DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF-7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
5869- CA,    Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
- in-vitro, ESCC, KYSE150
TumCP↓, Apoptosis↓, TumCMig↓, TumCCA↑, DNAdam↑, MAPK↓, γH2AX↑, TumMeta↓, TumCI↓, P21↑, ROS↑, EMT↓, ChemoSen↑,
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
5838- CAP,    Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
- in-vitro, NPC, NA
TumCG↓, TumCCA↑, TumAuto↑, Casp3↑, Ca+2↑, ROS↑, MMP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, p62↓, Fap1↓, PI3K↓, DNAdam↑,
5828- CAP,    Capsaicin: a novel radio-sensitizing agent for prostate cancer
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
RadioS↑, NF-kB↓, TumCCA↑, TumCG↓, TumCP↓, DNAdam↑, γH2AX↑, Ki-67↓,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
5896- CAR,  TV,    Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics
- Review, Var, NA
BioAv↑, AntiCan↑, *antiOx↑, *Inflam↑, *Bacteria↓, ROS↑, DNAdam↑,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
5862- carbop,  Cisplatin,    Molecular Mechanisms of Resistance and Toxicity Associated with Platinating Agents
- Review, Var, NA
DNAdam↑, ER Stress↑, UPR↑, ATF4↑, ATF6↑, XBP-1↑, GRP78/BiP↑, NP/CIPN↝, toxicity↝, eff↑, TrxR1⇅,
603- Catechins,    Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
- in-vitro, NA, HL-60
ROS↑, DNAdam↑, H2O2↑,
5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Neut↓, eff↑, Imm↑, Dose↝,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
2792- CHr,    Chrysin induces death of prostate cancer cells by inducing ROS and ER stress
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
DNAdam↑, TumCCA↑, MMP↓, ROS↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, PI3K↓, Akt↓, p70S6↓, MAPK↑,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1981- CUR,    Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity
- in-vitro, Lung, NA
eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
474- CUR,    Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
4830- CUR,    Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions
- in-vitro, Var, NA
eff↑, ROS↑, DNAdam↑, TumCG↓, Apoptosis↑, eff↓, Fenton↑, eff↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
1444- Deg,    Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
- in-vitro, GC, MKN-28
Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1851- dietFMD,  Chemo,    Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
- in-vitro, GBM, LN229 - in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, selectivity↑, ROS↑, DNAdam↑, BG↓,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, eff↑, HO-1↓, DNAdam↑, eff↑,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,

Showing Research Papers: 101 to 150 of 309
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 309

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Fenton↑, 3,   GSH↓, 2,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   H2O2↑, 3,   HO-1↓, 5,   HO-1↑, 1,   HO-2↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 2,   OXPHOS↑, 2,   ROS↑, 35,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,   SOD1↓, 1,   Trx2↓, 1,   TrxR↓, 1,   TrxR1⇅, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↑, 1,   Insulin↓, 2,   MMP↓, 12,   MMP↑, 2,   MPT↓, 1,   mtDam↑, 2,   XIAP↓, 5,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 5,   cMyc↓, 1,   CRM↑, 1,   ECAR↝, 1,   glucose↓, 1,   GlucoseCon↓, 1,   GLUT2↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDH↑, 1,   LDL↓, 1,   PDK1?, 2,   PDK1↓, 2,   PIK3CA↓, 1,   PPARα↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 12,   Akt↑, 2,   p‑Akt↓, 5,   p‑Akt↑, 1,   Apoptosis↓, 3,   Apoptosis↑, 17,   BAD↑, 1,   Bak↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 5,   Bcl-xL↓, 3,   Bcl-xL↑, 1,   cl‑BID↑, 1,   Casp↑, 8,   Casp3↓, 1,   Casp3↑, 14,   Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 6,   Cupro↑, 1,   Cyt‑c↑, 10,   Diablo↑, 1,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 1,   hTERT/TERT↓, 2,   iNOS↓, 2,   JNK↑, 3,   p‑JNK↑, 2,   JWA↑, 1,   MAPK↓, 8,   MAPK↑, 4,   Mcl-1↓, 2,   cl‑Mcl-1↑, 1,   MDM2↓, 1,   Myc↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↑, 3,   p‑p38↑, 1,   Paraptosis↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TRPV1↑, 1,   TumCD↑, 5,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   p‑p70S6↑, 1,   SOX9?, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↓, 1,   eIF2α↑, 1,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 3,   XBP-1↓, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes ⓘ

ATG3↑, 2,   ATG5↑, 1,   Beclin-1↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   p62↓, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATR↑, 1,   DNAdam↓, 1,   DNAdam↑, 45,   mt-DNAdam↑, 1,   DNMT1↓, 1,   GADD45A↑, 1,   p16↑, 1,   P53↑, 5,   p‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 3,   PCNA↓, 2,   SIRT6↑, 1,   TP53↑, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↑, 8,   p‑RB1↓, 1,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   AR-V7?, 1,   CDK8↓, 1,   CSCs↓, 4,   EMT↓, 5,   ERK↓, 5,   p‑ERK↓, 2,   p‑ERK↑, 1,   Gli1↓, 1,   HDAC↓, 2,   HDAC8↓, 1,   IGF-1↓, 4,   IGFBP7↑, 1,   mTOR↓, 7,   mTOR⇅, 1,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   NOTCH1↑, 1,   OCT4↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PTEN↑, 3,   SCF↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TRPM7↓, 2,   TumCG↓, 8,   Wnt↓, 1,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AXL↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   CLDN1↓, 1,   CXCL12↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   LAMs↓, 1,   MMP-10↓, 1,   MMP2↓, 5,   MMP9↓, 5,   NEDD9↓, 1,   PKCδ↓, 1,   Slug↓, 1,   SMAD3↓, 2,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 3,   Treg lymp↓, 1,   TSC1↑, 1,   TumCI↓, 2,   TumCMig↓, 4,   TumCP↓, 14,   TumMeta↓, 5,   Twist↓, 2,   VCAM-1↓, 1,   Vim↓, 3,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 8,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 4,   Endoglin↑, 1,   EPR↑, 1,   Hif1a↓, 8,   miR-210↓, 1,   VEGF↓, 9,   VEGFR2↓, 1,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

CTR1↑, 1,   GLUT1↓, 1,   NHE1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 4,   COX2↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 2,   Inflam↓, 2,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   M2 MC↓, 1,   Neut↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 3,   CYP19?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 2,   ChemoSen↑, 17,   Dose↝, 6,   Dose∅, 4,   DrugR↓, 1,   eff↓, 5,   eff↑, 41,   eff↝, 2,   RadioS↑, 11,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

AFP↓, 1,   ALAT↓, 1,   ALP↓, 1,   BG↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 4,   EZH2↓, 1,   GutMicro↑, 3,   hTERT/TERT↓, 2,   IL6↓, 2,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   ChemoSideEff↓, 2,   neuroP↑, 1,   NP/CIPN↝, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 2,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome ⓘ

CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 314

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 4,   SOD↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   LDH↓, 1,   LDL↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 3,   DNArepair↑, 1,  

Migration ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   Inflam↓, 8,   Inflam↑, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   Dose↝, 3,   Half-Life↓, 1,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   CRP↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 1,   OS↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 52

Scientific Paper Hit Count for: DNAdam, DNA damage
30 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
11 Curcumin
9 Fisetin
7 Ashwagandha(Withaferin A)
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Chemotherapy
6 Cisplatin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Piperlongumine
6 Quercetin
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Chrysin
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Emodin
4 Electrical Pulses
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 doxorubicin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Magnolol
3 Magnetic Field Rotating
3 Phenethyl isothiocyanate
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 chitosan
2 Moringa oleifera
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 diet Short Term Fasting
2 Disulfiram
2 EGCG (Epigallocatechin Gallate)
2 Gallic acid
2 Garcinol
2 γ-linolenic acid (Borage Oil)
2 Hydroxycinnamic-acid
2 Juglone
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 Zinc
1 carboplatin
1 Catechins
1 Chlorogenic acid
1 Chlorophyllin
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 chemodynamic therapy
1 Deguelin
1 immunotherapy
1 Butyrate
1 Ferulic acid
1 Galloflavin
1 Gambogic Acid
1 Honokiol
1 HydroxyTyrosol
1 Licorice
1 Luteolin
1 Nimbolide
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 Urolithin
1 Iron
1 Magnesium
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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