lactateProd Cancer Research Results

lactateProd, lactate production: Click to Expand ⟱
Source:
Type:
Lactate production has been linked to cancer development and progression. In normal conditions, lactate is produced in cells through a process called glycolysis, which breaks down glucose to generate energy. However, in cancer cells, this process is often upregulated, leading to increased lactate production, even in the presence of oxygen. This phenomenon is known as the Warburg effect.

-Lactate is the end product of glycolysis and induces TGFβ1 upregulation and the acidic microenvironment.
Scientific Papers found: Click to Expand⟱
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX↓, PDK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,
3145- VitC,    Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect
- in-vitro, CRC, HCT116
Warburg↓, TumCG↓, Glycolysis↓, GlucoseCon↓, ATP↓, lactateProd↓, selectivity↑, GLUT1↓, PKM2↓, LDHA↓, mTOR↓,
2369- VitD3,    Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation
- in-vitro, CRC, DLD1 - in-vitro, CRC, RKO
MEG3↑, Glycolysis↓, lactateProd↓, LDHA↓, PKM2↓, HK2↓,
2367- VitD3,    Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia
- in-vivo, AML, NA
FBP1↑, Warburg↓, Glycolysis↓, lactateProd↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, MCT4↓, LDH↓, lactateProd↓, ECAR↓, TumCP↓, Glycolysis↓,
2397- Wor,    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
- Review, Var, NA
lactateProd↓, GlucoseCon↓, GLUT3↓, HK2↓, PKM2↓, LDHA↓,
2414- β‐Ele,    Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumMeta↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, EGFR↓, GLUT1↓, LDHA↓, ECAR↓, OCR↓,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 101 to 118 of 118
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 118

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   NRF2↓, 1,   ROS↑, 6,   ROS∅, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 9,   i-ATP↓, 1,   MMP↓, 6,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 1,   AMPK↑, 4,   CAIX↓, 1,   cMyc↓, 3,   ECAR↓, 2,   FAO↑, 1,   FASN↓, 1,   FBP1↑, 1,   GlucoseCon↓, 7,   GlucoseCon↑, 2,   Glycolysis↓, 12,   Glycolysis↑, 1,   HK2↓, 8,   HK2↑, 1,   lactateProd↓, 14,   lactateProd↑, 3,   e-lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 7,   LDHA↑, 1,   MCT4↓, 1,   NADPH↓, 1,   PDH↓, 1,   p‑PDH↓, 1,   PDK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PGK1↓, 1,   PGM1↓, 1,   PKM2↓, 8,   TCA↓, 1,   Warburg↓, 3,  

Cell Death ⓘ

Akt↓, 4,   Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 4,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   GSDME-N↑, 1,   JNK↑, 2,   MEG3↑, 1,   p38↑, 1,   Pyro↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   mTORC1↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT3↓, 1,   TumCG↓, 5,  

Migration ⓘ

CD31↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   N-cadherin↓, 1,   PKA↓, 1,   Rho↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 1,   uPAR↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 2,   Hif1a↓, 3,   Hif1a↑, 2,   NO↑, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL17↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose∅, 1,   eff↓, 6,   eff↑, 7,   eff↝, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   EGFR↓, 2,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   OS↑, 1,   Risk↓, 1,   toxicity↑, 1,   toxicity∅, 1,  
Total Targets: 125

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   SOD↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   hepatoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: lactateProd, lactate production
18 Shikonin
8 Dichloroacetate
7 Quercetin
7 Resveratrol
5 EGCG (Epigallocatechin Gallate)
4 Artemisinin
4 Rosmarinic acid
3 Betulinic acid
3 Curcumin
3 Methylene blue
3 Ursolic acid
3 Vitamin K2
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 5-fluorouracil
2 Chrysin
2 Citric Acid
2 Metformin
2 Radiotherapy/Radiation
2 Magnetic Fields
2 Propolis -bee glue
2 Pterostilbene
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
1 3-bromopyruvate
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 2-DeoxyGlucose
1 tamoxifen
1 Capsaicin
1 Catechins
1 Bortezomib
1 salinomycin
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ellagic acid
1 Gossypol
1 Hydrogen Gas
1 Honokiol
1 Kaempferol
1 lambertianic acid
1 Melatonin
1 Magnetic Field Rotating
1 Oroxylin-A
1 Pachymic acid
1 Proanthocyanidins
1 Phenylbutyrate
1 Sulforaphane (mainly Broccoli)
1 Cisplatin
1 Selenite (Sodium)
1 triptolide
1 Vitamin B1/Thiamine
1 Arsenic trioxide
1 Wogonin
1 Worenine
1 β‐Elemene
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:739  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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