NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱
Source:
Type:
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.
Scientific Papers found: Click to Expand⟱
3008- RosA,    Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells
- in-vitro, Melanoma, SK-MEL-28
tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3615- RosA,    Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
- Review, AD, NA - Review, Park, NA
*NLRP3↓, *Inflam↓, *neuroP↑, *NRF2↑, *TNF-α↓, *NF-kB↓, *HO-1↑, *ROS↓,
4738- Se,  doxoR,    Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway
- in-vivo, Nor, NA
*NRF2↑, *NLRP3↓, *cardioP↑,
6059- SeNPs,    Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice
- in-vivo, AD, NA
*Dose↝, *Aβ↓, *BBB↑, *GutMicro↑, *NLRP3↓, *Inflam↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
3657- SFN,    Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages
- NA, AD, THP1
*NLRP3↓, *Inflam↓, *IL1β↓, *NRF2↑, *HO-1↑,
3186- SFN,    A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- in-vivo, Nor, NA
*NLRP3↓, *ASC↓, *Casp1↓, *IL1β↓, *ALAT↓, *AST↓, *AMPK↑, *mTOR↓, *P70S6K↓,
3185- SFN,    Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis
- in-vivo, Nor, RAW264.7
*IL18↓, *IL1β↓, *NLRP3↓, *Inflam↓,
3331- SIL,    The clinical anti-inflammatory effects and underlying mechanisms of silymarin
- Review, NA, NA
*Inflam↓, *NF-kB↓, *NLRP3↓, *COX2/PTGS2↓, *iNOS↓, *neuroP↑, *p‑ERK↓, *p38↓, *MAPK↓, *EGFR↓, *ROS↓, *lipid-P?, *5LO↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3324- SIL,    Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
*ROS↓, *TAC↑, *NF-kB↓, *IL2↓, *NRF2↑, *HO-1↑, *neuroP↑, *Inflam↓, *NLRP3↓,
2354- SK,    PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
- in-vivo, Sepsis, NA
PKM2↓, *PKM2↓, *IL1β↓, *IL18↓, *HMGB1↓, *Casp1↓, *NLRP3↓, *AIM2↓, *p‑eIF2α↓, *Sepsis↓,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
3419- TQ,    Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients
- in-vitro, BC, NA
*NLRP3↓, *IL1β↓, *Casp1?,
3418- TQ,    Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
- in-vitro, Melanoma, A375 - in-vivo, NA, NA
TumMeta↓, TumCMig↓, NLRP3↓, Casp1↓, IL1β↓, IL18↓, ROS↓, NF-kB↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
3125- VitC,    Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice
- in-vivo, Nor, NA
*Hear↑, *Inflam↓, *NLRP3↓,
3126- VitC,    Safety of High-Dose Vitamin C in Non-Intensive Care Hospitalized Patients with COVID-19: An Open-Label Clinical Study
- Study, NA, NA
*NLRP3↓, *ROS↓, *antiOx↑,
3127- VitC,    NLRP3_inflammasome_by_scavenging_mitochondrial_ROS">Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS
- in-vitro, Nor, NA - in-vivo, Nor, NA
*NLRP3↓, *AIM2↓, *mt-ROS↓, *IL1β↓,

Showing Research Papers: 101 to 124 of 124
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 124

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 6,   GSR↓, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 2,   NQO1↓, 1,   NRF2↓, 4,   NRF2↑, 1,   ROS↓, 6,   ROS↑, 18,   SOD↓, 2,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   mitResp↓, 1,   mtDam↑, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   ECAR↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   Glycolysis↝, 1,   GSK‐3β↑, 2,   HK2↓, 3,   lactateProd↓, 1,   LDHA↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 3,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↑, 18,   ASC↓, 1,   ASC↑, 2,   BAX↑, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   BNIP3↑, 1,   Casp↑, 2,   Casp1↓, 4,   cl‑Casp1↓, 1,   cl‑Casp1↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 4,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   DR5↑, 1,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   GSDMD↑, 3,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   necrosis↑, 1,   p‑p38↑, 1,   Perforin↝, 1,   PUMA↑, 1,   Pyro↑, 5,   survivin↓, 1,   XIAP↓, 4,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   p‑Akt↓, 2,   CIP2A↓, 1,   EGFR↓, 1,   EGFR↑, 1,   ERK↓, 2,   HCAR2↑, 1,   HGF/c-Met↓, 1,   IKKα↓, 2,   JAK2↓, 2,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MARK4↓, 1,   mTOR↓, 6,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↓, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT3↓, 9,   STAT3↑, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   miR-124-3p↓, 1,   miR-25-5p↓, 1,   other↝, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 2,   HSP27↓, 1,   HSP90↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↑, 3,   p62↓, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 2,   P53↑, 5,   PARP↑, 2,   cl‑PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 3,   CDK6↑, 1,   CHK1↓, 1,   Chk2↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 2,   E2Fs↑, 1,   GADD45A↑, 1,   Ki-67↓, 2,   P21↑, 3,   p27/CDKN1B↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 1,   Gli1↓, 1,   IGF-1?, 1,   Ki-67↓, 2,   NOTCH↓, 2,   NOTCH1↓, 1,   STAT1↑, 1,   TumCG↓, 7,   TumCP↓, 14,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AXL↓, 1,   Cdc42↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   EMT↓, 4,   FAK↓, 2,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   GIT1↓, 1,   ITGB1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP2↓, 3,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 2,   Rac1↓, 1,   Rho↓, 1,   Smad1↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 7,   TumCMig↓, 11,   TumMeta↓, 7,   TumMeta↑, 2,   TXNIP↑, 1,   Tyro3↓, 1,   uPAR↓, 1,   Vim↓, 1,   Vim↑, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 1,   Hif1a↓, 4,   VEGF↓, 11,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 2,   GLUT1↓, 1,   MMP↓, 4,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   cGAS–STING↑, 1,   COX2/PTGS2↓, 3,   CXCR4↓, 1,   FOXP3↑, 1,   HCAR2↑, 1,   ICAM-1↓, 2,   IL1↓, 1,   IL18↓, 2,   IL1β↓, 7,   IL2↑, 1,   IL6↓, 6,   IL6↑, 1,   Imm↑, 3,   Inflam↓, 5,   NF-kB↓, 8,   NK cell↑, 1,   NLRP3↓, 23,   NLRP3↑, 9,   p‑p65↓, 2,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 1,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 11,   CompStab?, 1,   CompStab↑, 1,   CYP1A1↓, 1,   DDS↑, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 3,   eff↝, 1,   Half-Life↝, 2,   MDR1↓, 1,   RadioS↑, 4,   selectivity↑, 4,   selectivity∅, 1,   Synergy↑, 7,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↓, 1,   CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   IL6↓, 6,   IL6↑, 1,   LDH↓, 4,   NSE↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cachexia↓, 1,   chemoP↑, 6,   chemoPv↑, 2,   hepatoP↑, 2,   neuroP↑, 2,   NP/CIPN↓, 1,   OS∅, 1,   PFS↑, 1,   PFS∅, 1,   QoL↑, 2,   radioP↑, 2,   RenoP↑, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 287

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 40,   ARE↑, 2,   Bil↑, 2,   Catalase↑, 18,   Fenton↓, 3,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↑, 9,   GPx1↑, 1,   GSH↑, 14,   GSR↑, 2,   GSTs↑, 2,   HNE↓, 2,   HO-1↑, 31,   Keap1↓, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 18,   MDA↓, 17,   MPO↓, 5,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 5,   NQO1↝, 1,   NRF2↑, 40,   RNS↓, 1,   ROS?, 1,   ROS↓, 65,   ROS↑, 3,   ROS↝, 1,   mt-ROS↓, 3,   SOD↑, 24,   SOD1↑, 3,   TAC↑, 2,   TBARS↓, 1,   TrxR↑, 1,   uricA↓, 2,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↑, 1,   MFN1↓, 1,   MFN2↓, 1,   mtDam↓, 5,   OPA1↓, 1,   PGC-1α↓, 1,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 3,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ALAT↓, 9,   AMPK↑, 17,   p‑AMPK↑, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   glucose↓, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   LDL↓, 4,   NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PKM2↓, 3,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 17,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   ASC?, 1,   ASC↓, 5,   ASK1↓, 1,   BAX↓, 3,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1?, 1,   Casp1↓, 11,   cl‑Casp1↓, 2,   proCasp1↓, 2,   Casp12↓, 1,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp3↓, 2,   Casp9↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   GSDMD?, 1,   GSDMD↓, 2,   iNOS↓, 15,   p38↓, 4,   p38↑, 1,   p‑p38↓, 1,   Pyro?, 1,   Pyro↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 6,   p‑Akt↑, 1,   CREB↑, 3,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IKKα↓, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 4,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 11,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 8,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   PI3K↑, 5,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 1,   STAT↓, 2,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 2,   cJun↓, 1,   FOXO↑, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↓, 1,   other↑, 1,   other↝, 5,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 2,   ER Stress↓, 6,   ER Stress↑, 1,   GRP78/BiP↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   IRE1↓, 2,   p‑PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   MitoP↑, 2,   p62↓, 2,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   cl‑PARP1↓, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 2,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 4,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 3,   Ca+2↑, 1,   Cartilage↑, 5,   COL1↓, 1,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 3,   MMP9↑, 1,   TGF-β↑, 1,   TGF-β1↓, 2,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 5,   TXNIP↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,   Hif1a↓, 1,   NO↓, 10,   VCAM-1↓, 4,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 12,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   IBI↑, 2,   MMP↓, 1,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   OCLN↓, 1,   TJ↓, 1,   TJ↑, 2,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIM2↓, 2,   CD25+↑, 1,   CD4+↑, 2,   cGAS–STING↓, 1,   COX2/PTGS2↓, 20,   DCells↑, 1,   FOXP3↑, 1,   HMGB1↓, 6,   ICAM-1↓, 5,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 5,   IL12↓, 1,   IL17↓, 2,   IL18↓, 7,   IL1β↓, 41,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 34,   IL8↓, 4,   Imm↑, 3,   Inflam?, 1,   Inflam↓, 70,   Inflam↑, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MIP2↓, 2,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 92,   NLRP3↑, 4,   NOD1↓, 1,   p65↓, 1,   PGE2↓, 10,   RAGE↓, 1,   RANTES↓, 1,   TLR3↓, 1,   TLR4↓, 11,   TLR4↑, 1,   TNF-α↓, 31,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 6,   BChE↓, 1,   BDNF↑, 11,   BrainVol↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 2,   NGF↑, 1,   PSD95↑, 1,   SNAP25↑, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 4,   Aβ↓, 22,   BACE/β-secretase↓, 6,   tau↓, 3,   p‑tau↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 17,   BioAv↝, 6,   CYP2E1↓, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   eff↑, 7,   GSTA1↑, 1,   Half-Life↝, 4,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   AST↓, 10,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   creat↓, 1,   CRP↓, 2,   EGFR↓, 1,   IL6↓, 34,   LDH↓, 1,   RAGE↓, 1,   SpO2↑, 1,   TMAO↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 5,   AntiCan↑, 4,   AntiDiabetic↑, 5,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 15,   chemoP↑, 1,   cognitive↓, 2,   cognitive↑, 18,   cough?, 1,   diuretic↑, 1,   Hear↑, 1,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 17,   motorD↑, 2,   neuroP↑, 36,   NP/CIPN↓, 1,   Obesity↓, 5,   OS↑, 3,   Pain↓, 2,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 7,   Risk↓, 3,   SoreThr?, 1,   Strength↑, 1,   Stroke↓, 5,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 6,   Weight↑, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 14,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 358

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3
11 Hydrogen Gas
9 Resveratrol
5 Luteolin
5 Quercetin
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
4 Thymoquinone
3 Silver-NanoParticles
3 Cucurbitacin
3 EGCG (Epigallocatechin Gallate)
3 Ferulic acid
3 Methylsulfonylmethane
3 Piperlongumine
3 Pterostilbene
3 Silymarin (Milk Thistle) silibinin
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Beta-Caryophyllene
2 Carnosic acid
2 Chlorogenic acid
2 Curcumin
2 Emodin
2 Isoliquiritigenin
2 isoorientin
2 isoquercitrin
2 Licochalcone A
2 Magnetic Fields
1 1,8-Cineole
1 2-DeoxyGlucose
1 Selenite (Sodium)
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Cannabidiol
1 Boron
1 Butyrate
1 Caffeic acid
1 Celastrol
1 chitosan
1 Choline
1 Crocetin
1 Fucoidan
1 Galloflavin
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 hydrogen sulfide
1 Hyperoside
1 Isobavachalcone
1 Licorice
1 Lycopene
1 Metformin
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Phenylbutyrate
1 Propolis -bee glue
1 Radiotherapy/Radiation
1 Selenium
1 doxorubicin
1 Selenium NanoParticles
1 Shikonin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:908  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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