E-cadherin Cancer Research Results

E-cadherin, E-cadherin: Click to Expand ⟱
Source: HalifaxProj(restore)
Type:
Also known as Cadherin1 (CDH1)
E-cadherin, is a type of cell adhesion molecule that plays a crucial role in maintaining tissue structure and cell-cell interactions. In the context of cancer, E-cadherin has been found to be a tumor suppressor gene.

E-cadherin is a transmembrane protein that mediates cell-cell adhesion through its extracellular domain, which interacts with other E-cadherin molecules on adjacent cells. This interaction helps to maintain tissue integrity and prevent cancer cells from invading surrounding tissues.

In many types of cancer, including breast, colon, and prostate cancer, E-cadherin expression is often reduced or lost.
cell adhesion molecules spanning four families of 1) Integrins (α2β1, α5/β1, αL/β2); 2) Cadherins (E-cad, P-cad, N-cad); 3) Ig-CAMs (VCAM, NCAM, ICAM, Nectins, Necl); and 4) Selectins (E-selectin, P-selectin, L-selectin).
Scientific Papers found: Click to Expand⟱
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
1113- FIS,    Fisetin suppresses migration, invasion and stem-cell-like phenotype of human non-small cell lung carcinoma cells via attenuation of epithelial to mesenchymal transition
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, MMP2↓, CD44↓, CD133↓, β-catenin/ZEB1↓, NF-kB↓, EGFR↓, STAT3↓, CSCs↓,
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, p42↑, p44↑, MAPK↑, TumMeta↓, hepatoP↑, *antiOx↑, *TumCP↓, Vim↓, E-cadherin↓, Fibronectin↓, NDRG1↑, VMP-1↑, TumMeta↓,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, Var, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
1117- GBE,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CCN2/CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
1118- GSE,    Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF- β Signaling Pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 5637
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Vim↓, Slug↓, E-cadherin↑, ZO-1↑, p‑SMAD2↓, p‑SMAD3↓, p‑Akt↓, p‑ERK↓, p‑p38↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
7928- H2,    Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis
- in-vivo, Asthma, NA
*IL33↓, *NF-kB↓, *IL1RL1/ST2↓, *ILC2↓, *E-cadherin↑, *ZO-1↑, *Inflam↓, *antiAll↑,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
2880- HNK,    Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vivo, NA, NA
tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,
2882- HNK,    Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling
- in-vitro, PC, PANC1
TumCI↓, TumCMig↓, p‑SMAD2↓, p‑SMAD3↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, Snail↓, Slug↓, Rho↓, ROCK1↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
1119- HNK,    Honokiol inhibits epithelial—mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E‐cadherin axis
- vitro+vivo, BC, NA
EMT↓, MSCmark↓, EM↑, STAT3↓, Zeb1↓, E-cadherin↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7639- Ins,    Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells
- in-vitro, Nor, MCF10
EMT↓, E-cadherin↑, AntiCan↑, MMP9↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7696- IP6,  Ins,    The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7
- vitro+vivo, Colon, SW48 - in-vitro, Colon, SW-620
AntiCan↑, CLDN7↑, EMT↓, E-cadherin↑, N-cadherin↓, Synergy↑, TumCG↓,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
7744- ISL,    Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway
- vitro+vivo, Thyroid, NA
AntiTum↑, TumCP↓, TumCMig↓, E-cadherin↑, N-cadherin↓, FASN↓, SREBP1/SREBF1↓, ATP↓, p‑AMPK↑, lipidLev↓, TumCG↓, lipoGen↓,
7783- ISL,    Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
EMT↓, E-cadherin↑, TumCMig↓, TumCI↓, OS↑, Zeb1↓, Vim↓, N-cadherin↓,
9253- ISO, IH,    Progress in the antitumor molecular mechanisms of Isorhamnetin
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiTum↑, TumCP↓, Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, ChemoSen↑, PI3K↓, Akt↓, TumCCA↑, MAPK↓, TumCG↓, CDK2↑, PPARγ↑, PTEN↓, CAIX/CA9↓, Casp8↑, Casp9↑, Casp3↑, ROS↑, ER Stress↑, UPR↑, BAX↑, Cyt‑c↑, cl‑PARP↑, Bcl-2↓, MMP↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, EMT↓, MMP2↓, MMP9↓,
9252- ISO, IH,    Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
9241- ISO, IH,    Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, LDH↓, selectivity↑, TumCMig?, TumCI?, MET↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓, Bcl-2↓, BAX↑, Cyt‑c↑, cl‑PARP↑, E-cadherin↑, Vim↓, N-cadherin↓,
9177- ITCs,  SFN,    Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
- Review, Var, NA
CSCs↓, GutMicro↑, Bacteria↓, TumCCA↑, Apoptosis↑, TumAuto↑, angioG↓, TumCI↓, TumMeta↓, NRF2↑, Glycolysis↓, Wnt↓, β-catenin/ZEB1↓, HH↓, NOTCH↓, NK cell↑, EMT↓, angioG↓, BioAv↓, BioAv↑, AntiBio↑, Bacteria↓, HK2↓, PDH↓, OXPHOS↓, AKT1↓, ACC1↓, FASN↓, ACC-α↓, ACLY↓, SREBP1/SREBF1↓, OCT4↓, Nanog↓, YAP/TEAD↓, miR-21↓, miR-29b↓, ALDH1A1↓, miR-140↑, CD44↓, BMI1↓, miR-200c↑, TumCG↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, α-SMA↓, Slug↓, Snail↓, Twist↓, DNAdam⇅, BioAv↓, ChemoSen↑,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
1121- JG,    Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3β/Snail signaling pathway
- in-vitro, Pca, LNCaP
E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, GSK‐3β↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
9004- L-THE,    L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail
- vitro+vivo, Pca, PC3 - in-vitro, Pca, DU145
TumCI↓, TumCMig↓, EMT↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, ERK↓, NF-kB↓, TumMeta↓, Dose↝, Dose↝,
863- Lae,    Amygdalin inhibits the growth of renal cell carcinoma cells in vitro
- in-vitro, RCC, NA
TumCG↓, TumCP↓, TumCCA↑, CDK1↓, CycB/CCNB1↓, E-cadherin↝, N-cadherin↝,
864- Lae,    Can Amygdalin Provide any Benefit in Integrative Anticancer Treatment?
- Review, Var, NA
TumCCA↑, COX2/PTGS2↝, E-cadherin↑, other∅, other∅,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
2905- LT,    Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions
- in-vivo, Nor, HMrSV5
*ROS↓, *p‑Akt↓, *Vim↓, *E-cadherin↑, *PI3K↓,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,

Showing Research Papers: 101 to 150 of 248
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 248

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 5,   Catalase↑, 1,   Copper↑, 1,   ENOX2↓, 1,   GPx↓, 3,   GPx4↓, 4,   GSH↓, 12,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 7,   p‑NRF2↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 85,   ROS⇅, 3,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 9,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC?, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 6,   CDC25↓, 5,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 3,   MKK7↓, 1,   mtDam↑, 13,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↝, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   p‑ACLY↓, 1,   adiP↑, 1,   ALAT↓, 2,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 2,   ATP↓, 8,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   FASN↓, 3,   GAPDH↓, 1,   glucose↝, 1,   GlucoseCon↓, 5,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 6,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 6,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 1,   lactateProd↓, 5,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 4,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 2,   PFK↓, 1,   PFK1↓, 2,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 5,   Pyruv↑, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   SIRT1↓, 7,   SIRT1↑, 3,   SIRT2↓, 1,   SREBP1/SREBF1↓, 3,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 80,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 6,   Bak↑, 4,   BAX↓, 1,   BAX↑, 55,   Bax:Bcl2↑, 10,   Bcl-2↓, 63,   Bcl-2↑, 2,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 8,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 12,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 55,   cl‑Casp3↑, 16,   Casp6↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 40,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 41,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↑, 11,   FADD↑, 3,   Fas?, 1,   Fas↑, 13,   FasL↑, 1,   Ferroptosis↑, 3,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 9,   MDM2↓, 6,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 3,   p38↑, 4,   p‑p38↓, 4,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 16,   survivin↝, 1,   TNFR 1↑, 2,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 13,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 64,   Akt↑, 3,   p‑Akt↓, 23,   AKT1↓, 3,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 2,   p‑cMET↓, 1,   cSrc↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 9,   ERK5↑, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 4,   p‑IκB↓, 2,   JAK↓, 2,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 1,   JNK↑, 4,   p‑JNK↓, 2,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 12,   MAPK↑, 5,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MARK4↓, 2,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 42,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p42↑, 1,   p70S6↓, 1,   PDGFRA↓, 2,   PI3K↓, 58,   PI3K↑, 1,   p‑PI3K↓, 5,   p‑PI3K↑, 1,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 16,   Raf↓, 1,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 39,   p‑STAT3↓, 8,   p‑STAT3↑, 1,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 7,   p‑ATF4↝, 1,   cJun↓, 6,   cMyc↓, 26,   p‑cMyc↑, 1,   CREBBP↓, 1,   DNMT1↓, 3,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 7,   FOXM1↓, 4,   FOXO1↓, 3,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H19↓, 1,   H3↓, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 12,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   HES1↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 2,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 3,   miR-224↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-448↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 2,   NDRG1↑, 2,   OCT4↓, 12,   OCT4↑, 1,   other↓, 3,   other↑, 2,   other↝, 4,   other∅, 2,   PAX2↓, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   TCF-4↓, 1,   tumCV↓, 16,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   eIF2α↑, 2,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 14,   Erlin1↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 5,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 5,   p‑PERK↝, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 8,   LC3s↑, 1,   LysoPr↑, 1,   MitoP↑, 1,   p62↓, 8,   PARK2↑, 2,   TumAuto↓, 1,   TumAuto↑, 13,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 1,   BRCA1↓, 2,   DFF45↑, 2,   DNAdam↑, 20,   DNAdam⇅, 1,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 9,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 32,   p‑P53↑, 1,   ac‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↓, 1,   PARP↑, 9,   cl‑PARP↑, 27,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 18,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 6,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 8,   CDK1/2/5/9↓, 1,   CDK2↓, 22,   CDK2↑, 2,   CDK4↓, 26,   CDK4↑, 1,   CDK6↓, 11,   CDK6↑, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 41,   CycD3↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 17,   MAD↓, 1,   MKI67↑, 1,   P21↑, 26,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 13,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 4,   TumCCA↑, 79,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 2,   AXIN1↓, 1,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   BMPs↑, 1,   CD133↓, 4,   CD24↓, 2,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 30,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 9,   GTPBP4↓, 1,   HH↓, 8,   IGF-1↓, 6,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↓, 1,   Let-7↑, 5,   LRP6↓, 1,   p‑LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 2,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 13,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Piezo1↑, 1,   Pirin↓, 1,   PTCH1↓, 1,   SFRP5↑, 1,   Shh↓, 6,   Smo↓, 4,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 45,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 70,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 2,   AEG1↑, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 4,   AP-1↝, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 20,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 5,   COL1A1↓, 1,   COL3A1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 30,   E-cadherin↑, 211,   E-cadherin↝, 1,   EM↑, 1,   EMT↓, 148,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↑, 1,   FAK↓, 7,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 15,   Fibronectin↑, 1,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↑, 1,   ITGB1↓, 1,   ITGB1↑, 1,   ITGB4↓, 1,   LAMA5↑, 1,   LEF1↓, 1,   MALAT1↓, 3,   MET↓, 3,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 3,   MMP1:TIMP1↑, 1,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 88,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 88,   MMP9↝, 1,   pro‑MMP9↓, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1↑, 1,   N-cadherin↓, 107,   N-cadherin↑, 3,   N-cadherin↝, 1,   p44↑, 1,   p‑pax↓, 1,   PDGF↓, 2,   PIR↓, 1,   Rac1↓, 1,   Rho↓, 4,   ROCK1↓, 3,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 31,   Smad1↓, 3,   SMAD2↓, 4,   p‑SMAD2↓, 7,   SMAD3↓, 5,   p‑SMAD3↓, 6,   Snail?, 1,   Snail↓, 74,   Snail↑, 4,   TET1↑, 3,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 5,   TIMP3↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI?, 2,   TumCI↓, 83,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 53,   TumMeta↑, 2,   Twist↓, 34,   Twist↑, 2,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 2,   Vim?, 1,   Vim↓, 128,   Vim↑, 6,   vinculin↓, 1,   Zeb1↓, 31,   Zeb1↑, 2,   ZEB2↓, 3,   ZEB2↑, 2,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 55,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 34,   angioG↑, 3,   CD31/PECAM-1↓, 3,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 29,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 59,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CLDN1↓, 4,   CLDN2↓, 1,   CLDN2↑, 1,   CLDN7↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   MMP↓, 42,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 10,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD44↑, 1,   CD59↑, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR4↓, 9,   DR4↑, 2,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   FoxP3+↓, 1,   HMGB1↓, 3,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 2,   IL2↑, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 21,   IL6↑, 1,   IL8↓, 11,   IL8↑, 1,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 8,   IRAK1↓, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MIP-1β↑, 1,   Neut↑, 1,   NF-kB↓, 65,   NF-kB↑, 2,   p‑NF-kB↑, 2,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 6,   PD-L1↑, 1,   PD-L2↓, 1,   PGE2↓, 13,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR4↓, 2,   TNF-α↓, 12,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 7,   AR↑, 1,   ER(estro)↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 13,   BioAv↝, 5,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   ChemoSen⇅, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose↑, 3,   Dose↝, 21,   Dose∅, 5,   eff↓, 9,   eff↑, 21,   eff↝, 7,   eff∅, 1,   Half-Life↓, 6,   Half-Life↑, 1,   Half-Life↝, 3,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P450↓, 3,   RadioS↑, 23,   selectivity↑, 27,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 56,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 7,   AR↑, 1,   AST↓, 1,   BRCA1↓, 2,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 21,   IL6↑, 1,   LDH↓, 6,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 6,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 21,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 12,   cachexia↓, 3,   cardioP↑, 6,   chemoP↑, 12,   chemoPv↑, 6,   ChemoSideEff↓, 5,   fatigue↓, 1,   hepatoP↑, 5,   neuroP↑, 4,   NKG2D↑, 1,   OS↑, 11,   Pain↓, 1,   Pin1↓, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 3,   Risk↓, 5,   toxicity?, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 10,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 891

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 31,   Catalase↑, 18,   GPx↓, 1,   GPx↑, 12,   GSH↑, 12,   GSR↑, 2,   GSTs↑, 6,   HDL↑, 1,   HO-1↑, 8,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 14,   MDA↓, 8,   MPO↓, 1,   NQO1↑, 3,   NRF2↑, 18,   RNS↓, 1,   ROS↓, 39,   SOD↓, 1,   SOD↑, 19,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   ALAT↓, 5,   AMPK↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   lipidLev↓, 1,   NAD↑, 1,   NH3↓, 1,   PLA2↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

BAX↓, 3,   Bcl-2↑, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp9↓, 3,   Cyt‑c↓, 3,   Ferroptosis↓, 1,   iNOS↓, 3,   MLKL↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   p‑Akt↓, 1,   p‑Akt↑, 1,   CaMKII ↓, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 5,   mTOR↑, 3,   p‑mTOR↓, 1,   PI3K↓, 3,   PI3K↑, 4,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   p‑cMyc↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 4,   EMT↑, 1,   F-actin↓, 1,   Fibronectin↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad7↑, 2,   Snail↓, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Vim↓, 6,   Zeb1↓, 1,   α-SMA↓, 6,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   Hif1a↓, 1,   NO↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   TRPC1↓, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 8,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL12↓, 1,   IL1RL1/ST2↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL5↓, 2,   IL6↓, 11,   IL8↓, 2,   ILC2↓, 1,   Imm↑, 2,   Inflam↓, 31,   Inflam↑, 1,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 10,   NK cell↑, 1,   PGE2↓, 7,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   BDNF↑, 1,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 5,   BioAv↝, 5,   BioEnh↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↝, 1,   eff↑, 2,   GSTA1↑, 1,   Half-Life↝, 3,   P450↓, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 3,   AST↓, 7,   BP↓, 1,   BUN↓, 1,   creat↓, 2,   CRP↓, 1,   IL6↓, 11,   LDH↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 6,   AntiTum↑, 4,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 13,   Learn↑, 1,   memory↑, 7,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 19,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 3,   toxicity↓, 10,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 228

Scientific Paper Hit Count for: E-cadherin, E-cadherin
16 Curcumin
11 Resveratrol
11 Luteolin
8 Sulforaphane (mainly Broccoli)
7 Fisetin
7 Quercetin
6 Pterostilbene
6 Thymoquinone
5 Honokiol
5 Matrine
4 Astragalus
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Berberine
4 Benzyl isothiocyanate
4 Chrysin
4 Inositol
4 Piperine
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Propolis -bee glue
3 Cinnamon
3 5-fluorouracil
3 Cyclopamine
3 Eugenol
3 phytic acid, Inositol hexakisphosphate
3 Isorhamnetin
3 Magnolol
3 Urolithin
2 Allicin (mainly Garlic)
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Boron
2 Capsaicin
2 Carvacrol
2 Chlorogenic acid
2 Hydroxycinnamic-acid
2 Citric Acid
2 Diindolylmethane
2 Ellagic acid
2 Emodin
2 Fucoidan
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Isoliquiritigenin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Juglone
2 Kaempferol
2 Laetrile B17 Amygdalin
2 Lycopene
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Piperlongumine
2 Shikonin
2 Selenite (Sodium)
2 Ursolic acid
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 brusatol
1 Butyrate
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Crocetin
1 Oxaliplatin
1 diet FMD Fasting Mimicking Diet
1 Indole-3-carbinol
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Sorafenib (brand name Nexavar)
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgolide B
1 Proanthocyanidins
1 Chemotherapy
1 HydroxyTyrosol
1 capecitabine
1 Allyl isothiocyanate
1 L-Theanine
1 Licorice
1 Metformin
1 Mangiferin
1 Melatonin
1 Morin
1 Naringin
1 Oroxylin-A
1 Oleuropein
1 Phenylbutyrate
1 Docetaxel
1 Rutin
1 salinomycin
1 Selenate
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 statins
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:89  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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