Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱

Source:

Type:

The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.

Scientific Papers found: Click to Expand⟱

1960-

GamB,

Vem,

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation

-

in-vitro,

Liver,

HepG2

-

in-vitro,

AML,

K562

Proteasome↓, Synergy↑, Casp↑, ER Stress↑, ROS↑, eff↑,

1955-

GamB,

Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer

-

in-vitro,

Pca,

PC3

185nM

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

DU145

ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, Synergy↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,

7090-

GAR,

-

in-vitro,

Var,

NA

AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,

810-

GAR,

GEM,

Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures

-

in-vitro,

PC,

NA

 Garcinol synergizes with gemcitabine to inhibit cell proliferation and induce apoptosis

TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,

1504-

GEN,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

-

Review,

Var,

NA

DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,

6562-

Ger,

Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings

-

Review,

Var,

NA

-

Review,

AD,

NA

*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,

7248-

Gink,

Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line

-

in-vitro,

Ovarian,

OVCAR-3

-

in-vitro,

Cerv,

HeLa

-

NA,

NA,

OV1369

Dose↝, TumCD↑, eff↓, Casp↑, H2O2↑, i-ROS↑,

7250-

Gink,

Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy

-

Review,

Var,

NA

AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,

7251-

Gink,

Ginkgetin: A Promising Multitarget Agent for Diverse Diseases

-

Review,

Var,

NA

*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,

7283-

Gins,

Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

BC,

MCF-10AT

-

in-vitro,

BC,

MCF7

MMP↓, Casp↑, BAX↑, Ca+2↑, ROS↑, cJun↑,

7335-

Gra,

Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review

-

Review,

Var,

NA

TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,

836-

Gra,

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism

-

vitro+vivo,

PC,

NA

mice

Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,

858-

Gra,

Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

-

in-vitro,

CRC,

HT-29

11.43 µg/ml

-

in-vitro,

CRC,

HCT116

8.98 µg/ml

TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,

856-

Gra,

https://pubmed.ncbi.nlm.nih.gov/33048613/

-

in-vitro,

BC,

MCF7

85.55 µg/mL

TumCCA↑, ROS↑, Casp↑,

7353-

HibSad,

Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy

-

in-vitro,

Melanoma,

A375

cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,

7461-

HNK,

Honokiol: a potent chemotherapy candidate for human colorectal carcinoma

-

vitro+vivo,

CRC,

RKO

mice

Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,

5049-

HPT,

Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer

-

vitro+vivo,

PC,

Panc02

-

vitro+vivo,

PC,

Bxpc-3

tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,

7542-

HT,

Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

C4-2B

-

in-vitro,

Nor,

RWPE-1

TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,

4639-

HT,

Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

C4-2B

TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,

7808-

IBC,

Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells

-

in-vitro,

Tong,

Tca8113

TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,

7771-

IBC,

Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME

-

vitro+vivo,

Thyroid,

CAL-62

This ROS overload subsequently triggers endoplasmic reticulum (ER) stress and induces mitochondria-mediated apoptosis

TumCG↓, TumCCA↑, Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, cl‑GSDME↑, TrxR1↓, ROS↑, ER Stress↑, Dose↝,

7674-

iod,

Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway

-

in-vitro,

BC,

NA

AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,

7689-

iod,

Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines

-

in-vitro,

Nor,

RWPE-1

-

in-vitro,

Pca,

LNCaP

-

vitro+vivo,

Pca,

DU145

nude mice xenotransplanted

Bax:Bcl2↑, Casp↑, TumCG↓,

7763-

ISL,

Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer

-

Review,

Var,

NA

AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,

9252-

ISO, IH,

Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery

-

Review,

Var,

NA

TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,

7853-

isoO,

Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review

-

Review,

Var,

NA

Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,

7797-

ISQ,

Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway

-

vitro+vivo,

ESCC,

KYSE-510

xenograft tumor model.

-

in-vitro,

ESCC,

KYSE450

TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,

7793-

ISQ,

Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway

-

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,

9191-

ITCs,

AITC,

BITC,

PEITC,

SFN

Molecular Targets of Isothiocyanates in Cancer: Recent Advances

-

Review,

Var,

NA

Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,

8027-

IVM,

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

-

Review,

Var,

NA

*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,

8085-

KAE,

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

-

Review,

Var,

NA

Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,

8060-

KAE,

Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells

-

in-vitro,

CRC,

HT-29

TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,

8254-

LCA,

Geld,

Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation

-

in-vitro,

Ovarian,

NA

MMP↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, ROS↑, GSH↓, eff↓,

8209-

LCA,

Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells

-

in-vitro,

Ovarian,

SKOV3

19.22 μM at 24 h

tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,

8235-

LCA,

Anticancer effects of licochalcones: A review of the mechanisms

-

Review,

Var,

NA

mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,

8276-

LE,

Cisplatin,

Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis

-

in-vitro,

NSCLC,

NA

tumCV↓, ChemoSen↑, Apoptosis↑, TumCCA↑, Bcl-xL↑, cl‑Casp↑, γH2AX↑, P53↑,

8326-

LIN,

Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development

-

Review,

Var,

NA

Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,

8403-

LT,

Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells

-

in-vitro,

CRC,

HT-29

tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,

2906-

LT,

Luteolin, a flavonoid with potentials for cancer prevention and therapy

-

Review,

Var,

NA

*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,

8734-

M-Blu,

From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue

-

Review,

AD,

NA

*ETC↑, *compIV↑, *ROS↓, *NeuroI↓, *neuroP↑, *Stroke↓, *cognitive↑, *BBB↑, *BloodF↑, *NOS2↓, *lipid-P↓, *Inflam↓, *Synergy↑, *OCR↑, *compIV↑, *ATP↑, *Casp↓, *MMP↑, *tau↓,

8506-

MAG,

Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells

-

in-vitro,

PC,

Panc02

-

in-vitro,

PC,

MIA PaCa-2

*Inflam↓, *antiOx↑, Ingr↝, tumCV↓, Apoptosis↑, ROS↑, MMP↓, Casp↑, selectivity↑, DNMT1↓, JAK2↓, STAT3↓, miR-148a↑, UTF1↑, IL6↓, survivin↓,

8532-

Matr,

Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells

-

in-vitro,

NSCLC,

NA

Apoptosis↑, Casp↑, p38↓, ROS↑, eff↓,

8526-

Matr,

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

-

Review,

Nor,

NA

*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,

8626-

MBZ,

The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells

-

in-vitro,

Lung,

NA

mitA↑, Apoptosis↑, Casp↑, Cyt‑c↑, AntiTum↑, TumMeta↓, toxicity↓,

8751-

MeSA,

PacT,

Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer

-

vitro+vivo,

BC,

MDA-MB-231

ChemoSen↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCG↓,

8742-

MeSA,

Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells

-

in-vitro,

Pca,

DU145

TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, p27/CDKN1B↑, P21↑, Apoptosis↑, Akt↓, ERK↓,

5795-

MET,

Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

-

Review,

AD,

NA

-

Review,

Park,

NA

-

Review,

Diabetic,

NA

*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,

8483-

MF,

Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies

-

Review,

Var,

NA

Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,

4353-

MF,

Chemo,

Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells

-

in-vitro,

BC,

MCF7

 1 hours PEMF session (2.5 mT at 70 Hz) thrice a day for three consecutive days.

TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,

7382-

MFrot,

Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells

-

vitro+vivo,

GBM,

NA

ROS↑, compI↓, DNAdam↑, TumCCA↑, Casp↓, Apoptosis↑, mt-NADH↓, selectivity?, *toxicity?,

Showing Research Papers: 101 to 150 of 205
Prev Page 3 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 205

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, antiOx⇅, 1, ARE↑, 1, Catalase↓, 1, Catalase↑, 1, Fenton↑, 1, GPx4↓, 3, GSH↓, 10, GSH↑, 2, GSH/GSSG↓, 1, H2O2↑, 1, HO-1↓, 2, HO-1↑, 3, Iron↑, 1, c-Iron↑, 1, lipid-P↓, 3, lipid-P↑, 8, MDA↓, 1, MDA↑, 3, NADH↓, 2, mt-NADH↓, 1, NQO1↓, 1, NRF2↓, 7, NRF2↑, 7, ROS↓, 11, ROS↑, 131, ROS⇅, 3, ROS↝, 1, i-ROS?, 1, i-ROS↑, 1, mt-ROS↑, 3, SOD↓, 1, SOD↑, 2, SOD1↓, 1, SOD2↓, 1, SOD2↑, 1, Thiols↓, 1, Trx↓, 1, Trx↑, 1, TrxR↓, 2, TrxR↑, 1, TrxR1↓, 4, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1, IRP1↑, 1, TfR1/CD71↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, compI↓, 4, compII↓, 1, compIII↓, 1, EGF↓, 1, ETC↓, 4, mitResp↓, 3, mtDam↑, 16, OCR↓, 2, OCR↑, 1, OXPHOS↓, 2, OXPHOS↑, 4, PDH↑, 1, SIRT3↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ACC↓, 1, ACSL4↑, 1, AMP↓, 1, AMPK?, 1, AMPK↑, 9, p‑AMPK↑, 1, ATP↓, 16, mt-ATP↓, 1, FASN↓, 5, G6PD↓, 1, GLO-I↓, 1, GLS↓, 1, GlucoseCon↓, 2, Glycolysis↓, 11, GSK‐3β↓, 3, GSK‐3β↑, 2, p‑GSK‐3β↓, 2, H2S↑, 1, HK2↓, 7, HMG-CoA↓, 2, lactateProd↓, 3, lactateProd↑, 2, LDHA↓, 3, LDL↓, 1, lipoGen↓, 1, NADPH↓, 2, PCK1↓, 1, PDK1 / PDPK1↓, 10, PDK3↑, 1, PKM2↓, 2, SCD1↓, 1, SIRT1↓, 5, SIRT1↑, 1, SREBP1/SREBF1↓, 1, SREBP2↓, 1, Warburg↓, 4,

Cell Death(tgid=5) ⓘ

AIF↑, 10, APAF1↑, 4, Apoptosis?, 1, Apoptosis↓, 4, Apoptosis↑, 126, mt-Apoptosis↑, 4, BAD↑, 4, Bak↑, 4, BAX↑, 44, Bax:Bcl2↑, 13, Bcl-2↓, 56, Bcl-2↑, 1, cl‑Bcl-2↑, 1, Bcl-xL↓, 19, Bcl-xL↑, 2, BID↑, 3, BIM↓, 1, BIM↑, 4, BNIP3↓, 1, BTG3↑, 1, Casp↓, 5, Casp↑, 184, Casp↝, 3, Casp∅, 1, cl‑Casp↑, 6, proCasp↑, 1, Casp3↓, 1, Casp3↑, 24, cl‑Casp3↑, 5, Casp6↑, 1, Casp7↑, 4, cl‑Casp7↑, 3, Casp8↑, 3, cl‑Casp8↑, 3, Casp9↑, 9, cl‑Casp9↑, 6, Cupro↑, 1, Cyt‑c↑, 63, Cyt‑c↝, 1, Diablo↑, 5, DR5↑, 9, Endon↑, 1, FADD↑, 2, Fas?, 1, Fas↓, 2, Fas↑, 9, FasL↑, 4, Ferroptosis↑, 7, GSDME↑, 1, cl‑GSDME↑, 1, IAP1↓, 2, IAP2/BIRC3↓, 2, cl‑IAP2/BIRC3↑, 1, ICAD↓, 1, ICD↑, 1, iNOS↓, 6, Mcl-1↓, 5, MDM2↓, 3, MLKL↑, 1, MOMP↑, 3, Necroptosis↑, 1, necrosis↑, 2, NOXA↑, 1, p38↓, 5, p38↑, 7, p‑p38↓, 2, p‑p38↑, 1, PUMA↑, 2, Pyro↑, 2, RIP3↑, 1, survivin↓, 25, TNFR 1↑, 2, TRAIL↑, 3, TumCD↑, 8, XIAP↓, 8, XIAP↑, 1, YAP/TEAD↓, 3,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55, p‑Akt↓, 7, CK2↓, 2, p‑cMET↑, 1, cSrc↓, 1, EGFR↓, 10, ERK↓, 14, ERK↑, 4, p‑ERK↓, 4, HCAR2↑, 1, HER2/EBBR2↓, 2, HGF/c-Met↓, 1, Hippo↓, 1, IKKα↓, 2, IκB↓, 1, JAK1↓, 1, JAK2↓, 8, JAK3↓, 1, JNK↓, 2, JNK↑, 8, p‑JNK↓, 1, p‑JNK↑, 2, MAPK?, 1, MAPK↓, 17, MAPK↑, 9, MEK↓, 3, mTOR↓, 33, mTOR⇅, 1, p‑mTOR↓, 1, mTORC2↓, 1, mTORC2↑, 1, p70S6↓, 1, P70S6K↓, 2, PDGFRA↓, 1, PI3K↓, 38, p‑PI3K↓, 1, PI3K/Akt↓, 2, PKCδ↓, 2, PP2A↑, 1, PRAS40↑, 1, PTEN↑, 6, Raf↓, 3, e-Raf↓, 1, RAS↓, 4, RIP1↓, 1, Sp1/3/4↓, 5, Sp1/3/4↑, 1, STAT↓, 2, STAT3↓, 29, p‑STAT3↓, 3, THEM4/CTMP↑, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1, ATF4↑, 5, cJun↓, 2, cJun↑, 1, cMyc↓, 8, cMyc↑, 1, DNMT1↓, 5, DNMT3A↓, 1, DNMT3B↓, 1, DNMTs↓, 4, EZH2↓, 1, FOXO↑, 1, FOXO1↓, 2, FOXO1↑, 1, FOXO3↓, 1, p‑H3↓, 2, ac‑H3↑, 2, ac‑H4↑, 2, HATs↓, 2, HATs↑, 2, HDAC↓, 11, HDAC1↓, 1, HDAC2↓, 1, HDAC3↓, 1, HDAC6↓, 1, miR-148a↑, 1, miR-203↑, 1, miR-21↝, 1, miR-34a↑, 1, miR-375↑, 1, NDRG1↑, 1, OCT4↓, 4, other↑, 3, other↝, 5, PhotoS↑, 1, SOX2↓, 4, TCF-4↓, 2, TFAP2A↓, 1, TFE3↑, 1, tumCV↓, 30, UTF1↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 5, eIF2α↓, 1, p‑eIF2α↓, 1, ER Stress↑, 17, GRP78/BiP↓, 1, GRP78/BiP↑, 3, HSF1↓, 1, HSP27↓, 1, HSP70/HSPA5↓, 2, HSP90↓, 3, HSPs↓, 1, IRE1↑, 4, PDI↑, 1, PERK↑, 2, Proteasome↓, 1, UPR↓, 1, UPR↑, 1, XBP-1↑, 2,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 2, ATG5↑, 3, ATG7↑, 1, Beclin-1/ATG6↓, 3, Beclin-1/ATG6↑, 4, LC3‑Ⅱ/LC3‑Ⅰ↑, 2, LC3B-II↑, 2, LC3I↓, 1, LC3II↑, 5, LC3s↑, 1, lysoMP↑, 1, p62↓, 4, p62↑, 1, RUBCN↓, 1, TumAuto↓, 1, TumAuto↑, 15, TumAuto↝, 1, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, BRCA1↓, 1, DNAdam↓, 1, DNAdam↑, 34, DNArepair↓, 2, hTERT/TERT↓, 4, p16↑, 2, P53↓, 2, P53↑, 38, P53↝, 2, p‑P53↑, 4, PARP↓, 1, PARP↑, 6, PARP↝, 1, cl‑PARP↑, 36, cl‑PARP1↑, 2, PCNA↓, 8, SIRT6↓, 1, Telomerase↓, 6, TOP1↓, 6, TOP2↓, 4, γH2AX↑, 4, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3, CDK2↓, 11, p‑CDK2↓, 1, CDK4↓, 12, CDK4↑, 1, CDK6↓, 4, CDK6↑, 1, cellSen↑, 1, CHK1↓, 1, CHK1↑, 1, Chk2↓, 1, Chk2↑, 1, ChrCon↑, 1, Cyc↓, 1, CycB/CCNB1↓, 4, CycB/CCNB1↑, 2, cycD1/CCND1↓, 23, cycD1/CCND1↑, 1, cycE/CCNE↓, 10, E2Fs↓, 1, E2Fs↑, 1, Ki-67↓, 8, mitA↓, 1, mitA↑, 2, P21↑, 28, p27/CDKN1B↓, 1, p27/CDKN1B↑, 11, PLK1↓, 1, pRB↓, 1, p‑pRB↓, 1, RB1↑, 1, TumCCA?, 1, TumCCA↓, 2, TumCCA↑, 88,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, ALDH1A1↓, 1, BMI1↓, 1, CD133↓, 2, cFos↓, 3, CSCs↓, 13, Diff↓, 1, Gli↓, 1, Gli1↓, 1, HMGCR↓, 1, IGF-1↓, 2, IGFBP3↑, 2, Ki-67↓, 8, mTORC1↓, 5, Nanog↓, 4, NOTCH↓, 2, NOTCH1↓, 3, NOTCH1↑, 1, NOTCH2↑, 1, SCF↓, 1, Shh↓, 1, Smo↓, 1, TumCG↓, 39, TumCG↑, 2, TumCP↓, 60, TumCP↑, 3, Wnt↓, 13,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 6, AXL↓, 1, CA↓, 1, Ca+2↓, 1, Ca+2↑, 22, cal2↑, 1, CCN2/CTGF↓, 2, COL1↓, 1, E-cadherin↑, 13, EMT↓, 19, EMT↝, 1, F-actin↓, 1, FAK↓, 4, p‑FAK↓, 2, GLI2↓, 1, ITGB4↓, 1, LAMs↓, 1, LEF1↓, 1, MMP-10↓, 1, MMP1↓, 2, MMP13↓, 1, MMP2↓, 26, MMP3↓, 1, MMP7↓, 2, MMP9↓, 29, MMP9↑, 2, MMPs↓, 10, MMPs↝, 1, MUC4↓, 1, N-cadherin↓, 7, PAK1↑, 1, PDGF↓, 2, RECK↑, 1, Rho↓, 3, ROCK1↓, 2, Slug↓, 1, Snail↓, 2, TGF-β↓, 3, TIMP1↑, 1, TIMP2↓, 1, TIMP2↑, 2, TRIB3↑, 1, TSC1↑, 2, TSP-1↑, 1, TumCI↓, 23, TumCI↑, 1, TumCMig↓, 22, TumCMig↑, 1, TumMeta↓, 25, TumMeta↑, 3, Twist↓, 4, uPA↓, 8, Vim↓, 10, Zeb1↓, 3, β-catenin/ZEB1↓, 17, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 37, angioG↑, 3, CCN1/CYR61↓, 1, CD31/PECAM-1↓, 3, HIF-1↓, 2, Hif1a↓, 17, Hif1a↑, 1, NO↓, 1, NO↑, 2, VCAM-1↓, 2, VEGF↓, 41, VEGF↝, 1, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 6,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, EPR↑, 4, GLUT1↓, 4, GLUT4↓, 2, MMP?, 2, MMP↓, 78, MMP↝, 1, MPT↑, 10, NHE1↓, 1, TRPM7↓, 1, TRPV1↑, 3,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD4+↑, 1, CD44↓, 3, CD59↑, 1, CD8+↑, 1, COX1↓, 1, COX2/PTGS2↓, 24, COX2/PTGS2↑, 1, CXCR2↓, 1, CXCR4↓, 5, DR4↑, 3, Eos↑, 1, HCAR2↑, 1, ICAM-1↓, 2, IFN-γ↓, 3, IFN-γ↑, 1, IL1↓, 2, IL10↓, 1, IL12↑, 1, IL1β↓, 5, IL1β↑, 1, IL2↓, 2, IL2↑, 3, IL4↓, 1, IL4↑, 1, IL6↓, 10, IL8↓, 1, Imm↑, 8, Inflam↓, 11, M2 MC↓, 1, MCT1↓, 1, MDSCs↓, 1, Neut↑, 1, NF-kB?, 1, NF-kB↓, 55, NF-kB↑, 3, NF-kB↝, 1, NK cell↑, 1, NLRP3↓, 2, p50↓, 1, p65↓, 3, PD-1↝, 1, PD-L1↓, 5, PD-L1↑, 1, PGE2↓, 5, PSA↓, 2, TCF↝, 1, TLR4↓, 1, TNF-α↓, 15, TNF-α↑, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1, i-pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, BChE↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8, AR-V7?, 1, CYP19?, 1, ER-α36↓, 1, Estro↝, 1, PPARγ↓, 1, PPARγ↑, 1, SXR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 16, BioAv↑, 16, BioAv↝, 4, BioEnh↑, 2, ChemoSen↓, 1, ChemoSen↑, 64, CompStab↝, 2, CYP1A1↓, 1, CYP1A1↑, 1, CYP1A2↓, 1, CYP3A4↓, 2, DDS↑, 1, Dose?, 1, Dose↑, 2, Dose↝, 25, Dose∅, 5, eff↓, 33, eff↑, 37, eff↝, 6, eff∅, 1, GSTA1↑, 1, GSTZ1↓, 1, GSTZ1↝, 1, Half-Life↓, 6, Half-Life↝, 2, MDR1↓, 4, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 6, P450↓, 2, RadioS↑, 20, RadioS↝, 1, selectivity?, 1, selectivity↑, 40, selectivity↝, 1, Synergy↑, 41, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, AR↓, 8, BMD↑, 1, BRCA1↓, 1, CRP↓, 1, E6↓, 2, E7↓, 2, EGFR↓, 10, EZH2↓, 1, HER2/EBBR2↓, 2, hTERT/TERT↓, 4, IL6↓, 10, LDH↓, 1, LDH↑, 1, PD-L1↓, 5, PD-L1↑, 1, PSA↓, 2, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 1, AntiCan↑, 21, AntiTum↑, 9, AntiTum↝, 1, cardioP↑, 4, chemoP↑, 17, chemoPv↑, 5, ChemoSideEff↓, 1, fatigue↓, 2, hepatoP↑, 5, hepatoP∅, 1, Mucositis↓, 1, neuroP↑, 2, NP/CIPN↑, 1, Obesity↓, 1, OS↑, 4, Pain↓, 2, QoL↑, 1, radioP↑, 4, Remission↑, 2, RenoP↑, 1, Risk↓, 7, Sleep↑, 1, toxicity↓, 12, toxicity↑, 2, toxicity↝, 4, toxicity∅, 2, TumVol↓, 9, TumW↓, 6, Weight↑, 2, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, GutMicro↑, 5, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1, Ingr↝, 3,
Total Targets: 629

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6, antiOx↑, 23, Catalase↑, 11, GPx↑, 9, GSH↑, 7, GSR↑, 2, GSTs↑, 2, HO-1↑, 8, Keap1↓, 2, lipid-P↓, 6, MDA↓, 4, NRF2?, 1, NRF2↓, 1, NRF2↑, 14, ROS↓, 27, ROS↝, 1, ROS∅, 2, SOD↑, 12, SOD2↑, 1, TBARS↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2, ETC↑, 1, Insulin↓, 1, OCR↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2, ACSL4↓, 1, ALAT↓, 3, AMPK↑, 2, ATP↑, 1, CRM↑, 1, cytoP450↓, 1, glucose↓, 2, glyC↓, 1, NAD↑, 1, SIRT1↑, 2,

Cell Death(tgid=5) ⓘ

BAX↓, 1, Bcl-2↑, 1, Casp↓, 5, Ferroptosis↓, 1, iNOS↓, 1, survivin↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↑, 1, JAK2↑, 1, JNK↓, 1, MAPK↓, 2, PKCδ↓, 1, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, cJun↓, 1, p‑cMyc↑, 1, other↓, 2,

DNA Damage & Repair(tgid=10) ⓘ

Migration(tgid=13) ⓘ

AntiAg↑, 2, Ca+2↓, 1, Ca+2↑, 1, TGF-β↓, 1, TIMP1↓, 1, α-SMA↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1, NO↓, 2,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 2, MMP↑, 1, TRPC1↓, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5, HMGB1↓, 1, IL1↓, 1, IL10↑, 1, IL17↓, 2, IL1β↓, 3, IL6↓, 8, IL8↓, 2, Imm↑, 4, Inflam↓, 33, Inflam↑, 1, NeuroI↓, 1, NF-kB↓, 7, NK cell↑, 1, PGE2↓, 1, TLR4↓, 1, TNF-α↓, 8,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4, AChE∅, 1, BChE∅, 1, BDNF↑, 1, proBDNF↑, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 5, tau↓, 1, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11, BioAv↑, 8, BioAv↝, 2, BioEnh↑, 2, CompStab↑, 1, Dose↝, 2, eff↑, 2, GSTA1↑, 1, Half-Life↓, 3, Half-Life↝, 3, Half-Life∅, 1, Synergy↑, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3, ALP↓, 1, AST↓, 3, BloodF↑, 1, BMD↑, 1, BP↓, 1, CRP↓, 2, IL6↓, 8, LDH↓, 2, LDH↑, 1, NOS2↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, antiAll↑, 3, AntiArt↑, 3, AntiCan↑, 4, antiD↑, 1, AntiDiabetic↑, 3, AntiTum↑, 1, ANXi↓, 1, cardioP↑, 8, chemoP↑, 3, chemoPv↑, 2, cognitive↓, 1, cognitive↑, 4, hepatoP↑, 6, memory↑, 3, Mood↑, 1, neuroP↑, 15, Pain↓, 1, radioP↑, 2, RenoP↑, 1, Sleep↑, 1, Stroke↓, 3, toxicity?, 1, toxicity↓, 5, toxicity↑, 2, toxicity↝, 3, toxicity∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiP↑, 1, AntiViral↑, 1, Bacteria↓, 4, GutMicro↑, 4,
Total Targets: 149

Scientific Paper Hit Count for: Casp, caspase

7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Graviola
4 Sulforaphane (mainly Broccoli)
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cucurbitacin
3 Dichloroacetate
3 Gambogic Acid
3 Ginkgetin
3 Licochalcone A
3 Melatonin
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 chaetocin
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 Chlorella (Chlorella vulgaris)
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Isoliquiritigenin
2 Garcinol
2 HydroxyTyrosol
2 Isobavachalcone
2 iodine
2 isoquercitrin
2 Phenethyl isothiocyanate
2 Kaempferol
2 Luteolin
2 Matrine
2 methylseleninic acid
2 Magnetic Fields
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Isovitexin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Indole-3-carbinol
1 Deguelin
1 Diindolylmethane
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Eugenol
1 Ferulic acid
1 Fenbendazole
1 Formononetin
1 Flaxseed Oil
1 Fucoidan
1 verapamil
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginseng
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperthermia
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Ivermectin
1 Geldanamycin
1 Licorice
1 Linalool
1 Methylene blue
1 Magnolol
1 mebendazole
1 Paclitaxel/Taxol
1 Metformin
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Naringin
1 Phenylbutyrate
1 Phycocyanin
1 Pterostilbene
1 Rhein
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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