Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
Source:
Type:
The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,
1929- TQ,    Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
- in-vitro, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, eff↑, eff↝,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4841- Uro,    Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, Bcl-2↓, Cyt‑c↑, Casp↑, ROS↑, *ROS↓,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1↓, BNIP3↓,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,

Showing Research Papers: 101 to 108 of 108
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 108

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↑, 6,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↑, 1,   PDK1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 5,   BAX↑, 3,   Bcl-2↓, 3,   Casp↑, 8,   Chk2↓, 1,   Cyt‑c↑, 3,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   p38↑, 2,   survivin↓, 2,   TRAIL↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↓, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

BRCA1↓, 1,   CHK1↓, 1,   DNAdam↑, 1,   P53↑, 4,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   ERK↑, 1,   FOXO1↑, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 3,  

Migration ⓘ

E-cadherin↑, 1,   MMPs↓, 1,   N-cadherin↓, 1,   Rho↓, 1,   TumCI↓, 1,   TumCP↓, 4,   TumMeta↓, 3,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   angioG↑, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 4,   eff↓, 3,   eff↑, 3,   eff↝, 1,   MDR1↓, 1,   RadioS↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BRCA1↓, 1,   GutMicro↑, 2,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 2,   OS↑, 1,   Risk↓, 1,   toxicity∅, 1,  
Total Targets: 88

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 4,   SOD↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Fisetin
4 Silver-NanoParticles
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Apigenin (mainly Parsley)
3 Gambogic Acid
3 Graviola
3 Selenite (Sodium)
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Cisplatin
2 Selenium
2 Chrysin
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Magnetic Fields
2 Nimbolide
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 chitosan
1 Selenate
1 Dichloroacetate
1 Deguelin
1 Ellagic acid
1 Emodin
1 Ferulic acid
1 verapamil
1 Garcinol
1 Gemcitabine (Gemzar)
1 Genistein (soy isoflavone)
1 Hyperthermia
1 HydroxyTyrosol
1 Luteolin
1 Iron
1 Chemotherapy
1 Naringin
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Rosmarinic acid
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page