Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, Var, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27/CDKN1B↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
1525- Ba,  almon,    Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway
- in-vitro, Lung, H1975 - in-vivo, Lung, NA
Synergy↑, TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, ROS↑, eff↓,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2477- Ba,    Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells
- in-vitro, CRC, T24/HTB-9
TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
2473- BA,    Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H460
EMT↓, PDK1 / PDPK1↓, Akt↓, TumCMig↓, E-cadherin↑, Vim↓,
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
2620- Ba,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, GC, NA
Hif1a↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, p‑Akt↓, PTEN↑, GlucoseCon↓, lactateProd↓, Glycolysis↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2295- Ba,  5-FU,    Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway
- in-vitro, GC, AGS
ChemoSen↑, HK2↓, LDHA↓, PDK1 / PDPK1↓, Akt↓, PTEN↑, Hif1a↓, Glycolysis↓, ROS↑, CHOP/DDIT3↑,
2298- Ba,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCG↓, TumCP↓, Hif1a↓, VEGF↓, ChemoSen↑, Glycolysis↓, HK2↓, PDK1 / PDPK1↓, LDHA↓, p‑Akt↓, PTEN↑,
5540- BBM,    Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCI↓, PI3K↓, Akt↓, MDM2↓, TumCP↓, TumMeta↓,
5549- BBM,    Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells
- in-vitro, GBM, NA
eff?, tumCV↓, TumCG↓, ROS↑, P53↑, CSCs↓, CD133↓, ALDH1A1↓, Nanog↓, SOX2↓, OCT4↓, CDK1↓, CaMKII ↓, STAT3↓, Akt↓, ERK↓,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, Var, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, Synergy↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2/PTGS2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, Var, NA
TumCCA↑, TP53↑, COX2/PTGS2↓, Bax:Bcl2↑, ROS↑, VEGFR2/KDR/Flk1↓, Akt↓, ERK↓, MMP2↓, MMP9↓, IL8↑, P21↑, p27/CDKN1B↑, E-cadherin↓, Fibronectin↓, cMyc↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
TumCG↓, Apoptosis↑, LC3B↑, ROS↑, PI3K↓, Akt↓, mTOR↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2707- BBR,    Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
GLUT1↓, Akt↓, mTOR↓, ATP↓, GlucoseCon↓, TumCP↓, Warburg↓, selectivity↑, TumCCA↑, Glycolysis↓,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
*Inflam↓, *antiOx↑, *Ca+2↓, *BioAv↓, *BioAv↑, *BioAv↑, *angioG↑, *MAPK↓, *AMPK↓, *NF-kB↓, VEGF↓, PI3K↓, Akt↓, MMP2↓, Bcl-2↓, ERK↓,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1102- BBR,    Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells
- in-vitro, Melanoma, B16-BL6
TumCMig↓, TumCI↓, EMT↓, p‑PI3K↓, p‑Akt↓, RARα↓, RARβ↑, RARγ↑, E-cadherin↑, N-cadherin↓,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3681- BBR,    The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology
- in-vivo, AD, NA
*memory↑, *cognitive↑, MAPK↑, *Akt↑, *PI3K↑, *TP53↑, *Jun↓, *HSP90↑, *neuroP↑, *Inflam↓, *antiOx↑, *p16↓, *ER Stress↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1/ATG6↑,
5181- BBR,  Cisplatin,    Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
tumCV↓, MDR1↓, ChemoSen↑, PI3K↓, Akt↓, mTOR↓,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
6514- BCP,    Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
- in-vitro, BC, NA
TumCP↓, CB2 / CNR2↓, STAT3↓, mTOR↓, Akt↓, Hypoxia↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
- in-vitro, Var, NA
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6498- BCP,    β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, 5637
tumCV↓, ROS↑, Apoptosis↑, MMP↓, TumCMig↓, STAT3↓, mTOR↓, Akt↓,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
6504- BCP,    β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer Cells
- in-vitro, CRC, CT26 - in-vitro, CRC, HCT116
RadioS↑, TumCCA↑, γH2AX↑, DNAdam↑, p‑Akt↓, cycD1/CCND1↓, PPARγ↑, Bax:Bcl2↑, Casp3↑, Apoptosis↑,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
2757- BetA,    Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
- in-vitro, GBM, U251
tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2753- BetA,    Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells
- in-vitro, Cerv, HeLa
PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27/CDKN1B↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, Synergy↑,
5729- BF,    Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling
- in-vitro, Lung, NA
TumCCA↑, Apoptosis↑, TumCG↓, EGFR↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓,
5728- BF,    Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2/PTGS2↝, p‑VEGFR2/KDR/Flk1↓, EGFR↓, Akt↓, NF-kB↓, p44↓,

Showing Research Papers: 101 to 150 of 978
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 978

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 2,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 13,   antiOx⇅, 2,   ARE↓, 1,   Catalase↓, 15,   Catalase↑, 5,   Copper↓, 1,   Fenton↑, 4,   frataxin↑, 1,   GPx↓, 5,   GPx↑, 4,   GPx1↓, 1,   GPx4↓, 10,   GSH↓, 40,   GSH↑, 10,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 2,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 3,   H2O2↑, 2,   HO-1↓, 13,   HO-1↑, 28,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 7,   Iron↝, 1,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 8,   lipid-P↑, 19,   MDA↓, 3,   MDA↑, 14,   MPO↓, 1,   NADH↓, 2,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 4,   NRF2↓, 29,   NRF2↑, 27,   NRF2↝, 4,   p‑NRF2↓, 1,   OSI↑, 1,   PAO↑, 1,   Prx↓, 1,   Prx4↑, 1,   PYCR1↓, 2,   RNS↑, 2,   ROS?, 1,   ROS↓, 43,   ROS↑, 342,   ROS⇅, 9,   ROS↝, 4,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   mt-SOD↑, 1,   SOD1↓, 3,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 4,   TAC↓, 3,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR1↓, 4,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 3,   IronCh∅, 1,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 9,   CDC2↑, 1,   p‑CDC2↓, 1,   CDC25↓, 13,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   CS↓, 1,   EGF↓, 10,   EGF↑, 1,   ETC↓, 5,   HSP60/HSPD1↓, 2,   Insulin↓, 3,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 31,   OCR↓, 8,   OCR↑, 3,   OXPHOS↓, 5,   OXPHOS↑, 3,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PDH↓, 3,   PDH↑, 3,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 2,   SIRT3↓, 3,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 5,   5LO↓, 7,   AApath↓, 1,   ACADS/SCAD↓, 1,   ACC↓, 2,   ACC↑, 4,   p‑ACC↑, 2,   Acetyl-CoA↓, 1,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 6,   ALDOA↓, 1,   AMPK?, 1,   AMPK↓, 4,   AMPK↑, 43,   p‑AMPK↑, 4,   ATGL/PNPLA2↓, 1,   ATP↓, 44,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   i-Cer↑, 1,   CholSyn↓, 1,   DHODH↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ECAR∅, 1,   ENO1↓, 3,   p‑ENO1↓, 1,   FABP4↓, 1,   FABP4↑, 1,   FABP5/E-FABP↓, 1,   FASN↓, 11,   FASN↑, 1,   FBPase↑, 1,   FFA/NEFA↓, 1,   G6PD↓, 2,   GAPDH↓, 3,   GLO-I↓, 2,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↓, 25,   GlucoseCon↑, 2,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 70,   Glycolysis↑, 1,   p‑GS3Kβ↓, 1,   GSK‐3β↓, 26,   GSK‐3β↑, 15,   GSK‐3β↝, 2,   p‑GSK‐3β↓, 14,   p‑GSK‐3β↑, 3,   H2S↑, 1,   HK1↓, 1,   HK2?, 1,   HK2↓, 39,   HK2↑, 1,   HMG-CoA↓, 1,   HSD17B4↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 25,   lactateProd↑, 3,   LDHA↓, 18,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 4,   NADPH↑, 3,   O-Glc↓, 1,   PA↑, 1,   p‑PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 20,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 4,   PFK1↓, 5,   PFK2↓, 2,   PFKP↓, 1,   PIP3↑, 1,   PKM2↓, 27,   PKM2↑, 1,   PKM2:PKM1↓, 1,   polyA↓, 1,   Pyruv↓, 2,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 3,   SCD1↓, 3,   SIRT1↓, 8,   SIRT1↑, 10,   SIRT2↓, 2,   SREBF2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   SSAT↑, 1,   TCA↓, 4,   TCA↑, 2,   TS↓, 3,   Warburg↓, 15,  

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1,   AIF↑, 13,   APAF1↑, 13,   Apoptosis?, 5,   Apoptosis↓, 7,   Apoptosis↑, 384,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 7,   BAD↑, 27,   p‑BAD↓, 2,   Bak↓, 1,   Bak↑, 15,   BAX↓, 5,   BAX↑, 200,   BAX↝, 4,   Bax:Bcl2↑, 52,   Bcl-2↓, 222,   Bcl-2↑, 6,   Bcl-2↝, 3,   Bcl-2∅, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 52,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 13,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 13,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 2,   Casp↑, 50,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 4,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 3,   Casp3↓, 4,   Casp3↑, 227,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 58,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   proCasp3↑, 5,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 19,   cl‑Casp7↑, 6,   Casp8↓, 3,   Casp8↑, 52,   Casp8∅, 2,   cl‑Casp8↑, 9,   proCasp8↑, 3,   pro‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 127,   p‑Casp9↑, 1,   cl‑Casp9↑, 24,   proCasp9↓, 1,   proCasp9↑, 3,   cFLIP↓, 9,   Cyt‑c↓, 1,   Cyt‑c↑, 133,   Cyt‑c↝, 2,   Diablo↑, 12,   DR5↓, 1,   DR5↑, 43,   Endon↑, 1,   FADD↑, 7,   Fap1↓, 1,   Fas↓, 3,   Fas↑, 28,   FasL↓, 1,   FasL↑, 10,   FasL⇅, 1,   Ferroptosis↑, 19,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDMD↑, 1,   GSDME↑, 2,   HEY1↓, 2,   IAP1↓, 14,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 19,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 46,   p‑Mcl-1↓, 1,   MDM2↓, 17,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 2,   MOMP↑, 2,   NAIP↓, 2,   Necroptosis↑, 5,   necrosis↑, 4,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 14,   p38↑, 33,   p‑p38↓, 3,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↓, 2,   PUMA↑, 6,   Pyro↑, 8,   RIP1↓, 3,   RIP1↑, 1,   p‑RIP1↑, 1,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 78,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD↑, 29,   XIAP↓, 46,   XIAP↑, 2,   YAP/TEAD↓, 9,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 2,   Akt↓, 641,   Akt↑, 29,   Akt↝, 4,   Akt∅, 1,   p‑Akt↓, 232,   p‑Akt↑, 9,   AKT1↓, 3,   Akt2↓, 2,   AMPKα↑, 3,   CaMKII ↓, 3,   CaMKII ↑, 1,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 7,   cMET↓, 9,   p‑cMET↑, 2,   CREB↓, 1,   cSrc↓, 4,   DDIT4?, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 71,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 9,   ERK↓, 113,   ERK↑, 14,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 39,   p‑ERK↑, 10,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 24,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 2,   Hippo↑, 1,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 15,   IGF-1R↑, 1,   p‑IGF-1R↓, 1,   IGF-2R↑, 2,   IGFR↓, 3,   p‑IGFR↓, 1,   IKKα↓, 7,   IKKα↑, 2,   p‑IKKα↓, 3,   ILK↓, 1,   IP6K1↓, 1,   IκB↓, 3,   IκB↑, 2,   p‑IκB↓, 4,   JAK↓, 12,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 17,   JNK↓, 11,   JNK↑, 35,   JNK↝, 2,   p‑JNK↓, 6,   p‑JNK↑, 7,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 70,   MAPK↑, 22,   MAPK↝, 3,   p‑MAPK↓, 2,   p‑MAPK↑, 3,   MARK4↓, 1,   MEK↓, 14,   p‑MEK↓, 1,   MKK4↓, 2,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 243,   mTOR↑, 4,   mTOR⇅, 1,   mTOR↝, 3,   mTOR∅, 1,   p‑mTOR↓, 50,   mTORC2↓, 5,   mTORC2↑, 2,   p‑p42↓, 1,   p70S6↓, 5,   p70S6↑, 1,   p‑p70S6↓, 3,   p‑p70S6↑, 1,   P70S6K↓, 15,   P70S6K↑, 1,   p‑P70S6K↓, 7,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K?, 1,   PI3K↓, 381,   PI3K↑, 13,   PI3K↝, 5,   p‑PI3K↓, 45,   PI3K/Akt↓, 5,   PI3k/Akt/mTOR↓, 3,   PIAS-3↑, 1,   PIK3CA↓, 2,   p‑PIK3R1↓, 1,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 15,   PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 6,   PTEN↑, 59,   PTEN↝, 1,   p‑PTEN↓, 2,   Raf↓, 12,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 20,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   RPS6KA1↓, 1,   S6K↓, 1,   p‑S6K↓, 3,   SHP1↑, 2,   Sp1/3/4↓, 16,   Src↓, 6,   Src↑, 1,   p‑Src↓, 1,   STAT↓, 11,   p‑STAT↓, 1,   STAT3↓, 113,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 3,   STAT5↓, 2,   STAT6↓, 4,   p‑STAT6↓, 1,   STK11/LKB1↑, 2,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 5,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 4,   ATF4↓, 1,   ATF4↑, 11,   ATF4↝, 1,   CBP↓, 3,   ChrMod↑, 1,   cJun↓, 10,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 56,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 6,   EZH2↓, 9,   FOXM1↓, 10,   FOXO↑, 3,   FOXO1↓, 3,   FOXO1↑, 5,   FOXO3↓, 7,   FOXO3↑, 10,   FOXO3↝, 1,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 2,   H3↓, 3,   H3↑, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H3K4↓, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 7,   HATs↑, 1,   HDAC↓, 21,   HDAC∅, 1,   HDAC1↓, 7,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 5,   HDAC4↓, 2,   HDAC8↓, 5,   HES1↓, 3,   JPT1/HN1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-125b↝, 1,   miR-126↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 1,   miR-205↑, 1,   miR-206↑, 1,   miR-21↓, 9,   miR-21↑, 1,   miR-210↓, 1,   miR-218↑, 1,   miR-224↓, 2,   miR-27a-3p↓, 1,   miR-29b↑, 2,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↓, 3,   miR-34a↑, 8,   miR-34b-5p↑, 1,   miR-375↝, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-429↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 7,   MYCN↓, 1,   n-MYC↓, 2,   NR1D2↓, 1,   OCT4↓, 16,   other?, 1,   other↓, 6,   other↑, 2,   other↝, 15,   PCAF↓, 2,   PhotoS↑, 1,   SOX2↓, 16,   SOX4↓, 4,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TCF-4↓, 2,   TFAP2A↓, 1,   TFE3↑, 2,   TLE1↓, 1,   tumCV?, 3,   tumCV↓, 103,   tumCV↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 30,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 3,   eIF2α↑, 8,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 60,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 7,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 9,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSP90↓, 30,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 9,   p‑PERK↑, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 13,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 5,   ATG5↑, 11,   ATG7↑, 4,   Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 31,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↑, 6,   LC3I↓, 1,   LC3II↓, 3,   LC3II↑, 25,   LC3s↑, 2,   MitoP↑, 1,   p62↓, 14,   p62↑, 7,   PARK2↑, 2,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto?, 1,   TumAuto↓, 3,   TumAuto↑, 97,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↓, 2,   DNAdam↑, 87,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC3↑, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   MGMT↓, 1,   p16↑, 4,   P53?, 1,   P53↓, 6,   P53↑, 136,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 7,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   p73↑, 2,   PARP↓, 8,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↑, 116,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 43,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 2,   Telomerase↓, 14,   TOP1?, 1,   TOP1↓, 5,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 5,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 13,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 26,   CDK1↑, 2,   p‑CDK1↓, 2,   CDK1/2/5/9↓, 1,   CDK2↓, 51,   CDK2↑, 4,   CDK4↓, 62,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 26,   CDK6↑, 4,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CHK1↓, 4,   p‑CHK1↑, 2,   Chk2↓, 3,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 37,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 122,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 28,   cycE/CCNE↑, 1,   cycE1↓, 2,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 50,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   p19↑, 2,   P21↓, 8,   P21↑, 93,   P21↝, 2,   p27/CDKN1B↓, 8,   p27/CDKN1B↑, 49,   PLK1↓, 1,   pRB↓, 4,   pRB↑, 1,   p‑pRB↓, 6,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 3,   TAp63α↑, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 307,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 5,   ALDH↓, 8,   ALDH1A1↓, 5,   AXIN1↑, 2,   Axin2↑, 1,   BMP2↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 3,   CD133↓, 11,   CD133↑, 1,   CD24↓, 2,   CD34↓, 2,   cFos↓, 11,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 51,   CSCs↑, 1,   Diff↓, 2,   Diff↑, 5,   EIF4E↓, 2,   EP2↓, 1,   EP4/PTGER4↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 8,   HH↓, 10,   HMGCR↓, 1,   IGF-1↓, 21,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 3,   IGFBP7↑, 1,   JAG1↓, 1,   Jun↓, 1,   p‑Jun↓, 1,   p‑Jun↑, 1,   Ki-67↓, 50,   Let-7↓, 1,   Let-7↑, 3,   mTORC1↓, 14,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 24,   NOTCH↑, 1,   NOTCH1↓, 22,   NOTCH1↑, 3,   NOTCH3↓, 3,   OGFr↑, 1,   p300↓, 4,   Piezo1↑, 1,   PTCH1↓, 1,   SCF↓, 2,   Shh↓, 10,   Smo↓, 4,   STAT1↓, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 146,   TumCG↑, 5,   TumCP?, 2,   TumCP↓, 295,   TumCP↑, 5,   tyrosinase↓, 2,   WDR72↓, 1,   Wnt?, 1,   Wnt↓, 73,   Wnt↑, 2,   Wnt↝, 1,   Wnt/(β-catenin)↓, 8,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 21,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 4,   CA↓, 3,   Ca+2↓, 6,   Ca+2↑, 34,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Chl↓, 1,   Chl↑, 1,   Cofilin↓, 2,   p‑Cofilin↑, 2,   COL1↓, 2,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 67,   EM↑, 1,   EMT↓, 133,   EMT↑, 4,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 27,   FAK↑, 1,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 6,   Furin↓, 2,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA2↓, 1,   ITGA5↓, 3,   ITGA6↓, 1,   ITGB1↓, 7,   ITGB1↑, 1,   ITGB3↓, 4,   ITGB4↓, 2,   ITGB6↓, 1,   KRAS↓, 2,   LAMs↓, 2,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 4,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 3,   MMP17↓, 1,   MMP2↓, 141,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 13,   MMP7↓, 14,   MMP9↓, 160,   MMP9↑, 2,   MMPs↓, 44,   MTA1↓, 2,   MUC1↑, 1,   MUC4↓, 2,   N-cadherin↓, 52,   N-cadherin↑, 1,   NCAM↑, 1,   NEDD9↓, 3,   p44↓, 1,   p‑p44↓, 2,   PAK1↓, 5,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 6,   Rac1↓, 4,   RECK↑, 1,   Rho↓, 4,   Rho↑, 2,   Rho↝, 1,   ROCK1↓, 5,   ROCK1↑, 1,   SDC1↑, 1,   Sharpin↓, 2,   Slug?, 1,   Slug↓, 25,   Smad1↓, 2,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   p‑SMAD3↓, 1,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 46,   Snail↑, 1,   STAC2↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 22,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 15,   TIMP2↓, 4,   TIMP2↑, 9,   TRIB3↑, 3,   TSC1↑, 2,   TSP-1↑, 3,   TumCA↓, 5,   TumCA↑, 1,   TumCI↓, 158,   TumCI↑, 3,   TumCMig↓, 158,   TumCMig↑, 4,   TumMeta↓, 117,   TumMeta↑, 6,   TumPF↓, 1,   Twist↓, 32,   Twist↑, 1,   Tyro3↓, 2,   uPA↓, 27,   uPAR↓, 3,   Vim?, 1,   Vim↓, 59,   Vim↑, 3,   vinculin↓, 1,   Zeb1↓, 18,   Zeb1↑, 1,   ZEB2↓, 2,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 2,   α-tubulin↑, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 90,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 148,   angioG↑, 4,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   EGR1↑, 2,   Endoglin↑, 2,   eNOS↓, 4,   HIF-1↓, 14,   Hif1a↓, 106,   Hif1a↑, 3,   Hif1a↝, 1,   Hypoxia↓, 2,   LOX1↓, 1,   NO↓, 5,   NO↑, 4,   NO↝, 1,   PGI2↓, 1,   VCAM-1↓, 4,   VEGF↓, 162,   VEGF↑, 3,   VEGF↝, 1,   VEGFR1↓, 6,   VEGFR2/KDR/Flk1↓, 29,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↓, 1,   BBB↑, 8,   BBB∅, 2,   CellMemb↑, 1,   CLDN1↓, 5,   CLDN2↓, 2,   CTR1↑, 1,   CX43/GJA1↓, 1,   EPR↑, 4,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT2↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 161,   MMP↑, 4,   MPT↑, 8,   NHE1↓, 1,   TRPM7↓, 5,   TRPM7↑, 1,   TRPV1↑, 2,   TRPV1↝, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,   CB2 / CNR2↑, 2,   CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD44↓, 16,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 5,   COX2/PTGS2↓, 113,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 10,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 3,   HLA-I/II↑, 1,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 4,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 3,   IL12↓, 3,   IL12↑, 2,   IL17↓, 2,   IL1α↓, 1,   IL1β↓, 19,   IL2↓, 4,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 2,   IL6↓, 55,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   IL8↑, 1,   Imm↑, 15,   Imm↝, 4,   Inflam↓, 43,   Inflam↑, 1,   IRAK1↓, 2,   LPS↓, 1,   LRIG1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB?, 1,   NF-kB↓, 265,   NF-kB↑, 7,   NF-kB↝, 3,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 8,   NLRP3↓, 3,   NLRP3↑, 4,   NOD1↓, 1,   p50↓, 3,   p65↓, 7,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 12,   PGE2↓, 28,   PSA↓, 12,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 2,   SOCS1↑, 1,   T-Cell↑, 3,   TCF↓, 4,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 7,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 43,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRAF2↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   IM↓, 1,   pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AhR↓, 2,   AR↓, 25,   AR↝, 1,   AR-V7?, 1,   COMT↓, 2,   CYP19?, 1,   CYP19↓, 3,   ER-α36↓, 4,   ER(estro)↓, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARγ↓, 3,   PPARγ↑, 10,   PPARγ↝, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   AKR1B10↓, 1,   BioAv↓, 46,   BioAv↑, 58,   BioAv↝, 12,   BioEnh?, 1,   BioEnh↑, 7,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 220,   ChemoSen⇅, 2,   ChemoSen↝, 1,   CompStab↓, 4,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 4,   Dose↓, 3,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 76,   Dose∅, 8,   DrugR↓, 1,   eff?, 2,   eff↓, 62,   eff↑, 117,   eff↝, 13,   eff∅, 3,   Half-Life↓, 12,   Half-Life↝, 13,   Half-Life∅, 2,   MDR1↓, 12,   MRP1/ABCC1↓, 5,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 28,   P450↓, 5,   RadioS↑, 67,   selectivity?, 1,   selectivity↑, 109,   selectivity∅, 1,   Synergy↑, 122,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 6,   ALP↓, 5,   AR↓, 25,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   BG↓, 1,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CEA↓, 2,   CRP↓, 3,   E6↓, 5,   E7↓, 5,   EGFR↓, 71,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 9,   EstroRS/ERS↓, 1,   EZH2↓, 9,   FOXM1↓, 10,   HemoG↓, 1,   HER2/EBBR2↓, 24,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 14,   IL6↓, 55,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 12,   PSA↓, 12,   PSA↝, 1,   RAGE↓, 2,   TF-Ag↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 5,   TRIB3↑, 3,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 72,   AntiCan⇅, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 3,   AntiTum↑, 29,   Appetite↑, 2,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 14,   CardioT↑, 1,   chemoP↓, 1,   chemoP↑, 38,   chemoPv↑, 29,   ChemoSideEff↓, 6,   ChemoSideEff∅, 1,   cognitive?, 1,   cognitive↑, 1,   fatigue↓, 2,   FTO↓, 1,   hepatoP↑, 6,   K17↓, 1,   Mucositis↓, 1,   neuroP↑, 9,   NP/CIPN↓, 1,   OS↑, 15,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 9,   radioP↑, 12,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 18,   Risk↑, 1,   Sleep↑, 3,   Strength↑, 2,   Symptoms↓, 1,   toxicity↓, 24,   toxicity↑, 2,   toxicity↝, 12,   TumVol↓, 35,   TumVol∅, 1,   TumW↓, 19,   TumW∅, 1,   Weight↑, 2,   Weight∅, 3,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 12,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1413

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 3,   antiOx↓, 8,   antiOx↑, 138,   ARE↑, 4,   Catalase↑, 61,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 4,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 42,   GPx1↑, 3,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 66,   GSH/GSSG↑, 1,   GSR↑, 8,   GSS↑, 1,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 17,   H2O2↓, 7,   H2O2∅, 1,   HDL↓, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↑, 51,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 5,   Keap1↑, 2,   lipid-P↓, 42,   lipid-P↑, 1,   MDA↓, 45,   MDA↑, 1,   MPO↓, 7,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 6,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 89,   Prx↑, 1,   RNS↓, 4,   ROS?, 1,   ROS↓, 178,   ROS↑, 3,   ROS⇅, 1,   ROS∅, 3,   mt-ROS↓, 2,   SOD↓, 1,   SOD↑, 73,   SOD1↑, 4,   SOD2↑, 5,   TAC↑, 8,   TBARS↓, 4,   Trx↑, 1,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 2,   VitC↑, 1,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↓, 1,   IronCh↑, 8,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   MFN2↑, 1,   mtDam↓, 2,   PGC-1α↑, 4,   SIRT3↑, 3,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   adiP↑, 2,   ALAT↓, 15,   AMP↓, 1,   AMPK↓, 3,   AMPK↑, 20,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 6,   Buty↑, 1,   cAMP↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   glucose↓, 6,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 5,   GSK‐3β↓, 11,   GSK‐3β↑, 5,   p‑GSK‐3β↑, 3,   H2S↑, 2,   LDHA↑, 1,   LDL↓, 9,   lipidLev↓, 2,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 4,   NADPH∅, 1,   p‑PDK1 / PDPK1↓, 1,   PIP3↑, 1,   PKM2↓, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 9,   SIRT1↝, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 27,   ASC↓, 1,   BAD↓, 2,   BAX↓, 19,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 4,   Bcl-2↑, 14,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 27,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 3,   Casp6↓, 1,   Casp9↓, 6,   Cyt‑c↓, 5,   Cyt‑c∅, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 26,   iNOS↑, 1,   p38↓, 7,   p38↑, 3,   p‑p38↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 28,   Akt↑, 72,   Akt↝, 3,   p‑Akt↓, 11,   p‑Akt↑, 20,   e-Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 2,   CREB↑, 6,   p‑CREB↑, 3,   EGFR↓, 1,   ERK↓, 5,   ERK↑, 15,   p‑ERK↑, 5,   e-ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK↓, 26,   MAPK↑, 8,   MAPK↝, 2,   Mst1↓, 1,   mTOR↓, 11,   mTOR↑, 14,   mTOR↝, 1,   p‑mTOR↓, 3,   p‑mTOR↑, 3,   p‑p70S6↓, 1,   P70S6K↓, 1,   p‑P70S6K↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 21,   PI3K↑, 50,   PI3K↝, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PKA↑, 3,   PKCδ?, 1,   PKCδ↓, 3,   PKCδ↑, 4,   PP2A↑, 3,   PTEN↓, 7,   PTEN↑, 2,   p‑PTEN↓, 1,   PTP1B↓, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 3,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 8,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO1↝, 1,   FOXO3↑, 2,   HDAC↓, 1,   HDAC↑, 1,   HOTAIR↑, 1,   miR-107↑, 1,   other↓, 3,   other↑, 6,   other↝, 12,   RUNX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   HSP90↑, 2,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3II↓, 2,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 5,   DNArepair↑, 2,   p16↓, 2,   P53↓, 4,   PCNA↓, 1,   Telomerase↓, 1,   TOP1↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 3,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 2,   CEBPA↓, 1,   cFos↑, 1,   Diff↑, 1,   Diff↝, 1,   FGF↑, 2,   HH↓, 1,   IGF-1↑, 1,   Jun↓, 1,   neuroG↑, 1,   p300↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 14,   AP-1↓, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 6,   Ca+2↑, 2,   Ca+2↝, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP2↓, 1,   MMP3↓, 2,   MMP9↓, 8,   MMPs↑, 1,   MUC1↑, 1,   N-cadherin↑, 1,   Na+↑, 1,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   SLIT2↑, 1,   SMAD3↓, 1,   TGF-β↓, 6,   TGF-β↑, 3,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 3,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 16,   NO↑, 2,   VCAM-1↓, 5,   VEGF↓, 6,   VEGF↑, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 23,   BBB↝, 1,   GastroP↑, 2,   GLUT1↓, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↑, 14,   MMP∅, 1,   MUC5AC↓, 1,   Na+↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 45,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 9,   IL10↑, 9,   IL12↓, 1,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 39,   IL2↓, 2,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 2,   IL5↓, 3,   IL6?, 1,   IL6↓, 55,   IL6↑, 2,   IL8↓, 7,   Imm↓, 1,   Imm↑, 10,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 166,   Inflam↑, 3,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↓, 1,   NeuroI↓, 3,   NF-kB↓, 81,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NLRP3↓, 11,   NLRP3↑, 1,   p65↓, 1,   PGE1↓, 1,   PGE2↓, 19,   PGE2↑, 1,   RAGE↓, 3,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR3↓, 1,   TLR4↓, 10,   TNF-α↓, 66,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 7,   AChE↓, 30,   AChE↑, 1,   ADAM10↑, 3,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 24,   BDNF⇅, 1,   ChAT↑, 2,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   TPH1↓, 1,   TrkB↓, 1,   TrkB↑, 8,   TrkB↝, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 7,   Aβ↓, 34,   Aβ42↓, 4,   BACE/β-secretase↓, 14,   BACE/β-secretase↑, 1,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 10,   p‑tau↓, 15,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 4,   PPARγ↑, 6,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 53,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 40,   BioEnh↑, 2,   ChemoSen↑, 3,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   DDS↑, 1,   Dose↓, 2,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 20,   eff↓, 2,   eff↑, 14,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 4,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 12,   Half-Life∅, 2,   MRP↓, 1,   P-gp/ABCB1↓, 2,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 3,   anemia↓, 1,   AST↓, 18,   BloodF↑, 2,   BMD↑, 5,   BP↓, 4,   BP↝, 1,   p‑BRCA1↑, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 6,   EGFR↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 55,   IL6↑, 2,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 8,   RAGE↓, 3,   RBC↑, 1,   SpO2↑, 1,   TMAO↓, 1,   TP53↑, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 8,   antiAll↑, 20,   AntiArt↑, 10,   AntiCan↑, 21,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 30,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 6,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 56,   chemoP↑, 9,   chemoPv↑, 9,   cognitive↓, 1,   cognitive↑, 50,   cough?, 1,   diuretic↑, 3,   fatigue↓, 1,   GFR↑, 1,   hepatoP↑, 51,   Learn?, 1,   Learn↑, 2,   memory?, 1,   memory↑, 50,   motorD↑, 7,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 126,   Obesity↓, 15,   OS↑, 2,   Pain↓, 6,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 20,   Risk↓, 2,   SoreThr?, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 12,   toxicity↓, 40,   toxicity↑, 4,   toxicity↝, 12,   toxicity∅, 10,   Weight↑, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 9,   AntiP↑, 8,   AntiViral↑, 15,   Bacteria↓, 18,   Bacteria↑, 1,   Diar↓, 2,   GutMicro↑, 20,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 9,  
Total Targets: 613

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
30 Quercetin
26 Apigenin (mainly Parsley)
25 Thymoquinone
22 Baicalein
22 Fisetin
20 Luteolin
20 Resveratrol
19 Kaempferol
16 Berberine
16 Chrysin
14 Lycopene
14 Magnolol
14 Matrine
14 Shikonin
13 Alpha-Lipoic-Acid
12 Magnetic Fields
12 Emodin
12 Sulforaphane (mainly Broccoli)
12 Melatonin
12 Morin
11 Formononetin
10 5-fluorouracil
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
10 Licochalcone A
9 Silver-NanoParticles
9 Cisplatin
9 Carvacrol
9 Indole-3-carbinol
9 EGCG (Epigallocatechin Gallate)
9 HydroxyTyrosol
9 Isobavachalcone
9 Inositol
9 Ivermectin
9 Licorice
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Garcinol
8 Hyperoside
8 phytic acid, Inositol hexakisphosphate
8 isoorientin
8 Piperlongumine
8 Urolithin
7 Isovitexin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 Radiotherapy/Radiation
7 Gambogic Acid
7 Isoliquiritigenin
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 Paclitaxel/Taxol
6 Celastrol
6 Diindolylmethane
6 Dandelion Root
6 Ferulic acid
6 Fucoidan
6 Gallic acid
6 Vitexin
6 methylseleninic acid
5 Allicin (mainly Garlic)
5 doxorubicin
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Ginkgolide B
5 Ginseng
5 itraconazole
5 Lactoferrin/Talactoferrin
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Caffeic acid
4 Celecoxib
4 Ginkgetin
4 Hydrogen Gas
4 Hibiscus sabdariffa
4 Juglone
4 Lasiodin
4 Lutein
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 3-bromopyruvate
3 Gemcitabine (Gemzar)
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Thymol-Thymus vulgaris
3 chaetocin
3 Hydroxycinnamic-acid
3 Cucurbitacin
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Evodiamine
3 Flaxseed/Linseed
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 isoquercitrin
3 lambertianic acid
3 SDG/lignans
3 Linalool
3 Moringa oleifera
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Trastuzumab
2 Sorafenib (brand name Nexavar)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geldanamycin
2 Genistein (soy isoflavone)
2 Geraniol
2 Huperzine A/Huperzia serrata
2 Inulin Prebiotic
2 Modified Citrus Pectin
2 MCT oil
2 Metformin
2 Magnesium
2 Mushroom Chaga, Inonotus obliquus
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 chemodynamic therapy
1 Camptothecin
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 Photodynamic Therapy
1 gefitinib, erlotinib
1 Cynaropicrin
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Bortezomib
1 chitosan
1 Ginkgolic acids
1 Ginkgo biloba
1 Gossypol/AT-101
1 Graviola
1 hydrogen sulfide
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 isoflavones
1 Laetrile B17 Amygdalin
1 low dose naltrexone
1 Lemongrass Extract/Citral
1 Mung Bean Sprouts
1 mebendazole
1 vp16, etoposide
1 Methylglyoxal
1 Methylene blue
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Phenolic Acids
1 Psoralidin
1 Rhein
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 acetazolamide
1 statins
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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