AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
Source:
Type: general indicator
Anticancer Effect


Scientific Papers found: Click to Expand⟱
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5896- CAR,  TV,    Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics
- Review, Var, NA
BioAv↑, AntiCan↑, *antiOx↑, *Inflam↑, *Bacteria↓, ROS↑, DNAdam↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓, CompStab?,
6656- Cen,    Recent insights into therapeutic potential and nanostructured carrier systems of Centella asiatica: An evidence-based review
- Review, Var, NA - Review, AD, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *antiOx↑, *cardioP↑, *Inflam↓, *hepatoP↑, *AntiAge↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P↓, Casp3↑, *memory↑, *Wound Healing↑, eff↑,
6021- CGA,    Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action
- in-vitro, Var, NA
*hepatoP↑, *Bacteria↓, *Imm↑, *antiOx↑, *AntiDiabetic↓, *AntiCan↑, TumCCA↑, Apoptosis↑, TumCP↓,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
7177- CHA,    Chaetocin inhibits the progression of neuroblastoma by targeting JAK2/STAT3 signaling pathway in SH-SY5Y cells
- in-vitro, neuroblastoma, SH-SY5Y
AntiCan↑, Inflam↓, tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, JAK2↓, STAT3↓,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6081- CHL,    Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review
- Review, Nor, NA
*antiOx↑, *toxicity↓, *BioAv↓, *BioAv↑, *neuroP↑, *Obesity↓, *AntiCan↑, *TumCP↓, *PhotoS↑, *neuroP↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓, *antiAll↑,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
6154- CoQ10,    Coenzyme Q10 (BPM31510-IV in clinical trials) increases mitochondrial Q-pool and modulates electron transport chain function to elicit cell death in pancreatic cancer cells
- vitro+vivo, PC, MIA PaCa-2
ETC?, ROS↑, NADPH↓, AntiCan↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1/ATG6↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
6370- CPLE,    Delving into the Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
- Review, Var, NA
CIT↓, *Imm↑, *AntiDiabetic↑, *AntiCan↑, angioG↓, *Bacteria↓, *antiOx↑,
5810- CPT,  CPT-11,    Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index
- Review, Var, NA
AntiCan↑, BioAv↓, toxicity⇅, TOP1↓, Apoptosis↑, TumCP↓, other↝, BioAv↑, other↝, eff↑,
5808- CPT,    Repair of Topoisomerase I-Mediated DNA Damage
- Review, Var, NA
TOP1↓, AntiCan↑, Dose?, CHK1↑, Chk2↑,
9273- CRAN,    Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
- vitro+vivo, ESCC, NA
AntiCan↑, Casp↑, TumAuto↑, necrosis↑, PI3K↓, Akt↓, mTOR↓, BAX↑, Bcl-xL↑, Cyt‑c↑, PARP↑, TumCG↓, toxicity↓,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2/PTGS2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, Nor, NA
*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,
6305- Cro,    Bridging Preclinical and Clinical Evidence on Crocin in Breast Cancer
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, TumCG↓, ChemoSen↑,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
6520- CRV,    Health Benefits and Pharmacological Properties of Carvone
- Review, Nor, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *Inflam↓, AntiCan↑, *AntiDiabetic↑, *Obesity↓, TumCCA↑, *AntiArt↑, Imm↑, *P450↓, *GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, TumCP↓, TumCMig↓, Apoptosis↑,
6523- CRV,    Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion
- in-vitro, Melanoma, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCI↓, p‑p38↓,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
7413- CS,  Poly,    Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines
- in-vitro, SCC, SCC25
AntiCan↑, tumCV↓, TumCG↓, Apoptosis↑, selectivity↑, BAX↑, Casp9↑, Bcl-2↓, TumCCA↑, other↝, hepatoP↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6188- Cuc,    Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation
- in-vitro, Var, NA
TumCCA↑, p‑H3↓, cl‑PARP↑, Casp↑, AntiCan↑, JAK2↓, STAT3↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, chemoPv↑, *AntiAge↑, *neuroP↑, *Wound Healing↑,
4673- CUR,    Curcumin and colorectal cancer: An update and current perspective on this natural medicine
- Review, CRC, NA
AntiCan↑, GutMicro↝,
4708- CUR,    Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers
- Review, GC, NA
chemoPv↑, AntiCan↑, *antiOx↑, *Inflam↓, miR-21↓, miR-34a↑, miR-200b↑, miR-27a-3p↓,
6207- CUR,    Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment
- Review, Var, NA - Review, AD, NA
*AntiCan↑, *Obesity↓, *Inflam↓, *lipid-P↓, *BioAv↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *mt-SOD↑, *MDA↓, *BBB↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroG↑, *memory↑, cardioP↑,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2/PTGS2↓, CRP↓,

Showing Research Papers: 101 to 150 of 491
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 491

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 23,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 24,   GSH↑, 3,   GSH↝, 1,   GSH∅, 1,   GSH/GSSG↓, 1,   GSTs↑, 4,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 5,   i-Iron↑, 3,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 11,   MDA↓, 2,   MDA↑, 3,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 11,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 25,   ROS↑, 167,   ROS⇅, 3,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↓, 1,   SOD↓, 6,   SOD↑, 4,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 3,   Trx↓, 2,   TrxR↓, 4,   TrxR1↓, 3,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 4,   compI↓, 1,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC?, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   mtDam↑, 12,   OCR↓, 6,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   SIRT3↑, 1,   TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   AApath↓, 1,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   Alanine↓, 1,   ALAT↓, 2,   AMPK↑, 9,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 11,   i-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   DHCR24↓, 1,   DHODH↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↓, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   Histones↑, 1,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 2,   lactateProd∅, 1,   LDHA↓, 3,   LDL↓, 1,   NAD↓, 1,   NADPH↓, 3,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PDKs↓, 1,   PFK↓, 1,   PKM2↓, 8,   PLA2↓, 1,   polyA↓, 1,   SIRT1↓, 6,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 182,   mt-Apoptosis↑, 2,   BAD↓, 3,   BAD↑, 5,   Bak↓, 1,   Bak↑, 7,   BAX↓, 1,   BAX↑, 71,   Bax:Bcl2↑, 15,   Bcl-2↓, 78,   Bcl-2↑, 1,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 1,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp12↑, 2,   Casp12↝, 1,   Casp3↓, 3,   Casp3↑, 75,   cl‑Casp3↑, 15,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 11,   cl‑Casp7↑, 2,   Casp8↑, 21,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 51,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 51,   Diablo↑, 2,   DIDO1/DIO-1↑, 1,   DR5↑, 9,   FADD↑, 3,   Fas?, 1,   Fas↓, 2,   Fas↑, 12,   FasL↑, 5,   Ferroptosis↑, 10,   GRP58↓, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 3,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   p‑Mcl-1↓, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↑, 4,   Necroptosis↑, 3,   necrosis↑, 5,   p38↓, 2,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   pS2/TFF1↓, 1,   PUMA↓, 1,   PUMA↑, 3,   Pyro↑, 2,   RIP3↓, 1,   survivin↓, 21,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 16,   XIAP↓, 13,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↑, 3,   p‑Akt↓, 17,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CIP2A↓, 2,   CK2↓, 2,   CREB↓, 1,   EGFR↓, 18,   EGFR↑, 1,   ERK↓, 33,   ERK↑, 4,   p‑ERK↓, 7,   FGFR1↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 10,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 8,   p‑JNK↑, 3,   MAPK↓, 22,   MAPK↑, 11,   MARK4↓, 1,   MEK↓, 2,   MKP1↝, 1,   mTOR↓, 43,   p‑mTOR↓, 7,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 69,   PI3K↑, 2,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PI3K/Akt↑, 1,   PIK3CA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 7,   PKCδ↑, 1,   PTEN↓, 2,   PTEN↑, 10,   Raf↓, 1,   RAS↓, 6,   Rictor↓, 1,   RIP1↓, 1,   S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 36,   STAT3↑, 3,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 1,   STK11/LKB1↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF2↓, 2,   ATF4↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 1,   cMyc↓, 16,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 15,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 4,   miR-106b↓, 1,   miR-155↓, 1,   miR-199↓, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 4,   miR-590-3p↑, 1,   MTA2↓, 1,   Myc↓, 3,   OCT4↓, 6,   other↓, 5,   other↑, 5,   other↝, 18,   other∅, 1,   PCAF↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX9↓, 1,   TLE1↓, 1,   tumCV?, 2,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 7,   eIF2α↑, 1,   ER Stress↑, 22,   ERStress↑, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HTRA↓, 1,   PERK↑, 1,   PSMB5↓, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↑, 1,   p62↓, 4,   p62↑, 4,   TumAuto↓, 3,   TumAuto↑, 42,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 49,   DNArepair↓, 1,   DNArepair↑, 2,   hTERT/TERT↓, 3,   p16↑, 2,   P53↓, 1,   P53↑, 42,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 2,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 18,   Telomerase↓, 8,   TOP1↓, 7,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 26,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 6,   CDKN1C/p57↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 2,   Chk2↑, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 34,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 2,   E2Fs↓, 2,   GADD34↑, 1,   Ki-67↓, 12,   MAD↓, 1,   mitA↑, 1,   p19↑, 1,   P21↓, 4,   P21↑, 33,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 18,   pRB↓, 3,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 141,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 19,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 4,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 12,   IGFBP3↑, 1,   Ki-67↓, 12,   Let-7↑, 2,   LRP6↓, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH1↓, 7,   NOTCH3↓, 1,   p300↓, 2,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 68,   TumCG↑, 3,   TumCP↓, 110,   TumCP↑, 3,   Wnt↓, 22,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 3,   AP-1↑, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 17,   Ca+2↝, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   CTNNB1↓, 1,   E-cadherin↑, 23,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 3,   FAK↓, 9,   FAK↑, 1,   p‑FAK↓, 2,   hnRNPA1↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP2↓, 44,   MMP3↓, 5,   MMP7↓, 3,   MMP9↓, 55,   MMP9↑, 1,   MMPs↓, 12,   MTA1↓, 1,   N-cadherin↓, 11,   NFAT↑, 1,   PAK1↓, 1,   PDGF↓, 3,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 2,   Smad1↓, 2,   SMAD4↓, 2,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 11,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 6,   TIMP2↓, 3,   TIMP2↑, 6,   TIMP3↑, 1,   TRIB3↑, 2,   TSP-1↑, 1,   TumCA↓, 5,   TumCI↓, 46,   TumCMig↓, 56,   TumCMig↑, 2,   TumMeta↓, 55,   TumMeta↑, 4,   Twist↓, 6,   TXNIP↑, 1,   uPA↓, 7,   uPAR↓, 1,   Vim↓, 13,   Zeb1↓, 5,   ZEB2↓, 2,   α-tubulin↓, 3,   β-catenin/ZEB1↓, 27,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 34,   LOX1↓, 2,   LymphAG↓, 1,   NO↓, 2,   PHDs↓, 1,   VEGF↓, 49,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 1,   BBB↑, 3,   CellMemb↓, 1,   CellMemb↑, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN7↑, 1,   EPR↑, 6,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   LAT↓, 1,   MMP↓, 73,   MMP↑, 3,   MPT↑, 3,   NHE1↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CD14↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 6,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL12↓, 1,   CXCR4↓, 5,   DCells↑, 1,   Dectin1↝, 1,   DR4↑, 4,   FOXP3↓, 1,   HCAR2↑, 2,   HMGB1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 3,   Igs↓, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 2,   IL12↑, 2,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 2,   IL5↓, 1,   IL6↓, 22,   IL8↓, 7,   Imm↑, 12,   Imm↝, 2,   INF-γ↓, 1,   INF-γ↑, 1,   Inflam↓, 36,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 79,   NF-kB↑, 5,   p‑NF-kB↓, 1,   NK cell↑, 10,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 10,   PSA↓, 11,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 4,   TNF-α↓, 15,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN2/PS-2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↓, 1,   AR↓, 7,   CYP19↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,   RANKL↓, 2,   SRC3↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 42,   BioAv⇅, 1,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↓, 3,   ChemoSen↑, 124,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↑, 2,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1A2↓, 2,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP2E1↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 6,   Dose↝, 47,   Dose∅, 11,   eff↓, 26,   eff↑, 75,   eff↝, 12,   eff∅, 3,   GSTM1↑, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 13,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 28,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 65,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 67,   UGT1A↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   AR↓, 7,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CIT↓, 1,   CRP↓, 2,   EGFR↓, 18,   EGFR↑, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 6,   LDH↑, 1,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 3,   PD-L1↓, 5,   Polyps↓, 2,   PSA↓, 11,   PSA∅, 1,   TF-Ag↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 11,   AntiCan↑, 368,   AntiCan⇅, 2,   AntiCan↝, 1,   AntiCan?, 1,   AntiCan∅, 3,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 16,   APG↓, 1,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 10,   CardioT↓, 1,   chemoP↑, 31,   chemoPv↑, 23,   ChemoSideEff↓, 6,   cognitive↑, 1,   FTO↓, 1,   hepatoP↑, 9,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 9,   OS⇅, 1,   Pain↓, 4,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 30,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 18,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 9,   toxicity∅, 2,   TumNum↓, 1,   TumVol↓, 17,   TumW↓, 7,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   Dectin1↝, 1,   GutMicro↑, 6,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 832

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 10,   antiOx↑, 150,   ARE↑, 1,   Catalase↑, 40,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 30,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 34,   GSR↑, 6,   GSTs↓, 1,   GSTs↑, 12,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HDL∅, 1,   HO-1↓, 1,   HO-1↑, 16,   HO-1⇅, 1,   hyperG↓, 2,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 33,   MDA↓, 26,   MDA↑, 2,   MPO↓, 5,   NOX↓, 1,   NQO1↑, 3,   NQO1↝, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 38,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 109,   ROS↑, 2,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 4,   SOD↑, 50,   mt-SOD↑, 1,   SOD1↑, 6,   SOD2↑, 2,   TAC↑, 3,   TBARS↓, 3,   Trx↑, 1,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 1,   ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 1,   ATP↑, 4,   ATP↝, 1,   CRM↑, 2,   Eic↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 3,   glyC↓, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   LDL↓, 11,   lipidLev↓, 2,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   SIRT1↑, 4,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   Apoptosis↑, 1,   BAX↓, 8,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp3↓, 10,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 5,   Cyt‑c↓, 2,   Fas↓, 1,   Ferroptosis↓, 2,   GSDMD↓, 1,   iNOS↓, 15,   iNOS↑, 1,   necrosis↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   Akt2↓, 1,   ERK↓, 2,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   MAPK↓, 8,   MAPK↑, 2,   mTOR↓, 4,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 4,   PI3K↑, 3,   PKCδ↑, 1,   PP2A↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO3↑, 1,   HATs↓, 2,   HDAC↓, 2,   HDAC2↓, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 20,   PhotoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 8,   DNArepair↑, 1,   P53↓, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMPs↑, 1,   EP300↓, 1,   GH↑, 1,   HH↓, 1,   Ki-67↓, 1,   mTORC1↓, 1,   neuroG↑, 4,   TumCP↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 10,   AP-1↓, 4,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 3,   Ca+2∅, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   PAI-1/SERPINE1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP1↓, 1,   TumCI↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 2,   Hif1a↓, 1,   NO↓, 9,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 4,   BBB↑, 9,   GastroP↑, 4,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 2,   MMP↑, 7,   OCLN↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 3,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 25,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 4,   IL1?, 1,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 4,   IL17↓, 4,   IL1β↓, 19,   IL22↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IL8↓, 6,   Imm↓, 1,   Imm↑, 22,   Imm⇅, 2,   Imm↝, 2,   Inflam?, 1,   Inflam↓, 173,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NF-kB?, 1,   NF-kB↓, 36,   NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 10,   PGE2↑, 1,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 40,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 17,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 5,   ChAT↑, 2,   NGF↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APOE4↓, 1,   APP↓, 1,   cl‑APP↑, 1,   Aβ↓, 18,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   PSEN1/PS1↑, 1,   tau↓, 5,   p‑tau↓, 5,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   PPARγ↑, 2,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 35,   BioAv↑, 47,   BioAv⇅, 2,   BioAv↝, 22,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 21,   eff↑, 13,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 10,   Half-Life∅, 1,   P450↓, 2,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   ALB↑, 1,   ALP↓, 2,   AST↓, 18,   AST∅, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 4,   BP↓, 11,   BUN↓, 3,   Calcium↑, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 3,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IRes↓, 1,   IRes↝, 1,   LDH↓, 6,   Mag↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 15,   antiAll?, 1,   antiAll↑, 14,   AntiArt↑, 13,   AntiCan?, 1,   AntiCan↓, 4,   AntiCan↑, 105,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 56,   antiM↑, 1,   antiPy↑, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 64,   CardioT↓, 1,   chemoP↑, 9,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 25,   cough?, 1,   diuretic↑, 3,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 60,   Learn↑, 1,   memory↑, 24,   Mood↑, 2,   motorD↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 98,   NP/CIPN↓, 1,   Obesity↓, 15,   OS↑, 3,   Pain↓, 4,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 14,   Risk↓, 1,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 1,   Stroke↓, 12,   Stroke↝, 1,   toxicity↓, 39,   toxicity↑, 3,   toxicity↝, 17,   toxicity∅, 6,   Weight↓, 4,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 29,   AntiFungal↓, 1,   AntiFungal↑, 11,   AntiP↑, 4,   AntiViral↑, 18,   Bacteria↓, 51,   Diar↓, 2,   GutMicro↑, 25,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 5,   Ingr↝, 14,   Phen↑, 1,   QC↑, 1,  
Total Targets: 442

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
19 Silver-NanoParticles
12 Lycopene
11 Selenium NanoParticles
10 Thymoquinone
10 phytic acid, Inositol hexakisphosphate
9 Emodin
9 Inositol
9 Sulforaphane (mainly Broccoli)
8 Capsaicin
8 Magnolol
8 Phenethyl isothiocyanate
8 Quercetin
7 Allicin (mainly Garlic)
7 Curcumin
7 Gambogic Acid
7 Kaempferol
6 Vitamin C (Ascorbic Acid)
6 Astaxanthin
6 Baicalein
6 Eugenol
6 Honokiol
6 Isoliquiritigenin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Artemisinin
5 EGCG (Epigallocatechin Gallate)
5 Lactoferrin/Talactoferrin
4 chitosan
4 Apigenin (mainly Parsley)
4 Boron
4 Carvacrol
4 Chlorogenic acid
4 Crocetin
4 Dandelion Root
4 Ferulic acid
4 Isovitexin
4 Licochalcone A
4 Licorice
4 Naringin
4 Selenium
3 Cisplatin
3 Melatonin
3 Aloe anthraquinones
3 beta-glucans
3 Biochanin A
3 Benzyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Hydroxycinnamic-acid
3 Resveratrol
3 Spermidine
3 Carvone
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Cucurbitacin
3 Date Fruit Extract
3 Diindolylmethane
3 Indole-3-carbinol
3 Lemongrass Extract/Citral
3 Ellagic acid
3 flavonoids
3 Formononetin
3 Flaxseed/Linseed
3 Fucoidan
3 Gallic acid
3 Garcinol
3 Geraniol
3 Ginkgetin
3 HydroxyTyrosol
3 Hyperoside
3 Isobavachalcone
3 Luteolin
3 Matrine
3 Mung Bean Sprouts
3 Propolis -bee glue
3 Pterostilbene
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Vitamin D3
3 Vitamin K2
2 3-bromopyruvate
2 5-fluorouracil
2 Auranofin
2 doxorubicin
2 Alpha-Lipoic-Acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Baicalin
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 Butyrate
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Chrysin
2 Cinnamon
2 Camptothecin
2 Dichloroacetate
2 diet Fermented Foods
2 Ginkgo biloba-EGb 761
2 Flaxseed Oil
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 iodine
2 isoquercitrin
2 Isothiocyanates
2 Ivermectin
2 Juglone
2 SDG/lignans
2 Vitexin
2 Magnetic Fields
2 Morin
2 Bicarbonate(Sodium)
2 Marjoram (Origanum majorana)
2 Purple Corn / Purple Maize
2 Phycocyanin
2 Piperine
2 Rosmarinic acid
2 Rauwolfia serpentina/Indian Snakeroot
2 Sesamin
2 Shikonin
2 Ursolic acid
2 Urolithin
2 VitK3,menadione
1 1,8-Cineole
1 Astragalus
1 Citric Acid
1 Allyl isothiocyanate
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Berberine
1 Betulinic acid
1 Bromelain
1 borneol
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Vitamin B3,Niacin
1 Caffeic acid
1 Caffeine
1 urea
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Carica papaya leaf extract
1 irinotecan
1 Cranberry
1 Calorie Restriction Mimetics
1 Aspirin
1 Polyphenols
1 Chlorella (Chlorella vulgaris)
1 Diclofenac
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 diet Plant based
1 Ormeloxifene (Centchroman)
1 Electrical Pulses
1 Eurycomanone
1 Evodiamine
1 ferumoxytol
1 Fisetin
1 Paclitaxel/Taxol
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Geldanamycin
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 alpha Linolenic acid
1 Graviola
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Chemotherapy
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 isoorientin
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lecithin
1 Linalool
1 Lutein
1 Methylene blue
1 Photodynamic Therapy
1 mebendazole
1 methylseleninic acid
1 Metformin
1 Magnetic Field Rotating
1 Mangiferin
1 Methylglyoxal
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleocanthal
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Psoralidin
1 Parthenolide
1 Gold NanoParticles
1 Salvia officinalis
1 Radiotherapy/Radiation
1 α-Santalol/Sandalwood oil
1 Calcium
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Magnesium
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:813  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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