AntiTum Cancer Research Results

AntiTum, AntiTumor: Click to Expand ⟱
Source:
Type:
AntiTumor


Scientific Papers found: Click to Expand⟱
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, Synergy↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5007- DSF,  Cu,    Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
- vitro+vivo, Oral, NA
AntiTum↑, TumCP↓, Ferroptosis↑, Iron↑, lipid-P↑, NRF2↓, HO-1↓,
5009- DSF,  Cu,    Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines
- vitro+vivo, lymphoma, NA
AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,
1037- EA,    Unripe Black Raspberry (Rubus coreanus Miquel) Extract and Its Constitute, Ellagic Acid Induces T Cell Activation and Antitumor Immunity by Blocking PD-1/PD-L1 Interaction
- in-vivo, CRC, NA
AntiTum↑, PD-L1↓,
3593- EGCG,    Epigallocatechin Gallate (EGCG)
- Review, AD, NA
AntiTum↑, *Inflam↓, *neuroP↑, *Aβ↓, *BioAv↝, cognitive↑,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6848- EVO,    Evodiamine: A Extremely Potential Drug Development Candidate of Alkaloids from Evodia rutaecarpa
- Review, Nor, NA
AntiTum↑, cardioP↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, BioAv↓, toxicity↑, NF-kB↓, MAPK↓, NOD1↓, p‑Akt↓, BAX↑, cl‑Casp3↑, γH2AX↑, cl‑PARP↑, ROS↑, BBB↑, neuroP↑, BioAv↑,
1112- FA,    Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA
tumCV↓, Apoptosis↑, AntiTum↑, TumMeta↓, EMT↓, TumVol↓, TumW↓,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6993- Form,  ISL,    Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell
- in-vitro, CRC, HCT116
AntiTum↑, TumCG↓, Apoptosis↑, Casp↑, Bcl-2↓, Bcl-xL↓,
7018- Fuc,    Absorption Study of Mozuku Fucoidan in Japanese Volunteers
- Trial, Nor, NA
*Dose↝, *BioAv↝, *eff↝, *Inflam↓, *AntiThr↑, angioG↓, *AntiViral↑, *AntiTum↑, *antiOx↓, *BioAv↝,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
7042- GA,    Gallic acid reduces cell growth by induction of apoptosis and reduction of IL-8 in HepG2 cells
- in-vitro, Liver, HepG2
*Inflam↓, *AntiTum↑, *antiOx↑, TumCP↓, IL8↓, IL10↑, IL12↑, Apoptosis↑,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
1969- GamB,    Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
AntiTum↑, TumCI↓, Apoptosis↑, ROS↑, Cyt‑c↑, Akt↓, mTOR↓, TumCG↓, TumMeta↓,
1954- GamB,    Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
- in-vitro, HCC, SMMC-7721 cell
AntiTum↑, TrxR↓, TrxR1↓, ROS↑, Apoptosis↑, Dose∅, Dose?,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7204- GAs,    The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba
- Review, Nor, NA
AntiTum↑, SUMO↓, antiNeop↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *toxicity↑, *ROS↑, *toxicity↝,
7117- Ge-132,    Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts
- in-vitro, Nor, NA
*IL6↓, *Apoptosis↓, *toxicity↓, Imm↑, IFN-γ↑, NK cell↑, AntiTum↑, Pain↓, *Wound Healing↑,
7126- Ge-132,    Immune activation of Bio-Germanium in a randomized, double-blind, placebo-controlled clinical trial with 130 human subjects: Therapeutic opportunities from new insights
- Trial, Nor, NA
AntiTum↑, AntiCan↑, *AntiAge↑, *AntiViral↑, *Inflam↓, *NK cell↑, *Imm↑, *TNF-α↑,
7124- Ge-132,    Physiological Activity of Trace Element Germanium including Anticancer Properties
- Review, Var, NA
*toxicity↓, Risk↓, Dose↝, AntiCan↑, AntiTum↑, Inflam↓, OXPHOS↝, *toxicity↓, *toxicity↓, other↑, Synergy↑, *Bacteria↓, *AntiFungal↑, eff↑, Synergy↑, ROS↑, Synergy↑, toxicity↝, *H2O2↓, *ROS↓, Warburg↓,
7096- Geld,    A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues
- Study, Var, NA
HSP90↓, AntiTum↑,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
7135- GI,    Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
- Trial, Nor, NA
*Dose↝, *Half-Life↝, *antiOx↑, *Inflam↓, *AntiTum↑, *Half-Life↓,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
2522- H2,    A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
- Review, Var, NA
chemoP↑, OS↑, QoL↑, TumVol↑, ROS↑, AntiTum↑, other↝,
3152- H2,  VitC,  Rad,    Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
AntiTum↑, OS↑, QoL↑, TumVol↓, radioP↑, Dose↑, Dose↝, Synergy↑,
4645- HT,    Hydroxytyrosol: Bioavailability, toxicity, and clinical applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, AntiTum↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↓,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,
7600- I3C,    Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection
- Review, Nor, NA
*ROS↓, *hepatoP↑, *AntiTum↑, *Imm↑, *Inflam↓,
7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
- in-vitro, Var, NA
2/16-OHE1↑, CYP1B1↓, 4-OHE1↓, Apoptosis↑, cycD1/CCND1↓, TumCCA↑, AntiTum↑,
7608- I3C,    Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
- in-vitro, Pca, PC3
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, Akt↓, EGF↓, PI3K↓, Bcl-xL↓, BAD↓,
7647- Ins,    Chemoprevention of pulmonary carcinogenesis by myo-inositol
- Review, Lung, NA
AntiTum↑,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7679- iod,    Molecular iodine impairs chemoresistance mechanisms, enhances doxorubicin retention and induces downregulation of the CD44+/CD24+ and E-cadherin+/vimentin+ subpopulations in MCF-7 cells resistant to low doses of doxorubicin
- in-vivo, BC, MCF7
AntiTum↑, tumCV↓, Apoptosis↑, Bax:Bcl2↑, Bcl-2↓, MDR1↑, PPARγ↑, CD44↓,
7653- IP,    Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel
- in-vivo, Var, NA
GutMicro↑, T-Cell↑, AntiTum↑, Synergy↑, TumCG↓,
7657- IP,    Dietary inulin suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young Fisher 344 rats
- in-vivo, Var, NA
Dose↝, AntiTum↑,
7658- IP,    Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition
- in-vivo, CRC, NA
AntiTum↑, GutMicro↑,
7667- IP,  H2,    Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption
- in-vitro, Var, NA
*AntiTum↑, *other↑, NA↝, *CD4+↑, *CD8+↑, TumCG↓, Imm↑,
7645- IP6,  Ins,    Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview
- in-vitro, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, Diff↑, p27/CDKN1B↓, pRB↓, PI3K↓, RAS↓, ERK↓, Akt↓, NF-kB↓, Inflam↓, AntiTum↓,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
1088- IP6,    Preventive Inositol Hexaphosphate Extracted from Rice Bran Inhibits Colorectal Cancer through Involvement of Wnt/β-Catenin and COX-2 Pathways
- in-vivo, CRC, NA
AntiTum↑, β-catenin/ZEB1↓, COX2/PTGS2↓,
7744- ISL,    Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway
- vitro+vivo, Thyroid, NA
AntiTum↑, TumCP↓, TumCMig↓, E-cadherin↑, N-cadherin↓, FASN↓, SREBP1/SREBF1↓, ATP↓, p‑AMPK↑, lipidLev↓, TumCG↓, lipoGen↓,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,

Showing Research Papers: 101 to 150 of 252
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Copper↓, 1,   GPx4↓, 4,   GSH↓, 5,   GSH↑, 1,   GSH/GSSG↓, 2,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 2,   Iron↑, 3,   Iron↝, 1,   Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 5,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 7,   NRF2↑, 6,   NRF2↝, 1,   ROS?, 2,   ROS↓, 6,   ROS↑, 79,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 2,   SOD↑, 2,   SOD1↓, 1,   Thiols↓, 1,   TKT↓, 1,   Trx↓, 2,   TrxR↓, 2,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 3,   EGF↓, 1,   HSP60/HSPD1↓, 1,   mtDam?, 1,   mtDam↑, 9,   OCR↓, 1,   OCR↑, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACADS/SCAD↓, 1,   p‑ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 1,   ALDOA↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 6,   CAIX/CA9↓, 1,   FASN↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 10,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HK2↓, 3,   HMG-CoA↓, 2,   lactateProd↓, 2,   LDHA↓, 1,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PDK3↓, 1,   PFKP?, 1,   PKM2↓, 2,   PPP↓, 2,   SCFAs↑, 1,   SIRT1↓, 1,   SREBP1/SREBF1↓, 2,   TCA↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 1,   Apoptosis↓, 3,   Apoptosis↑, 83,   BAD↓, 2,   BAD↑, 1,   Bak↓, 1,   BAX↑, 34,   Bax:Bcl2↑, 4,   Bcl-2↓, 44,   Bcl-xL↓, 7,   BIM↑, 1,   Casp↑, 11,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 31,   cl‑Casp3↑, 10,   proCasp3↑, 1,   Casp6↓, 1,   Casp7↑, 5,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 5,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 24,   cl‑Casp9↑, 4,   proCasp9↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   DR5↑, 2,   DR5↝, 1,   FADD↑, 1,   Fas↓, 1,   Fas↑, 3,   FasL↓, 1,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 5,   GSDME↑, 1,   IAP1↓, 1,   iNOS↓, 4,   Mcl-1↓, 4,   MDM2↓, 2,   MOMP↑, 1,   p38↓, 1,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 2,   pS2/TFF1↓, 1,   PUMA↓, 1,   Pyro↑, 1,   survivin↓, 6,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 10,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 31,   Akt↑, 4,   p‑Akt↓, 9,   CaMKII ↑, 1,   CREB↑, 1,   EGFR↓, 8,   ERK↓, 9,   ERK↑, 1,   p‑ERK↓, 5,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   p‑IKKα↓, 1,   JAK↓, 1,   JAK1↑, 1,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 4,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 11,   MAPK↑, 5,   p‑MAPK↓, 1,   mTOR↓, 18,   mTOR↑, 3,   p‑mTOR↓, 2,   PDGFRB↓, 1,   PI3K↓, 23,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 7,   e-Raf↓, 1,   RAS↓, 4,   Sp1/3/4↓, 2,   STAT3↓, 8,   STAT3↑, 1,   p‑STAT3↓, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↑, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↑, 1,   FOXO3↑, 1,   FOXO4↑, 1,   HDAC↓, 4,   HDAC1↓, 1,   HES1↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-182-5p↓, 1,   miR-19b↓, 1,   miR-21↓, 3,   miR-34a↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↓, 2,   other↑, 2,   other↝, 8,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 1,   SOX4↓, 1,   SUMO↓, 1,   TBX3↑, 1,   tumCV↓, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 2,   CHOP/DDIT3↝, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   ER Stress↑, 11,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 2,   HSPs↑, 1,   IRE1↑, 1,   NQO2↑, 1,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↓, 1,   p62↓, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 17,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 11,   DNArepair↓, 2,   hTERT/TERT↓, 1,   P53↓, 4,   P53↑, 16,   p‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↑, 5,   cl‑PARP↑, 16,   PCNA↓, 3,   PCNA↑, 1,   TOP1↓, 1,   γH2AX↑, 2,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 5,   CDK6↓, 1,   CDKN1C/p57↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 15,   cycE/CCNE↓, 3,   Ki-67↓, 10,   mitA↑, 1,   P21↑, 11,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 4,   pRB↓, 1,   RB1↑, 1,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 48,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   BMI1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CSCs↓, 8,   CSCs↑, 1,   Diff↑, 3,   FGF↓, 1,   GTPBP4↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   JAG1↓, 1,   Ki-67↓, 10,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↓, 4,   NOTCH3↓, 1,   Piezo1↑, 1,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 43,   TumCG↑, 1,   TumCP↓, 45,   TumCP↑, 2,   TumCP⇅, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   APC↑, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↑, 8,   Ca+2↝, 2,   i-Ca+2↑, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 16,   EMT↓, 20,   EMT↑, 1,   FAK↓, 3,   p‑FAK↓, 1,   LEF1↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 24,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 26,   MMP9↑, 1,   MMPs↓, 5,   MUC1↑, 1,   N-cadherin↓, 10,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   Rho↓, 1,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 1,   Smad1↑, 1,   SMAD4↓, 1,   Snail↓, 5,   TGF-β↓, 2,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↑, 3,   TumCI?, 1,   TumCI↓, 30,   TumCMig↓, 29,   TumMeta↓, 29,   TumMeta↑, 2,   Twist↓, 1,   uPA↓, 5,   uPAR↓, 1,   Vim↓, 11,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 24,   CD31/PECAM-1↓, 4,   HIF-1↓, 2,   Hif1a↓, 7,   HIF2a↓, 1,   VCAM-1↓, 1,   VEGF↓, 17,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CTR1↑, 1,   EPR↑, 4,   GLUT1↓, 1,   IBI↑, 1,   MMP↓, 30,   MMP↑, 1,   MPT↑, 1,   TJ↑, 1,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 3,   CD8+↑, 5,   COX2/PTGS2↓, 12,   COX2/PTGS2↑, 1,   DCells↑, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↑, 2,   IL1↓, 1,   IL10↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL1β↑, 2,   IL2↓, 1,   IL6↓, 7,   IL8↓, 3,   IL8↑, 1,   Imm↑, 13,   Imm↝, 1,   Inflam↓, 16,   IRAK1↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NAF1↓, 1,   Neut↓, 1,   NF-kB↓, 29,   NK cell↑, 3,   NOD1↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-1↝, 1,   PD-L1↓, 3,   PGE2↓, 3,   PSA↓, 1,   SOCS-3↓, 1,   T-Cell↑, 2,   TLR4↓, 2,   TNF-α↓, 5,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   TAMS↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   AhR↓, 1,   AR↝, 1,   ER-α36↓, 1,   FGF21↓, 1,   PPARγ↑, 3,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioAv↝, 2,   chemoR↓, 1,   ChemoSen↑, 49,   ChemoSen⇅, 1,   CYP1A1↑, 1,   CYP1B1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 30,   Dose∅, 1,   eff↓, 13,   eff↑, 38,   eff↝, 3,   GSTA1↑, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 3,   MDR1↑, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 7,   P450↓, 1,   RadioS↑, 14,   selectivity↓, 1,   selectivity↑, 28,   Synergy↑, 30,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↝, 1,   AST↓, 1,   CIT↓, 1,   CRP↓, 1,   EGFR↓, 8,   EZH2↓, 1,   Ferritin↑, 1,   FOXM1↓, 1,   hTERT/TERT↓, 1,   IL6↓, 7,   LDH↓, 1,   LDH↑, 1,   e-LDH↑, 1,   Myc↓, 1,   NLR↓, 1,   PD-L1↓, 3,   PSA↓, 1,   TG/TAG↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↓, 8,   AntiTum↑, 204,   AntiTum⇅, 1,   AntiTum↝, 1,   AntiTum∅, 1,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 14,   chemoPv↑, 4,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 3,   hepatoP↝, 1,   neuroP↑, 3,   OS↑, 16,   Pain↓, 2,   QoL↑, 4,   radioP↑, 6,   RenoP↑, 3,   Risk↓, 8,   toxicity↓, 7,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 3,   TumNum↓, 1,   TumVol↓, 8,   TumVol↑, 1,   TumW↓, 5,   Weight↓, 1,   Weight↑, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 9,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 537

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 55,   Catalase↑, 6,   GPx↑, 8,   GPx4↑, 1,   GSH↑, 6,   GSTs↑, 4,   H2O2↓, 2,   HDL↑, 3,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 8,   hyperG↓, 1,   Keap1↓, 1,   lipid-P↓, 9,   MDA↓, 5,   MPO↓, 3,   NADH↓, 1,   NOX4↓, 2,   NQO1↑, 3,   NQO1↝, 1,   NRF2↑, 17,   RNS↓, 1,   ROS↓, 32,   ROS↑, 1,   ROS∅, 2,   selenoP↑, 2,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 2,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 2,   AMPK↑, 2,   ATP↑, 1,   FFA/NEFA↓, 1,   glucose↓, 4,   glucose↝, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HMG-CoA↓, 1,   LDL↓, 4,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5,   Casp12↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,   STAT3↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   HOTAIR↑, 1,   miR-34a↓, 1,   other?, 1,   other↓, 3,   other↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   ER Stress↓, 3,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   PROK2↑, 1,   TIMP1↓, 1,   TumMeta↓, 1,   α-SMA↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   p‑eNOS↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 4,   P-sel↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 3,   GLUT2↑, 1,   IBI↑, 2,   MMP↑, 2,   OCLN↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 4,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 6,   IL6↓, 5,   Imm↑, 13,   Inflam↓, 66,   Inflam↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   NK cell↑, 2,   NLRP3↓, 2,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 8,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 5,   BChE↓, 1,   BDNF↑, 1,   proBDNF↑, 1,   GABA↑, 1,   GABA↝, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 2,   PPARγ↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 12,   BioAv↝, 12,   BioEnh↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↝, 4,   eff↑, 4,   eff↝, 2,   Half-Life↓, 4,   Half-Life↝, 3,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 2,   BP↝, 1,   CRP↓, 1,   IL6↓, 5,   LDH↓, 2,   NOS2↓, 1,   TC↓, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 2,   AntiCan↑, 3,   antiD↑, 1,   AntiDiabetic↑, 16,   AntiTum↓, 2,   AntiTum↑, 36,   ANXi↓, 1,   cardioP↑, 19,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   diuretic↑, 2,   hepatoP↑, 17,   Learn↑, 1,   memory↑, 3,   Mood↑, 1,   neuroP↑, 23,   Obesity↓, 5,   QoL↓, 1,   radioP↑, 3,   RenoP↑, 5,   Risk↓, 1,   Sleep↑, 1,   Stroke↓, 5,   toxicity↓, 23,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 8,   Bacteria↓, 20,   GutMicro↑, 9,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 7,  
Total Targets: 210

Scientific Paper Hit Count for: AntiTum, AntiTumor
7 Licochalcone A
6 chitosan
6 Selenite (Sodium)
5 Silver-NanoParticles
5 Astaxanthin
5 immunotherapy
5 Isoliquiritigenin
5 Hydrogen Gas
5 Kaempferol
4 Radiotherapy/Radiation
4 Chlorogenic acid
4 Indole-3-carbinol
4 Inulin Prebiotic
4 Ivermectin
4 Matrine
4 Quercetin
4 Resveratrol
4 Selenium NanoParticles
3 Astragalus
3 Ashwagandha(Withaferin A)
3 Melatonin
3 beta-glucans
3 Betulinic acid
3 Benzyl isothiocyanate
3 Brucea javanica
3 brusatol
3 Capsaicin
3 Copper and Cu NanoParticles
3 Chlorella (Chlorella vulgaris)
3 Diindolylmethane
3 Disulfiram
3 Gallic acid
3 Gambogic Acid
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Vitamin C (Ascorbic Acid)
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 Spermidine
2 1,8-Cineole
2 Auranofin
2 Cisplatin
2 Allicin (mainly Garlic)
2 Artemisinin
2 Atorvastatin
2 Aloe anthraquinones
2 Baicalein
2 Berberine
2 Bifidobacterium
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Camu camu
2 Chlorophyllin
2 Gemcitabine (Gemzar)
2 Cucurbitacin
2 Curcumin
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Formononetin
2 Fucoidan
2 Paclitaxel/Taxol
2 iodine
2 Licorice
2 Magnolol
2 mebendazole
2 Naringin
2 Phycocyanin
2 Psoralidin
2 α-Santalol/Sandalwood oil
2 Shikonin
2 Thymol-Thymus vulgaris
1 3-bromopyruvate
1 acetazolamide
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 probiotics
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 Caffeine
1 Carnosine
1 Cannabidiol
1 Celastrol
1 Prebiotic
1 Choline
1 Cinnamon
1 Carica papaya leaf extract
1 Camptothecin
1 Crocetin
1 Carvone
1 Vitamin B1/Thiamine
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Cynaropicrin
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 Bortezomib
1 Dipyridamole
1 Dandelion Root
1 Ellagic acid
1 Evodiamine
1 Ferulic acid
1 Ginkgolic acids
1 Geldanamycin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 HydroxyTyrosol
1 Hyperoside
1 capecitabine
1 Isorhamnetin
1 Lactobacillus
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Luteolin
1 Methylene blue
1 Honokiol
1 Mung Bean Sprouts
1 Modified Citrus Pectin
1 MCT oil
1 Magnetic Fields
1 Moringin
1 Moringa oleifera
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Oxygen, Hyperbaric
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Piperlongumine
1 Polyphenols
1 Pterostilbene
1 Radio Frequency
1 Rutin
1 salinomycin
1 Selenium
1 Chemotherapy
1 Sulforaphane (mainly Broccoli)
1 erastin
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 tetrathiomolybdate
1 Turmerones
1 Urolithin
1 Vitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:913  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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