TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱
Source:
Type:
Tumor Cell Death
Scientific Papers found: Click to Expand⟱
6576- EU,    Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
- in-vitro, HCC, HepG2
TumCD↑, selectivity↑, Apoptosis↓, ChrMod↑, DNAdam↑, P53↑, BAX↑, Bcl-2↓, Cyt‑c↑, eff↑, TumCCA↑,
6584- EU,    Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
- Review, Var, NA
*AntiAge↑, *Inflam↓, *antiOx↑, TumCD↑, Bcl-2↓, cl‑Casp7↑, cl‑PARP↑, BAX↑, P53↑, tumCV↓, selectivity↑, *testos↑, *PSA∅,
6586- EU,    Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
TumCD↑, DNAdam↑, TumCCA↑, Cyt‑c↑, Casp3↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6339- Eug,    Induction of apoptosis by eugenol in human breast cancer cells
- in-vitro, BC, NA
TumCG↓, TumCP↓, TumCD↑, GSH↓, lipid-P↑,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp/ABCB1∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, Synergy↑, Dose↝, TumCG↓,
2497- FBZ,    In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells
- in-vitro, GBM, NA
Dose?, selectivity↑, TumCD↑, α-tubulin↓,
6890- Fer,    Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
- vitro+vivo, Var, NA
TumMeta↓, TumCD∅, Casp3↑, ROS↑, H2O2↑, TumCG↓, Dose↝, other↑,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
2849- FIS,    Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7051- Gallo,  MET,    Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells
- in-vitro, PC, MIA PaCa-2
LDH↓, TumCP↓, TumCD↑, Synergy↑,
7211- GBE,    Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53
- in-vitro, CRC, HCT116
P53↑, MDM2↓, TumCD↓, tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Ferroptosis↑, ChemoSen↑,
7248- Gink,    Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line
- in-vitro, Ovarian, OVCAR-3 - in-vitro, Cerv, HeLa - NA, NA, OV1369
Dose↝, TumCD↑, eff↓, Casp↑, H2O2↑, i-ROS↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
7310- Gos,    Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, AML, NA
TumCD↑, MOMP↑, ROS↑, ATP↓, BAX↑, Cyt‑c↑, AIF↑,
7337- Gra,    Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer
- in-vitro, Pca, NA
other↝, eff↝, BioAv↝, TumCD↓, TumCG↓, Dose↝, other↝,
7331- GSE,    Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract
- in-vivo, Nor, NA
*ROS↓, TumCD↑, *RenoP↑,
2518- H2,    Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity
- in-vitro, BC, 4T1 - in-vitro, Nor, 3T3
TumCD↑, CD4+↑, ROS↓,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
7466- HNK,  PDT,  MET,    Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin
- in-vitro, BC, NA
TumCD↓, Dose↝, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, TumCP↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7625- HPT,    Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair
- in-vitro, sarcoma, NA
TumCD↑, TumCCA↑, Apoptosis↑, BRCA2↓, ChemoSen↑,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7802- IBC,    Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression
- in-vitro, Liver, HepG2
TumCD↑, Apoptosis↑, ROS↑, mtDam↑, p‑Akt↓, eff↓,
7818- IBC,    Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma
- in-vitro, neuroblastoma, NA
TumCD↑, selectivity↑, Apoptosis↑, DNAdam↑, pro‑Casp3↑, pro‑Casp9↑, cl‑Casp3↑, cl‑Casp9↑, NA↑, BAX?,
7703- Ins,    Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation
- in-vitro, AML, PLB-985
TumCG↓, TumCD↑, Diff↑, NOX2↑, ROS↑,
7682- iod,    Molecular Iodine Induces Anti- and Pro-Neoplastic Effects in Prostate Cancer Models
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
PPARγ↑, antiNeop↑, TumCD↑, TumCI↓, AntiCan⇅, antiOx↑, Inflam↓, Apoptosis↑, tumCV↓,
7713- IP6,  PacT,    Inositol hexaphosphate and paclitaxel: symbiotic treatment of oral cavity squamous cell carcinoma
- in-vitro, Oral, Ca9-22 - in-vitro, Oral, HN5
NF-kB↓, ChemoSen↑, TumCP↓, TumCD↑, Apoptosis↑,
7719- IP6,    Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells
- in-vitro, CML, NA
TumCD↑, TumCCA↑, selectivity↑, TumCP↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
9193- ITCs,  PEITC,  BITC,  SFN,    Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research
- Review, Var, NA
Risk↓, TumCCA↑, TumCD↑, selectivity↑, TumCP↓, angioG↓, EMT↓, CSCs↓, NF-kB↓, NOTCH↑, BioAv↑, AntiCan↑, Synergy↑, Polyps↓, ROS↑, compIII↓, ChemoSen↑, RadioS↑, *p‑4E-BP1↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8021- IVM,    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- vitro+vivo, AML, HL-60 - NA, lymphoma, U937 - NA, Pca, DU145
AntiP↑, TumCD↑, selectivity↑, TumCG↓, i-Chl↑, ROS↑, ChemoSen↑,
8042- IVM,    Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
- vitro+vivo, Var, NA
Dose↝, TumCD↑, eff↓, TumCCA↑, ChemoSen↑, tumCV↓, TumVol↓, TumW↓,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8046- IVM,    Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
- in-vitro, CML, NA
TumCD↑, mtDam↑, ROS↓, selectivity↑, compI↓, mitResp↓, eff↓,
8100- KAE,    Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
- in-vitro, Cerv, HeLa
*antiOx↑, *AntiTum↑, Apoptosis↑, TumCD↑, tumCV↓, PI3K↓, Akt↓, hTERT/TERT↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8114- LA,    Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate
- in-vitro, Cerv, HeLa
AntiTum↑, TumCD↑, selectivity↓,
869- Lae,    Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review
- Review, Var, NA
TumCD↑,
8152- lamb,  TRAIL/rTRAIL,    Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
TumCD↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, cFLIP↓, XIAP↓, BID↑, DR4↑, p‑NF-kB↓, p‑IκB↓,
8149- lamb,    Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, TumCCA↑, AMPK↑, Akt↓, FOXM1↓, Bcl-2↓, CycB/CCNB1↓, APOE4↑,

Showing Research Papers: 101 to 150 of 232
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 232

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↓, 3,   Catalase↑, 2,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 16,   GSH↑, 1,   GSH⇅, 1,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 1,   H2O2↑, 11,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 1,   Iron↑, 4,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 9,   MDA↑, 4,   NOX2↑, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 2,   ROS↓, 8,   ROS↑, 102,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↑, 7,   SOD↓, 1,   SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 3,   TrxR↓, 1,   TrxR1?, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compI↓, 3,   compIII↓, 1,   ETC↓, 4,   ETC↝, 1,   Insulin↓, 1,   mitResp↓, 4,   mtDam↓, 1,   mtDam↑, 12,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↓, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↓, 9,   ATP↑, 1,   FASN↓, 2,   GLS↓, 1,   GlucoseCon↓, 4,   Glycolysis↓, 7,   Glycolysis↑, 1,   GSK‐3β↑, 1,   HK2?, 1,   HK2↓, 4,   lactateProd↓, 3,   LDHA↓, 3,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 2,   p‑PKM2↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis↓, 5,   Apoptosis↑, 78,   mt-Apoptosis↑, 1,   autoS↑, 1,   BAD↑, 2,   Bak↑, 1,   BAX?, 1,   BAX↓, 1,   BAX↑, 26,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 31,   Bcl-xL↓, 5,   BID↑, 2,   BIM↑, 1,   BNIP3?, 1,   Casp↑, 8,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 40,   cl‑Casp3↑, 12,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 1,   Casp8↑, 7,   Casp9↓, 1,   Casp9↑, 19,   cl‑Casp9↑, 6,   pro‑Casp9↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 27,   Endon↑, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 6,   HEY1↓, 1,   IAP1↓, 1,   ICD↑, 1,   iNOS↓, 1,   Mcl-1↓, 6,   MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   Necroptosis↑, 2,   necrosis↑, 5,   p38↓, 1,   p38↑, 7,   p‑p38↑, 2,   Paraptosis↑, 2,   survivin↓, 1,   TumCD?, 1,   TumCD↓, 11,   TumCD↑, 215,   TumCD∅, 4,   XIAP↓, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 23,   Akt↑, 1,   p‑Akt↓, 6,   p‑Akt↑, 2,   AKT1↓, 1,   CK2↓, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   ERK↓, 7,   ERK↑, 1,   p‑ERK↑, 2,   HER2/EBBR2↓, 1,   Hippo↓, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↓, 4,   JNK↑, 5,   p‑JNK↑, 2,   MAPK↓, 3,   MAPK↑, 2,   p‑MAPK↓, 1,   Mst1↑, 1,   mTOR↓, 9,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PI3K↓, 14,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 9,   STAT3↑, 1,   p‑STAT3↓, 3,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 3,   ChrMod↑, 2,   cMyc↓, 3,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↑, 1,   FOXO4↑, 1,   H3↑, 1,   H3K4↓, 1,   H3K9↓, 1,   HDAC↓, 2,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 10,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 1,   SOX4↓, 1,   SUV39H↓, 1,   TFE3↑, 1,   tumCV↓, 19,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 16,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 5,   IRE1↑, 1,   p‑IRE1↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   Proteasome?, 1,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 3,   Beclin-1/ATG6↑, 3,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 1,   LC3B-II↑, 2,   LC3II↑, 1,   MitoP↑, 2,   p62↑, 1,   p‑p62↑, 1,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 18,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 2,   DNAdam↑, 31,   hTERT/TERT↓, 1,   p16↑, 2,   P53↓, 1,   P53↑, 23,   PARP↓, 3,   PARP↑, 4,   cl‑PARP↑, 17,   PCNA↓, 3,   γH2AX↑, 5,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 8,   CDK4↓, 7,   CDK6↓, 2,   CDKN2C/p18↑, 1,   cellSen↑, 1,   CHK1↓, 1,   Chk2↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 3,   E2Fs↓, 2,   Ki-67↓, 2,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 69,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   CD133↓, 2,   cFos↑, 1,   CSCs↓, 13,   CSCs↑, 1,   CSCs↝, 1,   Diff↓, 1,   Diff↑, 2,   IGF-1↓, 2,   IGF-2↑, 1,   Ki-67↓, 2,   mTORC1↓, 1,   NOTCH↓, 1,   NOTCH↑, 1,   NOTCH1↓, 2,   TumCG?, 1,   TumCG↓, 29,   TumCP?, 1,   TumCP↓, 37,   TumCP↑, 2,   TumCP∅, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   ATPase↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 13,   i-Ca+2↑, 1,   CD11b↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   EMT↓, 7,   EpCAM↓, 2,   FAK↓, 1,   Fibronectin↓, 1,   hnRNPA1↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MMP1↓, 1,   MMP15↓, 1,   MMP2↓, 9,   MMP9↓, 8,   MMPs↓, 5,   N-cadherin↓, 4,   PAK1↑, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 4,   Snail?, 1,   Snail↓, 6,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 12,   TumCMig↓, 16,   TumMeta↓, 18,   Twist↓, 1,   TXNIP↑, 1,   uPA↓, 1,   Vim↓, 3,   Zeb1↓, 2,   α-SMA↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   NO↑, 2,   VEGF↓, 7,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   CellMemb↑, 4,   CLDN1↓, 1,   EPR↑, 2,   GLUT1↓, 3,   GLUT3↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 44,   MMP↝, 1,   MPT↑, 2,   SVCT-2↝, 1,   TRPM7↑, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   CD44↓, 3,   CD8+↑, 2,   COX2/PTGS2↓, 7,   COX2/PTGS2↑, 1,   DCells↑, 1,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 6,   IL8↓, 3,   Imm↑, 10,   Imm↝, 1,   Inflam↓, 6,   M2 MC↓, 1,   NF-kB↓, 21,   NF-kB↑, 3,   p‑NF-kB↓, 1,   p65↓, 2,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   TCF↝, 1,   TNF-α↓, 3,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1,   Temp↓, 1,   Temp∅, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1,   ER-α36↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 7,   BioAv↝, 5,   ChemoSen↑, 35,   CompStab↑, 2,   CYP3A4↓, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 1,   Dose↝, 30,   Dose∅, 1,   eff↓, 39,   eff↑, 42,   eff↝, 4,   eff∅, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   P-gp/ABCB1∅, 1,   RadioS↑, 14,   selectivity↓, 1,   selectivity↑, 53,   Synergy↑, 27,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↑, 1,   BG↓, 1,   BloodF↑, 1,   E6↓, 2,   E7↓, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 6,   LDH?, 1,   LDH↓, 3,   LDH↑, 2,   PD-L1↓, 1,   Polyps↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 8,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 2,   chemoP↑, 8,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 4,   MusCon↓, 2,   NP/CIPN↓, 1,   OS↑, 8,   OS⇅, 1,   Pain↓, 2,   PFS↑, 1,   QoL↑, 2,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 3,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 498

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 13,   Catalase↑, 5,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 1,   GSTs↑, 3,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 1,   hyperG↝, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 3,   Prx↑, 1,   RNS↓, 2,   ROS↓, 12,   ROS↑, 1,   ROS∅, 2,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 2,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1,   Insulin↑, 1,   mitResp↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   ATP↑, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   LDL↓, 1,   lipidLev↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   BAX↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 2,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   RIP1↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMP2↑, 1,   neuroG↑, 1,   TumCG∅, 1,  

Migration(tgid=13) ⓘ

COL1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,   VCAM-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 2,   MMP∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 4,   Inflam↓, 10,   pol-M2 MC↑, 1,   NF-kB↓, 3,   PGE2↓, 1,   PSA∅, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 1,   BDNF↑, 2,   MAOA↓, 1,   NGF↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 10,   BioAv↝, 2,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↝, 1,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BMD↑, 1,   BP↓, 2,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 4,   PSA∅, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 2,   AntiCan↑, 4,   antiCG↑, 1,   AntiDiabetic↑, 5,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 3,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 5,   Obesity↓, 2,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Stroke↓, 2,   toxicity↓, 15,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 2,   AntiViral↑, 2,   Bacteria↓, 4,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 143

Scientific Paper Hit Count for: TumCD, Tumor Cell Death
23 Silver-NanoParticles
12 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
9 Magnetic Field Rotating
6 Electrical Pulses
6 Phenethyl isothiocyanate
6 Selenite (Sodium)
5 Curcumin
5 Copper and Cu NanoParticles
5 Dandelion Root
5 Disulfiram
5 Ivermectin
4 Radiotherapy/Radiation
4 Chemotherapy
4 Photodynamic Therapy
4 Metformin
4 Eugenol
4 Quercetin
4 VitK3,menadione
3 Rosmarinic acid
3 Hyperthermia
3 Astaxanthin
3 Melatonin
3 Chrysin
3 Date Fruit Extract
3 Eurycomanone
3 Fisetin
3 salinomycin
2 3-bromopyruvate
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 chaetocin
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fenbendazole
2 Ginkgetin
2 Gossypol/AT-101
2 Honokiol
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoorientin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 lambertianic acid
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Methylene blue
2 Matrine
2 mebendazole
2 Magnesium
2 Methylglyoxal
2 Phenylbutyrate
2 Selenium
1 1,8-Cineole
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Allyl isothiocyanate
1 Anethole/trans-Anethole
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Bullatacin
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Chlorophyllin
1 Docetaxel
1 Zinc
1 Cranberry
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Deguelin
1 Diclofenac
1 Echinacea
1 Cannabichromene
1 Bortezomib
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Galloflavin
1 Ginkgo biloba
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Indole-3-carbinol
1 Inositol
1 iodine
1 Paclitaxel/Taxol
1 Isothiocyanates
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Linalool
1 Luteolin
1 SonoDynamic Therapy UltraSound
1 Magnolol
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 Caffeine
1 methotrexate
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Nimbolide
1 Propyl gallate
1 Phycocyanin
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Vitexin
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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