CDK4 Cancer Research Results

CDK4, Cyclin-dependent kinase 4: Click to Expand ⟱
Source:
Type:
Cyclin-dependent kinase 4 (CDK4) is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression and activity are often altered in various cancers, contributing to tumorigenesis.
CDK4 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker.
Scientific Papers found: Click to Expand⟱
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
1293- IP6,    Inositol Hexaphosphate Inhibits Growth and Induces G1 Arrest and Apoptotic Death of Androgen-Dependent Human Prostate Carcinoma LNCaP Cells
- vitro+vivo, Pca, LNCaP
TumCG↓, TumCCA↑, P21↑, CDK4↓, cycD1/CCND1↓, RB1↑, E2Fs↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
7965- JG,    Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
1040- LE,    Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
- in-vivo, Lung, H1975
TumCCA↑, CDK4↓, cycD1/CCND1↓, PD-L1↑, TumVol↓,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
2928- LT,    Luteolin-mediated increase in miR-26a inhibits prostate cancer cell growth and induces cell cycle arrest targeting EZH2
- in-vitro, Pca, NA
EZH2↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8774- MSM,    Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells
- in-vitro, Oral, YD-38
P21↑, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, Cyt‑c↑, TumCCA↑,
8935- MushCha,    Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-10AT
Ingr↝, tumCV↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, ChemoSen↑, Imm↑, Dose↝, Ingr?,
8954- mushLions,    Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis
- in-vitro, GC, SGC-7901
TumCP↓, Tumccf↓, Apoptosis↑, TumCCA↑, Bcl-2↓, PI3K↓, Akt↓, Casp8↑, Casp3↑, P53↑, CDK4↑, BAX↑, BAD↑, ROS↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
3256- PBG,    Mechanisms of Apoptosis and Cell Cycle Arrest Induced by Propolis in Cancer Therapy
- Review, Var, NA
TumCCA↑, CDK2↓, CDK4↓, cycA1/CCNA1↓, CycB/CCNB1↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3088- RES,    Notch signaling mediated repressive effects of resveratrol in inducing caspasedependent apoptosis in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
NOTCH1↓, BAX↑, CDK4↝, Casp3↑, P21↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
2191- SK,    Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
- in-vitro, Melanoma, NA
PKM2↓, ATF4↓, CDK4↓, COX2/PTGS2↓, MAPK↓,

Showing Research Papers: 101 to 150 of 156
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 156

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   GSTs↝, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 9,   hyperG↓, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 3,   NRF2↑, 12,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 10,   ROS↑, 68,   ROS⇅, 2,   i-ROS↓, 1,   i-ROS↑, 2,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 3,   Trx↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 3,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 2,   mtDam↑, 11,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 3,   ALAT↓, 3,   ALDOA↓, 1,   AMP↑, 1,   AMPK↓, 2,   AMPK↑, 11,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 7,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 2,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 4,   Glycolysis↓, 9,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   p‑GSK‐3β↑, 1,   H2S↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2↓, 4,   IDO1↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 5,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 63,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 4,   BAX↓, 2,   BAX↑, 48,   BAX⇅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 49,   Bcl-xL↓, 12,   BID↓, 1,   BID↑, 5,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 2,   BOK↑, 2,   Casp↑, 13,   Casp1↓, 1,   Casp1↑, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 60,   cl‑Casp3↑, 10,   Casp7↑, 7,   cl‑Casp7↑, 5,   Casp8↓, 1,   Casp8↑, 19,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 44,   mt-Cyt‑c↓, 1,   Diablo↑, 11,   DR5↑, 12,   DR5∅, 1,   FADD↑, 4,   FADD∅, 1,   Fas↑, 14,   FasL↑, 1,   Ferroptosis↑, 2,   HEY1↓, 1,   IAP1↓, 3,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   NAIP↓, 2,   NOXA↑, 2,   p38↓, 3,   p38↑, 10,   p‑p38↓, 1,   PUMA↓, 1,   PUMA↑, 4,   survivin↓, 18,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↑, 6,   XIAP↓, 15,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55,   Akt↑, 3,   p‑Akt↓, 14,   AKT1↓, 2,   Akt2↓, 1,   CK2↓, 5,   cMET↓, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 21,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 3,   p‑ERK↓, 4,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 1,   IKKα↓, 5,   p‑IKKα↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 7,   p‑JAK2↓, 1,   JNK↓, 3,   JNK↑, 10,   p‑JNK↓, 2,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 17,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 2,   mTOR↓, 28,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 3,   p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 4,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 7,   p‑S6K↓, 1,   Sp1/3/4↓, 6,   Src↓, 1,   STAT↓, 2,   STAT3↓, 25,   p‑STAT3↓, 7,   p‑STAT3↑, 1,   STAT5↓, 1,   STAT6↓, 3,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AFAP1-AS1↓, 1,   ATF3↑, 1,   ATF4↓, 2,   ATF4↑, 7,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 7,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 24,   DNMT1↓, 1,   DNMTs↓, 3,   EZH2↓, 4,   FOXM1↓, 4,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 10,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 1,   miR-195↑, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 2,   miR-30a-5p↑, 1,   miR-34a↑, 5,   miR-545↑, 1,   MTA2↓, 1,   Myc↓, 2,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 6,   other↑, 1,   other↝, 3,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 5,   SOX4↓, 2,   SOX4↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 17,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 8,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 16,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   p62↓, 2,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 5,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 5,   ATR↑, 2,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 25,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 5,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 48,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 35,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 13,   Telomerase↓, 8,   TOP1↓, 3,   TOP2↓, 4,   TOP2↑, 1,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 73,   CDK2↑, 3,   CDK4↓, 147,   CDK4↑, 8,   CDK4↝, 1,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK6↓, 39,   CDK6↑, 8,   CDK6∅, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 1,   CHK1↑, 3,   Chk2↓, 1,   Chk2↑, 3,   cycA1/CCNA1↓, 10,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 106,   cycD1/CCND1↑, 1,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 45,   cycE/CCNE↑, 3,   cycE1↓, 2,   E2F4↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   Ki-67↓, 8,   mitA↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 69,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 37,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 7,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 115,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 2,   BMPs↑, 1,   CD133↓, 4,   CD133↑, 1,   cFos↓, 8,   CSCs↓, 15,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 3,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 2,   NOTCH↓, 7,   NOTCH1↓, 4,   NOTCH3↓, 1,   p300↓, 1,   PTCH1↓, 1,   Shh↓, 2,   STAT1↓, 1,   TumCG↓, 27,   TumCG↑, 1,   TumCP↓, 62,   TumCP↑, 1,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 15,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 10,   ATPase↓, 2,   AXL↓, 2,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 17,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 22,   EMT↓, 30,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 2,   GIT1↓, 1,   ITGA5↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 42,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 49,   MMP9↑, 1,   MMPs↓, 11,   N-cadherin↓, 11,   PAK1↑, 1,   PDGF↓, 5,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 7,   Smad1↑, 1,   Snail?, 1,   Snail↓, 9,   TET1↓, 1,   TGF-β↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 27,   TumCI↑, 1,   TumCMig↓, 32,   TumCMig↑, 1,   TumMeta↓, 29,   TumMeta↑, 2,   Twist↓, 10,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 17,   Zeb1↓, 10,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 19,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 35,   angioG↑, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 22,   LOX1↓, 1,   NO↓, 2,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 45,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 43,   MPT↑, 1,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 39,   CXCL1↓, 1,   CXCR4↓, 6,   DR4↑, 3,   DR4∅, 1,   FOXP3↓, 2,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 4,   IL10↓, 1,   IL10↑, 1,   IL12↓, 3,   IL1α↓, 1,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 7,   Imm↑, 2,   Inflam↓, 10,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 61,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 2,   NLRP3↓, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 13,   PSA↓, 9,   PSA∅, 1,   T-Cell↑, 1,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 13,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   ER-α36↓, 2,   GR↑, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 16,   BioAv↝, 2,   BioEnh↑, 4,   ChemoSen↓, 1,   ChemoSen↑, 55,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 17,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 9,   eff∅, 1,   Half-Life↓, 7,   Half-Life↝, 6,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 10,   P450↓, 1,   P450↝, 1,   RadioS↑, 16,   selectivity?, 1,   selectivity↑, 37,   Synergy↑, 54,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 9,   ascitic↓, 1,   AST↓, 2,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 21,   p‑EGFR↓, 1,   EZH2↓, 4,   Ferritin↓, 2,   FOXM1↓, 4,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 16,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 1,   Myc↓, 2,   PD-L1↓, 3,   PD-L1↑, 1,   PSA↓, 9,   PSA∅, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 20,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 5,   PFS↑, 1,   QoL↑, 2,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 3,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 8,   TumW↓, 5,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 706

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 29,   Catalase↑, 13,   GPx↓, 1,   GPx↑, 8,   GSH↑, 12,   GSR↑, 3,   GSTs↑, 3,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 9,   Keap1↑, 1,   lipid-P↓, 10,   MDA↓, 8,   MPO↓, 2,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↑, 13,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 25,   SOD↓, 1,   SOD↑, 13,   SOD1↑, 1,   SOD2↑, 1,   Trx↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ALAT↓, 6,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 6,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 1,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 1,   p‑cMyc↑, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSPs↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   Ca+2↓, 1,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   MMP9↓, 2,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   MMP↑, 2,   OCLN↝, 1,   TJ↑, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 9,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 28,   LPS↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 12,   NLRP3↓, 2,   PGE2↓, 4,   RAGE↓, 1,   SOCS-3↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 13,   BioAv↑, 5,   BioAv↝, 3,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 1,   Half-Life↑, 1,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 1,   AST↓, 6,   BMD↑, 1,   BP↓, 3,   creat↓, 1,   CRP↓, 2,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 2,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 6,   AntiArt↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 6,   antiPs↑, 1,   cardioP↑, 12,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 10,   Learn↑, 1,   memory↑, 7,   motorD↑, 1,   neuroP↑, 22,   Obesity↓, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   Stroke↓, 3,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   GutMicro↑, 7,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 239

Scientific Paper Hit Count for: CDK4, Cyclin-dependent kinase 4
14 Fisetin
7 Ferulic acid
6 Honokiol
4 Artemisinin
4 Baicalein
4 Berberine
4 Boswellia (frankincense)
4 Capsaicin
4 Sulforaphane (mainly Broccoli)
4 Lycopene
4 Silymarin (Milk Thistle) silibinin
3 Propolis -bee glue
3 Carvacrol
3 Chrysin
3 Diindolylmethane
3 Garcinol
3 Luteolin
3 Magnolol
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Curcumin
2 Chemotherapy
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Indole-3-carbinol
2 Ellagic acid
2 Flaxseed/Linseed
2 Gallic acid
2 HydroxyTyrosol
2 phytic acid, Inositol hexakisphosphate
2 Kaempferol
2 lambertianic acid
2 Morin
2 Piperlongumine
2 Resveratrol
2 Shikonin
1 Silver-NanoParticles
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Radiotherapy/Radiation
1 Biochanin A
1 Betulinic acid
1 Bufalin/Huachansu
1 Boron
1 Cisplatin
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Thymol-Thymus vulgaris
1 Cinnamon
1 Hydroxycinnamic-acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginseng
1 5-fluorouracil
1 Hydrogen Gas
1 Inulin Prebiotic
1 isoorientin
1 Ivermectin
1 Juglone
1 Licochalcone A
1 Licorice
1 Linalool
1 Matrine
1 Metformin
1 Melatonin
1 Lemon Balm/Melissa officinalis
1 doxorubicin
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Orlistat
1 Pterostilbene
1 Quercetin
1 Rosmarinic acid
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:894  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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