Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Scientific Papers found: Click to Expand⟱

6881-

FA,

Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight

-

Review,

Var,

NA

ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,

7512-

FA,

Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro

-

in-vitro,

PC,

MIA PaCa-2

cycD1/CCND1↓, CDK4↓, CDK6↓, Casp10↓, Casp8↓, P53↑, BAX↑, PTEN↑, Casp3↑, Casp9↑, TumCCA↑, TumCI↑,

7507-

FA,

Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

PC3

Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,

6899-

FIS,

Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

22Rv1

Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,

2852-

FIS,

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

-

Review,

CRC,

NA

Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,

2853-

FIS,

Fisetin Inhibits Cell Proliferation and Induces Apoptosis via JAK/STAT3 Signaling Pathways in Human Thyroid TPC 1 Cancer Cells

-

in-vitro,

Thyroid,

TPC-1

Apoptosis↑, ROS↑, MMP↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, JAK1↓, STAT3↓,

2857-

FIS,

A review on the chemotherapeutic potential of fisetin: In vitro evidences

-

Review,

Var,

NA

COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,

2844-

FIS,

Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells

-

in-vitro,

OS,

U2OS

tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,

2824-

FIS,

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,

2828-

FIS,

Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review

-

Review,

Var,

NA

*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,

2829-

FIS,

Fisetin: An anticancer perspective

-

Review,

Var,

NA

TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,

2830-

FIS,

Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent

-

Review,

Var,

NA

TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,

2841-

FIS,

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer

-

in-vitro,

Nor,

RAW264.7

LPS-induced Raw264.7 cells

-

in-vitro,

Liver,

HepG2

10, 25, 100, and 200 μM, 24 h

-

in-vitro,

Liver,

Hep3B

-

in-vitro,

Liver,

HUH7

*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,

1155-

Fuc,

The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

-

Review,

Var,

NA

100 μg/mL

*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,

7020-

Fuc,

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

Nor,

WI38

tumCV↓, selectivity↑, Apoptosis↑, Casp8↑, Casp9↑,

7035-

GA,

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway

-

in-vitro,

IBD,

Caco-2

*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,

7049-

GA,

Pharmacological effects of gallic acid in health and diseases: A mechanistic review

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,

1086-

GA,

Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation

-

in-vitro,

AML,

K562

tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,

7059-

GamB,

Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells

-

in-vitro,

CRC,

HCT15

TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,

5148-

GamB,

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics

-

Review,

Var,

NA

AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,

5149-

GamB,

Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells

-

in-vitro,

lymphoma,

JeKo-1

TumCG↓, Apoptosis↑, selectivity↑, MMP↓, Casp3↑, Casp9↑, Casp8↑, Bax:Bcl2↑,

1967-

GamB,

Gambogic acid induces apoptotic cell death in T98G glioma cells

-

in-vitro,

GBM,

T98G

BAX↑, AIF↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↓, Bcl-2↓, ROS↑,

7092-

GAR,

Garcinol and Its Role in Chronic Diseases

-

Review,

Var,

NA

antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,

821-

GAR,

Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis

-

in-vitro,

Liver,

Hep3B

ROS↑, CHOP/DDIT3↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,

823-

GAR,

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

-

in-vitro,

BC,

MCF7

-

in-vitro,

Nor,

MCF10

-

in-vitro,

CRC,

HCT116

Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

6573-

Ger,

Systematic elucidation of the mechanism of geraniol via network pharmacology

-

Study,

Nor,

NA

-

Study,

Var,

NA

HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,

7138-

GI,

6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways

-

vitro+vivo,

BC,

MDA-MB-231

-

in-vitro,

Pca,

DU145

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Lung,

A549

TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,

7261-

Gink,

Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway

-

in-vitro,

RCC,

786-O

TumCG↓, Casp3↑, Casp8↑, Casp9↑, JAK2↓, STAT3↓,

7247-

Gink,

Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

BT474

-

vitro+vivo,

BC,

MCF7

MCF-7 xenograft nude mice

TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,

7315-

Gos,

Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells

-

vitro+vivo,

CRC,

HT29

-

in-vitro,

CRC,

COLO205

TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,

843-

Gra,

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

-

in-vitro,

NMSC,

A431

3.5 µg/mL

DCM fraction proved to be by far the most potent in inhibiting the proliferation

-

in-vitro,

NMSC,

UW-BCC1

4.0 µg/mL

-

in-vitro,

Nor,

NHEKn

38.8 µg/mL

10-fold higher than in noncancerous NHEKn cells

TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,

848-

Gra,

AgNPs,

Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles

-

in-vitro,

CRC,

HCT116

ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,

2516-

H2,

Hydrogen Gas in Cancer Treatment

-

Review,

Var,

NA

*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,

1644-

HCAs,

PBG,

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis

-

in-vitro,

Pca,

LNCaP

NF-kB↓, TRAILR↑, Casp8↑, Casp3↑, MMP↓, Dose?,

7359-

HibSad,

Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed

-

Review,

Var,

NA

AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,

7365-

HibSad,

Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L

-

Review,

Var,

NA

chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,

7357-

HibSad,

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells

-

in-vitro,

CRC,

LoVo

0, 1, 2, and 3 mg/mL) were administered over 0, 12, 24, and 48 h

Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,

7345-

Hne,

A root extract of Helleborus niger possess cytotoxic properties in neuroblastoma cells

-

in-vitro,

neuroblastoma,

NXS2

TumCP↓, Casp8↑, Casp9↑, Ca+2↑,

1286-

HNK,

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells

-

in-vitro,

CLL,

NA

Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, BAX↑,

2885-

HNK,

Honokiol: a novel natural agent for cancer prevention and therapy

-

Review,

Var,

NA

NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,

7567-

HYP,

Hyperoside: A review on its sources, biological activities, and molecular mechanisms

-

Review,

Var,

NA

*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,

7555-

HYP,

RT,

Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells

-

in-vitro,

Colon,

HT29

tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,

7560-

HYP,

Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

-

Review,

Nor,

NA

-

Review,

AD,

NA

*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,

7584-

I3C,

Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

CRC,

HCT8

-

in-vitro,

Liver,

HepG2

TumCP↓, Apoptosis↑, TumCI↓, *antiOx↑, AhR↑, MMP↓, Casp3↑, Casp8↑,

7763-

ISL,

Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer

-

Review,

Var,

NA

AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,

9253-

ISO, IH,

Progress in the antitumor molecular mechanisms of Isorhamnetin

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiTum↑, TumCP↓, Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, ChemoSen↑, PI3K↓, Akt↓, TumCCA↑, MAPK↓, TumCG↓, CDK2↑, PPARγ↑, PTEN↓, CAIX/CA9↓, Casp8↑, Casp9↑, Casp3↑, ROS↑, ER Stress↑, UPR↑, BAX↑, Cyt‑c↑, cl‑PARP↑, Bcl-2↓, MMP↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, EMT↓, MMP2↓, MMP9↓,

7798-

ISQ,

MOR,

Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin

-

in-vitro,

AD,

NA

*ROS↓, *Casp3↓, *Casp8↓, *Casp9↓, *Aβ↓,

7848-

ISQ,

Review of anticancer mechanisms of isoquercitin

-

Review,

Var,

NA

BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,

7965-

JG,

Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

HT-29

Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,

1918-

JG,

ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro

-

in-vitro,

Liver,

HepG2

1-30uM

-

in-vivo,

NA,

NA

4mg/kg

mice were intraperitoneally injected with 10%
dimethyl sulfoxide (DMSO) or JG (4 mg/kg) every other day for ten
times in tota

TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,

Showing Research Papers: 101 to 150 of 235
Prev Page 3 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 235

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 3, Catalase↓, 7, Catalase↑, 1, GCLM↓, 1, GPx↓, 1, GPx↑, 1, GSH↓, 20, GSH↑, 3, GSH/GSSG↓, 1, GSR↓, 1, GSR↑, 1, GSTs↓, 2, GSTs↑, 1, GSTs↝, 1, H2O2↓, 1, H2O2↑, 4, i-H2O2↑, 1, HO-1↓, 2, HO-1↑, 6, HO-1↝, 1, Iron↓, 1, Iron↑, 1, lipid-P?, 1, lipid-P↓, 3, lipid-P↑, 4, MDA↑, 5, MPO↓, 2, NQO1↓, 1, NQO1↑, 2, NRF2↓, 4, NRF2↑, 7, p‑NRF2↑, 1, RNS↑, 1, ROS?, 3, ROS↓, 8, ROS↑, 106, ROS⇅, 3, ROS∅, 1, i-ROS?, 1, i-ROS↑, 2, mt-ROS↑, 3, SOD↓, 5, SOD↑, 3, SOD1↑, 1, SOD2↓, 2, SOD2↑, 2, TAC↓, 1, TBARS↑, 1, ox-Trx1↑, 1, TrxR↓, 4, TrxR1↓, 1, VitC↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1, IronCh↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2, CDC2↓, 6, CDC25↓, 13, CDC25↑, 1, compIV↓, 1, EGF↓, 1, ETC↓, 1, HSP60/HSPD1↑, 1, mtDam↑, 9, OCR↓, 1, OXPHOS↓, 1, PDH↓, 1, PINK1↑, 1, SDH↓, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 2, ACC↑, 1, ACLY↓, 1, ALAT↓, 4, AMP↑, 1, AMPK↓, 1, AMPK↑, 9, AMPK↝, 1, ATP↓, 4, ATP↝, 1, CAIX/CA9↓, 1, citrate↓, 1, CPT1A↓, 1, ENO1↓, 1, FABP4↓, 1, FASN↓, 2, FASN↑, 2, FBPase↑, 1, glucoNG↑, 1, GlucoseCon↓, 4, Glycolysis↓, 6, GSK‐3β↓, 5, GSK‐3β↑, 4, p‑GSK‐3β↓, 3, H2S↑, 1, HK2↓, 5, lactateProd↓, 5, LDHA↓, 3, LDL↓, 1, PDK1 / PDPK1↓, 1, PFK↓, 2, PFK1↓, 1, PFK2?, 1, PFK2↓, 1, PKM2↓, 3, PKM2∅, 1, p‑S6↓, 1, SCD1↓, 1, SIRT1↓, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 1, TCA↓, 2, TCA↑, 1, Warburg↓, 2, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 14, APAF1↑, 6, Apoptosis↓, 4, Apoptosis↑, 116, mt-Apoptosis↑, 1, ASC↓, 1, ASK1↑, 1, BAD↓, 3, BAD↑, 11, Bak↓, 1, Bak↑, 4, BAX↑, 86, BAX⇅, 1, BAX∅, 1, Bax:Bcl2↑, 15, Bcl-2↓, 80, Bcl-2↑, 4, Bcl-2∅, 2, Bcl-xL↓, 19, Bcl-xL↑, 2, Bcl-xL∅, 1, BID↓, 2, BID↑, 9, cl‑BID↑, 6, BIM↑, 4, BOK↑, 1, Casp↑, 5, Casp↝, 1, Casp1↓, 1, Casp1↑, 2, Casp10↓, 1, Casp10↑, 2, Casp10∅, 1, Casp12↑, 2, Casp2↑, 4, Casp3↓, 3, Casp3↑, 146, Casp3↝, 1, Casp3∅, 1, cl‑Casp3↑, 29, proCasp3↓, 2, proCasp3↑, 2, CASP4↑, 1, Casp6↓, 1, Casp6↑, 1, Casp7↑, 13, cl‑Casp7↑, 4, Casp8↓, 5, Casp8↑, 181, Casp8↝, 1, Casp8∅, 4, cl‑Casp8↑, 30, proCasp8↓, 2, proCasp8↑, 4, pro‑Casp8↑, 1, Casp9?, 1, Casp9↓, 2, Casp9↑, 129, Casp9↝, 1, cl‑Casp9↑, 18, proCasp9↓, 2, proCasp9↑, 2, cFLIP↓, 8, Cyt‑c↑, 70, Cyt‑c↝, 1, Diablo↑, 4, DR5↑, 26, DR5∅, 1, FADD↑, 9, FADD∅, 1, Fas↓, 1, Fas↑, 34, FasL↓, 1, FasL↑, 16, Ferroptosis↑, 1, IAP1↓, 7, IAP2/BIRC3↓, 4, cl‑IAP2/BIRC3↑, 1, ICAD↓, 1, iNOS↓, 5, Mcl-1↓, 18, cl‑Mcl-1↑, 1, MDM2↓, 5, MDM2↑, 1, p‑MDM2↓, 1, MLKL↑, 1, p‑MLKL↓, 1, MOMP↑, 1, NAIP↓, 1, Necroptosis↑, 2, necrosis↑, 2, p38↓, 2, p38↑, 15, p‑p38↓, 1, p‑p38↑, 6, PUMA↑, 3, PUMA↝, 1, Pyro↑, 2, RIP3↑, 1, p‑RIP3↑, 1, survivin↓, 31, TNFR 1↑, 2, TRAIL↑, 9, TRAILR↑, 3, TumCD↓, 1, TumCD↑, 7, XIAP↓, 23, XIAP↑, 1, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 56, Akt↑, 3, p‑Akt↓, 15, AKT1↓, 2, AMPKα↑, 1, CaMKII ↓, 1, CK2↓, 2, cMET↓, 3, cSrc↓, 2, EGFR↓, 16, EGFR↑, 2, p‑EGFR↓, 1, ERK↓, 23, ERK↑, 6, p‑ERK↓, 7, p‑ERK↑, 1, p‑ERK⇅, 1, FOXD3↑, 1, HER2/EBBR2↓, 6, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 1, HRAS↓, 1, IGF-1R↓, 3, IGF-1R↑, 1, IKKα↓, 7, IKKα↑, 1, p‑IKKα↓, 1, p‑IκB↓, 1, JAK1↓, 5, p‑JAK1↓, 1, JAK2↓, 7, p‑JAK2↓, 4, JNK↓, 2, JNK↑, 14, p‑JNK↓, 2, p‑JNK↑, 2, cl‑JNK↑, 1, MAPK↓, 12, MAPK↑, 8, MEK↓, 2, p‑MEK↓, 2, mTOR↓, 28, mTOR↑, 2, mTOR↝, 1, p‑mTOR↓, 3, mTORC2↓, 1, p70S6↓, 1, P70S6K↓, 6, p‑P70S6K↓, 1, P90RSK↓, 1, p‑PDGFR-BB↓, 1, PI3K↓, 40, p‑PI3K↓, 4, PI3K/Akt↓, 1, PI3k/Akt/mTOR↝, 1, PIAS-3↑, 1, PIK3CA↓, 1, PKA↓, 1, PKCδ↓, 5, p‑PKCδ↓, 1, cl‑PKCδ↑, 1, PTEN↓, 2, PTEN↑, 10, Raf↓, 3, RAS↓, 6, RIP1↑, 1, SHP1↓, 1, SHP1↑, 1, Sp1/3/4↓, 3, Src↓, 1, p‑Src↓, 2, STAT↓, 1, STAT3↓, 21, STAT3↑, 1, p‑STAT3↓, 5, STAT6↓, 2, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 5, ATFs↑, 1, cJun↓, 2, cJun↑, 3, p‑cJun↑, 2, cMyc↓, 11, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 3, DNMT3A↓, 1, DNMTs↓, 1, FOXM1↓, 2, FOXO↑, 2, FOXO1↑, 2, FOXO3↓, 1, FOXO3↑, 1, p‑FOXO3↓, 1, FOXO4↑, 1, H3↓, 2, ac‑H3↑, 1, H4↓, 1, ac‑H4↑, 1, HATs↓, 2, HDAC↓, 5, HDAC1↓, 2, HDAC3↓, 1, HES1↓, 1, miR-130a↓, 1, miR-200b↑, 1, miR-200c↑, 1, miR-21↓, 2, Myc↓, 3, MYCN↓, 1, OCT4↓, 2, other↓, 2, other↑, 1, other↝, 3, PCAF↓, 1, SOX2↓, 1, SOX9↓, 1, SUV39H↓, 1, tumCV?, 1, tumCV↓, 36,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↑, 16, eIF2α↓, 1, eIF2α↑, 1, p‑eIF2α↑, 4, ER Stress↓, 2, ER Stress↑, 15, GRP78/BiP↓, 1, GRP78/BiP↑, 8, HSP27↓, 2, HSP70/HSPA5↓, 2, HSP70/HSPA5↑, 1, HSP72↓, 1, HSP90↓, 3, HSPs↓, 1, IRE1↑, 1, PERK↑, 3, UPR↑, 4, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4, ATG5↝, 1, ATG7↑, 1, Beclin-1/ATG6↑, 7, Beclin-1/ATG6↝, 1, CTSB↓, 1, CTSD↓, 1, LC3B↑, 2, LC3B-II↑, 2, LC3I↑, 1, LC3II↑, 6, p62↓, 2, p62↑, 2, PARK2↑, 1, TumAuto↑, 17, TumAuto⇅, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, ATR↑, 1, DFF45↑, 2, DNA-PK↑, 1, DNAdam↑, 35, DNArepair↓, 1, hTERT/TERT↓, 5, p16↑, 2, P53↓, 1, P53↑, 48, p‑P53↑, 4, p53 Wildtype↓, 1, PARP↓, 1, PARP↑, 16, p‑PARP↑, 1, cl‑PARP↓, 2, cl‑PARP↑, 73, cl‑PARP1↑, 2, PCNA↓, 13, SIRT6↓, 1, Telomerase↓, 6, TOP1↓, 2, TOP2↓, 4, TOP2↑, 1, TP53↓, 1, TP53↑, 2, UHRF1↓, 1, γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1, AURKB↑, 1, CDK1↓, 9, CDK1↑, 4, p‑CDK1↓, 2, p‑CDK1↑, 1, CDK2↓, 18, CDK2↑, 2, p‑CDK2↓, 1, CDK4↓, 23, CDK4↑, 2, CDK4∅, 1, CDK4/6↓, 1, CDK6↓, 8, CDK6↑, 3, CDK6∅, 1, CDK8↓, 1, CHK1↓, 1, Cyc↓, 2, cycA1/CCNA1↓, 7, CycB/CCNB1↓, 16, CycB/CCNB1↑, 3, cycD1/CCND1↓, 33, cycD1/CCND1↑, 2, cycD1/CCND1∅, 1, CycD3↓, 1, cycE/CCNE↓, 15, cycE1↓, 1, cycF↑, 1, E2F4↑, 1, E2Fs↓, 2, GADD45A↑, 1, Ki-67↓, 6, mitA↑, 1, p19↑, 1, P21↑, 37, p27/CDKN1B↑, 15, pRB↑, 1, p‑pRB↓, 1, RB1↓, 1, RB1↑, 2, p‑RB1↓, 3, Securin↓, 1, TumCCA?, 1, TumCCA↑, 91, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1, ALDH1A1↓, 1, BMP7/OP1↓, 1, CD133↓, 2, CD24↓, 1, CD34↓, 1, cFos↓, 2, cFos↑, 1, CSCs↓, 9, Diff↑, 2, FGF↓, 1, Gli1↓, 2, HH↓, 1, IGF-1↓, 2, IGFBP3↑, 1, JAG1↓, 1, p‑Jun↑, 1, Ki-67↓, 6, Let-7↑, 1, mTORC1↓, 2, Nanog↓, 2, NICD↓, 1, NOTCH↓, 4, NOTCH1↓, 6, NOTCH3↓, 1, p300↓, 1, Shh↓, 2, Smo↓, 2, STAT1↓, 1, Sufu↑, 1, TAZ↓, 1, TumCG?, 1, TumCG↓, 43, TumCG↑, 1, TumCP↓, 60, tyrosinase↓, 1, Wnt↓, 12, Wnt↑, 2, Wnt/(β-catenin)↓, 1, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg↑, 1, AP-1↓, 5, AXL↓, 1, Ca+2↓, 1, Ca+2↑, 14, Ca+2↝, 4, i-Ca+2↑, 3, cal2↓, 1, cal2↑, 1, CCN2/CTGF↓, 1, Cdc42↓, 1, Cdc42↑, 1, Cofilin↓, 1, COL1↓, 1, COL3A1↓, 1, DLC1↑, 1, E-cadherin↓, 5, E-cadherin↑, 9, EM↑, 1, EMT↓, 18, EMT↑, 1, FAK↓, 7, p‑FAK↓, 2, Fibronectin↓, 1, GLI2↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB4↓, 1, LEF1↓, 1, LIMK2↓, 1, LRP1↓, 1, MET↓, 1, p‑MET↓, 1, MMP1↓, 3, MMP13↓, 1, MMP2↓, 35, MMP3↓, 1, MMP7↓, 3, MMP9↓, 41, MMPs↓, 11, MTA1↓, 1, N-cadherin↓, 10, PAK1↓, 1, PDGF↓, 2, Rac1↓, 1, Rho↓, 2, ROCK1↓, 2, Sharpin↓, 1, Slug?, 1, Slug↓, 8, SMAD3↓, 1, SMAD3↑, 1, p‑SMAD4↓, 1, Snail?, 1, Snail↓, 15, TET1↓, 1, TGF-β↓, 7, TGF-β↑, 1, TIMP1↓, 1, TIMP1↑, 3, TIMP2↓, 3, TIMP2↑, 7, TIMP3↑, 1, TSP-1↑, 1, TumCI↓, 31, TumCI↑, 1, TumCMig↓, 25, TumMeta↓, 16, Twist↓, 6, Tyro3↓, 1, uPA↓, 11, Vim↓, 7, Vim↑, 1, Zeb1↓, 2, Zeb1↑, 1, ZEB2↓, 1, α-tubulin↓, 1, β-catenin/ZEB1↓, 16,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32, CD31/PECAM-1↓, 2, Endoglin↑, 1, HIF-1↓, 2, Hif1a↓, 12, NO↑, 1, VCAM-1↓, 2, VEGF↓, 38, VEGF↑, 1, VEGFR2/KDR/Flk1↓, 5,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, CLDN1↓, 1, CLDN2↓, 1, EPR↑, 1, GLUT1↓, 4, GLUT2↓, 1, memfluid↓, 1, MMP?, 1, MMP↓, 75, MMP↑, 1, MPT↑, 2, TRPM7↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1, CD4+↑, 1, CD44↓, 4, CD8+↑, 1, cDC2↓, 1, COX1↓, 1, COX2/PTGS2↓, 29, COX2/PTGS2↑, 1, CXCL1↓, 1, CXCR2↓, 1, CXCR4↓, 6, DR4↑, 7, DR4∅, 2, DR6↑, 1, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 2, IFN-γ↓, 2, IL1↓, 2, IL10↓, 1, IL12↓, 2, IL17↓, 1, IL1α↓, 1, IL1β↓, 6, IL2↑, 2, IL6↓, 12, IL8↓, 5, Imm↑, 1, Imm↝, 1, Inflam↓, 12, MCP1/CCL2↓, 2, MIP2↓, 1, NF-kB↓, 55, NF-kB↑, 6, p‑NF-kB↓, 2, p‑NF-kB↑, 1, NK cell↑, 1, NLRP3↓, 2, p50↓, 2, p65↓, 3, p‑p65↓, 1, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 8, PSA↓, 2, RAGE↓, 2, T-Cell↝, 1, TCF↑, 1, TLR4↓, 2, TNF-α↓, 14, TNF-α↑, 5, TNF-α∅, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2, TRADD↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1, AR↓, 7, PPARα↓, 1, cl‑PPARα↓, 1, PPARγ↑, 3,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 13, BioAv↑, 25, BioAv↝, 2, ChemoSen↓, 2, ChemoSen↑, 41, CompStab↑, 1, CompStab↝, 1, CYP1A1↓, 1, CYP1B1↑, 1, DDS↑, 1, Dose?, 3, Dose↓, 2, Dose↑, 4, Dose⇅, 1, Dose↝, 13, Dose∅, 3, eff↓, 24, eff↑, 30, eff↝, 8, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 3, Half-Life∅, 1, MDR1↓, 2, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 5, P450↓, 2, P450↝, 1, RadioS↑, 15, selectivity↓, 1, selectivity↑, 51, Synergy↑, 20, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 4, ALP↓, 2, AR↓, 7, ascitic↓, 1, AST↓, 4, CEA↓, 2, EGFR↓, 16, EGFR↑, 2, p‑EGFR↓, 1, FOXM1↓, 2, HER2/EBBR2↓, 6, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 5, IL6↓, 12, LDH↑, 1, Myc↓, 3, NSE↓, 1, PD-L1↓, 1, PSA↓, 2, RAGE↓, 2, TP53↓, 1, TP53↑, 2, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18, antiCG↓, 1, antiD↑, 1, antiNeop↑, 1, AntiTum↑, 4, cachexia↓, 2, cardioP↑, 2, chemoP↑, 8, chemoPv↑, 8, chemoPv⇅, 1, ChemoSideEff↓, 1, hepatoP↑, 2, OS↑, 4, QoL↑, 1, radioP↑, 2, RenoP↑, 4, Risk↓, 2, toxicity↓, 9, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 7, Weight↑, 1, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 3, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 750

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 34, Catalase↑, 17, GPx↑, 13, GSH↑, 15, GSR↑, 2, GSTs↑, 10, H2O2↓, 1, HDL↑, 2, HO-1↑, 5, hyperG↝, 1, Keap1↓, 1, Keap1↑, 1, lipid-P↓, 9, MDA↓, 13, MPO↓, 3, NADH↓, 1, NQO1↑, 2, NRF2↓, 1, NRF2↑, 11, RNS↓, 3, ROS↓, 32, ROS↑, 3, ROS⇅, 1, ROS∅, 1, SOD?, 1, SOD↑, 20, SOD1↑, 1, TBARS↓, 2, uricA↓, 1, VitC↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1, IronCh↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 1, ALAT↓, 8, AMPK↑, 2, ATP↑, 2, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, GSK‐3β↑, 1, H2S↑, 1, HMG-CoA↓, 1, LDL↓, 3, lipidLev↓, 1, SIRT1↑, 4, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5, ASC↓, 1, BAD↓, 1, BAX↓, 8, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↑, 3, Casp1↓, 3, Casp3↓, 10, Casp3↑, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 1, Casp8↓, 5, Casp8↑, 1, cl‑Casp8↓, 1, cl‑Casp8↑, 3, Casp9↓, 4, Casp9↑, 1, cl‑Casp9↑, 1, Cyt‑c↓, 4, Fas↑, 2, iNOS↓, 8, p38↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 1, p‑Akt↑, 2, JNK↓, 1, p‑JNK↓, 1, MAPK↓, 5, MAPK↑, 2, mTOR↑, 1, PI3K↓, 1, PI3K↑, 1, PKCδ↓, 1, RIP1↓, 1, STAT3↑, 1, p‑STAT3↑, 1, STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF4↓, 1, cJun↓, 1, HDAC↓, 1, HDAC3↓, 1, HOTAIR↑, 1, other↓, 1, other↑, 2, other↝, 1, RUNX2↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2, ER Stress↓, 1, GRP78/BiP↓, 1, UPR↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1, P53↓, 2, P53↑, 2, PARP↑, 1, cl‑PARP↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, Ki-67↓, 1, P21↓, 2, P21↑, 3, TumCCA↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Ki-67↓, 1, neuroG↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, BACH1↓, 1, Ca+2?, 1, Ca+2↝, 1, COL1↓, 1, COL1↑, 1, MMP13↓, 1, MMP3↓, 1, PAI-1/SERPINE1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, TGF-β↓, 1, TXNIP↓, 1, α-SMA↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5, NO↑, 1, VCAM-1↓, 1,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1, BBB↓, 1, BBB↑, 2, BBB↝, 1, CLDN1↓, 1, GastroP↑, 4, IBI↑, 1, MMP↓, 2, MMP↑, 3, OCLN↓, 1, OCLN↑, 1, TJ↑, 1, ZO-1↓, 1, ZO-1↑, 3,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1, CD4+↑, 2, CD40↓, 1, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 12, ICAM-1↓, 1, IFN-γ↓, 1, IFN-γ↑, 1, IL10↓, 1, IL10↑, 2, IL13↑, 1, IL18↓, 1, IL1β↓, 9, IL2↓, 1, IL6↓, 12, IL6↑, 1, IL8↓, 2, Imm↑, 4, Inflam↓, 33, IP-10/CXCL-10↓, 1, NF-kB↓, 10, NF-kB↑, 1, NK cell↑, 1, NLRP3↓, 2, PGE2↓, 4, PGE2↑, 1, Th1 response↓, 1, Th2↑, 2, TLR4↓, 3, TNF-α↓, 16, TNF-α↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4, BChE↓, 2, BDNF↑, 2, NGF↑, 2, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 2, BACE/β-secretase↓, 1, XO↝, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1, PPARα↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11, BioAv↑, 9, BioAv↝, 5, BioEnh↑, 1, CYP2E1↓, 2, Dose↝, 6, eff↓, 1, eff↑, 8, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 5, P-gp/ABCB1↓, 1, P450↓, 1, P450↝, 1, selectivity↑, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8, ALP↓, 2, AST↓, 9, BP↓, 3, BUN↓, 1, CEA↓, 1, creat↓, 3, CRP↓, 1, IL6↓, 12, IL6↑, 1, LDH↓, 4, NOS2↓, 1, TG/TAG↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 1, antiAll↑, 7, AntiArt↑, 3, AntiCan↑, 6, antiCG↑, 1, antiD↓, 1, AntiDiabetic↑, 7, antiNeop↑, 1, AntiTum↑, 3, cardioP↑, 16, chemoP↑, 5, chemoPv↑, 1, cognitive↑, 4, hepatoP↑, 16, memory↑, 2, motorD↑, 1, neuroP?, 1, neuroP↑, 17, Obesity↓, 2, Pain↓, 1, radioP↑, 3, RenoP↓, 1, RenoP↑, 4, Stroke↓, 3, toxicity↓, 16, toxicity↝, 1, toxicity∅, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4, AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 5, GutMicro↑, 4, Sepsis↓, 1,
Total Targets: 257

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

11 Apigenin (mainly Parsley)
10 Fisetin
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
5 Silver-NanoParticles
5 Magnolol
4 Phenethyl isothiocyanate
4 Curcumin
4 Emodin
4 Gambogic Acid
4 Morin
4 Luteolin
3 Allyl isothiocyanate
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Benzyl isothiocyanate
3 Photodynamic Therapy
3 Citric Acid
3 Ferulic acid
3 Gallic acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Kaempferol
3 Licorice
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Boron
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Fucoidan
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 isoquercitrin
2 Juglone
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Patchouli Oil (Pogostemon cablin)
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Metformin
1 Cisplatin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Chlorophyllin
1 Crocetin
1 Carvone
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Isorhamnetin
1 L-Theanine
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Lutein
1 Matrine
1 Methyl Jasmonate
1 Chemotherapy
1 Mangiferin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:44  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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