AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
- Review, Var, NA
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
683- EGCG,    Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy
- Review, Var, NA
AMPK↑, TumCP↓, P21↑, mTOR↓, COX2/PTGS2↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
6898- FIS,    Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
mTOR↓, Akt↓, AMPK↑, TumCG↓, mTORC1↓, mTORC2↓, 4E-BP1↑, LC3II↑, TumAuto↑,
2849- FIS,    Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
2860- FIS,    Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3 - in-vitro, Nor, hTERT-HPNE - in-vivo, NA, NA
AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
1186- GAs,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7710- IBC,    Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
- vitro+vivo, AD, NA
*p‑AMPK↑, *NLRP3↓, *NA↝, *cognitive↑, *memory↑, *motorD↑, *Aβ↓, *Inflam↓, *BBB↑,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
- Review, Nor, NA
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *Synergy↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, NA↑,
7637- Ins,    Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes
- vitro+vivo, BC, 4T1
TumVol↓, Dose↝, *toxicity↓, AMPK↓, Ki-67↓,
7632- Ins,    The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
- Review, Var, NA
AMPK↑, AntiCan⇅, p‑Akt↓, PI3K↓,
7744- ISL,    Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway
- vitro+vivo, Thyroid, NA
AntiTum↑, TumCP↓, TumCMig↓, E-cadherin↑, N-cadherin↓, FASN↓, SREBP1/SREBF1↓, ATP↓, p‑AMPK↑, lipidLev↓, TumCG↓, lipoGen↓,
7859- isoO,    Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells
- in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, EMT↓, MMPs↓, VEGF↓, AMPK↑, TumCP↓, Dose↝, TumCMig↓, TumCI↓,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
7793- ISQ,    Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,
7983- itraC,    Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
- in-vitro, Nor, HUVECs
angioG↓, VDAC1↓, mt-ATP↓, AMPK↑, mTOR↓, TumCP↓,
7999- itraC,    Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
- vitro+vivo, ESCC, NA
AMPK↑, EGFR↓, PDGFRA↓, PDGFRB↓, Akt↓, TumCG↓,
7982- itraC,    Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- in-vitro, Nor, HUVECs - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
angioG↓, mTOR↓, NPC1L1↓, AMPK↑, VDAC1↓,
5117- JG,    https://pubmed.ncbi.nlm.nih.gov/31283929/
- vitro+vivo, Liver, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
9009- L-Theanine,    Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose↝, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,

Showing Research Papers: 101 to 150 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 4,   GSH↓, 5,   GSH↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 5,   i-Iron↓, 1,   lipid-P↑, 8,   MDA↑, 5,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 9,   Prx↓, 1,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 8,   ROS↑, 74,   ROS⇅, 3,   mt-ROS↑, 8,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   TKT↝, 1,   Trx↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 5,   compI↓, 3,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam↑, 8,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 3,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↓, 5,   ACC↑, 5,   p‑ACC↑, 2,   p‑ACC-α↑, 1,   ACLY↓, 5,   adiP↑, 1,   AMP↑, 2,   AMPK?, 1,   AMPK↓, 6,   AMPK↑, 128,   AMPK↝, 2,   p‑AMPK↑, 20,   ATP↓, 17,   mt-ATP↓, 1,   CRM↑, 2,   ECAR↓, 3,   FAO↑, 1,   FASN↓, 9,   FDG↓, 1,   G6PD↓, 3,   GLS↓, 3,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 7,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 23,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 15,   HK2↑, 1,   lactateProd↓, 8,   lactateProd↑, 3,   LDHA↓, 6,   LDHA↑, 1,   LDL↓, 1,   lipidLev↓, 2,   lipoGen↓, 2,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PFK1↓, 1,   PKM2↓, 11,   PKM2↑, 1,   PPP↓, 2,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 5,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↑, 58,   ASC↑, 1,   BAD↓, 1,   BAD↑, 4,   Bak↑, 4,   BAX↓, 2,   BAX↑, 28,   Bax:Bcl2↑, 7,   Bcl-2↓, 37,   Bcl-xL↓, 11,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp10↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 10,   Casp7↑, 4,   Casp8↑, 11,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 23,   cl‑Casp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 26,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   FADD↑, 6,   Fas↓, 1,   Fas↑, 9,   FasL↑, 7,   Ferroptosis↑, 9,   IAP1↓, 2,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 7,   Mcl-1↑, 1,   MDM2↓, 3,   MOMP↑, 1,   NAIP↓, 1,   p38↓, 1,   p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 12,   TRAIL↑, 2,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 46,   Akt↑, 5,   p‑Akt↓, 11,   p‑Akt↑, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   cMET↓, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 12,   ERK↓, 12,   ERK↑, 3,   p‑ERK↓, 3,   IGF-1R↓, 1,   IKKα↓, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 10,   MAPK?, 1,   MAPK↓, 9,   MAPK↑, 4,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 1,   mTOR↓, 58,   mTOR↑, 11,   mTOR↝, 1,   mTOR∅, 1,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   P70S6K↑, 1,   P90RSK↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 30,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PP2A↑, 1,   PTEN↑, 5,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   p‑S6K↓, 4,   Sp1/3/4↓, 3,   Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   STAT3↑, 1,   p‑STAT3↓, 6,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 4,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 12,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   H3↑, 1,   p‑H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 4,   HDAC∅, 1,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 3,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   miR-326-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-592↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↓, 3,   other↑, 1,   other↝, 3,   SOX2↓, 3,   SOX4↓, 2,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 17,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 4,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 10,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 6,   PARK2↑, 2,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 27,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↑, 22,   DNArepair↓, 1,   NBR2↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 30,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 20,   cl‑PARP1↑, 1,   PCNA↓, 6,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 16,   CDK4↑, 2,   CDK6↓, 5,   CDK6↑, 2,   CDK7↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 24,   cycE/CCNE↓, 7,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 8,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 15,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 52,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMI1↓, 2,   BMP7/OP1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 2,   cFos↓, 5,   CSCs?, 1,   CSCs↓, 16,   Diff↓, 1,   Diff↑, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGFBP1↑, 2,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH1↓, 3,   NOTCH3↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 3,   Smo↓, 1,   Sufu↓, 1,   TumCG↓, 34,   TumCG↑, 1,   TumCP↓, 49,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 17,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 4,   ASAP2↓, 1,   Ca+2↑, 7,   CAFs/TAFs↝, 1,   cal2↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 18,   EMT↓, 27,   EMT↑, 1,   EMT↝, 1,   F-actin↑, 1,   FAK↓, 3,   Fibronectin↓, 1,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 24,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 27,   MMPs↓, 7,   N-cadherin↓, 10,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   Snail↓, 7,   talin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP2↓, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 31,   TumCMig↓, 24,   TumMeta↓, 22,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↓, 1,   uPA↓, 6,   Vim↓, 14,   Zeb1↓, 5,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   angioG↑, 1,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   Hypoxia↓, 1,   LOX1↓, 1,   NO↑, 4,   PHDs↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 27,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 7,   GLUT1↑, 2,   GLUT2↓, 1,   GLUT3↓, 1,   MMP↓, 40,   MPT↑, 2,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 28,   CXCL1↓, 1,   CXCR4↓, 4,   DCells↑, 1,   DR4↑, 2,   DR4∅, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 4,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 11,   IL6↑, 1,   IL8↓, 3,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 7,   LRIG1↑, 1,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 40,   NF-kB↑, 3,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PGE2↓, 9,   PSA↓, 2,   TCF↓, 2,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 10,   BioAv↑, 5,   BioAv↝, 4,   ChemoSen↑, 45,   ChemoSen⇅, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 3,   Dose↝, 14,   Dose∅, 4,   eff↓, 21,   eff↑, 24,   eff↝, 6,   Half-Life↓, 3,   Half-Life↝, 5,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P450↓, 1,   RadioS↑, 20,   selectivity↑, 17,   Synergy↑, 28,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BMD↑, 1,   EGFR↓, 12,   Ferritin↓, 1,   FOXM1↓, 4,   IL6↓, 11,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 5,   p‑LDH↓, 1,   Myc↓, 3,   PD-L1↓, 6,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 7,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 6,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 7,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   PFS∅, 1,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 7,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 3,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 1,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 658

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 45,   mt-antiOx↑, 1,   Catalase↑, 15,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 9,   GPx4↑, 2,   GSH↑, 25,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 2,   H2O2∅, 1,   HO-1↑, 20,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 19,   mt-lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 16,   MPO↓, 3,   NQO1↑, 5,   NRF2↓, 1,   NRF2↑, 36,   RNS↓, 1,   ROS↓, 68,   ROS↑, 1,   SOD↑, 22,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TOS↓, 1,   Trx1↑, 1,   TrxR1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 4,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 2,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 7,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACC↑, 1,   p‑ACC↑, 1,   Acetyl-CoA↓, 2,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 13,   AMPK↓, 4,   AMPK↑, 77,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 8,   ATP↓, 1,   ATP↑, 8,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 4,   ECAR↓, 1,   ECAR↑, 1,   FAO↑, 4,   FASN↓, 1,   G6PD↑, 1,   glucoNG↓, 1,   glucose↓, 9,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 7,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PDKs↓, 1,   PGM1?, 1,   PKM2↓, 2,   PKM2↑, 1,   SIRT1↑, 27,   SIRT1↝, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 10,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 10,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 4,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 4,   iNOS↓, 9,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 5,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 2,   ERK↑, 4,   p‑ERK↓, 1,   p‑ERK↑, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 6,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 11,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 12,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   p‑mTOR↑, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 2,   PP2A↑, 3,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 2,   p‑cMyc↑, 1,   FOXO↑, 2,   FOXO1↝, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 4,   ER Stress↓, 4,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 2,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 2,   p62↓, 4,   p62↑, 1,   PARK2↑, 4,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 3,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   P21↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   MMP3↓, 2,   MMP9↓, 6,   PDGF↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TXNIP↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 4,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 3,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 10,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 11,   TRPC1↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 14,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL10↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 17,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam↓, 61,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 33,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 7,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 23,   TNF-α↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 1,   AChE↓, 8,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 10,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 15,   BioAv↝, 12,   BioEnh↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   eff↓, 1,   eff↑, 8,   eff↝, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 2,   AST↓, 11,   BG↓, 1,   BloodF↑, 1,   BMD↑, 4,   BP↓, 5,   BP↝, 1,   BP∅, 1,   CRP↓, 3,   IL6↓, 21,   IRes↑, 1,   IRes↝, 1,   LDH↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 12,   antiAll↑, 6,   AntiCan↑, 4,   antiCG↑, 1,   AntiDiabetic↑, 9,   AntiTum↑, 2,   cardioP↑, 18,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 21,   diuretic↑, 1,   hepatoP↑, 23,   Learn↑, 1,   memory↑, 22,   motorD↑, 5,   neuroP↑, 47,   NP/CIPN↓, 1,   Obesity↓, 8,   OS↑, 4,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 3,   toxicity↓, 15,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 11,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 407

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
17 Resveratrol
14 Metformin
12 Berberine
10 Capsaicin
9 Alpha-Lipoic-Acid
8 Fisetin
7 Curcumin
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Hydrogen Gas
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Betulinic acid
4 Caffeic acid
4 diet Short Term Fasting
4 lambertianic acid
4 Morin
4 Quercetin
4 Urolithin
3 HydroxyCitric Acid
3 Aspirin
3 Ashwagandha(Withaferin A)
3 Chrysin
3 Calorie Restriction Mimetics
3 diet FMD Fasting Mimicking Diet
3 Emodin
3 Honokiol
3 Inositol
3 isoorientin
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnolol
3 Magnetic Field Rotating
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Baicalin
2 bempedoic acid
2 Boron
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Gambogic Acid
2 Juglone
2 Luteolin
2 Methylene blue
2 Methyl salicylate / Sweet Birch oil
2 Magnetic Fields
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Shikonin
2 Thymoquinone
2 Vitamin K2
2 Vitexin
1 Astragalus
1 Andrographis
1 Radiotherapy/Radiation
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Chemotherapy
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Spermidine
1 Garcinol
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dandelion Root
1 Ellagic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Hibiscus sabdariffa
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 L-Theanine
1 Licochalcone A
1 Licorice
1 Lycopene
1 Matrine
1 MCT oil
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Piperine
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Selenium NanoParticles
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Gallic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:9  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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