Wnt Cancer Research Results

Wnt, Wingless-related integration site: Click to Expand ⟱
Source:
Type:
The Wnt signaling pathway is a complex network of proteins that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and migration. It is particularly important during embryonic development and tissue homeostasis. Dysregulation of the Wnt pathway has been implicated in various cancers, making it a significant area of research in oncology.
Wnt Ligands
Wnt1: Often overexpressed in breast cancer and some types of leukemia.
Wnt Receptors
Frizzled (Fzd) Receptors: Different Fzd receptors (e.g., Fzd1, Fzd2, Fzd7) have been implicated in various cancers:
Fzd1: Overexpressed in colorectal cancer.
Fzd2: Associated with breast cancer and prostate cancer.
Fzd7: Linked to gastric cancer and glioblastoma.
Scientific Papers found: Click to Expand⟱
8031- IVM,    Antiparasitic agents in oncology: Innovative mechanisms, emerging evidence and clinical potential in cancer treatment
- Review, Nor, NA
*AntiP↑, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, HH↓, Imm↑, CSCs↓, P-gp/ABCB1↓, Chl↓, angioG↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, Synergy↑, *AntiP↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
5120- JG,    Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling
- in-vitro, PC, NA
angioG↓, Wnt↓, VEGF↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8197- LGE,    Citral induced apoptosis in MDA-MB-231 spheroid cells
- in-vitro, BC, MDA-MB-231
eff↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓,
8195- LGE,    In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity
- vitro+vivo, BC, 4T1
TumCD↑, Dose↝, TumVol↓, cl‑Casp3↑, β-catenin/ZEB1↑, ALDH↓, Wnt↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
1171- LT,    The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma
- in-vitro, CCA, NA
Wnt↓, TumCCA↑, Apoptosis↑, TumCMig↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4793- Lyco,    Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
- in-vitro, GC, AGS
antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
8561- Matr,    Matrine triggers colon cancer cell apoptosis and G0/G1 cell cycle arrest via mediation of microRNA-22
- in-vitro, Colon, SW480 - in-vitro, CRC, SW-620
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, miR-22↑, Wnt↓, β-catenin/ZEB1↓, MEK↓, ERK↓,
8571- Matr,    Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling
- in-vitro, PC, Capan1
Dose↝, TumCP↓, Wnt↓, β-catenin/ZEB1↓, MMP14↓,
8537- Matr,    Matrine restrains the development of colorectal cancer through regulating the AGRN/Wnt/β-catenin pathway
- vitro+vivo, CRC, NA
TumCG↓, AGRN↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓,
8536- Matr,    Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
- vitro+vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, angioG↓,
8529- Matr,    Matrine targets β-catenin and blocks the formation of β-catenin/TCF7L2 complex to promote ferroptosis and inhibit metastasis in triple-negative breast cancer
- in-vitro, BC, NA
β-catenin/ZEB1↓, Wnt↓, TCF7/TCF1↓, GPx4↝, Ferroptosis↑, EMT↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
2240- MF,    Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathway
- in-vitro, Nor, C3H10T1/2
*Ca+2↑, *Diff↑, *BMD↑, *Wnt↑, *β-catenin/ZEB1↑, *eff↝,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
8865- MOR,    Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells
- in-vitro, Liver, HepG2
Mst1↑, cl‑Casp3↑, YAP/TEAD↓, Apoptosis↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, TumCD↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4972- Nimb,    Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms
- Review, Var, NA
Apoptosis↑, TumCP↓, NF-kB↓, Wnt↓, PI3K↓, MAPK↓, JAK↓, STAT↓,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
1989- PTL,    Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
- Review, Var, NA
eff↑, NF-kB↓, STAT↓, ROS↑, Inflam↓, Wnt↓, TCF-4↓, LEF1↓, GSH↓, MMP↓, Casp↑, eff↓, CSCs↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3085- RES,    Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1
- in-vitro, Cerv, NA
TET1↑, Wnt↓, β-catenin/ZEB1↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,

Showing Research Papers: 101 to 150 of 177
Prev Page 3 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 177

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 1,   GPx↑, 4,   GPx4↓, 7,   GPx4↝, 1,   GSH↓, 6,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 9,   Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   NADH↓, 1,   NRF2↓, 4,   NRF2↑, 10,   p‑NRF2↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 67,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↑, 3,   mt-SOD↑, 1,   TAC?, 1,   TrxR↓, 2,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 5,   compI↓, 3,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 6,   OCR↓, 3,   OXPHOS↓, 4,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 1,   AMPK?, 1,   AMPK↑, 16,   ATP↓, 9,   FAO↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 10,   GSK‐3β↓, 10,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 3,   HK1↓, 1,   HK2↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   PKM2↓, 2,   PKM2↑, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 67,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 5,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 4,   Bcl-2↓, 33,   Bcl-2↑, 2,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 2,   BIM↑, 5,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 11,   cl‑Casp↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 39,   cl‑Casp3↑, 11,   Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 12,   cl‑Casp8↑, 2,   Casp9↑, 21,   cl‑Casp9↑, 5,   cFLIP↓, 1,   Cyt‑c↑, 28,   Diablo↑, 3,   DR5↑, 17,   FADD↑, 1,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 10,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICD↑, 3,   iNOS↓, 4,   Mcl-1↓, 14,   MDM2↓, 7,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 1,   p38↓, 2,   p38↑, 7,   p‑p38↓, 1,   PUMA↓, 2,   Pyro↑, 1,   survivin↓, 19,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 3,   XIAP↓, 6,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 70,   p‑Akt↓, 10,   CIP2A↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   DDIT4↑, 1,   EGFR↓, 25,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   FGFR1↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 2,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 7,   JAK1↓, 3,   JAK2↓, 2,   JNK↓, 3,   JNK↑, 8,   p‑JNK↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 18,   MAPK↑, 8,   MAPK↝, 1,   p‑MAPK↓, 1,   MEK↓, 2,   Mst1↑, 1,   mTOR↓, 46,   p‑mTOR↓, 4,   mTORC2↓, 2,   p‑p70S6↓, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 60,   PI3K↑, 1,   PI3K↝, 1,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↑, 16,   Raf↓, 1,   e-Raf↓, 1,   RAS↓, 7,   RET↓, 1,   Sp1/3/4↓, 3,   STAT↓, 3,   STAT3↓, 32,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 5,   CBP↓, 1,   cJun↓, 5,   cMyc↓, 20,   p‑cMyc↑, 1,   DNMT1↓, 9,   DNMT3A↓, 4,   DNMTs↓, 5,   EZH2↓, 4,   FOXM1↓, 3,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↑, 1,   FOXO4↑, 1,   H3K9↓, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-330-5p↑, 1,   miR-340↓, 2,   miR-34a↓, 1,   miR-34a↑, 4,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 2,   Myc↓, 5,   MYCN↓, 1,   MYCN↑, 1,   OCT4↓, 6,   OLIG2↓, 1,   other↑, 2,   other↝, 5,   PCAF↓, 1,   SOX2↓, 6,   SOX4↓, 4,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 3,   TFE3↑, 1,   tumCV↓, 13,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 12,   eIF2α↓, 3,   eIF2α↑, 1,   ER Stress↑, 17,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 3,   IRE1↑, 3,   PERK↑, 2,   UPR↑, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 9,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   p62↓, 2,   p62↑, 1,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 5,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 29,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 17,   cl‑PARP↝, 1,   PCNA↓, 7,   SIRT6↓, 1,   Telomerase↓, 4,   TOP1↓, 2,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 5,   CDK1↑, 3,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 15,   CDK6↓, 5,   CDKN1C/p57↓, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 35,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 3,   Ki-67↓, 7,   P21↑, 26,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 2,   Securin↓, 2,   TumCCA↓, 4,   TumCCA↑, 59,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 6,   ALDH1A1↓, 4,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 7,   CD24↓, 2,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 45,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 3,   FGF↓, 1,   Gli1↓, 8,   HH↓, 7,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 7,   Let-7↓, 1,   Let-7↑, 2,   LRP6↓, 5,   p‑LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 9,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 16,   NOTCH⇅, 1,   NOTCH↝, 1,   NOTCH1↓, 9,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 5,   TAZ↓, 1,   TumCG↓, 29,   TumCP?, 1,   TumCP↓, 59,   Wnt?, 1,   Wnt↓, 165,   Wnt↑, 2,   Wnt↝, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   AGRN↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 12,   CCN2/CTGF↓, 2,   Chl↓, 1,   Chl↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 23,   EMT↓, 43,   FAK↓, 6,   FAK↑, 1,   FAK↝, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 5,   GLI3↑, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LEF1↓, 2,   MALAT1↓, 3,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 7,   MMP14↓, 1,   MMP16↓, 2,   MMP2↓, 39,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 42,   MMPs↓, 11,   N-cadherin↓, 15,   PAK1↓, 2,   PDGF↓, 4,   Rho↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   Slug↓, 7,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 19,   TET1↑, 2,   TGF-β↓, 10,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 2,   TIMP2↑, 3,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 29,   TumCMig↓, 31,   TumMeta↓, 26,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 5,   uPA↓, 16,   uPAR↓, 2,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 8,   Zeb1↑, 1,   β-catenin/ZEB1↓, 120,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   CCN1/CYR61↓, 1,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 14,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 1,   VEGF↓, 41,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   GLUT1↓, 4,   MMP↓, 30,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 15,   COX1↓, 2,   COX2/PTGS2↓, 38,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 9,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 3,   IL12↓, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↑, 4,   IL4↑, 1,   IL6↓, 16,   IL8↓, 2,   Imm↑, 8,   Imm↝, 1,   Inflam↓, 14,   IRAK1↓, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MIP2↓, 1,   NF-kB?, 1,   NF-kB↓, 77,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↑, 2,   p65↓, 3,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 14,   PSA↓, 5,   TCF↓, 5,   TCF↑, 1,   TCF7/TCF1↓, 3,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 12,   EstroRS/ERS↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 19,   BioAv↑, 13,   BioAv↝, 8,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 57,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose↑, 4,   Dose↝, 17,   eff↓, 8,   eff↑, 20,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 5,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 10,   P450↓, 3,   P450↝, 1,   RadioS↑, 20,   selectivity↑, 21,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 29,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALB↑, 1,   ALP↓, 1,   AR↓, 12,   ascitic↓, 1,   AST?, 1,   CEA↓, 1,   CRP↓, 1,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 25,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 5,   IBIL↓, 1,   IL6↓, 16,   IRes↓, 1,   KRAS↓, 1,   LDH↑, 1,   Myc↓, 5,   PD-L1↓, 5,   PSA↓, 5,   TBIL↓, 1,   TP53↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 20,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 5,   chemoP↑, 10,   chemoPv↑, 8,   ChemoSideEff↓, 2,   hepatoP↑, 2,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 6,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 6,   toxicity↓, 6,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 4,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 704

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 3,   Fenton↓, 1,   GPx↑, 1,   GPx4↑, 2,   GSH↑, 5,   GSTs↑, 3,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 9,   i-Iron↓, 1,   lipid-P↓, 4,   MDA↓, 5,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 16,   RNS↓, 1,   ROS?, 1,   ROS↓, 24,   ROS↑, 2,   SOD↑, 5,   SOD1↑, 2,   TAC↑, 1,   TBARS↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   glucose↓, 1,   GSK‐3β↓, 3,   LDL↓, 2,   NADPH↓, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   JAK2↑, 1,   JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   mTOR↑, 1,   PI3K↑, 2,   STAT↓, 2,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↝, 1,   RUNX2∅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   Diff↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   NOTCH↓, 1,   TumCP↓, 1,   Wnt↓, 3,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2?, 1,   Ca+2↑, 2,   Ca+2↝, 1,   COL1∅, 1,   FAK↑, 1,   MMP9↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   MUC19↓, 1,   MUC2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 3,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 3,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 6,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 24,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 10,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 5,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 9,   BioAv↝, 7,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   eff↑, 3,   eff↝, 1,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP∅, 1,   AST↓, 1,   BMD↑, 1,   CRP↓, 1,   IL6↓, 6,   IRes↑, 1,   LDH↑, 1,   OCN∅, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 4,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↑, 2,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 10,   Learn↑, 1,   memory↑, 7,   neuroP↑, 17,   OS↑, 1,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 10,   toxicity↝, 2,   toxicity∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 3,   Bacteria↓, 4,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 208

Scientific Paper Hit Count for: Wnt, Wingless-related integration site
16 Curcumin
12 salinomycin
11 Fisetin
8 Matrine
8 Resveratrol
7 Ivermectin
5 EGCG (Epigallocatechin Gallate)
5 Sulforaphane (mainly Broccoli)
4 Astragalus
4 Honokiol
4 HydroxyTyrosol
4 Luteolin
4 Lycopene
4 Nimbolide
3 Baicalein
3 Garcinol
3 Ginkgetin
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnetic Fields
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Deguelin
2 Diindolylmethane
2 Indole-3-carbinol
2 Dandelion Root
2 Hydrogen Gas
2 Isobavachalcone
2 isoorientin
2 Lemongrass Extract/Citral
2 Morin
2 Niclosamide (Niclocide)
2 Silymarin (Milk Thistle) silibinin
2 Urolithin
1 1,8-Cineole
1 Isovitexin
1 Chemotherapy
1 Artemisinin
1 Baicalin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Caffeic Acid Phenethyl Ester (CAPE)
1 chaetocin
1 Chrysin
1 Coenzyme Q10
1 Cucurbitacin
1 5-fluorouracil
1 Dipyridamole
1 Juglone
1 Licochalcone A
1 Magnetic Field Rotating
1 Melatonin
1 Zeolite
1 Naringin
1 Piperine
1 Parthenolide
1 Quercetin
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:377  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page