mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱
Source:
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Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.
Scientific Papers found: Click to Expand⟱
2863- HNK,    Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells
- in-vitro, Liver, Hep3B
ER Stress↑, Ca+2↑, mtDam↑, PTEN↑, PARK2↑, Alix/AIP‑1↓, ROS↑, mt-ROS↑,
2889- HNK,  doxoR,    Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- in-vivo, Nor, NA
*SIRT3↑, chemoP↑, *cardioP↑, mtDam↑, ROS↑, *ROS↓, *MMP↑,
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
7537- HT,    Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1 α Signaling
- in-vitro, Nor, PC12
*ROS↓, *mtDam↓, *PI3K↑, *Akt↑, *mTOR↑, *Hif1a↑,
7545- HYP,    Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2
- in-vitro, CML, K562
xCT/SLC7A11↓, GPx4↓, Ferroptosis↑, ROS↑, lipid-P↑, mtDam↑, NRF2↓,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7802- IBC,    Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression
- in-vitro, Liver, HepG2
TumCD↑, Apoptosis↑, ROS↑, mtDam↑, p‑Akt↓, eff↓,
7767- IBC,    Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway
- vitro+vivo, GC, NA
TumCG↓, ROS↑, DHODH↓, MMP↓, cGAS–STING↑, Imm↑, mtDam↑,
7770- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- in-vitro, Lung, NA - vitro+vivo, BC, 4T1
necrosis↑, ROS↑, mtDam↑, Ca+2↑, NA↑, MMP↓, TumCG↓,
7775- IBC,    Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells
- vitro+vivo, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Necroptosis↑, TumAuto↑, Akt↓, BAX↑, cl‑Casp3↑, RIP3↑, p‑RIP3↑, MLKL↑, LC3‑Ⅱ/LC3‑Ⅰ↑, mtDam↑, ATP↓, ROS↑, TumCG↓,
7663- IP,    Industrial additive and dietary fiber inulin induces tumor-selective necrotic death via mitochondrial lipid peroxidation involving MYC and YAP
- in-vivo, Var, NA
GutMicro↑, lipid-P↑, mtDam↑, eff↑, Myc↓, YAP/TEAD↓, AR↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
9252- ISO, IH,    Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
7865- isoO,    Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis
- in-vivo, Diabetic, NA
*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7838- ISQ,    Protective effects of isoquercitrin on streptozotocin‐induced neurotoxicity
- in-vivo, AD, NA
*Apoptosis↓, *mtDam↓, *ROS↓, *Diff↑, *cognitive↑,
7835- ISQ,  QC,    Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves
- in-vitro, AD, HT22
*Apoptosis↓, *ROS↓, *SOD2↑, *Ca+2↓, *mtDam↓, *NRF2↑, *HO-1↑, *other↑, *AIF↓, *LC3‑Ⅱ/LC3‑Ⅰ↓, *Synergy↑,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8035- IVM,    Ivermectin and non-parasitic disorders: An update
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*AntiP↑, angioG↓, *AntiCan↓, mtDam↑, Apoptosis↑, necrosis↑, TumAuto↑, ROS↑, *neuroP↑, *Stroke↝, *cardioP↑,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8024- IVM,    Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, NE3
TumCP↓, mtDam↑, Apoptosis↑, ROS↑, NF-kB↓, Bax:Bcl2↑, LDH↝, TumCCA↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, eff↓,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8046- IVM,    Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
- in-vitro, CML, NA
TumCD↑, mtDam↑, ROS↓, selectivity↑, compI↓, mitResp↓, eff↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8169- Lap,    Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
- in-vitro, Liver, HepG2
toxicity↑, mtDam↑, ROS↑, NRF2↑, GSH↑, GSSG↑, SOD2↑,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8275- LCA,    Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage
- vitro+vivo, GBM, NA
AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, mtDam↑, Bcl-2↓, ROS↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
4789- Lyco,    Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *NF-kB↓, *neuroP↑, *MMP↓, *mtDam↓, *OCR↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,

Showing Research Papers: 101 to 150 of 201
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 201

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   ARE↓, 1,   Catalase↓, 2,   Catalase↑, 2,   Fenton↑, 3,   GPx↓, 4,   GPx↑, 1,   GPx4↓, 5,   GSH↓, 17,   GSH↑, 1,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSSG↑, 1,   H2O2↑, 4,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↑, 4,   Iron↑, 7,   i-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 11,   MDA↓, 1,   MDA↑, 4,   i-MDA↑, 1,   NADPH/NADP+↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 2,   Prx↓, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 6,   ROS↑, 128,   ROS⇅, 1,   ROS∅, 1,   mt-ROS↑, 7,   SOD↓, 5,   SOD↑, 1,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 6,   compI↓, 4,   compII↓, 2,   compIV↓, 1,   compV↓, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   HTRA2/Omi/PARK13↑, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam?, 1,   mtDam↓, 3,   mtDam↑, 160,   OCR↓, 5,   OXPHOS↓, 1,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PINK1↑, 4,   SDH↓, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ALAT↓, 3,   AMP↑, 1,   AMPK↑, 7,   ATP↓, 23,   DHODH↓, 2,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 13,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 2,   HK2↓, 12,   lactateProd↓, 5,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFKP↓, 2,   PKM2↓, 3,   PKM2↑, 2,   Pyruv↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 86,   mt-Apoptosis↑, 2,   BAD↑, 3,   Bak↑, 2,   BAX↓, 3,   BAX↑, 27,   Bax:Bcl2↑, 8,   Bcl-2↓, 26,   Bcl-xL↓, 7,   BID↑, 2,   cl‑BID↑, 2,   BIM↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 14,   Casp1↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   Casp3↓, 1,   Casp3↑, 44,   cl‑Casp3↑, 12,   proCasp3↓, 1,   Casp6↑, 1,   Casp7↑, 4,   Casp8↑, 8,   cl‑Casp8↑, 1,   Casp9↑, 28,   cl‑Casp9↑, 4,   CellShr↑, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 33,   mt-Cyt‑c↓, 1,   Diablo↑, 2,   DR5↑, 5,   FADD↑, 2,   Fas↓, 1,   Fas↑, 6,   FasL↑, 1,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDME-N↑, 1,   IAP1↓, 2,   ICD↑, 2,   iNOS↓, 2,   iNOS↑, 1,   Mcl-1↓, 3,   MDM2↓, 3,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 2,   p38↓, 1,   p38↑, 1,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 5,   TNFR 1↑, 1,   TumCD↑, 13,   XIAP↓, 2,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 1,   p‑Akt↓, 8,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ↓, 1,   CK2↓, 1,   p‑cMET↑, 1,   EGFR↓, 5,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 1,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   Hippo↝, 1,   IGFR↓, 1,   JAK↓, 2,   JAK2↓, 2,   JNK↑, 2,   p‑JNK↑, 2,   MAPK↓, 5,   MAPK↑, 5,   mTOR↓, 15,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↑, 1,   PI3K↓, 18,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 6,   p‑PTEN↓, 1,   RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 15,   STAT3↑, 1,   p‑STAT3↓, 2,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 5,   p‑ATF4↝, 1,   cJun↓, 1,   cMyc↓, 4,   DNMT3B↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO4↓, 1,   HDAC↓, 3,   HDAC8↓, 1,   miR-34a↑, 2,   MTA2↓, 1,   Myc↓, 1,   OCT4↓, 4,   other↝, 9,   PAX2↓, 1,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 27,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↝, 1,   ER Stress↑, 28,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP90↓, 2,   IRE1↑, 1,   PERK↑, 3,   p‑PERK↝, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG7↑, 2,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 5,   LC3s↑, 2,   MitoP↓, 1,   MitoP↑, 4,   p62↓, 3,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 4,   RUBCN↓, 1,   TumAuto↓, 2,   TumAuto↑, 24,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   DNAdam↑, 20,   hTERT/TERT↓, 4,   P53↑, 18,   P53↝, 1,   p‑P53↑, 3,   PARP↓, 2,   PARP↑, 3,   cl‑PARP↑, 15,   PCNA↓, 2,   Telomerase↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TP53↓, 1,   γH2AX↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK2↓, 7,   CDK4↓, 11,   CDK6↓, 4,   CDKN1C/p57↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 13,   cycE/CCNE↓, 3,   GADD45A↑, 1,   Ki-67↓, 5,   P21↓, 2,   P21↑, 12,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   TumCCA↑, 52,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 3,   CD133↓, 1,   CD24↓, 1,   cFos↓, 1,   CSCs↓, 8,   CSCs↑, 1,   Diff↑, 1,   EIF4E↓, 2,   FGF↓, 1,   Gli1↓, 1,   HH↓, 2,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 5,   NOTCH1↓, 1,   PTCH1↓, 1,   Shh↓, 1,   STAT1↓, 2,   TumCG↓, 30,   TumCG↑, 1,   TumCP↓, 43,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 2,   AP-1↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 17,   Ca+2↝, 1,   i-Ca+2↑, 2,   cal2↑, 1,   COL1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 11,   EMT↓, 16,   EMT↝, 1,   FAK↓, 2,   p‑FAK↑, 1,   Fibronectin↓, 1,   MMP-10↓, 1,   MMP2↓, 8,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 2,   N-cadherin↓, 7,   PAK1↓, 1,   PDGF↓, 1,   Slug↓, 2,   Smad1↓, 1,   Snail↓, 5,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 16,   TumCMig↓, 20,   TumMeta↓, 10,   TumPF↓, 1,   Twist↓, 2,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 8,   Zeb1↓, 4,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   Hif1a↓, 8,   Hif1a↑, 1,   Hypoxia↓, 1,   NO↓, 1,   NO↑, 3,   VCAM-1↓, 2,   VEGF↓, 13,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 53,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 8,   TRPV1↑, 2,   TRPV2↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 2,   cGAS–STING↑, 2,   COX2/PTGS2↓, 11,   CXCR4↓, 1,   DR4↑, 2,   Eos↑, 1,   HCAR2↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL4↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 9,   Imm↝, 2,   Inflam↓, 6,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 21,   NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 2,   p65↓, 2,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 2,   PSA↓, 2,   TCF↓, 2,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 3,   TNF-α↓, 5,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 1,   AR↑, 1,   PPARγ↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   AKR1B10↓, 1,   BioAv↓, 8,   BioAv↑, 5,   BioAv↝, 3,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 35,   Dose?, 2,   Dose↑, 1,   Dose↝, 25,   Dose∅, 4,   eff↓, 28,   eff↑, 32,   eff↝, 2,   eff∅, 1,   Half-Life↝, 3,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   RadioS↑, 6,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 39,   Synergy?, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 1,   AR↑, 1,   AST↓, 3,   EGFR↓, 5,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 9,   LDH↓, 8,   LDH↑, 2,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 9,   cachexia↓, 1,   CardioT↑, 1,   chemoP↑, 7,   chemoPv↑, 4,   ChemoSideEff↓, 1,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 6,   QoL∅, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↑, 3,   toxicity↝, 4,   TumVol↓, 3,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 553

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 20,   ARE↑, 2,   Catalase↑, 13,   GPx↑, 7,   GPx4↑, 3,   GSH↑, 11,   GSH/GSSG↑, 1,   GSS↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 15,   Iron↓, 1,   i-Iron↓, 2,   Keap1↓, 2,   lipid-P↓, 14,   MDA↓, 12,   MPO↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 31,   Prx↓, 1,   ROS↓, 47,   ROS↑, 1,   ROS⇅, 2,   ROS↝, 1,   mt-ROS↓, 2,   SOD↑, 18,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 2,   Trx↑, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 5,   DRP1/DNM1L↑, 1,   FIS1↓, 6,   MFN1↓, 1,   MFN1↑, 2,   MFN2↓, 1,   MFN2↑, 4,   mtDam↓, 37,   mtDam↑, 1,   OCR↓, 1,   OPA1↓, 1,   OPA1↑, 2,   PGC-1α↑, 3,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 2,   ALAT↓, 3,   AMPK↑, 7,   ATP↑, 3,   ATP∅, 1,   CRM↑, 2,   glucose↓, 1,   GSK‐3β↓, 4,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↑, 2,   PKM2↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 13,   ASC↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 5,   Casp↓, 1,   cl‑Casp1↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 3,   Casp9↓, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 5,   GSDMD↓, 1,   iNOS↓, 3,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   Akt↝, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 1,   JNK↓, 3,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↑, 1,   PI3K↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   p‑cJun↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 3,   HSP70/HSPA5↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2↓, 4,   Ca+2↝, 1,   MMP9↓, 1,   MMPs↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 2,   GastroP↑, 1,   MMP↓, 2,   MMP↑, 4,   TJ↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD40↓, 1,   COX2/PTGS2↓, 6,   ICAM-1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 7,   IL6↓, 7,   Inflam↓, 30,   IP-10/CXCL-10↓, 1,   NeuroI↓, 4,   NF-kB↓, 11,   NK cell↑, 1,   NLRP3↓, 5,   p65↓, 1,   PGE2↓, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR4↓, 1,   TNF-α↓, 12,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 3,   AChE∅, 1,   BDNF↑, 6,   BDNF∅, 1,   ChAT↑, 1,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 3,   Aβ↓, 8,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   IDE↑, 1,   PSEN1/PS1↓, 1,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   ER(estro)↓, 1,   PPARα↝, 1,   PPARγ↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 5,   BioAv↝, 5,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↓, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 9,   Half-Life↝, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 2,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   BUN↓, 1,   creat↓, 3,   IL6↓, 7,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 4,   AntiTum↑, 1,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 17,   hepatoP↑, 11,   Learn↑, 4,   memory↑, 15,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 24,   NP/CIPN↓, 1,   Obesity↓, 2,   OS↑, 1,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 5,   Stroke↝, 1,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 1,   AntiP↑, 4,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 2,  
Total Targets: 241

Scientific Paper Hit Count for: mtDam, mitochondrial damage
14 Silver-NanoParticles
8 Ivermectin
6 Curcumin
6 Licochalcone A
5 Honokiol
5 Isobavachalcone
5 Luteolin
5 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Resveratrol
4 EGCG (Epigallocatechin Gallate)
4 Lycopene
4 Selenite (Sodium)
3 3-bromopyruvate
3 Berberine
3 Betulinic acid
3 Capsaicin
3 Centella asiatica / Gotu kola → asiaticoside
3 Quercetin
3 Dandelion Root
3 Kaempferol
3 SonoDynamic Therapy UltraSound
3 Magnolol
3 Magnetic Fields
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorogenic acid
2 chitosan
2 Chrysin
2 Copper and Cu NanoParticles
2 Ferulic acid
2 Diclofenac
2 Indole-3-carbinol
2 D-limonene
2 Electrical Pulses
2 Formononetin
2 Gallic acid
2 Gossypol/AT-101
2 Hydrogen Gas
2 doxorubicin
2 Hyperthermia
2 HydroxyTyrosol
2 Isoliquiritigenin
2 isoorientin
2 isoquercitrin
2 Linalool
2 Mangiferin
2 Melatonin
2 Phycocyanin
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Astragalus
1 Glucose
1 entinostat
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Radiotherapy/Radiation
1 Beta-Caryophyllene
1 bempedoic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 chaetocin
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Cyclopamine
1 Cynaropicrin
1 Docosahexaenoic Acid
1 Dihydrocaffeic Acid
1 Diindolylmethane
1 Docetaxel
1 Disulfiram
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Flaxseed Oil
1 Fucoidan
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hibiscus sabdariffa
1 Hyperoside
1 Inulin Prebiotic
1 Isorhamnetin
1 Lapatinib
1 Cisplatin
1 Methylene blue
1 Matrine
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Morin
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Nimbolide
1 Pachymic acid
1 Phenylbutyrate
1 Piperlongumine
1 Plumbagin
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenium
1 Ursolic acid
1 Urolithin
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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