DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
766- Bor,    In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration
- in-vitro, Liver, HepG2
TumCCA↑, DNAdam↑, Apoptosis↑,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
- in-vivo, AD, NA
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
3514- Bor,  CUR,    Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta
- in-vivo, AD, NA
*DNAdam↓, *MDA↓, *AChE↓, *neuroP↑, *ROS↓, *NO↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
5647- BP,    Black Phosphorus Quantum Dots Enhance the Radiosensitivity of Human Renal Cell Carcinoma Cells through Inhibition of DNA-PKcs Kinase
- in-vitro, RCC, NA
RadioS↑, DNAdam↑,
5698- BRU,    Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
- in-vitro, HCC, NA
TumCMig↓, EMT↓, STAT3↓, E-cadherin↑, NRF2↓, ChemoSen↑, RadioS↑, DNAdam↑, TumCMig↓, TumCI↓, toxicity↓,
5703- BRU,    Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
NRF2↓, RadioS↑, DNAdam↑, ROS↑,
5707- Brut,    Targeting Redox Homeostasis and Cell Survival Signaling with a Flavonoid-Rich Extract of Bergamot Juice in In Vitro and In Vivo Colorectal Cancer Models
- in-vitro, CRC, HCT116
Risk↓, TumCG↓, Apoptosis↑, TumCCA↑, ROS↑, MMP↓, DNAdam↑, TumMeta↓, TumCP↓,
5706- Brut,    Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cells
- in-vitro, CRC, HT29
TumCG↓, MAPK↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, AntiCan↑,
6554- BSB,  doxoR,    α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats
- in-vivo, Nor, NA
*cardioP↑, *chemoP↑, *antiOx↑, *ROS↓, *toxicity↓, *DNAdam↓, *lipid-P↓, *ER Stress↓,
7952- BuckWS,  RT,  QC,    Pasta containing tartary buckwheat sprouts prevents DNA damage in spontaneously hypertensive rats
- in-vivo, Nor, NA
*DNAdam↓, *DNArepair↑, *Dose?,
5748- CA,    Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties
- in-vitro, Var, NA
DNAdam↑, eff↑,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
5869- CA,    Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
- in-vitro, ESCC, KYSE150
TumCP↓, Apoptosis↓, TumCMig↓, TumCCA↑, DNAdam↑, MAPK↓, γH2AX↑, TumMeta↓, TumCI↓, P21↑, ROS↑, EMT↓, ChemoSen↑,
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
5838- CAP,    Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
- in-vitro, NPC, NA
TumCG↓, TumCCA↑, TumAuto↑, Casp3↑, Ca+2↑, ROS↑, MMP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, p62↓, Fap1↓, PI3K↓, DNAdam↑,
5828- CAP,    Capsaicin: a novel radio-sensitizing agent for prostate cancer
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
RadioS↑, NF-kB↓, TumCCA↑, TumCG↓, TumCP↓, DNAdam↑, γH2AX↑, Ki-67↓,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
8700- CAP,    Cold plasma irradiation inhibits skin cancer via ferroptosis
- vitro+vivo, Melanoma, A431
Ferroptosis↑, tumCV↓, TumCMig↓, TumCI↓, ROS↑, DNAdam↑, ATM↑, P53↑, xCT/SLC7A11↓, GPx4↓,
8699- CAP,    Antitumor effects of plasma‑activated solution on a murine melanoma model in vivo and in vitro
- vitro+vivo, Melanoma, A375
AntiTum↑, ROS↑, mtDam↑, DNAdam↑, toxicity↓, Dose↝,
8698- CAP,    Cold atmospheric plasma as a novel “drug” for cancer therapy
- Review, Var, NA
AntiTum↓, ChemoSen↑, selectivity↑, ROS↑, Synergy↑, mtDam↑, DNAdam↑, Cyt‑c↑, PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Ki-67↓, Ca+2↑, ER Stress↑, Synergy↑, TumCI↓, TumCCA↑, MAPK↓, Synergy↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
5896- CAR,  TV,    Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics
- Review, Var, NA
BioAv↑, AntiCan↑, *antiOx↑, *Inflam↑, *Bacteria↓, ROS↑, DNAdam↑,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5862- carbop,  Cisplatin,    Molecular Mechanisms of Resistance and Toxicity Associated with Platinating Agents
- Review, Var, NA
DNAdam↑, ER Stress↑, UPR↑, ATF4↑, ATF6↑, XBP-1↑, GRP78/BiP↑, NP/CIPN↝, toxicity↝, ChemoSen↑, TrxR1⇅,
603- Catechins,    Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
- in-vitro, AML, HL-60
ROS↑, DNAdam↑, H2O2↑,
5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Neut↓, eff↑, Imm↑, Dose↝,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
6630- CGA,    In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480
tumCV↓, DNAdam↑, mt-ROS↑, MMP↓, Casp3↑, eff↝,
7173- CHA,    Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations
- in-vitro, Lung, A549
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, CD47↓, *toxicity↓, MMP↓, Casp3↑, mtDam↓,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
6139- CHr,    Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials
- Review, Var, NA
RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, Synergy↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, Synergy↑, Synergy↑, *Synergy↑, RadioS↑, Synergy↑, ChemoSen↑, eff↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓, *antiAll↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
2792- CHr,    Chrysin induces death of prostate cancer cells by inducing ROS and ER stress
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
DNAdam↑, TumCCA↑, MMP↓, ROS↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, PI3K↓, Akt↓, p70S6↓, MAPK↑,
6631- Cic,    Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity.
- in-vitro, Nor, NA
*MMP↑, *BAX↓, *DNAdam↓, *Casp3↓, *NF-kB↓, *antiOx↑, *Inflam↓,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,

Showing Research Papers: 101 to 150 of 452
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 7,   Catalase↑, 3,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 8,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 5,   GSH↓, 30,   GSH↑, 5,   GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 2,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs∅, 1,   H2O2↓, 1,   H2O2↑, 14,   HO-1↓, 7,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 4,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 3,   i-MDA↑, 1,   mt-NADH↓, 1,   NADPH/NADP+↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 12,   Prx4↑, 1,   PrxII↓, 1,   ROS↓, 22,   ROS↑, 253,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   i-ROS↑, 3,   m-ROS↑, 1,   mt-ROS↑, 6,   SOD↓, 6,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC?, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 4,   Trx↑, 1,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 10,   TrxR1↓, 2,   TrxR1⇅, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ADP:ATP↑, 1,   BCR↓, 1,   CDC2↓, 3,   CDC25↓, 10,   CDC25↝, 1,   compI↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↝, 1,   Insulin↓, 2,   mitResp↓, 2,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 19,   OCR↓, 1,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 2,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 2,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 22,   ATP↑, 1,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   p‑ENO1↓, 1,   FASN↓, 2,   G6PD∅, 1,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlucoseCon∅, 1,   Glycolysis↓, 21,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 2,   HK2↓, 8,   lactateProd↓, 9,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   LDL↓, 2,   MCT4↓, 1,   NAD↓, 5,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 7,   PPP↓, 1,   Pyruv↓, 2,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 4,   SIRT1↑, 6,   SIRT2↓, 1,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 6,   Apoptosis↓, 6,   Apoptosis↑, 208,   mt-Apoptosis↑, 4,   BAD↓, 1,   BAD↑, 8,   Bak↑, 4,   BAX?, 1,   BAX↓, 2,   BAX↑, 74,   Bax:Bcl2↑, 26,   Bcl-2↓, 74,   Bcl-2↑, 2,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 3,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↑, 5,   Casp↓, 2,   Casp↑, 33,   Casp3↓, 3,   Casp3↑, 129,   cl‑Casp3↑, 19,   proCasp3↑, 1,   pro‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 20,   cl‑Casp7↑, 2,   Casp8↑, 28,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 71,   cl‑Casp9↑, 11,   proCasp9↑, 1,   pro‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 64,   Diablo↑, 8,   DR5↑, 6,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 5,   Ferroptosis↑, 8,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 8,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 4,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 4,   Necroptosis↑, 5,   necrosis↑, 6,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 4,   p38↑, 13,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 4,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 23,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 32,   XIAP↓, 11,   YAP/TEAD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 81,   Akt↑, 2,   p‑Akt↓, 17,   p‑Akt↑, 2,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 4,   p‑ERK↓, 5,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HRAS↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JAK↓, 5,   p‑JAK↓, 1,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 4,   JNK↑, 13,   p‑JNK↑, 2,   MAPK↓, 23,   MAPK↑, 10,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 3,   MKK4↓, 1,   mTOR↓, 41,   mTOR↑, 2,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 2,   NRAS↓, 1,   p70S6↓, 2,   p‑p70S6↑, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 47,   PI3K↑, 4,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PIK3CA↓, 1,   PKCδ↓, 9,   cl‑PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 4,   RAS↓, 6,   RIP1↑, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 6,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 4,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 23,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   FOXO3↝, 1,   FOXO4↑, 2,   ac‑H3↑, 3,   H3K18↓, 1,   ac‑H4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-218↑, 1,   miR-27a-3p↓, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 7,   other↓, 1,   other↑, 9,   other↝, 9,   OV6↓, 1,   PhotoS↑, 2,   SOX2↓, 5,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 58,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1↑, 4,   NPL4↓, 1,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 10,   XBP-1↓, 1,   XBP-1↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 2,   ATG7↑, 1,   autoF↓, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 3,   LC3s↝, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 3,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 3,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 14,   DNAdam↑, 377,   mt-DNAdam↑, 2,   DNArepair↓, 3,   FEN1↓, 2,   HR↓, 1,   hTERT/TERT↓, 6,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 2,   P53↓, 3,   P53↑, 67,   P53↝, 3,   p‑P53↑, 5,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 56,   cl‑PARP↝, 1,   PARP1↑, 3,   PCNA↓, 21,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 6,   TOP1∅, 1,   TOP2↓, 8,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 25,   p‑γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 24,   CDK2↑, 1,   CDK4↓, 26,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 4,   CHK1↑, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 5,   p‑Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 54,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 19,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↑, 2,   Ki-67↓, 12,   mitA↑, 3,   P21↓, 3,   P21↑, 55,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 20,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 166,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   CD133↓, 7,   CD133↑, 1,   cFos↓, 7,   CSCs↓, 34,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 4,   FGF↓, 1,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   Ki-67↓, 12,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 7,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 5,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH1↑, 2,   NOTCH2↓, 1,   p300↓, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 2,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 63,   TumCG↑, 1,   TumCP↓, 97,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 20,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 6,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 26,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   CD11b↑, 1,   Cdc42↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 17,   EMT↓, 33,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 42,   MMP3↓, 4,   MMP7↓, 6,   MMP9↓, 43,   MMPs↓, 10,   MUC4↓, 1,   N-cadherin↓, 11,   NCAM↑, 1,   NEDD9↓, 1,   PDGF↓, 1,   RECK↑, 1,   Slug?, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 7,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 7,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 2,   TumCI↓, 34,   TumCMig↓, 37,   TumMeta↓, 42,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↑, 1,   uPA↓, 8,   Vim↓, 14,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   HIF-1↓, 4,   Hif1a↓, 29,   Hif1a↑, 1,   Hypoxia↓, 2,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 3,   VEGF↓, 51,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 4,   CLDN1↓, 1,   CTR1↑, 2,   EPR↑, 11,   GLUT1↓, 5,   GLUT2↓, 1,   MMP↓, 115,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 1,   TRPM7↓, 2,   TRPV1↓, 1,   TRPV1↑, 1,   TRPV1↝, 1,   VGCC↑, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 34,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 2,   IL4↓, 2,   IL4↑, 1,   IL6↓, 22,   IL8↓, 3,   Imm↑, 13,   Inflam↓, 19,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 65,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 3,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 14,   PSA↓, 2,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PRL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen↓, 2,   ChemoSen↑, 114,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 6,   Dose↓, 5,   Dose↑, 7,   Dose↝, 34,   Dose∅, 10,   DrugR↓, 1,   eff↓, 48,   eff↑, 88,   eff⇅, 1,   eff↝, 12,   GSTA1↑, 2,   Half-Life↓, 5,   Half-Life↝, 5,   MDR1↓, 8,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 13,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 59,   selectivity?, 2,   selectivity↓, 2,   selectivity↑, 99,   selectivity↝, 1,   Synergy↑, 62,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   AST↓, 1,   BG↓, 2,   BloodF↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 6,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   LDH↝, 1,   Myc↓, 4,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 42,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 6,   ChemoSideEff↓, 5,   hepatoP↑, 4,   K17↓, 1,   LC↑, 1,   neuroP↑, 3,   NKG2D↑, 1,   NP/CIPN↓, 1,   NP/CIPN↝, 1,   OS↑, 13,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 4,   Risk↓, 10,   Strength↑, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 4,   Weight↑, 2,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   Sepsis↓, 2,  
Total Targets: 831

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 57,   Bil↓, 1,   Catalase↑, 28,   DPPH↓, 1,   Fenton↓, 1,   GPx↑, 21,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 24,   GSR↑, 2,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 4,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 22,   lipid-P↑, 1,   MDA↓, 20,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 20,   p‑NRF2↑, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 75,   ROS↑, 3,   ROS∅, 4,   selenoP↑, 5,   SOD↓, 2,   SOD↑, 31,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   FIS1↓, 1,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↓, 1,   ALAT↓, 7,   AMPK↑, 2,   Buty↑, 1,   DGAT1↓, 1,   FASN↓, 2,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   HMG-CoA↓, 1,   LDL↓, 6,   lipidLev↓, 1,   NADPH↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAX↓, 7,   Bax:Bcl2↓, 1,   Bcl-2↑, 5,   Bcl-xL↑, 1,   Casp↓, 1,   Casp3↓, 7,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   iNOS↓, 10,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   STAT3↓, 2,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 4,   other↑, 4,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 63,   DNAdam↑, 3,   DNAdam∅, 1,   DNArepair↑, 2,   SIRT6↑, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↓, 1,   Ki-67↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   FGF↑, 1,   Ki-67↓, 2,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   ROCK1↓, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC19↓, 1,   MUC2↓, 1,   TJ↑, 1,   VGCC↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD25+↑, 1,   CD4+↑, 2,   cGAS–STING↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 16,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 5,   IL17↓, 3,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 2,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 70,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 19,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 23,   TNF-α↑, 1,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE↑, 1,   AChE↝, 1,   BChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 25,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 1,   eff↓, 1,   eff↑, 16,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   ALB↝, 1,   ALP↓, 3,   AST↓, 8,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 5,   BUN↓, 2,   creat↓, 3,   CRP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   NOS2↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 4,   AntiCan↑, 13,   AntiDiabetic↑, 16,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 19,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 10,   diuretic↑, 2,   hepatoP↑, 20,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 11,   RenoP↑, 7,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity?, 2,   toxicity↓, 27,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 339

Scientific Paper Hit Count for: DNAdam, DNA damage
33 Silver-NanoParticles
19 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
14 Magnetic Fields
12 Curcumin
11 Fisetin
9 Cisplatin
8 Quercetin
8 Lycopene
7 Chemotherapy
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Chrysin
7 salinomycin
7 Selenium NanoParticles
7 Sulforaphane (mainly Broccoli)
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Licorice
4 Magnolol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Moringa oleifera
3 Anethole/trans-Anethole
3 Melatonin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 mebendazole
3 Nimbolide
3 Marjoram (Origanum majorana)
3 Phenethyl isothiocyanate
3 Phycocyanin
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 methylseleninic acid
2 Morin
2 Mucuna pruriens/Velvet Bean
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Linalool
1 Luteolin
1 MCT, metronomic chemo
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Aromatherapy
1 5-fluorouracil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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