Cyt‑c Cancer Research Results

Cyt‑c, cyt-c Release into Cytosol: Click to Expand ⟱
Source:
Type:
Cytochrome c
** The term "release of cytochrome c" ** an increase in level for the cytosol.
Small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration. Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It also plays a major role in cell apoptosis.

The term "release of cytochrome c" refers to a critical step in the process of programmed cell death, also known as apoptosis.
In its new location—the cytosol—cytochrome c participates in the apoptotic signaling pathway by helping to form the apoptosome, which activates caspases that execute cell death.
Cytochrome c is a small protein normally located in the mitochondrial intermembrane space. Its primary role in healthy cells is to participate in the electron transport chain, a process that helps produce energy (ATP) through oxidative phosphorylation.
Mitochondrial outer membrane permeability leads to the release of cytochrome c from the mitochondria into the cytosol.
The release of cytochrome c is a pivotal event in apoptosis where cytochrome c moves from the mitochondria to the cytosol, initiating a chain reaction that leads to programmed cell death.

On the one hand, cytochrome c can promote cancer cell survival and proliferation by regulating the activity of various signaling pathways, such as the PI3K/AKT pathway. This can lead to increased cell growth and resistance to apoptosis, which are hallmarks of cancer.
On the other hand, cytochrome c can also induce apoptosis in cancer cells by interacting with other proteins, such as Apaf-1 and caspase-9. This can lead to the activation of the intrinsic apoptotic pathway, which can result in the death of cancer cells.
Overexpressed in Breast, Lung, Colon, and Prostrate.
Underexpressed in Ovarian, and Pancreatic.
Scientific Papers found: Click to Expand⟱
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6543- BSB,    alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells
- in-vitro, GBM, U87MG
tumCV↓, selectivity↑, TumCD↑, Apoptosis↑, MOMP↓, Cyt‑c↑, cl‑PARP↑,
6544- BSB,    Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis
- in-vitro, GBM, NA
*Inflam↓, *AntiBio↑, selectivity↑, Apoptosis↑, Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, MPT↑, ROS↑, eff↓, OCR↓, eff↑,
6559- BSB,    Modulatory effect of α-Bisabolol on induced apoptosis via mitochondrial and NF-κB/Akt/PI3K Signaling pathways in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, TumCP↓, Apoptosis↓, ROS↑, Bcl-2↓, BAX↑, BAD↑, Casp3↑, Casp9↑, Cyt‑c↑, NF-kB↓, p‑PI3K↓, p‑Akt↓,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,
5835- CAP,    Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+-mediated mitochondrial pathway
- in-vitro, GBM, U251
tumCV↓, Apoptosis↑, selectivity↑, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Casp↑, eff↑, MPT↑, ETC↓, Casp3↑, Casp9↑,
5831- CAP,    Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
TRPV1↑, Ca+2↑, AntiCan↑, TumCP↓, Pain↓, TumCG↓, ChemoSen↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑,
5826- CAP,    Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload
- in-vitro, Thyroid, NA
TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, eff↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
1287- CAR,    Carvacrol induces apoptosis in human breast cancer cells via Bcl-2/CytC signaling pathway
- in-vitro, BC, HCC1937
TumCP↓, TumCCA↑, Apoptosis↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↓,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6306- Cro,    Crocetin induces apoptosis of BGC-823 human gastric cancer cells
- in-vitro, GC, BGC-823
TumCP↓, MMP↓, Casp3↑, Cyt‑c↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
6189- Cuc,    Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, Cyt‑c↑, STAT3↓, Casp3↑, Casp9↑, MMP↓,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
TumCP↓, TumMeta↓, TumCCA↑, Apoptosis↑, CSCs↓, NF-kB↓, Telomerase↓, Cyt‑c↑, Casp9↑, Casp3↑, E-cadherin↑,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
3580- CUR,    Curcumin Acts as Post-protective Effects on Rat Hippocampal Synaptosomes in a Neuronal Model of Aluminum-Induced Toxicity
- in-vivo, AD, NA
*ROS↓, *Cyt‑c↓, *Casp3↓, *neuroP↑,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,
484- CUR,  PDT,    Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
- in-vitro, Melanoma, NA
Cyt‑c↑, Casp9↑, Casp8↑, NF-kB↓, EGFR↓,
481- CUR,  CHr,  Api,    Flavonoid-induced glutathione depletion: Potential implications for cancer treatment
- in-vitro, Liver, A549 - in-vitro, Pca, PC3 - in-vitro, AML, HL-60
GSH↓, mtDam↑, MMP↓, Cyt‑c↑,

Showing Research Papers: 101 to 150 of 408
Prev Page 3 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 408

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Catalase↑, 1,   compI↓, 1,   Fenton↑, 3,   Ferroptosis↑, 2,   GPx↓, 2,   GPx4↓, 1,   GSH↓, 6,   GSH↑, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron↑, 2,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NRF2↓, 3,   NRF2↑, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↑, 30,   mt-ROS↑, 1,   SOD↓, 2,   SOD2↓, 1,   SOD2↑, 1,   TBARS↓, 1,   Trx2↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 2,   compIII↓, 1,   ETC↓, 3,   MMP↓, 24,   MMP↑, 1,   MPT↑, 8,   mtDam↑, 9,   OCR↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALAT↓, 1,   AMPK↑, 3,   cMyc↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 1,   LDH↑, 1,   LDL↓, 1,   PDK1↓, 1,   PFKP↓, 1,   PIK3CA↓, 1,   PPARα↓, 1,   Pyruv↓, 1,   SIRT1↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   p‑Akt↓, 3,   Apoptosis↓, 2,   Apoptosis↑, 37,   BAD↑, 3,   Bak↓, 1,   Bak↑, 2,   BAX↑, 20,   Bax:Bcl2↑, 4,   Bcl-2↓, 18,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BID↑, 1,   cl‑BID↑, 1,   Casp↑, 12,   Casp3↓, 1,   Casp3↑, 24,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 6,   proCasp8↑, 1,   Casp9↑, 19,   cl‑Casp9↑, 1,   Cupro↑, 2,   Cyt‑c↑, 46,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 1,   FADD↑, 2,   Fap1↓, 1,   Fas↑, 5,   FasL↑, 2,   Ferroptosis↑, 2,   hTERT/TERT↓, 4,   ICAD↓, 1,   iNOS↓, 2,   JNK↑, 5,   p‑JNK↑, 3,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MOMP↓, 1,   p27/CDKN1B↑, 1,   p38↑, 5,   p‑p38↑, 1,   Paraptosis↑, 1,   Pyro↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TNFR 1↑, 1,   TRPV1↑, 5,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 3,   eIF2α↑, 1,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP90↓, 2,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   BNIP3↝, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 9,   mt-DNAdam↑, 1,   P53↑, 8,   PARP↑, 4,   cl‑PARP↑, 9,   PCNA↓, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 4,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AR-V7?, 1,   CSCs↓, 1,   Diff↑, 1,   EMT↓, 3,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 1,   p‑ERK↑, 1,   FGF↓, 1,   Gli1↓, 1,   HDAC↓, 2,   HDAC8↓, 1,   Let-7↑, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↑, 2,   PI3K↓, 5,   PI3K↑, 1,   p‑PI3K↓, 1,   SCF↓, 1,   SHP1↑, 1,   Smo↓, 1,   STAT3↓, 3,   STAT3↑, 1,   p‑STAT3↓, 1,   TOP1↓, 2,   TOP2↓, 2,   TRPM7↓, 2,   TumCG↓, 10,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2?, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↑, 6,   F-actin↓, 1,   FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP-10↓, 1,   MMP2↓, 2,   MMP9↓, 4,   N-cadherin↓, 3,   Slug↓, 1,   Snail↓, 1,   TET1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 2,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 16,   TumCP↑, 1,   TumMeta↓, 7,   TumMeta↑, 1,   Twist↓, 2,   Vim↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 3,   EGFR↑, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 7,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HCAR2↑, 1,   IL10↓, 1,   IL1β↓, 3,   IL6↓, 3,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 6,   NF-kB↓, 6,   NF-kB↑, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CYP19?, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 10,   DDS↑, 1,   Dose↝, 4,   eff↓, 7,   eff↑, 29,   eff↝, 1,   RadioS↑, 6,   selectivity↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   CEA↓, 1,   creat↓, 1,   EGFR↓, 3,   EGFR↑, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 3,   cardioP↑, 1,   CardioT↑, 1,   chemoP↑, 1,   chemoPv↑, 4,   hepatoP↓, 1,   hepatoP↑, 2,   neuroP↑, 2,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   toxicity↑, 1,   TumW↓, 1,   Weight↑, 2,  
Total Targets: 292

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 13,   Catalase↑, 5,   GPx↑, 2,   GSH↑, 4,   GSR↑, 2,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 5,   MDA↓, 3,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 9,   ROS↝, 1,   ROS∅, 1,   SOD↑, 5,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 2,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   GAPDH↑, 1,   LDH↓, 2,   lipidLev↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↓, 2,   BAX↓, 3,   Bcl-2↑, 3,   Casp3↓, 5,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c↓, 5,   Cyt‑c∅, 1,   iNOS↓, 3,   MAPK↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   MMP13↓, 1,   MMP9↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CRP↓, 1,   CXCR4↓, 1,   IL10↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 3,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 14,   Inflam↑, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   Dose⇅, 1,   eff↑, 2,   eff↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 2,   AST↓, 3,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 3,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 1,   hepatoP↑, 4,   motorD↑, 1,   neuroP↑, 6,   Obesity↓, 1,   Pain↓, 1,   RenoP↑, 2,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,   CD8+↑, 1,  
Total Targets: 107

Scientific Paper Hit Count for: Cyt‑c, cyt-c Release into Cytosol
16 Betulinic acid
15 Curcumin
15 Fisetin
14 Silver-NanoParticles
14 Baicalein
14 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Quercetin
11 Thymoquinone
10 Berberine
10 Emodin
9 Allicin (mainly Garlic)
9 Capsaicin
9 Phenethyl isothiocyanate
8 Carvacrol
8 Chrysin
7 Honokiol
7 Magnetic Fields
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Gambogic Acid
6 Juglone
6 Luteolin
6 Silymarin (Milk Thistle) silibinin
5 Artemisinin
5 Graviola
5 Hibiscus sabdariffa
5 isoorientin
5 Resveratrol
5 Vitamin K2
4 3-bromopyruvate
4 Cisplatin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Thymol-Thymus vulgaris
4 Magnolol
4 Nimbolide
4 Shikonin
4 Selenite (Sodium)
3 Ashwagandha(Withaferin A)
3 Photodynamic Therapy
3 Crocetin
3 Dichloroacetate
3 D-limonene
3 Dandelion Root
3 Ellagic acid
3 Formononetin
3 Garcinol
3 Ginkgetin
3 Indole-3-carbinol
3 Lycopene
3 Magnetic Field Rotating
3 Propolis -bee glue
3 Rosmarinic acid
3 Spermidine
2 Chemotherapy
2 Celastrol
2 Citric Acid
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Cynaropicrin
2 salinomycin
2 Diclofenac
2 Electrical Pulses
2 Eurycomanone
2 Radiotherapy/Radiation
2 Evodiamine
2 Gossypol/AT-101
2 Hyperthermia
2 HydroxyTyrosol
2 Hyperoside
2 Isoliquiritigenin
2 Phenylbutyrate
2 Piperine
2 Piperlongumine
2 Plumbagin
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 chemodynamic therapy
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 Gemcitabine (Gemzar)
1 Ajoene (compound of Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Andrographis
1 Metformin
1 2-DeoxyGlucose
1 Biochanin A
1 Bufalin/Huachansu
1 Bromelain
1 Boron
1 Butyrate
1 Cat’s Claw
1 chaetocin
1 Chlorophyllin
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Fenbendazole
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgo biloba
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Baicalin
1 Isobavachalcone
1 iodine
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Isovitexin
1 Methylene blue
1 Iron
1 Methylglyoxal
1 Pterostilbene
1 Kaempferol
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 α-Santalol/Sandalwood oil
1 Selenium
1 chitosan
1 Selenium NanoParticles
1 Docetaxel
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:77  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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