GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Scientific Papers found: Click to Expand⟱
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1779- MEL,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, NA, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1↓,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
2311- MFrot,  MF,    Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
- in-vivo, Nor, HaCaT
*COX2↓, *Inflam↓, *MMP9↑, *GPx↑, *Diff↑,
3839- Moringa,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
1683- PBG,  Rad,    Protective effect of propolis in protecting against radiation-induced oxidative stress in the liver as a distant organ
- in-vivo, Nor, NA
GPx↑, SOD↓, RadioS↑,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
4954- PEITC,    Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
- vitro+vivo, Ovarian, SKOV3
ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
2956- PL,    Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- in-vitro, PC, NA
ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
*Inflam↓, *COX2↓, *5LO↓, *antiOx↑, *BioAv↝, *GPx↑, *SOD↑, *Ach↑, *4-HNE↓, *CREB↑, *BDNF↑, *ROS↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *eff↑, *ROS↓, *cognitive↑, *eff↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
*antiOx↑, *Keap1↓, *NRF2↑, *HO-1↑, *GPx↑, *SOD↑,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,

Showing Research Papers: 101 to 150 of 202
Prev Page 3 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 202

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 7,   CYP1A1↓, 1,   Ferroptosis↓, 1,   GPx↓, 5,   GPx↑, 10,   GSH↓, 6,   GSH↑, 4,   GSR↓, 1,   GSR↑, 2,   GSTA1↑, 1,   GSTs↓, 1,   H2O2↓, 1,   H2O2↑, 2,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 3,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 3,   OXPHOS↑, 1,   ROS↓, 3,   ROS↑, 12,   ROS↝, 1,   mt-ROS↑, 1,   SOD↓, 4,   SOD↑, 7,   SOD2↓, 2,   SOD2↑, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   p‑MEK↓, 1,   MMP↓, 2,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CAIX↑, 1,   cMyc↓, 2,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   NADPH↑, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARγ↑, 2,   SIRT1↓, 1,   SIRT1↑, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 10,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 5,   BAX↓, 1,   BAX↑, 7,   Bcl-2↓, 5,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp↑, 1,   Casp1↓, 1,   Casp3↑, 7,   cl‑Casp3∅, 1,   Casp8↑, 2,   Casp9↑, 3,   Chk2↓, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↓, 1,   HGF/c-Met↓, 2,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   p‑MDM2↓, 1,   p27↑, 2,   p‑p38↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   H4↓, 1,   pRB↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 1,   DNArepair↑, 1,   P53↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP∅, 1,   PCNA↓, 3,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 5,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 5,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   cFos↑, 1,   EMT↓, 3,   EMT↑, 1,   ERK↓, 3,   ERK↑, 1,   FOXO3↓, 1,   Gli1↓, 2,   GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   IGF-1↓, 1,   IGF-1R↓, 3,   mTOR↓, 3,   NOTCH1↓, 2,   P70S6K↓, 1,   PI3K↓, 5,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PTEN↓, 1,   PTEN↑, 4,   p‑Src↓, 1,   STAT3↓, 5,   p‑STAT6↓, 1,   TumCG↓, 3,   TumCG↑, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   FAK↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MARK4↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-155↓, 1,   MMP13↓, 1,   MMP2↓, 7,   MMP7↓, 2,   MMP9↓, 8,   MMPs↓, 1,   N-cadherin↓, 3,   Rac1↓, 1,   Rho↓, 1,   Snail↓, 1,   TIMP1↑, 2,   TIMP2↑, 1,   Treg lymp↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 7,   TumMeta↓, 5,   TumMeta↑, 2,   Tyro3↓, 1,   uPAR↓, 1,   Vim↓, 4,   Vim↑, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 1,   EGFR↑, 1,   HIF-1↓, 1,   Hif1a↓, 3,   NO↓, 1,   NO↑, 1,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD4+↑, 1,   COX2↓, 5,   CXCR4↓, 1,   FOXP3↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↑, 1,   IL10↑, 1,   IL1β↓, 1,   IL2↑, 2,   IL4↑, 2,   IL6↓, 7,   IL8↓, 2,   JAK1↓, 1,   NF-kB↓, 8,   NK cell↑, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 3,   PSA↓, 1,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 4,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   CDK6↓, 2,   GR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh?, 1,   ChemoSen↑, 11,   Dose↝, 3,   Dose∅, 2,   eff↓, 1,   eff↑, 19,   P450↓, 1,   RadioS↑, 3,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 4,   BP↓, 1,   CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   IL6↓, 7,   Ki-67↓, 1,   NSE↓, 1,   PSA↓, 1,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   cachexia↓, 1,   chemoP↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 1,   OS↑, 4,   Pin1↓, 1,   QoL↑, 2,   radioP↑, 2,   Risk↓, 1,   TumVol↓, 1,  
Total Targets: 258

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 20,   ARE↑, 1,   Bil↓, 1,   Catalase↑, 22,   Catalase↝, 1,   Copper↓, 2,   CYP2E1↓, 1,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 36,   GPx↝, 1,   GSH↑, 25,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 7,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 3,   HDL↓, 1,   HO-1↑, 14,   HO-1⇅, 1,   Iron↓, 3,   Keap1↓, 5,   lipid-P↓, 12,   MDA↓, 13,   MFN1↑, 1,   MFN2↑, 1,   MPO↓, 2,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 17,   OPA1↑, 1,   OXPHOS↑, 1,   Prx↑, 2,   ROS?, 1,   ROS↓, 34,   ROS↑, 1,   SOD↑, 27,   SOD↝, 1,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 1,   TBARS↑, 1,   Trx↑, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 3,   DRP1/DNM1L↓, 1,   ETC↑, 1,   MMP↑, 2,   mtDam↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   ALAT↓, 2,   AMPK↑, 2,   CREB↑, 2,   FAO↑, 1,   G6PD↑, 1,   glucose↓, 1,   GlucoseCon↓, 1,   GlutMet↑, 1,   Glycolysis↝, 2,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 2,   PDKs↑, 1,   PFK2↓, 1,   PKM1↑, 1,   PKM2↑, 1,   PONs↑, 1,   PPARγ↑, 1,   PPP↓, 1,   SIRT1↑, 6,   SREBP1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 3,   BAX↓, 2,   Bcl-2↑, 2,   Casp3↓, 5,   Casp9↓, 2,   Hippo↑, 1,   iNOS↓, 4,   JNK↓, 2,   MAPK↓, 2,   YAP/TEAD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   ERK↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   IGF-1↑, 1,   PI3K↑, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↝, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   PKCδ?, 1,   TGF-β↓, 2,   TGF-β1↑, 1,   TXNIP↓, 1,   VCAM-1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

LOX1↓, 1,   NO↓, 4,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 10,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL10↓, 2,   IL10↑, 4,   IL17↓, 1,   IL1β↓, 9,   IL23↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 8,   IL8↓, 2,   IL8↑, 1,   Inflam↓, 15,   MCP1/CCL2↓, 2,   NF-kB↓, 9,   PGE2↓, 2,   TLR4↓, 3,   TNF-α↓, 9,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 3,   GABA↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   GR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 10,   BioAv↝, 5,   Dose↝, 1,   eff↑, 5,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   Bil↓, 1,   BP↓, 1,   GutMicro↑, 3,   IL6↓, 8,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 6,   CardioT↓, 1,   cognitive↑, 4,   hepatoP↑, 7,   memory↑, 5,   motorD↑, 1,   neuroP↑, 16,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 4,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 197

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
9 Thymoquinone
8 Lycopene
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Melatonin
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hydrogen Gas
3 Sulforaphane (mainly Broccoli)
2 1,8-Cineole
2 Berberine
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Chemotherapy
2 Sesame seeds and Oil
2 Luteolin
2 Moringa oleifera
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Juglone
1 Magnolol
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Nimbolide
1 Phenethyl isothiocyanate
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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