GPx4 Cancer Research Results

GPx4, Glutathione Peroxidase 4: Click to Expand ⟱
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GPX4 (Glutathione Peroxidase 4) is a selenoprotein that plays a crucial role in the regulation of ferroptosis, a form of programmed cell death characterized by the iron-dependent accumulation of lipid reactive oxygen species (ROS).
GPX4 has been found to be upregulated in several tumor types, promoting cancer cell survival and resistance to therapy. For instance, GPX4 overexpression has been observed in renal cell carcinoma, pancreatic ductal adenocarcinoma, and triple-negative breast cancer, among others. -GPX4 is known as a lipid peroxidation inhibitor protein, and its antioxidant effect is closely related to ferrous iron
-GPX4 is a confirmed key regulator of ferroptosis.(downregulation of xCT and GPX4, confirming induces ferroptosis
Scientific Papers found: Click to Expand⟱
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
2202- SK,    Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
- in-vitro, Var, NA
Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
1068- SM,    Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA - Human, BC, NA
TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT/SLC7A11↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5094- SSE,  Matr,    Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
- vitro+vivo, Nor, NRK52E
*GPx4↑, *xCT/SLC7A11↑, *GSH↑, *RenoP↝, *Ferroptosis↓,
5090- SSE,    Sodium Selenite Induces Ferroptosis in Non-small Cell Lung Cancer A549 Cells Via Reactive Oxygen Species (ROS)/Glutathione (GSH)/Glutathione Peroxidase4 (GPx4) Axis
- in-vitro, Lung, A549
TumCP↓, ROS↑, GSH↓, MMP↓, GPx4↓, Iron↑,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT/SLC7A11↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4732- SSE,    Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
- in-vivo, Autism, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *other↝,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,
3405- TQ,  doxoR,    Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism
- vitro+vivo, CardioV, NA
*cardioP↑, *NRF2↑, *HO-1↑, *ROS↓, *NQO1↑, *COX2/PTGS2↓, *NOX4↓, *GPx4↑, *FTH1↑, *p‑mTOR↓, *TGF-β↓,
3399- TQ,    Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - NA, BC, MDA-MB-468
ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,
1215- VitC,  immuno,    Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma
- ex-vivo, HCC, NA - in-vivo, HCC, NA
other↓, *GPx4↑, *GSH↑, GPx4↓, GSH↓, selectivity↑,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 101 to 119 of 119
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 119

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   Fenton↑, 7,   GCLM↑, 1,   GPx↓, 3,   GPx1↓, 1,   GPx1⇅, 1,   GPx4↓, 88,   GPx4↑, 3,   GPx4↝, 1,   GPx4∅, 1,   GSH↓, 46,   GSH↑, 1,   GSH/GSSG↓, 5,   GSSG↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 6,   HO-1↑, 9,   Iron↓, 2,   Iron↑, 37,   Iron↝, 1,   i-Iron↑, 8,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 37,   MDA↓, 2,   MDA↑, 28,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NQO1↑, 1,   NRF2↓, 19,   NRF2↑, 8,   NRF2↝, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 76,   SOD↓, 6,   SOD↑, 1,   T-SOD↓, 1,   TrxR↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 18,   xCT/SLC7A11∅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   LIP↑, 1,   NCOA4↑, 3,   Tf↑, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↝, 1,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   ETC↓, 2,   mtDam↑, 5,   OXPHOS↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 6,   ACSL4∅, 1,   AMPK↑, 6,   ATP↓, 4,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 6,   GSK‐3β↓, 1,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 2,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 1,   PFKP↓, 1,   PKM2↓, 3,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 25,   BAD↑, 1,   p‑BAD↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 5,   cl‑Casp3↑, 5,   Casp7↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 2,   Cyt‑c↑, 7,   DR5↑, 4,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 79,   GranB/GZMB↝, 1,   iNOS↓, 1,   MOMP↑, 2,   p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 3,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 14,   p‑Akt↓, 2,   CaMKII ↓, 1,   cMET↓, 1,   EGFR↓, 1,   ERK↓, 3,   ERK↑, 2,   p‑ERK↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 4,   p‑MAP2K1/MEK1↓, 1,   MAPK↑, 4,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   mTOR↓, 9,   p‑mTOR↓, 2,   PI3K↓, 11,   p‑PI3K↓, 1,   PTEN↑, 3,   RET↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   ATFs↑, 1,   DLEU1↓, 1,   DNMT1↑, 1,   DNMTs↓, 1,   FOXO1↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-21↓, 2,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   miR-592↑, 1,   OCT4↓, 1,   other↓, 1,   other↑, 2,   other↝, 3,   sonoS↑, 1,   SOX2↓, 1,   SOX4↓, 2,   tumCV↓, 10,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 6,   eIF2α↓, 1,   eIF2α↑, 2,   ER Stress↑, 7,   Erlin1↑, 1,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 3,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 4,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   p62↓, 2,   p62↑, 2,   TumAuto↑, 13,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 5,   DNArepair↓, 1,   ERCC3↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 8,   cl‑PARP↑, 3,   PCNA↓, 1,   SIRT6↓, 1,   TOP2↑, 1,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↝, 1,   CDK4↓, 1,   CDK7↓, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 3,   Ki-67↓, 7,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs?, 1,   CSCs↓, 5,   GDF15↓, 1,   Ki-67↓, 7,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   Piezo1↑, 2,   TumCG↓, 21,   TumCP?, 1,   TumCP↓, 32,   TumCP↑, 1,   Wnt↓, 9,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ASAP2↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 3,   CAFs/TAFs↓, 1,   E-cadherin↑, 4,   EMT↓, 9,   FAK↓, 1,   MALAT1↓, 1,   MMP16↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 3,   PCBP1↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 1,   TumCI↓, 13,   TumCMig↓, 11,   TumMeta↓, 5,   TumPF↓, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 6,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   EGR1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   GLUT1↓, 3,   MMP↓, 17,   MPT↑, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   COX2/PTGS2↓, 4,   CXCR4↓, 1,   DR4↑, 1,   FOXP3↓, 1,   HLA↑, 1,   HMGB1↓, 3,   IL12↑, 1,   IL2↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm↝, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   NF-kB↓, 9,   p‑NF-kB↓, 1,   NK cell↑, 1,   PD-L1↓, 5,   TCF7/TCF1↓, 1,   TLR1↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 1,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 24,   CYP3A4↓, 1,   Dose?, 1,   Dose↝, 6,   eff↓, 12,   eff↑, 9,   eff↝, 3,   Half-Life↓, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 2,   RadioS↑, 5,   selectivity↑, 6,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   Ferritin↓, 2,   Ferritin↑, 1,   LDH↓, 1,   PD-L1↓, 5,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 10,   antiNeop↑, 1,   AntiTum↑, 3,   chemoP↑, 3,   hepatoP↑, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 1,   toxicity↓, 3,   toxicity↑, 2,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 375

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 10,   Catalase↑, 6,   GPx↑, 3,   GPx1↑, 6,   GPx4↓, 3,   GPx4↑, 23,   GPx4∅, 1,   GSH↓, 1,   GSH↑, 8,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 7,   HO-1↝, 1,   HO-1∅, 1,   Iron↓, 2,   Iron↝, 1,   i-Iron↓, 3,   lipid-P↓, 5,   lipid-P↑, 2,   MDA↓, 7,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 16,   NRF2∅, 1,   ROS↓, 17,   ROS↑, 1,   i-ROS↑, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 10,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 2,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   IronCh↑, 2,   NCOA4↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↓, 3,   OXPHOS↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACSL4↓, 4,   ACSL4∅, 1,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 2,   GSK‐3β↑, 1,   HK2↑, 2,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM2↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 3,   Cyt‑c↓, 1,   Ferroptosis↓, 18,   Ferroptosis↑, 1,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 1,   JNK↓, 2,   MAPK↓, 1,   p‑mTOR↓, 1,   PKCδ↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   FOXO3↑, 1,   other↓, 1,   other↑, 1,   other↝, 2,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,   GRP78/BiP↓, 2,   IRE1↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   neuroG↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

EMT↑, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumCMig↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   BBB∅, 2,   CLDN4↑, 1,   GLUT1↑, 2,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   MMP↑, 2,   MMP↝, 1,   OCLN↑, 1,   TJ↑, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL6↓, 3,   Inflam?, 1,   Inflam↓, 11,   NeuroI↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   NLRP3↓, 1,   RAGE↓, 1,   TLR4↓, 2,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   Dose?, 2,   Dose↝, 1,   eff↓, 1,   eff↑, 4,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↑, 1,   IL6↓, 3,   IRes↝, 1,   LDH↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 2,   cardioP↑, 5,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↓, 1,   hepatoP↑, 2,   Learn↑, 2,   memory↑, 3,   neuroP↑, 8,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 2,   RenoP↝, 1,   Stroke↓, 5,   toxicity?, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 195

Scientific Paper Hit Count for: GPx4, Glutathione Peroxidase 4
9 Shikonin
7 Artemisinin
7 Curcumin
7 Matrine
7 Selenite (Sodium)
6 Luteolin
6 Magnetic Fields
5 Cisplatin
4 Baicalein
3 immunotherapy
3 Honokiol
3 doxorubicin
3 Vitamin C (Ascorbic Acid)
2 Astragalus
2 Ashwagandha(Withaferin A)
2 Radiotherapy/Radiation
2 Boron
2 Formononetin
2 Ginkgetin
2 Hyperoside
2 Isoliquiritigenin
2 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
2 Juglone
2 Kaempferol
2 Magnetic Field Rotating
2 Rosmarinic acid
2 Thymoquinone
1 Auranofin
1 Silver-NanoParticles
1 Andrographis
1 Docetaxel
1 Astaxanthin
1 Betulinic acid
1 Boswellia (frankincense)
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 chemodynamic therapy
1 Celastrol
1 Citric Acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diindolylmethane
1 EGCG (Epigallocatechin Gallate)
1 erastin
1 ferumoxytol
1 Gallic acid
1 Gambogic Acid
1 Ginkgo biloba
1 HydroxyTyrosol
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Metformin
1 magnetic nanoparticles
1 Morin
1 Zeolite
1 Methylsulfonylmethane
1 Myricetin
1 Piperlongumine
1 Psoralidin
1 Quercetin
1 Resveratrol
1 salinomycin
1 Sulfasalazine
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:643  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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