Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.
Scientific Papers found: Click to Expand⟱
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
9069- L-THE,    Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model
- in-vivo, Colon, NA
Akt↓, mTOR↓, Ki-67↓, JAK2↓, STAT3↓, SMAD2↑, Dose↝,
9007- L-THE,    L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model
- in-vivo, CRC, NA
CRP↓, AFP↓, CEA↓, CA19-9↓, Ki-67↓, Apoptosis↑, Casp3↑, cl‑Casp3↑, BAX↑, Bcl-2↓, *ROS↓, *Inflam↓, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *IL1β↓, *TNF-α↓, *IL6↓, *IL10↓, *COX2/PTGS2↓, *NF-kB↓, *NLRP3↓, *GutMicro↑, *chemoPv↑, *Dose↝, Ki-67↓,
8220- LCA,    Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *memory↑, *PSD95↑, *Ki-67↑, *GLUT1↑, *Aβ↓, *Aβ42↓, *Inflam↓, *TREM2↓, *cognitive↑,
8337- LDN,    Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway
- in-vitro, CRC, NA
OGFr↑, BAX↑, Casp9↑, Casp3↑, PARP↑, Bcl-2↓, survivin↓, Ki-67↓, Apoptosis↑,
8314- lign,    Reduction in Ki-67 in Benign Breast Tissue of High Risk Women with the Lignan Secoisolariciresinol Diglycoside (SDG)
- Trial, BC, NA
Dose↝, ENL↑, Ki-67↓, BioAv↑,
8298- lign,    Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer
- in-vitro, BC, MDA-MB-231
Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,
8299- lign,    Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer
- Trial, BC, NA
TumCG↓, Dose↝, Ki-67↓, Apoptosis↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8323- LIN,  doxoR,    Efficacy of Combination Therapy with Linalool and Doxorubicin Encapsulated by Liposomes as a Two-in-One Hybrid Carrier System for Epithelial Ovarian Carcinoma
- vitro+vivo, Ovarian, NA
ChemoSen↑, TumCG↓, Ki-67↓, CD31/PECAM-1↓, Casp3↑, *toxicity↓, chemoP↑, *BioAv↓, EPR↑,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8385- LT,    Luteolin regulates pyroptosis of triple-negative breast cancer cells through AKT signaling
- vitro+vivo, BC, MDA-MB-231
Pyro↑, Akt↓, GSDMD↑, NLRP3↑, IL1β↓, IL6↓, TNF-α↓, PCNA↓, Ki-67↓,
8402- LT,    Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
- vitro+vivo, CRC, T24/HTB-9
tumCV↓, TumCCA↑, p‑S6↓, P21↑, Trx1↑, ROS↓, Ki-67↓, mTOR↓, TumCP↓,
8366- LT,    Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveillance
- Trial, Pca, NA
Dose↝, eff↑, SD↑, Ki-67↓, AR↓, NKX3.1↓, miR-29b↑, miR-30a-5p↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
8416- Lyco,    Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Dose↝, *Aβ42↓, *IL1β↓, *TNF-α↓, *MDA↓, *Ach↑, *MAOA↓, *LDH↓, *AChE↓, *NRF2↑, *5HT↑, *TGF-β1↑, *IL10↑, *Ki-67↓, *PCNA↓,
8415- Lyco,  CUR,    Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation
- in-vivo, BPH, NA
*Dose↝, *Synergy↑, *Ki-67↓, *testos↓, *DHT↓, *PSA↓, *IL1β↓, *IL6↓, *AKT1↓, *TNF-α↓, *EGFR↓, *STAT3↓, *COX2/PTGS2↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
8509- MAG,  Rad,    The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma
- in-vivo, HCC, NA
TumVol↓, TumW↓, *ERK↓, *NF-kB↓, Casp3↑, Casp9↑, RadioS↑, *toxicity↓, Ki-67↓, IL1β↓, TNF-α↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
8542- Matr,    Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, p‑PI3K↓, CHK1↓, p‑Akt↓, Bcl-2↓, MTA1↓, Vim↓, MMP2↓, MMP9↓, γH2AX↑, E-cadherin↑, BAX↑, cl‑Casp3↑, Ki-67↓, TumCG↓,
8654- MBZ,  SUL,    Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model
- in-vivo, Colon, HT-29 - in-vitro, Colon, SW48
Synergy↑, COX2/PTGS2↓, angioG↓, VEGFR2/KDR/Flk1↓, Ki-67↓, chemoPv↑,
8822- MCP,    Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3
- vitro+vivo, CRC, T24/HTB-9 - in-vitro, Bladder, J82
TumCCA↑, cycD1/CCND1↓, p‑cDC2↓, Casp3↑, cl‑Casp3↑, cl‑PARP↑, Gal-3↓, Akt↓, TumCG↓, Ki-67↓, Dose⇅,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, Var, NA
Synergy↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
8611- MO,    Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Casp7↑, Ki-67↓, TumVol↓,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,
9046- PatchO,    Patchouli alcohol suppresses castration-resistant prostate cancer progression by inhibiting NF-κB signal pathways
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCMig↓, TumCI↓, TumCP↓, Apoptosis↑, MMP↓, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Ki-67↓, Mcl-1↓, NF-kB↓, p65↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, TumCG↓, Dose↝,
8982- PCorn,    Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways
- vitro+vivo, Pca, LNCaP
TumCP↓, cycD1/CCND1↓, TumCCA↑, Dose↝, TumCG↓, Ki-67↓, ERK↓, MAPK↓, Ingr↝, PSA↓,
4948- PEITC,    Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4963- PEITC,    Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
9020- Phyco,    C-phycocyanin: a natural product with radiosensitizing property for enhancement of colon cancer radiation therapy efficacy through inhibition of COX-2 expression
- vitro+vivo, Colon, CT26 - in-vitro, CRC, DLD1 - in-vitro, CRC, HT-29 - in-vitro, Nor, CRL-1831
RadioS↑, Ki-67↓, Dose?,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
96- QC,  docx,    Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
PI3K/Akt↓, Ki-67↓, BAX↑, Bcl-2↓, EpCAM↓, Twist↓, E-cadherin↑, P-gp/ABCB1↓, TumCP↓, TumCMig↓, TumCI↓,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
EMT↓, E-cadherin↑, N-cadherin↓, Ki-67↓, PI3K/Akt↓, MALAT1↓, TumCG↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, Synergy↑, chemoPv↑, BioAv↑,

Showing Research Papers: 101 to 150 of 173
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 173

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 5,   Catalase↓, 2,   GPx↑, 2,   GPx4↓, 7,   GSH↓, 12,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Iron↑, 1,   Iron↝, 1,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 5,   MDA↑, 4,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 5,   NRF2↝, 1,   ox-PrxI↑, 1,   PYCR1↓, 1,   ROS↓, 7,   ROS↑, 56,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 2,   TAC↓, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   CDC25↝, 1,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↝, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 1,   Alanine↓, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 4,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ENO1↓, 1,   FABP4↑, 1,   FAO↑, 1,   FASN↓, 3,   FBI-1↓, 1,   glucose↓, 3,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 11,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HK1↓, 1,   HK2↓, 7,   lactateProd↓, 7,   LDHA↓, 3,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 1,   PGE3↑, 1,   PKM2↓, 7,   PPP↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↑, 1,   TPI↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 55,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 38,   Bax:Bcl2↑, 9,   Bcl-2↓, 43,   Bcl-xL↓, 7,   BIM↑, 1,   Casp↑, 7,   proCasp↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 19,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 4,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 14,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 16,   Diablo↑, 4,   DR5↑, 6,   FADD↑, 2,   Fas↑, 3,   Ferroptosis↑, 6,   GSDMD↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 8,   MDM2↓, 1,   MDM2↑, 2,   p‑MDM2↓, 1,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 19,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 2,   TUNEL↑, 1,   XIAP↓, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 45,   Akt↑, 1,   p‑Akt↓, 7,   AMPKα↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑CREB↑, 1,   cSrc↓, 2,   EGFR↓, 13,   p‑EGFR↓, 1,   ERK↓, 10,   ERK↑, 3,   p‑ERK↓, 5,   p‑ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 1,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK1↓, 2,   JAK2↓, 7,   JNK↓, 1,   JNK↑, 8,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 9,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   mTOR↓, 24,   p‑mTOR↓, 2,   mTORC2↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 30,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PKCδ↓, 2,   PTEN↑, 8,   RAS↓, 1,   p‑RSK↑, 1,   SHP1↓, 1,   Sp1/3/4↓, 2,   STAT3↓, 25,   STAT3↑, 2,   p‑STAT3↓, 5,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 9,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   FOXO1↓, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac∅, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   miR-106b↓, 1,   miR-107↑, 1,   miR-126↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   OCT4↓, 4,   other↑, 1,   other↝, 3,   SD↑, 1,   SOX2↓, 2,   SUV39H↓, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   LC3B↑, 1,   LC3B-II↓, 1,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 1,   TumAuto↑, 10,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 12,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 2,   NKX3.1↓, 1,   P53↓, 2,   P53↑, 24,   p‑P53↑, 2,   PARP↑, 5,   cl‑PARP↑, 18,   PARP1↑, 1,   PCNA↓, 31,   PCNA↑, 1,   POLD1↓, 1,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 1,   XRCC1↓, 1,   γH2AX↑, 5,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 2,   CDK1↝, 1,   CDK2↓, 12,   CDK2↑, 1,   CDK4↓, 9,   CDK6↓, 6,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 28,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   GADD45A↓, 1,   Ki-67↓, 164,   Ki-67↑, 3,   MAD↓, 1,   P21↓, 3,   P21↑, 15,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 4,   RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 54,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 2,   AXIN1↑, 2,   BMPs↑, 1,   CD133↓, 5,   CD34↓, 2,   cFos↓, 1,   CSCs↓, 9,   CSCsMark↓, 1,   Diff↑, 1,   FGF↓, 1,   Gli1↓, 5,   HH?, 1,   HH↓, 6,   IGF-1↓, 2,   IGFBP3↓, 1,   Jun↓, 1,   Ki-67↓, 164,   Ki-67↑, 3,   MCM2↓, 1,   mTORC1↓, 2,   Nanog↓, 3,   NOTCH↓, 6,   NOTCH1↓, 2,   NOTCH1↑, 2,   OGFr↑, 1,   p300↓, 1,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 56,   TumCG↑, 2,   TumCG∅, 1,   TumCP?, 1,   TumCP↓, 66,   tyrosinase↓, 1,   Wnt↓, 7,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 5,   i-Ca+2↓, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 17,   EMT?, 1,   EMT↓, 22,   EpCAM↓, 1,   FAK↓, 7,   p‑FAK↓, 2,   Fibronectin↓, 2,   Furin↓, 1,   GLI2↓, 2,   GLI3↑, 1,   ITGA5↓, 1,   ITGB1↓, 2,   KRAS↓, 1,   L-sel↑, 1,   MALAT1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 30,   MMP9↑, 1,   MMPs↓, 5,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 11,   pax↓, 2,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   SMAD2↓, 2,   SMAD2↑, 1,   SMAD3↓, 2,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 33,   TumCMig?, 1,   TumCMig↓, 26,   TumCMig↑, 1,   TumMeta↓, 23,   TumMeta↑, 2,   TumPF↓, 2,   Twist↓, 4,   uPA↓, 4,   Vim?, 1,   Vim↓, 10,   Zeb1↓, 3,   ZEB2↓, 2,   β-catenin/ZEB1↓, 10,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   CD31/PECAM-1↓, 9,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 12,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   PGI2↓, 1,   VEGF↓, 27,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 6,   GLUT3↓, 1,   IBI↑, 1,   MMP↓, 20,   MMP↑, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   p‑cDC2↓, 1,   COX2/PTGS2↓, 20,   CXCL12↓, 1,   CXCR3↓, 1,   CXCR4↓, 4,   DR4↑, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↑, 1,   IL10↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↑, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 4,   Inflam↓, 13,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 36,   NF-kB↑, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 2,   PD-1↝, 1,   PD-L1↓, 5,   PGE2↓, 3,   PSA↓, 3,   Th1 response↑, 1,   TIM-3↑, 1,   TNF-α↓, 14,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 4,   COMT↓, 2,   DHT↓, 1,   ENL↑, 1,   ER-α36↓, 1,   FGF21↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 10,   BioAv↝, 4,   CBR1↓, 1,   ChemoSen↑, 39,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 31,   Dose∅, 1,   eff↓, 11,   eff↑, 20,   eff↝, 3,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 15,   Synergy↑, 41,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 1,   ALP↓, 1,   AR↓, 4,   ascitic↓, 1,   AST↓, 1,   BG↓, 1,   BRCA1↓, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 2,   EGFR↓, 13,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 10,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 1,   PD-L1↓, 5,   PSA↓, 3,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 2,   chemoP?, 1,   chemoP↑, 6,   chemoPv↑, 6,   ChemoSideEff↓, 2,   hepatoP↑, 4,   K17↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 9,   Strength↑, 1,   toxicity↓, 10,   toxicity↝, 2,   TumNum↓, 3,   TumVol↓, 23,   TumW↓, 12,   Weight↓, 1,   Weight∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 600

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 15,   Bil↓, 1,   Catalase↑, 9,   GPx↑, 9,   GSH↑, 11,   GSR↑, 2,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 5,   Keap1↓, 1,   lipid-P↓, 6,   MDA↓, 9,   NQO1↑, 2,   NRF2↑, 11,   ROS↓, 20,   SOD↑, 14,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 1,   ATP↓, 1,   ATP↑, 2,   FASN↓, 1,   glucose↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   PFK↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   IKKα↓, 1,   MAPK↓, 1,   PI3K↑, 1,   PP2A↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 4,   Ki-67↑, 3,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 4,   Ki-67↑, 3,   Nestin↑, 1,   NOTCH1↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Cartilage↑, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   ROCK1↓, 1,   TGF-β1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   CD31/PECAM-1↓, 1,   NO↓, 3,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   MMP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   Eos↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 6,   IL22↓, 2,   IL6↓, 6,   Imm↓, 1,   INF-γ↑, 1,   Inflam↓, 18,   Inflam↑, 1,   NF-kB↓, 7,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   PGE2↓, 2,   PSA↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 11,  

Cellular Microenvironment(tgid=17) ⓘ

TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 4,   GABA↑, 2,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 1,   PSD95↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   Aβ42↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1,   Estro↓, 1,   FGF21↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 7,   BioAv↝, 7,   Dose↑, 1,   Dose↝, 7,   Half-Life↓, 1,   Half-Life↝, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 2,   AST↓, 5,   Bil↓, 1,   BP↝, 1,   CEA↓, 1,   CRP↓, 3,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 6,   LDH↓, 3,   PSA↓, 1,   TC↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 6,   AntiTum↑, 1,   cardioP↑, 14,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 5,   hepatoP↑, 8,   memory↑, 6,   neuroP↑, 16,   Obesity↓, 3,   OS↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 8,   toxicity↝, 5,   toxicity∅, 2,   Weight↓, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 4,  
Total Targets: 213

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
6 Benzyl isothiocyanate
5 Melatonin
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
5 Flaxseed/Linseed
5 Magnolol
5 Thymoquinone
4 Berberine
4 itraconazole
4 Luteolin
4 Lycopene
4 Resveratrol
3 Capsaicin
3 Formononetin
3 Phenethyl isothiocyanate
3 doxorubicin
3 L-Theanine
3 SDG/lignans
3 Linalool
3 Sulforaphane (mainly Broccoli)
2 Açaí, Euterpe oleracea
2 Silver-NanoParticles
2 Cisplatin
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Carnosic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 chaetocin
2 Chrysin
2 Docetaxel
2 Eugenol
2 Ferulic acid
2 Fisetin
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Ivermectin
2 Kaempferol
2 Metformin
2 Piperlongumine
2 Gemcitabine (Gemzar)
1 Astragalus
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Black Rice, Oryza sativa
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Cat’s Claw
1 Chlorogenic acid
1 Propolis -bee glue
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 D-limonene
1 Ellagic acid
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Bortezomib
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Inositol
1 phytic acid, Inositol hexakisphosphate
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Licochalcone A
1 low dose naltrexone
1 Curcumin
1 Radiotherapy/Radiation
1 Matrine
1 mebendazole
1 Sulindac
1 Modified Citrus Pectin
1 immunotherapy
1 Lemon Balm/Melissa officinalis
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Phycocyanin
1 Piperine
1 Psoralidin
1 Pterostilbene
1 Rosmarinic acid
1 Sesamin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Xylitol
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:425  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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