GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
1407- GoldNP,  Z,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Var, NA
ROS↑, GPx↓, Catalase↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓, *antiAll↑,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3764- H2,    Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
7562- HYP,  doxoR,    Hyperoside Inhibits Doxorubicin-Induced Ferroptosis in Cardiomyocytes via the Nrf2/GPX4 Pathway
- in-vivo, Nor, NA
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7561- HYP,    Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway
- in-vivo, Park, NA
*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,
7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, *ALAT↑, *AST↑, *ROS↑, *MDA↑, *Catalase↓, *GSH↓, *GPx↓, *i-Iron↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7881- isoO,    Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice
- in-vivo, Nor, NA
*Weight↑, *toxicity↓, *GutMicro↑, *SOD↑, *GPx↑, *MDA↓, *Inflam↓,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
9232- ITCs,  SFN,    The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
- Review, AD, NA
*ROS↓, *Inflam↓, *eff↑, *toxicity↓, *HDAC?, *neuroP↑, *NRF2↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑, *CHIP↑, *memory↑, *NeuroI↓, *ROS↓, *BACE/β-secretase↓, *BDNF↑, *GSH↑, *GPx↑, *AChE↓, *BChE↓, *TC↓, *TG/TAG↓, *LDL↓, ROS↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
9072- L-THE,  doxoR,    Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats
- in-vivo, Nor, NA
*Dose↝, *GSSG↓, *GGT/CD224↓, *NF-kB↓, *GSH↑, *GPx↑, *GSR↑, *GSTA1↑, *chemoP↑,
9003- L-THE,    L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability
- in-vitro, Nor, H9c2
*Dose↝, *Apoptosis↓, *GSH↑, *GPx↑, *SOD↑, *ROS↓, *proCasp3↑, *cl‑PARP↓, *antiOx↑, *Stroke↓,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8274- LE,    Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation
- in-vivo, Nor, NA
*AntiAge↑, *GutMicro↑, *p‑PI3K↓, *p‑Akt↓, *p‑mTOR↓, *antiOx?, *cognitive↑, *Dose↝, *GPx↑, *Catalase↑, *SOD↑, *MDA↓, *memory↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
8413- Lyco,  VitE,    Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation
- in-vivo, AD, NA
*memory↑, *MDA↓, *GPx↑, *tau↓, *Synergy↑,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2/PTGS2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
8755- MeSA,    The Inhibitory Efficacy of Methylseleninic Acid Against Colon Cancer Xenografts in C57BL/6 Mice
- in-vivo, CRC, NA
TumCG↓, Dose↝, GPx↑, TNF-α↓, IL6↓,

Showing Research Papers: 101 to 150 of 252
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 9,   Catalase↓, 12,   Catalase↑, 13,   GPx↓, 20,   GPx↑, 28,   GPx4↓, 3,   GSH↓, 20,   GSH↑, 9,   GSH⇅, 1,   GSH/GSSG↓, 2,   GSR↓, 3,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 2,   HO-1↑, 8,   Iron↑, 4,   Iron↝, 1,   lipid-P↓, 5,   lipid-P↑, 11,   MDA?, 1,   MDA↓, 5,   MDA↑, 6,   MPO↓, 2,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 12,   ROS↓, 15,   ROS↑, 71,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↑, 1,   SOD↓, 12,   SOD↑, 15,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↓, 1,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↑, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compIV↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 10,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 3,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 2,   ATP↓, 6,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 6,   lactateProd↓, 5,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 3,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 3,   Pyruv↓, 2,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 49,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 35,   Bax:Bcl2↑, 2,   Bcl-2↓, 29,   Bcl-2↑, 5,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 7,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 39,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 12,   Casp9↑, 27,   cl‑Casp9↑, 1,   Cyt‑c↑, 18,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 6,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 5,   Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 8,   TumCD↑, 5,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 33,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 6,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 5,   MAPK↑, 6,   MAPK↝, 1,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   mTOR↝, 1,   p‑mTOR↓, 3,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 25,   PI3K↑, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 2,   RAS↓, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 3,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 1,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 3,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 1,   tumCV↓, 14,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 9,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   p62↓, 3,   TumAuto↓, 1,   TumAuto↑, 6,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↓, 1,   DNAdam↑, 17,   DNArepair↑, 1,   P53↓, 3,   P53↑, 28,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 9,   cl‑PARP∅, 1,   PCNA↓, 13,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 2,   P21↑, 18,   p27/CDKN1B↑, 5,   pRB↓, 1,   pRB↑, 1,   RB1↑, 1,   TumCCA↑, 45,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 3,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 10,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 34,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 2,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 8,   EMT↓, 12,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 22,   MMP9↑, 2,   MMPs↓, 5,   N-cadherin↓, 9,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 18,   TumMeta↓, 17,   TumMeta↑, 3,   Twist↓, 2,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 18,   NO↓, 2,   NO↑, 2,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 23,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 18,   MMP↑, 2,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 2,   IL6↓, 15,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 8,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 5,   PSA↓, 2,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 14,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ER-α36↓, 1,   Estro↝, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 6,   BioAv↝, 4,   BioEnh?, 1,   ChemoSen↑, 43,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 5,   Dose↝, 15,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 1,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 13,   selectivity↑, 23,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 6,   AST↓, 2,   BP↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 6,   EGFR↑, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 15,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 2,   PSA∅, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 20,   antiNeop↑, 1,   AntiTum↑, 6,   Appetite↑, 1,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 7,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 8,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 10,   RenoP↑, 2,   Risk↓, 9,   Sleep↑, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 565

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 4,   antiOx↑, 102,   ARE↑, 2,   Bil↓, 2,   Catalase↓, 4,   Catalase↑, 123,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 6,   GPx↑, 202,   GPx↝, 1,   GPx∅, 1,   GPx4↓, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 89,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 25,   GSSG↓, 3,   GSTs↓, 2,   GSTs↑, 24,   H2O2↓, 9,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 5,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 8,   Keap1↝, 1,   lipid-P↓, 62,   MDA↓, 84,   MDA↑, 3,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 11,   NRF2↓, 1,   NRF2↑, 82,   Prx↓, 1,   Prx↑, 2,   RNS↓, 1,   ROS?, 2,   ROS↓, 164,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 5,   SOD?, 1,   SOD↓, 2,   SOD↑, 160,   SOD↝, 1,   SOD1↑, 4,   SOD2↑, 6,   TAC↑, 15,   TBARS↓, 3,   TBARS↑, 1,   Thiols↑, 2,   Trx↑, 3,   Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 7,   VitE↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTL↓, 1,   IronCh↑, 4,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   EGF↓, 1,   ETC↑, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN1↑, 1,   MFN2↑, 2,   mtDam↓, 2,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   mt-ACC⇅, 1,   ACSL4↓, 1,   adiP↓, 1,   ALAT↓, 25,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 11,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↑, 1,   glucose↓, 7,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 10,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 13,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDKs↑, 1,   PFK↓, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PONs↑, 1,   PPP↓, 1,   SCFAs↑, 2,   SIRT1↑, 14,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 18,   BAD↓, 1,   BAX↓, 15,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 11,   Bcl-2↝, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 26,   cl‑Casp3↓, 2,   proCasp3↑, 1,   Casp8↓, 1,   Casp9↓, 11,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 4,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 4,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 2,   IκB?, 1,   JAK2↓, 1,   JNK↓, 7,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 3,   PI3K↑, 4,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ?, 1,   PP2A↑, 1,   PTEN↓, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 2,   HDAC?, 1,   HDAC↓, 1,   miR-34a↓, 1,   other?, 1,   other↓, 7,   other↑, 12,   other↝, 3,   RUNX2↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   P53↓, 1,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CHIP↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↑, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   AP-1↑, 1,   ATPase↑, 1,   Ca+2↓, 8,   Ca+2↝, 2,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MUC1↑, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 2,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Vim↓, 3,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 22,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 16,   GastroP↑, 4,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 1,   MMP↑, 10,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPM7⇅, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 42,   COX2/PTGS2↑, 2,   Eos↓, 1,   GM-CSF↓, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↓, 5,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 1,   IL10↓, 7,   IL10↑, 12,   IL12↓, 2,   IL12↑, 1,   IL13↓, 1,   IL17↓, 5,   IL18↓, 1,   IL1β↓, 43,   IL2↓, 3,   IL2↑, 2,   IL23↓, 2,   IL4↓, 4,   IL4↑, 3,   IL5↓, 2,   IL6↓, 44,   IL6↑, 1,   IL8↓, 3,   IL8↑, 1,   Imm↓, 1,   Imm↑, 6,   INF-γ↓, 2,   Inflam↓, 106,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   NF-kB↓, 49,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 8,   p65↓, 1,   PGE2↓, 14,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 13,   TNF-α↓, 60,   TNF-α↑, 2,   TRAF6↓, 1,   TRIF↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 6,   Ach↑, 9,   AChE↓, 31,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 18,   BDNF⇅, 1,   ChAT↑, 8,   GABA↑, 3,   MAOA↓, 3,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 2,   BACE/β-secretase↓, 9,   tau↓, 8,   p‑tau↓, 8,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 5,   GR↝, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 40,   BioAv⇅, 1,   BioAv↝, 23,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 23,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 7,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 25,   ALAT↑, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 27,   AST↑, 1,   BG↓, 3,   Bil↓, 2,   BloodF↑, 1,   BMD↑, 1,   BP↓, 5,   BP↝, 1,   BUN↓, 3,   Calcium↑, 1,   CEA↓, 2,   creat↓, 5,   CRP↓, 8,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 44,   IL6↑, 1,   IRes↝, 1,   LDH↓, 10,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 5,   Urea↓, 3,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 12,   AntiArt↑, 4,   AntiCan↑, 12,   AntiDiabetic↑, 18,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↑, 1,   BOLD↑, 1,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 36,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 44,   Learn↑, 2,   memory↑, 37,   motorD↑, 6,   neuroP↑, 82,   NP/CIPN↓, 1,   Obesity↓, 12,   OS↑, 2,   Pain↓, 4,   radioP↑, 3,   RenoP↑, 14,   Risk↓, 7,   Sleep↑, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity↓, 14,   toxicity↝, 8,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 10,   GutMicro↑, 24,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 2,  
Total Targets: 535

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Lycopene
9 Thymoquinone
8 Melatonin
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Hydrogen Gas
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Sulforaphane (mainly Broccoli)
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hyperoside
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Luteolin
3 Moringa oleifera
3 Morin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Berberine
2 Phenethyl isothiocyanate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Sesame seeds and Oil
2 doxorubicin
2 isoorientin
2 Kaempferol
2 Matrine
2 Cisplatin
2 Methylsulfonylmethane
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Cichoric acid / Chicoric acid
1 Citicoline, CDP-Choline
1 Citric Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 Butein
1 Scopoletin
1 Isothiocyanates
1 Juglone
1 Lactoferrin/Talactoferrin
1 Vitamin E
1 Magnolol
1 Mung Bean Sprouts
1 methylseleninic acid
1 Magnetic Field Rotating
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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