck cancers.
Elevated Snail expression is frequently associated with a worse prognosis, including lower overall survival rates and increased likelihood of metastasis.
Scientific Papers found: Click to Expand⟱
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1137- Taur,    Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
- in-vitro, Pca, NA
N-cadherin↓, Twist↓, Zeb1↓, Snail↓, Vim↓, E-cadherin↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4844- Uro,    Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, eff↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,

Showing Research Papers: 101 to 107 of 107
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 107

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATG7↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BID↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   DR5↑, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↑, 2,   Myc↓, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 1,   TRAIL↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↑, 1,   DNMT1↓, 1,   p16↑, 1,   P53↑, 2,   p53 Wildtype↑, 1,   PARP↑, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cMET↓, 1,   EMT↓, 4,   ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC1↓, 1,   mTOR↓, 2,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   CLDN2↑, 1,   DLC1↑, 1,   E-cadherin↑, 6,   ITGA5↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 2,   N-cadherin↓, 6,   Slug↓, 1,   Snail↓, 7,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 1,   Twist↓, 2,   Vim↓, 7,   Zeb1↓, 3,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CXCL1↓, 1,   CXCR4↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 2,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   p65↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   eff↓, 1,   eff↑, 4,   RadioS↑, 1,   selectivity↑, 2,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

hTERT/TERT↓, 1,   IL6↓, 2,   Myc↓, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 4,  
Total Targets: 113

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Snail, Snail
7 Resveratrol
7 Sulforaphane (mainly Broccoli)
7 Quercetin
6 EGCG (Epigallocatechin Gallate)
6 Honokiol
5 Apigenin (mainly Parsley)
4 Ellagic acid
3 Boron
3 Curcumin
3 Cyclopamine
3 Eugenol
3 Fisetin
3 HydroxyTyrosol
3 Luteolin
3 Urolithin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Chrysin
2 Ginkgetin
2 Piperine
2 Pterostilbene
1 1,8-Cineole
1 Astragalus
1 alpha Linolenic acid
1 Cisplatin
1 Artemisinin
1 Baicalin
1 Betulinic acid
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Chlorogenic acid
1 Citric Acid
1 Genistein (soy isoflavone)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Juglone
1 Magnolol
1 5-fluorouracil
1 Metformin
1 Naringin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 isoflavones
1 Rosmarinic acid
1 salinomycin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Taurine
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:376  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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