Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
2157- dietP,    Plant-Based Diets and Disease Progression in Men With Prostate Cancer
- Study, Pca, NA
TumCG↓, Risk↓, eff↑,
5065- dietSTF,  dietFMD,    Nutrition, GH/IGF-I Signaling, and Cancer
- Review, Var, NA
GH↓, IGF-1↓, glucose↓, IGFBP1↑, OS↑, Imm↑, neuroP↑, BMD↑, Dose↝, Risk↓, other↑, TumCP↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
8829- DIM,    Anti-androgenic activity of absorption-enhanced 3, 3’-diindolylmethane in prostatectomy patients
- Human, Pca, NA
Risk↓, BioAv↑, Dose↝, Dose↝, AR↝, PSA↓, toxicity↓, chemoPv↑,
6730- Dipy,  ASA,    Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
- vitro+vivo, CRC, NA
*AntiThr↑, Synergy↑, ER Stress↑, UPR↑, *AntiAg↑, *COX1↓, Risk↓, TumCG↓, Apoptosis↑, HMG-CoA↓, *Inflam↓, *antiOx↓,
6804- EA,    Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status
- Human, Nor, NA
*other?, *Risk↓, *GutMicro↝,
7192- EGb 761,    Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases
- in-vitro, Nor, HMEC
Risk↓, *TumCP↓, *TumCMig↓, *angioG↓,
6777- EGCG,    Health Benefits and Chemical Composition of Matcha Green Tea: A Review
- Review, Nor, NA
*antiOx↑, *Inflam↓, AntiCan↑, Risk↓, TumCG↓, Apoptosis↑, *ROS↓, *cardioP↑, *Imm↑, *AntiViral↑, *cognitive↑,
6786- EGCG,    Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis
- Study, CRC, NA
Risk↓,
4138- Ex,    Relationship Between Exercise and Alzheimer’s Disease: A Narrative Literature Review
- Review, AD, NA
*other↑, *Risk↓, *cognitive↑,
2143- Ex,    The association between physical activity and bladder cancer: systematic review and meta-analysis
- Review, Bladder, NA
Risk↓, Dose↝,
2145- Ex,    Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
- Analysis, Var, NA
Risk↓, Dose↝, eff↑,
2146- Ex,    A systematic review and meta-analysis of physical activity and endometrial cancer risk
- Review, Endo, NA
Risk↓, eff↑,
2147- Ex,    The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis
- Review, GC, NA
Risk↓,
2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, BC, NA
Risk↓, Dose?, eff↑,
6870- FA,    Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*Dose↝, *cognitive↑, *Hcy/homoC↓, *MMP9↓, *Risk↓,
6952- FA,    Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop
- Review, AD, NA
*other↝, *other↝, *Dose↑, *Dose↝, *Risk↓, *cognitive↑, *toxicity↝,
6946- FA,    Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
- Review, Var, NA
Hcy/homoC↓, Risk∅, toxicity↓,
6945- FA,    Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials
- Review, Var, NA
Risk∅,
6944- FA,    Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals
- Review, Var, NA
Risk∅,
6953- FA,    Folic Acid Supplementation and Risk of Gestational Diabetes Mellitus: A Systematic Review of the Literature
- Review, Diabetic, NA
*Risk↑, *Risk↑, Dose↝, neuroP↑,
6957- FA,    Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
- Review, CRC, NA
Risk↓,
6959- FA,    Folate intake and pancreatic cancer risk: an overall and dose-response meta-analysis
- Review, PC, NA
Risk↓,
6960- FA,  VitA,RetA,  VitC,  VitD3,  VitE  Dietary supplement use and colorectal cancer risk: a systematic review and meta-analyses of prospective cohort studies
- Review, CRC, NA
Risk∅, eff↑,
6961- FA,  VitB12,  VitB6,  Silicon,  Alum  B Vitamins Prevent Iron-Associated Brain Atrophy and Domain-Specific Effects of Iron, Copper, Aluminum, and Silicon on Cognition in Mild Cognitive Impairment
- Trial, AD, NA
*BrainVol↝, *cognitive↝, *cognitive↑, *Dose↝, *other↝, *Hcy/homoC↓, *Risk↓, *BrainVol∅, *BrainVol↑, *other↝, *cognitive↑, *cognitive↑, *other↝, *Risk↝,
1623- FA,    Folic acid: friend or foe in cancer therapy
- Review, Var, NA
Risk↝,
2173- FA,  VitB12,    Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
- Study, CRC, NA
Risk↓, eff↝, eff↝, Hcy/homoC↓,
4076- FA,  VitE,  VitB6,    Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging
- Study, AD, NA
*Risk↓, *other↝, *Risk∅,
4059- FA,    Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons
- Study, AD, NA
*Risk↓, *cognitive↑,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
6926- Flav,    Dietary (Poly)phenols and Cognitive Decline: A Systematic Review and Meta-Analysis of Observational Studies
- Review, AD, NA
*cognitive↑, *Risk↓,
6925- Flav,    Important Flavonoids and Their Role as a Therapeutic Agent
- Review, Nor, NA
AntiCan↑, *antiOx↑, *Inflam↓, *AntiViral↑, *neuroP↑, *cardioP↑, *AChE↓, *cognitive↑, Risk↓, *Stroke↓, *AntiDiabetic↑, *AntiFungal↑,
8313- FS,    Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?
- Review, BC, NA
TumCG↓, ChemoSen↑, Risk↓, OS↑, TumCP↓, Apoptosis↑,
8300- FS,    Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
- Trial, Pca, NA
Dose↝, TumCP↓, Ki-67↓, *toxicity↓, Ingr↑, testos↓, DHT↓, Risk↓, Dose↝,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
8590- FS,    The Effect of Flaxseed in Breast Cancer: A Literature Review
- Review, BC, NA
*BioAv↑, *antiOx↑, *TC↓, *cardioP↑, *Ingr↑, *Ingr↑, chemoP↑, ChemoSen↑, TumVol↓, TumCG↓, Risk↓, Risk↓, Ki-67↓, OS↑, TumMeta↓,
8594- FS,    Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk
- Study, BC, NA
Risk↓,
7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, *ROS↓, *BioAv↓, *GutMicro↑, *neuroP↑, *glucose↝, *AntiThr↑, *chemoP↑, *Half-Life↝, *BBB∅, *AntiAge↑, Risk↑,
7187- GBE,    Ginkgo biloba for prevention of dementia: a randomized controlled trial
- Trial, AD, NA
*Dose↝, Risk∅, eff∅,
7124- Ge-132,    Physiological Activity of Trace Element Germanium including Anticancer Properties
- Review, Var, NA
*toxicity↓, Risk↓, Dose↝, AntiCan↑, AntiTum↑, Inflam↓, OXPHOS↝, *toxicity↓, *toxicity↓, other↑, Synergy↑, *Bacteria↓, *AntiFungal↑, eff↑, Synergy↑, ROS↑, Synergy↑, toxicity↝, *H2O2↓, *ROS↓, Warburg↓,
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, Myc↓, PTEN↑, Dose↝, NOTCH3↑, JAG1↑, ADCY4↑, NEU1↑,
7334- Gra,    Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism
- in-vivo, Park, NA
*other↑, *cognitive↓, *Risk↑,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7473- HRT,    Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women’s Health Initiative Randomized Clinical Trials
- Review, BC, NA
Risk↓,
7474- HRT,    Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
- Review, BC, NA
Risk↑,
7475- HRT,    Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial
- Review, Lung, NA
Risk↝,
7478- HRT,    Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Systematic Review to Update the 2002 and 2005 U.S. Preventive Services Task Force Recommendations
- Review, BC, NA
*Stroke↑, Risk⇅, *cognitive↓,
7605- I3C,    Indole-3-carbinol and prostate cancer
- Review, Pca, NA
Risk↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, ChemoSen↑,

Showing Research Papers: 101 to 150 of 303
Prev Page 3 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 303

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↓, 3,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   lipid-P↑, 1,   NRF2↓, 5,   NRF2↑, 2,   NRF2↝, 1,   PrxI↓, 1,   ROS↓, 9,   ROS↑, 31,   selenoP↑, 1,   SOD↑, 3,   SOD2↓, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   EGF↓, 1,   Insulin↓, 1,   mitResp↑, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 5,   ATP↓, 3,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 2,   glucose↓, 2,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HMG-CoA↓, 3,   lactateProd↑, 1,   LDL↓, 2,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 33,   BAX↑, 12,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 10,   cl‑Casp3↑, 4,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 14,   DR5↑, 2,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 2,   iNOS↓, 3,   MDM2↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 1,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ADCY4↑, 1,   Akt↓, 16,   Akt↑, 1,   p‑Akt↓, 4,   Akt2↓, 1,   cMET↓, 1,   EGFR↓, 4,   ERK↓, 3,   ERK↑, 3,   p‑ERK↓, 2,   HER2/EBBR2↓, 2,   IGFR↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 9,   mTOR↑, 2,   PI3K↓, 9,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 3,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   H3↓, 1,   HATs↑, 1,   HDAC↓, 7,   miR-194↑, 1,   miR-21↓, 1,   miR-590-3p↑, 1,   Myc↓, 1,   MYCN↓, 1,   other↓, 5,   other↑, 8,   other↝, 14,   other∅, 1,   SUZ12↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   IRE1∅, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   NEU1↑, 1,   TumAuto↓, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 8,   DNArepair↑, 1,   hTERT/TERT↓, 1,   P53↑, 12,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 4,   Telomerase↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 4,   CDK6↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   GADD34↑, 2,   GADD45A↓, 1,   Ki-67↓, 6,   P21↓, 2,   P21↑, 7,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑RB1↓, 1,   cl‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMP2↓, 1,   CSCs↓, 3,   EP300↓, 1,   GH↓, 1,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 7,   IGFBP1↑, 1,   JAG1↑, 1,   Ki-67↓, 6,   mTORC1↓, 2,   NOTCH↓, 1,   NOTCH3↑, 1,   TumCG↓, 26,   TumCG↑, 1,   TumCP↓, 35,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 7,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 1,   EMT↓, 4,   EMT↝, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 5,   pax↓, 2,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   serineP↓, 1,   Snail↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 11,   TumCI↑, 1,   TumCMig↓, 12,   TumCMig↑, 1,   TumMeta↓, 21,   UroPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   ECM/TCF↓, 1,   HIF-1↓, 3,   Hif1a↓, 7,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↑, 1,   GLUT1↓, 2,   GLUT2↓, 1,   MMP↓, 16,   MPT↑, 1,   TRPM7↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   DR4↑, 3,   FOXP3↑, 1,   IL10↓, 1,   IL1β↓, 5,   IL2↑, 1,   IL6↓, 2,   Imm↑, 9,   INF-γ↑, 1,   Inflam↓, 11,   MCT1↓, 1,   Neut↑, 1,   NF-kB↓, 14,   NF-kB⇅, 1,   p‑NF-kB↓, 1,   NK cell↑, 4,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 7,   SOCS-3↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AR↝, 1,   DHT↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARγ↑, 2,   SXR↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 7,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 40,   ChemoSen∅, 1,   CYP1A1↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 2,   Dose↓, 4,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 44,   Dose∅, 3,   eff↓, 4,   eff↑, 20,   eff↝, 11,   eff∅, 5,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 11,   selectivity↑, 16,   Synergy↑, 24,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BloodF↓, 1,   BMD↑, 2,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   Hcy/homoC↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 7,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiCan∅, 2,   antiNeop↑, 1,   AntiTum↑, 7,   APG↓, 1,   cardioP↑, 3,   chemoP↑, 17,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↓, 2,   OS↑, 16,   OS∅, 3,   Pain↓, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 213,   Risk↑, 16,   Risk⇅, 3,   Risk↝, 7,   Risk∅, 18,   Sleep↑, 1,   toxicity↓, 9,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 7,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 387

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 26,   Catalase↑, 6,   GPx↓, 1,   GPx↑, 10,   GPx1↑, 1,   GSH↑, 3,   GSR↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 7,   MDA↓, 4,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 6,   ROS↓, 36,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 10,   SOD↑, 9,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   Acetyl-CoA↑, 1,   adiP↓, 1,   ALAT↓, 1,   AMPK↑, 5,   ATP↑, 2,   ATP↝, 1,   CRM↑, 2,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   LDL↓, 9,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   JNK↓, 1,   MAPK↓, 2,   mTOR↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other?, 3,   other↓, 8,   other↑, 12,   other↝, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 9,   Ca+2↝, 1,   Cartilage↑, 2,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP-10↝, 1,   MMP9↓, 1,   MUC1↑, 1,   serineP↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   TXA2↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB∅, 1,   CLDN1↑, 1,   CLDN3↑, 1,   IBI↑, 1,   MMP↑, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 7,   COX2/PTGS2↓, 5,   IFN-γ↓, 2,   IL1↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 5,   Imm↑, 5,   Inflam↓, 38,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 12,   VitD↑, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 3,   AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 1,   BrainVol↑, 1,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 11,   Aβ↑, 1,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 2,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 24,   BioAv⇅, 1,   BioAv↝, 4,   Dose?, 1,   Dose↓, 2,   Dose↑, 5,   Dose↝, 28,   eff↓, 5,   eff↑, 6,   eff↝, 3,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 5,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BG↓, 1,   BMD↑, 4,   BP↓, 7,   Calcium↑, 2,   Calcium↝, 1,   CRP↓, 8,   Hcy/homoC↓, 3,   hs-CRP↓, 2,   IL6↓, 5,   Mag↑, 2,   TC↓, 1,   TG/TAG↓, 1,   TMAO↑, 3,   VitD↑, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 9,   AntiTum↓, 1,   BOLD↑, 1,   cardioP↑, 19,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 41,   cognitive↝, 2,   cognitive∅, 1,   hepatoP↑, 5,   memory↑, 11,   Mood↑, 2,   motorD↓, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 3,   Risk↓, 75,   Risk↑, 14,   Risk↝, 1,   Risk∅, 3,   Strength↑, 3,   Stroke↓, 5,   Stroke↑, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 3,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 18,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 5,  
Total Targets: 236

Scientific Paper Hit Count for: Risk, Risk
23 Selenium
18 Folic Acid, Vit B9
16 Boron
15 Selenite (Sodium)
14 Lycopene
13 Aspirin
10 Vitamin D3
10 Magnesium
9 Choline
8 Vitamin B6,pyridoxine
7 Vitamin K2
7 Metformin
6 Allicin (mainly Garlic)
6 Lutein
6 Vitamin C (Ascorbic Acid)
6 diet Plant based
6 Exercise
6 Vitamin B12
6 Flaxseed/Linseed
6 Kaempferol
6 Phenethyl isothiocyanate
5 Chemotherapy
5 Hormone replacement therapy
5 Calcium
5 diet Fermented Foods
5 isoflavones
5 Selenium NanoParticles
4 beta-carotene(VitA)
4 Zeaxanthin
4 Capsaicin
4 Coenzyme Q10
4 Vitamin E
4 Sulforaphane (mainly Broccoli)
4 Melatonin
4 Vitamin B5,Pantothenic Acid
3 Aluminum
3 Radiotherapy/Radiation
3 Celecoxib
3 Chlorogenic acid
3 Chocolate
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Silicic Acid
3 iodine
3 Urolithin
2 5-Hydroxytryptophan
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Bruteridin(bergamot juice)
2 Butyrate
2 EGCG (Epigallocatechin Gallate)
2 flavonoids
2 Indole-3-carbinol
2 Inulin Prebiotic
2 phytic acid, Inositol hexakisphosphate
2 Potassium
2 Quercetin
2 chitosan
2 Taurine
2 Vitamin B1/Thiamine
1 Anthocyanins
1 alpha Linolenic acid
1 Astaxanthin
1 beta-glucans
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Bullatacin
1 Carvacrol
1 Catechins
1 Chyawanprash
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Vitamin A, Retinoic Acid
1 Fisetin
1 Fucoidan
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Graviola
1 Grapeseed extract
1 Inositol
1 isoquercitrin
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 Oleuropein
1 Broccoli
1 Rutin
1 buckwheat sprouts
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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