mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱
Source:
Type:
Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.
Scientific Papers found: Click to Expand⟱
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
2006- PLB,    Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,
6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, *lipid-P↓, *MMP↑, *mtDam↓, *NLRP3↓, *ASC↓, *cl‑Casp1↓, *IL18↓, *IL1β↓, *GSDMD↓, *Pyro↓, *CYP2E1↓, *MFN1↓, *MFN2↓, *OPA1↓, *DRP1/DNM1L↑,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
3073- RES,    Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy
- in-vitro, Nor, NA
*NLRP3↓, *mtDam↓, *p38↑,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
1208- SANG,    Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region
- in-vitro, OS, NA
SSBP1↑, mtDam↑, Apoptosis↑, JAK↓, STAT3↓, PI3k/Akt/mTOR↓, ROS↑, MMP↓,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,
4480- SeNPs,  Chit,    Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HK-2
selectivity↑, *toxicity↓, ROS↑, mtDam↑, Apoptosis↑, LDH↑,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT↓, GPx4↓, GSH/GSSG↓, Keap1↑,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,
5111- SSE,    Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells
- in-vitro, BC, 4T1
ROS↑, NF-kB↓, p65↓, mtDam↑, Casp9↑, Casp3↑, Apoptosis↑, eff↓,
5095- SSE,    Extracellular thiol-assisted selenium uptake dependent on the xc− cystine transporter explains the cancer-specific cytotoxicity of selenite
- in-vitro, Lung, H157
toxicity↝, eff↓, other↝, ROS↑, mtDam↑,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,

Showing Research Papers: 101 to 119 of 119
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 119

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSH⇅, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   Iron↑, 1,   Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 1,   NRF2↓, 1,   ROS↑, 13,   mt-ROS↑, 2,   SOD1↓, 1,   Trx↓, 1,   TrxR1↓, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   MMP↓, 3,   MMP↑, 1,   mtDam↓, 1,   mtDam↑, 14,   SSBP1↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDH↑, 1,   NADPH↓, 1,   PFKP↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 9,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 4,   Ferroptosis↑, 1,   TumCD↑, 3,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,  

Autophagy & Lysosomes ⓘ

BNIP3↝, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

P53↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CSCs↑, 1,   EMT↓, 1,   ERK↓, 1,   p‑mTOR↓, 1,   STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   MMP9↓, 1,   PKA↓, 1,   TumCMig↓, 2,   TumCP↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL17↓, 1,   IL6↓, 1,   Inflam↓, 1,   JAK↓, 1,   NF-kB↓, 3,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 6,   eff↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   toxicity↝, 1,  
Total Targets: 90

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

DRP1/DNM1L↑, 1,   MFN1↓, 1,   MFN2↓, 1,   OPA1↓, 1,  

Redox & Oxidative Stress ⓘ

CYP2E1↓, 1,   lipid-P↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   mtDam↓, 4,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 2,   CRM↑, 2,   SIRT1↑, 1,  

Cell Death ⓘ

cl‑Casp1↓, 1,   GSDMD↓, 1,   p38↑, 1,   Pyro↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   IL18↓, 1,   IL1β↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   BP↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   hepatoP↑, 3,   motorD↑, 1,   toxicity↓, 2,  
Total Targets: 32

Scientific Paper Hit Count for: mtDam, mitochondrial damage
14 Silver-NanoParticles
6 Curcumin
5 Propolis -bee glue
4 Resveratrol
4 EGCG (Epigallocatechin Gallate)
4 Honokiol
4 Lycopene
4 Selenite (Sodium)
3 3-bromopyruvate
3 Berberine
3 Betulinic acid
3 Capsaicin
3 Dandelion Root
3 SonoDynamic Therapy UltraSound
3 Phenethyl isothiocyanate
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Chlorogenic acid
2 chitosan
2 Chrysin
2 Copper and Cu NanoParticles
2 Quercetin
2 Ferulic acid
2 D-limonene
2 Electrical Pulses
2 Hydrogen Gas
2 Hyperthermia
2 Luteolin
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Astragalus
1 Glucose
1 Alpha-Lipoic-Acid
1 entinostat
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Radiotherapy/Radiation
1 Beta-Caryophyllene
1 bempedoic acid
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Cyclopamine
1 Docetaxel
1 Disulfiram
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Gambogic Acid
1 Graviola
1 doxorubicin
1 Methylene blue
1 Magnolol
1 Magnetic Field Rotating
1 Magnetic Fields
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Nimbolide
1 Pachymic acid
1 Phenylbutyrate
1 Piperlongumine
1 Plumbagin
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenium
1 Ursolic acid
1 Urolithin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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