NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱
Source:
Type:
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.
Scientific Papers found: Click to Expand⟱
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3324- SIL,    Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
*ROS↓, *TAC↑, *NF-kB↓, *IL2↓, *NRF2↑, *HO-1↑, *neuroP↑, *Inflam↓, *NLRP3↓,
2354- SK,    PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
- in-vivo, Sepsis, NA
PKM2↓, *PKM2↓, *IL1β↓, *IL18↓, *HMGB1↓, *Casp1↓, *NLRP3↓, *AIM2↓, *p‑eIF2α↓, *Sepsis↓,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
3419- TQ,    Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients
- in-vitro, BC, NA
*NLRP3↓, *IL1β↓, *Casp1?,
3418- TQ,    Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
- in-vitro, Melanoma, A375 - in-vivo, NA, NA
TumMeta↓, TumCMig↓, NLRP3↓, Casp1↓, IL1β↓, IL18↓, ROS↓, NF-kB↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
3125- VitC,    Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice
- in-vivo, Nor, NA
*Hear↑, *Inflam↓, *NLRP3↓,
3126- VitC,    Safety of High-Dose Vitamin C in Non-Intensive Care Hospitalized Patients with COVID-19: An Open-Label Clinical Study
- Study, NA, NA
*NLRP3↓, *ROS↓, *antiOx↑,
3127- VitC,    NLRP3_inflammasome_by_scavenging_mitochondrial_ROS">Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS
- in-vitro, Nor, NA - in-vivo, Nor, NA
*NLRP3↓, *AIM2↓, *mt-ROS↓, *IL1β↓,

Showing Research Papers: 101 to 114 of 114
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 114

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↓, 2,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Casp↑, 1,   Casp1↓, 1,   Chk2↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 1,   DNAdam↑, 1,   GADD45A↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   P21↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   ERK↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCMig↓, 2,   TumCP↓, 2,   TumMeta↓, 2,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL18↓, 1,   IL1β↓, 1,   NF-kB↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 2,   GSH↑, 1,   GSR↑, 2,   HO-1↑, 3,   lipid-P↓, 3,   MPO↓, 1,   NRF2↑, 3,   PARK2↑, 1,   ROS↓, 7,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 3,   SOD1↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CREB↑, 1,   LDH↓, 1,   NAD↑, 1,   PKM2↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp1?, 1,   Casp1↓, 2,   Casp3↑, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,   Pyro?, 1,   Telomerase↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 2,   p62↓, 1,   p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,   MMP9↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIM2↓, 2,   ASC?, 1,   COX2/PTGS2↓, 1,   CRP↓, 1,   HMGB1↓, 1,   IL18↓, 2,   IL1β↓, 5,   IL2↓, 1,   IL6↓, 1,   Inflam↓, 5,   NF-kB↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,   tau↓, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   NLRP3↓, 11,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   GutMicro↑, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   Hear↑, 1,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 5,   OS↑, 1,   radioP↑, 1,   Risk↓, 2,   Strength↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 90

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3
11 Hydrogen Gas
9 Resveratrol
5 Quercetin
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
4 Thymoquinone
3 Silver-NanoParticles
3 Cucurbitacin
3 EGCG (Epigallocatechin Gallate)
3 Ferulic acid
3 Piperlongumine
3 Pterostilbene
3 Silymarin (Milk Thistle) silibinin
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Beta-Caryophyllene
2 Carnosic acid
2 Chlorogenic acid
2 Curcumin
2 Emodin
2 Isoliquiritigenin
2 isoquercitrin
2 Luteolin
2 Magnetic Fields
2 Methylsulfonylmethane
1 1,8-Cineole
1 2-DeoxyGlucose
1 Selenite (Sodium)
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Cannabidiol
1 Boron
1 Butyrate
1 Caffeic acid
1 Celastrol
1 chitosan
1 Choline
1 Crocetin
1 Fucoidan
1 Galloflavin
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 hydrogen sulfide
1 Hyperoside
1 Isobavachalcone
1 Lycopene
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Phenylbutyrate
1 Propolis -bee glue
1 Radiotherapy/Radiation
1 Selenium
1 doxorubicin
1 Selenium NanoParticles
1 Shikonin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:908  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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