GSK‐3β Cancer Research Results

GSK‐3β, Glycogen synthase kinase (GSK)3β: Click to Expand ⟱
Source:
Type:
GSK3β is a crucial member of the Wnt/β-catenin-, hedgehog (Hh)-, notch- and c-myc-mediated major pro-oncogenic pathways, while also being a negative regulator of epithelial–mesenchymal transition (EMT). Accumulating evidence defines GSK3β as a potential therapeutic target in cancer, thus encouraging the development of GSK3β inhibitors for cancer treatment.
Glycogen synthase kinase 3 beta (GSK-3β) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Its expression and activity have been implicated in several types of cancer, often with varying prognostic implications.

In many cancers, decreased GSK-3β activity is associated with poor prognosis, while in others, increased activity may correlate with aggressive disease.


Scientific Papers found: Click to Expand⟱
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
8494- MAG,    Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *PSD95?, *SYN1↑, *SYT1↑, *IL10↑, *TNF-α↓, *IL6↓, *Aβ42↓, *GFAP↓, *other↑, *cognitive↑, *NeuroI↓, *Aβ↓, *GSK‐3β↓, *NF-kB↓,
8507- MAG,    Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*Dose?, *cognitive↑, *Aβ↓, *NeuroI↓, *neuroP↑, *tau↓, *GFAP↓, *AIF1/Iba-1↓, *GSK‐3β↑, *SYP↑, *BDNF↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
3728- MF,    Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *Apoptosis↓, *ROS↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
496- MF,    Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, ZR-75-1 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB/CCNB1↓, TumCCA↑, p‑Akt↓, TumCP↓, selectivity↑, eff↓,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
8471- Mg,    Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model
- in-vivo, AD, NA
*Learn?, *memory?, *p‑tau↓, *GSK‐3β↑, *Akt↑, *PI3K↑, *cognitive↑,
9078- MGF,    Mangiferin Alleviates Formaldehyde-Induced Tau Hyperphosphorylation and Cognitive Impairment in Mice via the PI3K/AKT/GSK3β Pathway: Insights From Network Pharmacology and Experimental Validation
- in-vivo, AD, NA
*memory↑, *cognitive↑, *Apoptosis↓, *p‑tau↓, *PI3K↑, *Akt↑, *GSK‐3β↓,
9085- MGF,    The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
- vitro+vivo, AD, HT22
*p‑tau↓, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *GSK‐3β↓, *CaMKII ↓, *Ca+2↓, *ROS↓, *mtDam↓, *Dose↝, *Learn↑, *memory↑, *neuroP↑, *cognitive↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8916- MO,  AgNPs,  M-Blu,    Synergistic Neuroprotection in Tauopathic Mice via Green-Synthesized Silver Nanoparticles Co-delivering Methylene Blue and Moringa oleifera
- in-vivo, AD, NA
*Dose↝, *GSK‐3β↓, *motorD↑, *cognitive↑, *TNF-α↓, *IL6↓, *LC3B↑, *SOD↑, *neuroP↑, *p‑tau↓, *p‑Akt↑,
8869- MOR,    Morin attenuates tau hyperphosphorylation by inhibiting GSK3β
- vitro+vivo, AD, NA
*GSK‐3β↓, *p‑tau↓, *neuroP↑, *Aβ↓,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27/CDKN1B↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
2033- PB,    Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*p‑tau↓, *GSK‐3β↓, *ac‑Histones↑, *neuroP↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *Aβ↓, *p‑tau↓, *autophagy↓, *GSK‐3β↓, *NeuroI↓, *iNOS↓, *COX2/PTGS2↓, *BDNF↑, *MEF2D↑, *cognitive↑, *memory↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
62- QC,  GoldNP,    Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
EGFR↓, PI3k/Akt/mTOR↓, GSK‐3β↓, TumCP↓, Apoptosis↑, tumCV↓, mTOR↓, PTEN↑,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
7826- QC,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*Stroke↓, *Inflam↓, *AGEs↓, *cognitive↑, *memory↑, *Dose↝, *neuroP↑, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3066- RES,    Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells
- in-vitro, Ovarian, NA
GSK‐3β↑, Akt↓, CHOP/DDIT3↑, ER Stress↑, PERK↑, ATF6↑, UPR↑, GlucoseCon↓,
4666- RES,    Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway
- in-vitro, Lung, H23 - in-vitro, Lung, H292 - in-vitro, Lung, A549
CSCs↓, eff↑, Akt↓, GSK‐3β↑, SOX2↓, cMyc↓, TumCCA↑, ROS↑, Apoptosis↑,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
3792- RosA,    Molecular docking and dynamics simulations revealed the potential inhibitory activity of honey-iQfood ingredients against GSK-3β and CDK5 protein targets for brain health
- Analysis, AD, NA
*CDK5↓, *GSK‐3β↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
6055- SeNPs,  CUR,  RES,    Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems
- Review, AD, NA
*DDS↑, *Dose↝, *p‑Akt↑, *GSK‐3β↓, *NF-kB↓, *BBB↑, *AChE↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, EP2↓, EP4/PTGER4↓,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, Var, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,

Showing Research Papers: 101 to 150 of 155
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 155

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 3,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 10,   GSH↑, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 4,   hyperG↓, 1,   c-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 2,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 9,   Prx4↑, 1,   ROS↓, 4,   ROS↑, 43,   ROS⇅, 4,   mt-ROS↑, 1,   SOD↓, 4,   Trx1↓, 1,   TrxR↓, 2,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 3,   EGF↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 3,   SIRT3↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 2,   ALDOB↑, 1,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 3,   ECAR↓, 1,   ENO3↑, 1,   FASN↓, 2,   FBP1↑, 1,   FFA/NEFA↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 4,   GSK‐3β↓, 37,   GSK‐3β↑, 26,   GSK‐3β↝, 3,   p‑GSK‐3β↓, 20,   p‑GSK‐3β↑, 3,   HK2↓, 6,   HK3↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 3,   LDHA↓, 2,   NADPH↓, 1,   PCK1↓, 1,   PCK1↑, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 43,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 1,   BAX↓, 1,   BAX↑, 23,   Bax:Bcl2↑, 9,   Bcl-2↓, 23,   Bcl-2↑, 2,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 6,   BID↓, 1,   BID↑, 2,   BIM↑, 3,   BOK↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp3↑, 26,   cl‑Casp3↑, 8,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 9,   cl‑Casp8↑, 4,   Casp9↑, 17,   p‑Casp9↑, 1,   cl‑Casp9↑, 4,   Cyt‑c↑, 20,   mt-Cyt‑c↓, 1,   Diablo↑, 2,   DR5↑, 6,   FADD↑, 1,   Fas↓, 2,   Fas↑, 5,   FasL↓, 1,   FasL↑, 1,   Ferroptosis↑, 2,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 6,   Mcl-1↓, 6,   MDM2↓, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   necrosis↑, 1,   p38↑, 3,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 18,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 1,   XIAP↓, 5,   XIAP↑, 1,   YAP/TEAD↓, 1,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 47,   Akt↑, 3,   p‑Akt↓, 20,   AKT1↓, 2,   AMPKα↓, 1,   AMPKα↑, 1,   CK2↓, 4,   cMET↓, 2,   EGFR↓, 8,   ERK↓, 11,   p‑ERK↓, 2,   p‑ERK↑, 1,   HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   ILK↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 5,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 2,   MAPK↝, 1,   MKK4↓, 1,   mTOR↓, 20,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   P70S6K↓, 2,   PDE3B↓, 1,   PHKG1↑, 1,   PI3K↓, 33,   PI3K↑, 4,   p‑PI3K↓, 3,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 1,   PRAS40↓, 1,   PTEN↑, 7,   p‑PTEN↓, 1,   RAS↓, 4,   Rictor↓, 1,   Sp1/3/4↓, 3,   STAT3↓, 15,   p‑STAT3↓, 3,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 1,   ATF4↝, 1,   cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 15,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3B↓, 1,   DNMTs↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 3,   FOXO3↑, 2,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H3K9↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 1,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HES1↓, 1,   HMTs↓, 1,   KLF2↓, 1,   KLF4↓, 1,   KLF5↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-21↓, 2,   miR-34a↑, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 4,   other↓, 1,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 6,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   HSPs↓, 1,   PERK↑, 2,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↑, 4,   LC3s↑, 1,   p62↓, 3,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DFF45↑, 1,   DNAdam↑, 11,   DNArepair↓, 1,   hTERT/TERT↓, 2,   MGMT↓, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 2,   P53↑, 18,   p‑P53↑, 3,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 17,   proPARP↓, 1,   PARP1↑, 1,   PCNA↓, 7,   SIRT6↓, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 1,   p‑CDK1↓, 2,   CDK2↓, 8,   CDK4↓, 11,   CDK4↑, 2,   CDK6↓, 3,   CDK6↑, 2,   CHK1↑, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 10,   cycD1/CCND1↓, 23,   cycE/CCNE↓, 3,   cycE1↓, 1,   E2Fs↓, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↑, 17,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 7,   p‑pRB↓, 1,   p‑RB1↓, 2,   TumCCA↑, 39,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 2,   Axin2↑, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CSCs?, 1,   CSCs↓, 9,   EIF4E↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 1,   Gli↓, 1,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 2,   IGFBP3↑, 1,   JAG1↓, 1,   Ki-67↓, 3,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 3,   NICD↓, 1,   NOTCH↓, 3,   NOTCH1↓, 5,   PTCH1↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 13,   TumCP↓, 31,   TumCP↑, 1,   Wnt↓, 21,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   APC↑, 1,   BACH1↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   cal2↑, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 12,   EMT↓, 19,   EMT↑, 1,   EMT↝, 1,   FAK↓, 5,   p‑FAK↑, 1,   fascin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 2,   MMP13↓, 1,   MMP2↓, 16,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 17,   MMPs↓, 12,   N-cadherin↓, 10,   N-cadherin↑, 1,   pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 5,   Snail↓, 12,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP1↑, 2,   TIMP2↑, 2,   TSP-1↑, 1,   TumCI↓, 14,   TumCMig↓, 13,   TumMeta↓, 15,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 3,   Vim↓, 14,   Zeb1↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 36,   p‑β-catenin/ZEB1↓, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   angioG↑, 1,   CD31/PECAM-1↓, 2,   eNOS↓, 1,   Hif1a↓, 12,   VEGF↓, 25,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN2↓, 1,   MMP↓, 16,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 2,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 3,   IL6↓, 6,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 5,   NF-kB?, 1,   NF-kB↓, 33,   NF-kB↑, 1,   p‑NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 1,   p50↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 2,   PSA↓, 3,   RAGE↓, 1,   TCF7/TCF1↓, 1,   TLR4↓, 2,   TNF-α↓, 7,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 6,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 32,   ChemoSen⇅, 1,   CompStab↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 2,   Dose↝, 9,   Dose∅, 3,   eff↓, 6,   eff↑, 25,   eff↝, 1,   eff∅, 2,   Half-Life↓, 2,   Half-Life↝, 2,   MDR1↓, 3,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 7,   P450↓, 1,   RadioS↑, 6,   selectivity↑, 14,   Synergy↑, 18,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 7,   AST↓, 2,   BG↓, 1,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 8,   ERα/ESR1↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 6,   KRAS↓, 1,   Myc↓, 2,   PD-L1↓, 2,   PSA↓, 3,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiD↑, 1,   AntiTum↑, 2,   cachexia↓, 2,   cardioP↑, 3,   chemoP↑, 7,   chemoPv↑, 8,   ChemoSideEff↓, 2,   hepatoP↑, 4,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 3,   Pin1↓, 1,   QoL↑, 2,   RenoP↑, 3,   Risk↓, 2,   toxicity↓, 2,   toxicity↝, 2,   TumVol↓, 6,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 554

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↑, 31,   ARE↑, 1,   Catalase↑, 20,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 20,   GPx4↑, 1,   GSH↑, 17,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 4,   H2O2↓, 4,   HDL↓, 1,   HO-1↓, 1,   HO-1↑, 27,   Keap1↓, 2,   Keap1↝, 1,   lipid-P↓, 16,   mt-lipid-P↓, 1,   MDA↓, 22,   MPO↓, 4,   NQO1↑, 6,   NQO1↝, 1,   Nrf1↑, 2,   NRF2↑, 39,   ROS?, 1,   ROS↓, 61,   ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↑, 32,   mt-SOD↑, 1,   SOD1↑, 1,   TAC↑, 2,   TBARS↓, 2,   Trx1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   p‑DRP1/DNM1L↝, 1,   Insulin↑, 1,   MFN1↝, 1,   MFN2↑, 1,   MFN2↝, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 4,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 5,   AMPK↑, 10,   p‑AMPK↑, 1,   ATP↑, 7,   cytoP450↓, 1,   glucose↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 55,   GSK‐3β↑, 9,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 8,   ac‑Histones↑, 1,   LDL↓, 2,   NADH:NAD↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 7,   ASC↓, 1,   BAX↓, 4,   Bax:Bcl2↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 5,   Bcl-2∅, 1,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 14,   cl‑Casp3↓, 2,   Casp9↓, 4,   Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   iNOS↓, 8,   p38↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 12,   p‑Akt↑, 8,   CaMKII ↓, 2,   CREB↑, 1,   p‑CREB↑, 3,   ERK↓, 4,   ERK↑, 1,   p‑ERK↑, 1,   IκB?, 1,   IκB↑, 1,   JNK↓, 3,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 7,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 2,   PI3K↑, 9,   p‑PI3K↑, 1,   PKCδ↓, 1,   PP2A↑, 4,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   MEF2D↑, 1,   other↑, 2,   other↝, 2,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↑, 2,   LC3B↑, 1,   LC3II↑, 2,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 6,   Ki-67↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   Ki-67↑, 2,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   BACH1↓, 1,   Ca+2↓, 4,   MMP13↓, 2,   MMP3↓, 3,   MMP9↓, 3,   p‑T-cadherin↓, 2,   TXNIP↓, 1,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   Hif1a↓, 2,   NO↓, 5,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 15,   BBB↝, 2,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   MMP↑, 7,   MMP∅, 1,   MPT↑, 1,   MUC19↓, 1,   MUC2↓, 1,   OCLN↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 20,   COX2/PTGS2↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 2,   Imm↑, 4,   INF-γ↓, 1,   INF-γ↑, 1,   Inflam↓, 45,   Inflam↑, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 8,   NF-kB↓, 28,   p‑NF-kB↓, 1,   NLRP3↓, 6,   p65↓, 1,   PGE2↓, 9,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 7,   TNF-α↓, 29,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   Ach↑, 2,   AChE↓, 24,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 13,   BDNF⇅, 1,   ChAT↑, 3,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 1,   NGF↑, 3,   PSD95?, 1,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 1,   SYN1↑, 1,   SYP↑, 2,   SYT1↑, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 3,   Aβ↓, 25,   Aβ42↓, 2,   BACE/β-secretase↓, 13,   PSEN1/PS1↓, 1,   QPCT/QC↓, 1,   tau↓, 12,   p‑tau↓, 27,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   Estro↓, 1,   GR↑, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 7,   BioEnh↑, 1,   CompStab↑, 1,   DDS↑, 1,   Dose?, 1,   Dose↝, 11,   eff↓, 1,   eff↑, 7,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   P450↓, 1,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 2,   AST↓, 7,   BloodF↑, 1,   BP↓, 3,   colonLen↑, 1,   IL6↓, 19,   IRes↝, 1,   LDH↓, 2,   RAGE↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 7,   AntiArt↑, 2,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 13,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 35,   fatigue↓, 1,   hepatoP↑, 13,   Learn?, 1,   Learn↑, 7,   memory?, 1,   memory↑, 36,   Mood↑, 1,   motorD↑, 5,   neuroP↑, 57,   Obesity↓, 8,   OS↑, 2,   Pain↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 5,   Sleep↑, 2,   Stress↓, 1,   Stroke↓, 7,   toxicity↓, 15,   toxicity↝, 1,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 2,   AntiViral↑, 5,   Bacteria↓, 6,   GutMicro↑, 8,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 337

Scientific Paper Hit Count for: GSK‐3β, Glycogen synthase kinase (GSK)3β
13 Curcumin
9 Resveratrol
8 isoorientin
6 Luteolin
6 Thymoquinone
5 Apigenin (mainly Parsley)
5 Quercetin
4 Mung Bean Sprouts
4 Isoliquiritigenin
3 Baicalein
3 Bacopa monnieri
3 Caffeic acid
3 Chlorogenic acid
3 Formononetin
3 Hyperoside
3 Magnetic Fields
3 Nimbolide
3 Propolis -bee glue
2 1,8-Cineole
2 Astragalus
2 Astaxanthin
2 Berberine
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chrysin
2 Protocatechuic acid
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Ginkgetin
2 Honokiol
2 Juglone
2 Lycopene
2 Magnolol
2 Matrine
2 Mangiferin
2 Morin
2 salinomycin
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 5-fluorouracil
1 Biochanin A
1 Benzyl isothiocyanate
1 Brucea javanica
1 Boswellia (frankincense)
1 Carvacrol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Cinnamon
1 Crocetin
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ginkgo biloba-EGb 761
1 Emodin
1 Flaxseed/Linseed
1 Hydroxycinnamic-acid
1 Indole-3-carbinol
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 Ivermectin
1 Kaempferol
1 lambertianic acid
1 Licorice
1 Lactoferrin/Talactoferrin
1 Magnesium
1 Melatonin
1 Moringa oleifera
1 Silver-NanoParticles
1 Methylene blue
1 doxorubicin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 L-Theanine
1 Naringin
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Plumbagin
1 Gold NanoParticles
1 Arctigenin
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 Selenium NanoParticles
1 Shikonin
1 Vanillic Acid
1 Vitamin B1/Thiamine
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:385  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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