CDK4 Cancer Research Results

CDK4, Cyclin-dependent kinase 4: Click to Expand ⟱
Source:
Type:
Cyclin-dependent kinase 4 (CDK4) is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression and activity are often altered in various cancers, contributing to tumorigenesis.
CDK4 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker.
Scientific Papers found: Click to Expand⟱
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

Showing Research Papers: 101 to 101 of 101
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 101

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

i-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   MAPK↓, 1,   p27↑, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   other↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

p‑P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   RAS↓, 1,   TumCG↓, 1,  

Migration ⓘ

MMPs↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   eff↑, 4,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,   toxicity∅, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDK4, Cyclin-dependent kinase 4
10 Fisetin
5 Honokiol
4 Artemisinin
4 Baicalein
4 Berberine
4 Boswellia (frankincense)
4 Capsaicin
4 Lycopene
4 Silymarin (Milk Thistle) silibinin
3 Propolis -bee glue
3 Carvacrol
3 Ferulic acid
3 Magnolol
3 Sulforaphane (mainly Broccoli)
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Chemotherapy
2 Celastrol
2 Chrysin
2 Garcinol
2 Luteolin
2 Piperlongumine
2 Resveratrol
2 Shikonin
1 Astaxanthin
1 Radiotherapy/Radiation
1 Biochanin A
1 Betulinic acid
1 Bufalin/Huachansu
1 Boron
1 Curcumin
1 Cisplatin
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Thymol-Thymus vulgaris
1 diet FMD Fasting Mimicking Diet
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 HydroxyTyrosol
1 Inositol
1 Licorice
1 Melatonin
1 Metformin
1 Orlistat
1 Pterostilbene
1 Quercetin
1 Rosmarinic acid
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:894  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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