Casp7 Cancer Research Results

Casp7, Caspase-7: Click to Expand ⟱
Source:
Type:
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, −8, −9 and −10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, −6, and −7) that carry out the demolition phase of apoptosis. Downregulation of caspase-3 is an effective apoptosis-evading mechanism frequently observed in cancer cells in association with acquired chemoresistance to apoptosis-inducing anticancer drugs. Indeed, re-expression of caspase-3 often restores sensitivity to apoptosis.
Caspase-7:
Role: Executioner caspase similar to caspase-3.
Cancers: Expression levels can vary; often studied in breast and prostate cancers.
Prognosis: Its prognostic value is less clear and may depend on the cancer type.
Scientific Papers found: Click to Expand⟱
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2/PTGS2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
2112- TQ,    Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells
- in-vitro, BC, MCF7
Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,
2120- TQ,    Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3
- in-vitro, Melanoma, A431
ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,
2083- TQ,    Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- in-vitro, GC, HGC27 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vivo, NA, NA
p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, EGFR↓, ROS↑,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3416- TQ,    Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 253J - in-vitro, Nor, SV-HUC-1
TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,
3554- TQ,    Neuroprotective efficacy of thymoquinone against amyloid beta-induced neurotoxicity in human induced pluripotent stem cell-derived cholinergic neurons
- in-vitro, AD, NA
*GSH↑, *ROS↓, *neuroP↑, *Casp3↓, *Casp7↓, *antiOx↓, *H2O2↓,
1020- UA,    Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
- in-vitro, Melanoma, RPMI-8226
β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,

Showing Research Papers: 101 to 116 of 116
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 116

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 2,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 12,   GSH↑, 2,   GSH/GSSG↓, 2,   GSR↓, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   mt-H2O2↑, 1,   HO-1↑, 4,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 4,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 4,   OSI↑, 1,   Prx4↑, 1,   ROS↓, 4,   ROS↑, 44,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 4,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 4,   OCR↓, 2,   mt-OXPHOS↓, 1,   PHB↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACSL4↑, 1,   ALAT↝, 1,   AMP↑, 1,   AMPK↑, 3,   ATP↓, 4,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 5,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 3,   LDL↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 2,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 58,   BAD↓, 2,   BAD↑, 4,   p‑BAD↓, 1,   Bak↑, 3,   BAX↑, 36,   Bax:Bcl2↑, 7,   Bcl-2↓, 40,   Bcl-2↑, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 6,   BID↑, 4,   p‑BID↓, 1,   BIM↑, 2,   BOK↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 87,   cl‑Casp3↑, 13,   Casp6↑, 1,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 98,   cl‑Casp7↑, 15,   Casp8↑, 13,   cl‑Casp8↑, 4,   Casp9?, 1,   Casp9↑, 42,   cl‑Casp9↑, 7,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   Diablo↑, 1,   DR5↑, 3,   FADD↑, 2,   Fas↑, 8,   FasL↑, 2,   Ferroptosis↑, 2,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 2,   Mcl-1↓, 5,   p‑Mcl-1↓, 1,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   NAIP↓, 1,   p38↓, 1,   p38↑, 8,   p‑p38↑, 1,   PUMA↑, 2,   RIP3↑, 1,   survivin↓, 21,   TRAIL↑, 2,   TumCD↓, 1,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 20,   p‑Akt↓, 8,   AKT1↓, 2,   CK2↓, 2,   cMET↓, 1,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 9,   ERK↓, 12,   ERK↑, 2,   e-ERK↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 3,   p‑MAPK↓, 1,   MKK4↓, 1,   mTOR↓, 12,   p‑mTOR↓, 2,   PDGFRA↓, 1,   PI3K↓, 18,   PTEN↑, 5,   p‑PTEN↓, 1,   RAS↓, 2,   RIP1↑, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   c-Src↓, 1,   STAT3↓, 11,   p‑STAT3↓, 4,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF4↑, 4,   ATF4↝, 1,   cJun↓, 1,   cMyc↓, 13,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   p‑FOXO3↓, 1,   H3↓, 1,   HATs↓, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   miR-21↓, 1,   miR-339-5p↝, 1,   Myc↓, 2,   OCT4↓, 4,   other↑, 1,   other↝, 1,   SOX2↓, 1,   SOX4↑, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 9,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↑, 24,   P53↓, 1,   P53↑, 26,   P53∅, 1,   PARP↑, 8,   PARP↝, 1,   cl‑PARP↑, 33,   PARP1↑, 1,   PCNA↓, 8,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 6,   p‑CDK2↓, 2,   CDK4↓, 11,   p‑CDK4↓, 1,   CDK6↓, 4,   CDKN2C/p18↑, 1,   p‑CHK1↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 22,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   cycE1↓, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 3,   P21↑, 14,   p27/CDKN1B↑, 4,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 41,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   cFos↓, 1,   CSCs↓, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 4,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 3,   STAT1↓, 1,   TumCG↓, 20,   TumCP↓, 32,   TumCP↑, 2,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 6,   cal2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 7,   EM↑, 1,   EMT↓, 15,   FAK↓, 3,   GLI2↓, 2,   hnRNPA1↓, 1,   ITGB4↓, 1,   LEF1↓, 2,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 14,   MMPs↓, 5,   N-cadherin↓, 6,   PAI-1/SERPINE1↑, 1,   PCBP1↓, 1,   Slug↓, 5,   Snail↓, 9,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TumCI↓, 16,   TumCMig↓, 10,   TumMeta↓, 17,   Twist↓, 6,   TXNIP↑, 2,   uPA↓, 3,   Vim↓, 6,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 15,   angioG↑, 2,   CD31/PECAM-1↓, 2,   HIF-1↓, 1,   Hif1a↓, 11,   VCAM-1↓, 1,   VEGF↓, 21,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   EPR↑, 1,   GLUT1↓, 2,   IBI↑, 1,   MMP?, 1,   MMP↓, 21,   MMP∅, 1,   MPT↑, 2,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 12,   CXCR4↓, 3,   DR4↑, 1,   ICAM-1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 5,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 5,   MCT1↓, 1,   NF-kB↓, 19,   p‑NF-kB↑, 1,   NK cell↑, 2,   p50↓, 1,   PGE2↓, 3,   PSA↓, 2,   SOCS-3↓, 1,   TCF↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↑, 24,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose↑, 2,   Dose↝, 12,   Dose∅, 2,   eff↓, 12,   eff↑, 13,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   RadioS↑, 6,   selectivity?, 1,   selectivity↑, 24,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↝, 1,   ALP↝, 1,   AR↓, 3,   AST↝, 1,   p‑BRCA1↑, 1,   EGFR↓, 9,   EZH2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 5,   LDH↓, 1,   LDH↑, 1,   Myc↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 1,   chemoP↑, 6,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 1,   PFS↑, 1,   RenoP↑, 1,   Risk↓, 5,   toxicity↓, 2,   toxicity↝, 1,   TumNum↓, 1,   TumVol↓, 7,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 438

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 8,   GPx↑, 8,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 7,   MDA↓, 3,   NRF2↑, 2,   ROS↓, 13,   SOD↑, 8,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   HMG-CoA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp7↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   MAPK↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GastroP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 5,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 3,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 19,   NF-kB↓, 3,   NK cell↑, 2,   PGE2↓, 2,   PSA∅, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 3,   Dose↝, 2,   GSTA1↑, 1,   Half-Life↝, 2,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 3,   LDH↓, 1,   PSA∅, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 6,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 6,   chemoPv↑, 1,   diuretic↑, 1,   hepatoP↑, 6,   neuroP↑, 11,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↓, 1,   AntiViral↑, 4,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 104

Scientific Paper Hit Count for: Casp7, Caspase-7
8 Thymoquinone
6 EGCG (Epigallocatechin Gallate)
6 Kaempferol
5 Quercetin
5 Sulforaphane (mainly Broccoli)
5 Magnetic Fields
4 Silver-NanoParticles
3 Cisplatin
3 Chrysin
3 Fucoidan
3 Marjoram (Origanum majorana)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 Cinnamon
2 doxorubicin
2 Echinacea
2 Fisetin
2 Graviola
2 Lemon Balm/Melissa officinalis
2 Phenylbutyrate
2 Piperlongumine
1 Auranofin
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Bromelain
1 borneol
1 Black turtle bean
1 Caffeic acid
1 Carvacrol
1 Cat’s Claw
1 Cucurbitacin
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 Docetaxel
1 Emodin
1 Eurycomanone
1 Eugenol
1 Fenbendazole
1 Flaxseed/Linseed
1 Ginger/6-Shogaol/Gingerol
1 Hibiscus sabdariffa
1 Honokiol
1 Inulin Prebiotic
1 Isoliquiritigenin
1 Ivermectin
1 Juglone
1 Lapachol
1 Licochalcone A
1 Licorice
1 Luteolin
1 Lycopene
1 Magnolol
1 Matrine
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 Mangiferin
1 magnetic nanoparticles
1 Iron
1 Moringa oleifera
1 Methylsulfonylmethane
1 Nimbolide
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Shikonin
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:43  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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