SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Scientific Papers found: Click to Expand⟱
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
*SIRT1↑, *PGC-1α↑, *cMyc↑, *PDK1 / PDPK1↓,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
SIRT1↑, ROCK1↓, AMPK↑, *lipid-P↓, Aβ↓, COX2/PTGS2↓, angioG↓, Hif1a↓, VEGF↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3075- RES,  Rad,    The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice
- in-vivo, Nor, NA
*SIRT1↑, *radioP↑, *NLRP3↓, *Weight↑, *IL1β↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3096- RES,    Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCP↓, Apoptosis↑, Akt↓, mTOR↓, p38↑, MAPK↑, STAT3↓, ROS↑, SIRT1↑, SOX2↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3074- RES,    Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
- Review, BC, NA
NLRP3↓, SIRT1↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3059- RES,    Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- in-vivo, Nor, HK-2
*RenoP↑, *Inflam↓, *NRF2↑, *HO-1↑, *SIRT1↑, *ROS↓, AntiAge↑,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27/CDKN1B↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
chemoPv↑, SIRT1↑, Hif1a↓, VEGF↓, STAT3↓, NF-kB↓, COX2/PTGS2↓, PI3K↓, mTOR↓, NRF2↑, NLRP3↓, H2O2↑, ROS↑, P53↑, PUMA↑, BAX↑,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
*antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *AMPK↑, *SIRT1↑, *miR-155↓, *NLRP3↓,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
p65↓, SOD2↓, Prx↓, Catalase↓, Trx↓, TNF-α↓, IL8↓, MCP1/CCL2↓, SIRT1↑,
4706- RES,    Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications
- Review, Nor, NA
*SIRT1↑, *CLOCK↝,
4670- RES,  CUR,  EGCG,  TQ,    Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *SIRT1↑, *SIRT3↑, *FOXO↑, *ROS↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2/PTGS2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE/β-secretase↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP/DDIT3↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
1193- SM,    Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- in-vivo, Alcohol, NA - in-vitro, Liver, HepG2
*p‑AMPK↑, *SIRT1↑, *NRF2↑, *CYP2E1↓, *lipoGen↓, *ROS↓, *Inflam↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4878- Uro,    Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis
- Review, AD, NA
*memory↑, *SIRT1↑, *cognitive↑, *BDNF↑, *Apoptosis↓, *neuroG↑,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, Nor, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 101 to 140 of 140
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 140

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↓, 4,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 2,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 5,   GSH↑, 1,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 5,   HO-1↑, 3,   HO-2↓, 1,   HO-2↑, 1,   lipid-P↑, 3,   MDA↑, 2,   NADH↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 4,   Prx↓, 1,   ROS↓, 6,   ROS↑, 35,   ROS⇅, 1,   SOD↓, 4,   SOD↑, 3,   SOD2↓, 2,   SOD2↑, 1,   TKT↝, 1,   Trx↓, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   ETC↝, 1,   Insulin↓, 1,   mtDam↑, 2,   OCR↓, 2,   OXPHOS↓, 1,   OXPHOS↑, 2,   PDH↑, 1,   PDH↝, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 12,   p‑AMPK↑, 1,   ATP↓, 4,   ATP↑, 1,   CRM↑, 1,   ECAR↝, 1,   G6PD↓, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycolysis↓, 4,   Glycolysis↝, 1,   HK2↓, 2,   lactateProd↓, 1,   lactateProd∅, 1,   LDHA↓, 1,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1?, 2,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 1,   R5P↝, 1,   RARβ↑, 1,   SIRT1↓, 23,   SIRT1↑, 32,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 21,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 12,   Bax:Bcl2↑, 4,   Bcl-2↓, 14,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↓, 1,   BIM↑, 2,   Casp↑, 6,   Casp1↓, 1,   Casp3↑, 19,   cl‑Casp3↑, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 5,   Casp9↑, 11,   cFLIP↓, 2,   Cyt‑c↑, 12,   Diablo↑, 2,   DR5↑, 3,   Endon↑, 1,   FADD↑, 1,   Fas↓, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 3,   iNOS↓, 2,   Mcl-1↓, 2,   MDM2↓, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↑, 4,   p‑p38↑, 1,   Paraptosis↑, 1,   PUMA↑, 2,   RIP3↑, 1,   survivin↓, 9,   TumCD↑, 2,   XIAP↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 19,   Akt↑, 1,   p‑Akt↓, 5,   CIP2A↓, 1,   CK2↓, 1,   cSrc↓, 1,   EGFR↓, 8,   EGFR↑, 1,   ERK↓, 7,   p‑ERK↓, 3,   FOXD3↑, 1,   HGF/c-Met↓, 1,   IKKα↓, 1,   p‑IκB↑, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 14,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 18,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 2,   PTEN↓, 2,   PTEN↑, 8,   Raf↓, 1,   RAS↓, 1,   RIP1↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT3↓, 14,   p‑STAT3↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   cMyc↓, 6,   cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 3,   DNMTs↓, 2,   EZH2↓, 3,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↑, 3,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 6,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 3,   HMTs↑, 1,   miR-133a-3p↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   Myc↓, 2,   other↓, 1,   other↝, 1,   SOX2↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP72↓, 1,   HSP90↓, 3,   NQO2↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LAMP2↑, 1,   LC3II↑, 3,   p62↓, 1,   p62↑, 1,   TumAuto↑, 9,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 2,   DNAdam↓, 2,   DNAdam↑, 9,   hTERT/TERT↓, 2,   P53↓, 1,   P53↑, 16,   ac‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 9,   PCNA↓, 3,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 2,   CDK2↑, 3,   CDK4↓, 4,   CDK4↑, 2,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↓, 1,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 5,   Ki-67↓, 6,   MAD↓, 1,   P21↑, 10,   p27/CDKN1B↑, 3,   p‑RB1↓, 2,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 2,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 5,   Diff↑, 1,   EP2↓, 1,   Gli1↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 6,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 1,   TumCG↓, 16,   TumCP↓, 19,   TumCP⇅, 1,   Wnt↓, 8,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

ASAP2↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   Cdc42↓, 1,   CDH1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 8,   EMT↓, 14,   FAK↓, 3,   p‑FAK↓, 2,   Fibronectin↓, 1,   ITGB1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP13↓, 1,   MMP2↓, 13,   proMMP2↓, 1,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 17,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 5,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 5,   talin↓, 1,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 11,   TumCMig↓, 8,   TumMeta↓, 15,   TumMeta↑, 1,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim?, 1,   Vim↓, 8,   Vim↑, 1,   Zeb1↓, 4,   β-catenin/ZEB1↓, 11,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   ECM/TCF↓, 1,   EGR1↑, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 12,   LOX1↓, 1,   VEGF↓, 18,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP↓, 17,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCR4↓, 3,   DR4↑, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL1β↓, 3,   IL2↑, 2,   IL4↑, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 3,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 28,   p‑NF-kB↓, 1,   NLRP3↓, 4,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 3,   PSA↓, 1,   T-Cell↓, 1,   TCF↓, 1,   Th1 response↑, 1,   TNF-α↓, 5,   TNF-α↑, 1,   Treg lymp↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 2,   ER(estro)↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 19,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↓, 2,   Dose↑, 1,   Dose↝, 12,   Dose∅, 3,   eff↓, 7,   eff↑, 9,   eff↝, 2,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   RadioS↑, 11,   selectivity↑, 7,   Synergy↑, 12,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BG↓, 1,   BRCA1↑, 2,   CA125↓, 1,   CEA↓, 2,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 8,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   hTERT/TERT↓, 2,   IL6↓, 8,   LDH↓, 2,   Maspin↑, 1,   Myc↓, 2,   NSE↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 10,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 3,   memory↑, 1,   Obesity↓, 1,   OS↑, 3,   OS∅, 1,   PFS∅, 1,   QoL↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  
Total Targets: 494

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 43,   Catalase↑, 20,   GPx↑, 18,   GPx1↑, 1,   GSH↑, 22,   GSR↑, 4,   GSTs↑, 4,   H2O2↓, 2,   HDL∅, 1,   HO-1↑, 27,   HO-1⇅, 1,   Keap1↓, 2,   lipid-P↓, 22,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 19,   MPO↓, 4,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 2,   NRF2↓, 1,   NRF2↑, 33,   ROS↓, 66,   ROS↑, 1,   mt-ROS↓, 1,   SOD↑, 29,   SOD1↑, 1,   SOD2↑, 4,   TAC↑, 3,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 3,   ETC↑, 1,   FIS1↓, 1,   Insulin↓, 2,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 4,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 11,   SIRT3↑, 5,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   Acetyl-CoA↓, 2,   ALAT↓, 9,   AMPK↑, 26,   p‑AMPK↑, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 1,   FAO↑, 2,   G6PD↑, 1,   glucose↓, 2,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↑, 2,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PDKs↑, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 2,   PKM2↑, 2,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 4,   SIRT1↑, 84,   SIRT1↝, 1,   SIRT1∅, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAX↓, 5,   Bcl-2↑, 4,   Bcl-2↝, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 6,   cl‑Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   iNOS↓, 9,   necrosis↓, 1,   p38↓, 1,   p‑p38↓, 1,   Pyro?, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 1,   Hippo↑, 1,   JAK2↓, 1,   JNK↓, 3,   MAPK↓, 4,   mTOR↓, 6,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 3,   PKA↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 2,   cMyc↑, 1,   FOXO↑, 3,   FOXO1↑, 2,   FOXO3↑, 5,   miR-155↓, 1,   miR-34a↓, 1,   other↓, 1,   other↑, 4,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   ER Stress↓, 6,   GRP78/BiP↓, 4,   HSP27↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   IRE1↓, 1,   PDI↓, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   CTSZ↓, 1,   MitoP↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 4,   DNArepair↑, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   CLOCK↝, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 2,   Cartilage↑, 1,   COL1↓, 3,   Fibrosis↓, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   Na+↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TXNIP↓, 2,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 5,   eNOS↑, 2,   Hif1a↑, 4,   NO↓, 12,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 7,   BBB↝, 1,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 6,   Na+↑, 1,   NHE3↑, 1,   TJ↑, 1,   TRPV1↑, 3,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 13,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 16,   IL2↓, 4,   IL23↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 22,   IL8↓, 2,   INF-γ↓, 1,   Inflam↓, 58,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   NeuroI↓, 2,   NF-kB↓, 26,   NF-kB↑, 1,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 2,   PGE2↓, 6,   RAGE↓, 2,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 27,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 4,   AChE↓, 6,   ADAM10↑, 3,   BDNF↓, 1,   BDNF↑, 14,   ChAT↑, 2,   MAOA↝, 1,   NGF↑, 1,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 1,   p‑tau↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 3,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 18,   BioAv↝, 8,   BioEnh↑, 2,   CompStab↝, 1,   CYP2E1↓, 3,   Dose?, 2,   Dose↑, 1,   Dose↝, 10,   eff↓, 2,   eff↑, 11,   Half-Life↓, 4,   Half-Life↝, 3,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 1,   AST↓, 8,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 22,   IRes↑, 1,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 9,   antiAll↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 23,   chemoP↑, 1,   cognitive↑, 21,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 17,   motorD↑, 3,   neuroP↑, 41,   Obesity↓, 5,   OS↑, 5,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 7,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 3,   Stroke↓, 2,   toxicity↓, 7,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 1,   GutMicro↑, 12,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 331

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
36 Resveratrol
9 Capsaicin
7 Quercetin
6 Hydrogen Gas
6 Urolithin
5 Curcumin
5 EGCG (Epigallocatechin Gallate)
5 nicotinamide adenine dinucleotide
4 Gambogic Acid
4 Luteolin
4 Melatonin
4 Thymoquinone
3 Calorie Restriction Mimetics
3 Kaempferol
3 Shikonin
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 Crocetin
2 diet FMD Fasting Mimicking Diet
2 Chemotherapy
2 Ellagic acid
2 Electrical Pulses
2 Lycopene
2 Silymarin (Milk Thistle) silibinin
1 Astragalus
1 Magnetic Fields
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Artemisinin
1 Baicalein
1 Baicalin
1 Berberine
1 Beta-Caryophyllene
1 Carnosic acid
1 Carvacrol
1 Citicoline, CDP-Choline
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 HydroxyCitric Acid
1 Garcinol
1 Ferulic acid
1 Flaxseed/Linseed
1 Fucoidan
1 Honokiol
1 Hyperoside
1 Isoliquiritigenin
1 Butein
1 Scopoletin
1 isoorientin
1 Cisplatin
1 L-Theanine
1 lambertianic acid
1 Licochalcone A
1 Metformin
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Pterostilbene
1 Radiotherapy/Radiation
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Salvia miltiorrhiza
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:634  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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