EGFR Cancer Research Results

EGFR, Epidermal Growth Factor Receptor: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-Driver
Type: Oncogene
EGFR (Epidermal growth factor receptor), which belongs to the tyrosine kinase receptor family (RTKs)
Epidermal Growth Factor Receptor (EGFR) is a cell surface protein that plays a crucial role in the regulation of cell growth, survival, proliferation, and differentiation. It is part of the ErbB family of receptors and is activated by binding to its ligands, such as epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α).

-plays a crucial role in regulating cell growth and division.

Many cancers exhibit overexpression of EGFR, which can lead to enhanced signaling and contribute to tumor growth and survival. This overexpression is often associated with aggressive tumor behavior and poor prognosis.
Scientific Papers found: Click to Expand⟱
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2897- HNK,    Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, A549
TumCP↓, Apoptosis↑, EGFR↓, PI3K↓, Akt↓, STAT3↓, TumCI↓, TNF-α↑, NF-kB↓, VEGF↓, MMP9↓, COX2/PTGS2↓,
1153- HNK,    Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, Bcl-2↓, EGFR↓, CD133↓, Nestin↓, Akt↓, ERK↓, Casp3↑, p‑STAT3↓, TumCG↓,
7527- HT,    Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
EGFR↓, TumCP↓, TumCG↓,
7548- HYP,    Mechanistic evaluation of hyperoside against non-small cell lung cancer: a combined approach of network pharmacology and in vitro experimental validation
- in-vitro, NSCLC, A549
MMP9↓, cl‑Casp3↑, MAPK↑, EGFR↓, TumCP↓, p38↑, Apoptosis↑, BAX↑, ERK↓, FOXO1↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
7999- itraC,    Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
- vitro+vivo, ESCC, NA
AMPK↑, EGFR↓, PDGFRA↓, PDGFRB↓, Akt↓, TumCG↓,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
9008- L-THE,    Theanine and cancer: A systematic review of the literature
- Review, Var, NA
EGFR↓, VEGFR1↓, MET↓, Akt↓, mTOR↓, JAK2↓, STAT3↓, TumMeta↓, TumCMig↓, TumCI↓, TumCP↓,
8174- Lap,    Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases
- in-vitro, Var, NA
EGFR↓, HER2/EBBR2↓, BioAv↝, Synergy↑, Dose↝,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
1787- LE,    Licorice and cancer
- Review, Var, NA
Inflam↓, AntiCan↓, DNAdam↓, LOX1↓, COX2/PTGS2↓, PKCδ↓, EGFR↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8415- Lyco,  CUR,    Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation
- in-vivo, BPH, NA
*Dose↝, *Synergy↑, *Ki-67↓, *testos↓, *DHT↓, *PSA↓, *IL1β↓, *IL6↓, *AKT1↓, *TNF-α↓, *EGFR↓, *STAT3↓, *COX2/PTGS2↓,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
8524- MAG,    Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
Apoptosis↑, Akt?, BAD↑, Cyt‑c↑, cl‑Casp8↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, NA⇅, selectivity↑, p‑EGFR↓, p‑PI3K↓, p‑Akt↓,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8640- MBZ,  GB,    Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231
Synergy↑, tumCV↓, EGFR↓, RCC1↓, MMP2↓, STAT4↓, IL6↓, IL1β↓, TNF-α↑, IFN-γ↓,
3466- MF,    The effect of magnetic fields on tumor occurrence and progression: Recent advances
- Review, Var, NA
angioG↓, ROS↝, EGFR↝, TumCG↓,
518- MF,    Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferation
- in-vitro, Var, HCT116
EGFR↓, p‑TumCP↓,
8911- MO,    Anticancer Potential of Moringa Oleifera in Lung Cancer: A Mini Review of In vitro and In vivo Evidence
- Review, Lung, NA
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp↑, NF-kB↓, EGFR↓, STAT3↓, VEGF↓, eff↑, CD4+↑, CD8+↑,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
6491- Nimb,    Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
- Review, PC, NA
eff↑, uPA↓, uPAR↓, p‑EGFR↓, VEGFR1↓, NF-kB↓, IKKα↓, MMP2↓, MMP9↓, TIMP2↑, TumCP↓, IGFR↓, Akt↓, ERK↓, TumCCA↓, BAX↑, BAD↑, FasL⇅, Cyt‑c↑, EPR↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2940- PL,    Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors
- in-vitro, PC, PANC1 - in-vitro, Lung, A549 - in-vitro, Kidney, 786-O - in-vitro, BC, SkBr3
ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
9113- PRO,    Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers
- Review, Var, NA
ADRB2↓, Risk↓, other⇅, TumMeta↓, Inflam↓, angioG↓, EGFR↓, COX2/PTGS2↓, VEGF↓, Hypoxia↓, BloodF⇅, RadioS↑, PD-1↓, Synergy↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3603- QC,    Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
- Review, AD, NA - Review, Diabetic, NA
*MAPK↓, *neuroP↑, *ROS↓, *Akt↓, *PI3K↓, *IL6↓, *TNF-α↓, *VEGF↓, *EGFR↓, *Casp3↓, *Bcl-2↓, *IL1β↓,
62- QC,  GoldNP,    Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
EGFR↓, PI3k/Akt/mTOR↓, GSK‐3β↓, TumCP↓, Apoptosis↑, tumCV↓, mTOR↓, PTEN↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
95- QC,    EGFR_signaling_pathway">Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
85- QC,    Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)
- in-vitro, Pca, PC3
uPA↓, uPAR↓, EGFR↓, NRAS↓, Jun↓, NF-kB↓, β-catenin/ZEB1↓, p38↑, MAPK↑, cJun↓, cFos↓, Raf↓, TumCI↓, TumCMig↓,
80- QC,    Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway
- in-vitro, Pca, PC3
Vim↓, ERK↓, Snail↓, Slug↓, Twist↓, EGFR↓, p‑Akt↓, EGFR↓, N-cadherin↓, TumMeta↓, EMT↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
angioG↓, VEGF↓, EGFR↓, FGF↑, TumCMig↓, TumCI↓, TIMP1↑, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, PI3K↓, Akt↓, MAPK↓, EMT↓, AR↓,
3016- RosA,    Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling
- in-vitro, HNSCC, UM-SCC-6 - in-vitro, HNSCC, UM-SCC-10B
chemoP↓, EGF↓, tumCV↓, TumCMig↓, ROS↓, PI3K↓, Akt↓, ERK↓, antiOx↑, p‑EGFR↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,

Showing Research Papers: 101 to 150 of 167
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 167

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 3,   GSTs↝, 1,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 8,   HO-2↓, 1,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 11,   NRF2↑, 11,   NRF2↝, 1,   ROS↓, 11,   ROS↑, 64,   ROS⇅, 1,   ROS↝, 3,   mt-ROS↑, 2,   SOD↓, 2,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 5,   compI↓, 1,   compIII↓, 1,   EGF↓, 5,   EGF↑, 1,   ETC↓, 1,   mitResp↓, 1,   Mortalin↓, 1,   mtDam↑, 4,   OCR↓, 4,   mt-OXPHOS↓, 1,   PDH↑, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 2,   p‑ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 11,   AMPK↝, 1,   ATP↓, 8,   ECAR↓, 1,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 4,   FDG↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 6,   Glycolysis↓, 15,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 12,   HMG-CoA↓, 1,   lactateProd↓, 7,   LDHA↓, 2,   LDL↓, 1,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PKM2↓, 4,   Pyruv↓, 1,   SIRT1↓, 6,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis↓, 2,   Apoptosis↑, 59,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 6,   Bak↓, 1,   Bak↑, 1,   BAX↑, 35,   BAX⇅, 1,   BAX↝, 2,   Bax:Bcl2↑, 12,   Bcl-2↓, 32,   Bcl-2↑, 1,   Bcl-2↝, 2,   Bcl-xL↓, 7,   Bcl-xL↝, 1,   BID↑, 3,   BIM↑, 4,   BNIP3↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp3↓, 2,   Casp3↑, 43,   Casp3↝, 2,   cl‑Casp3↑, 7,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 2,   Casp8↑, 15,   Casp8∅, 1,   cl‑Casp8↑, 3,   Casp9↑, 28,   p‑Casp9↑, 1,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 37,   Cyt‑c↝, 2,   Diablo↑, 6,   DR5↑, 14,   FADD↑, 2,   Fas↓, 1,   Fas↑, 10,   FasL↑, 6,   FasL⇅, 1,   Ferroptosis↑, 2,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 6,   Mcl-1↓, 12,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 2,   Necroptosis↑, 2,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 4,   p38↑, 7,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 1,   RIP3↑, 1,   survivin↓, 20,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 3,   XIAP↓, 12,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 64,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 21,   AKT1↓, 5,   Akt2↓, 1,   CK2↓, 3,   cMET↓, 4,   p‑cMET↑, 2,   cSrc↓, 1,   EGFR↓, 152,   EGFR↑, 2,   EGFR↝, 2,   p‑EGFR↓, 10,   ERK↓, 38,   ERK↑, 3,   p‑ERK↓, 9,   p‑ERK↑, 1,   p‑ERK⇅, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 16,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   IGFR↓, 4,   IKKα↓, 5,   IR↓, 1,   IκB↓, 1,   JAK↓, 4,   JAK1↓, 4,   JAK2↓, 8,   p‑JAK2↓, 1,   JNK↓, 3,   JNK↑, 7,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 5,   MEK↓, 5,   MKK4↓, 1,   mTOR↓, 38,   mTOR↝, 2,   p‑mTOR↓, 6,   mTORC2↓, 2,   mTORC2↑, 1,   NRAS↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   PAK↓, 1,   PDGFR-BB↓, 1,   PDGFR-BB↑, 1,   PDGFRA↓, 2,   PDGFRB↓, 1,   PI3K↓, 48,   PI3K↝, 1,   p‑PI3K↓, 4,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PIK3CA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 12,   PTEN↝, 1,   Raf↓, 6,   RAS↓, 6,   RAS↑, 1,   RCC1↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RPS6KA1↓, 1,   RTK-RAS↓, 1,   S6K↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 11,   Src↓, 1,   Src↑, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 31,   p‑STAT3↓, 11,   STAT4↓, 2,   STAT5↓, 3,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 3,   cJun↓, 7,   cMyc↓, 17,   DNMT1↓, 3,   DNMTs↓, 2,   EZH2↓, 4,   FOXM1↓, 4,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   H3↓, 1,   ac‑H3↑, 1,   H3K9↓, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 9,   HDAC1↓, 2,   HDAC6↓, 1,   miR-133a-3p↑, 1,   miR-155↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   MTA2↓, 2,   Myc↓, 3,   MYCN↑, 1,   n-MYC↓, 1,   OCT4↓, 4,   OLIG2↓, 1,   other↓, 1,   other⇅, 1,   other↝, 9,   SOX2↓, 5,   SOX4↓, 2,   SOX9↓, 1,   SUV39H↓, 2,   TCF-4↓, 1,   tumCV↓, 20,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 12,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↝, 1,   HSP90↓, 10,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   p62↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 11,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA2↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 18,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 40,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 8,   PARP↝, 1,   cl‑PARP↑, 22,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 9,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 4,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 8,   CDK2↓, 18,   CDK2↑, 1,   CDK4↓, 21,   CDK4/6↓, 1,   CDK6↓, 7,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 36,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 2,   cycE/CCNE↓, 11,   cycE1↓, 1,   E2Fs↓, 2,   GADD45A↓, 1,   Ki-67↓, 14,   mitA↑, 1,   p19↑, 1,   P21↓, 2,   P21↑, 28,   P21↝, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 11,   pRB↑, 1,   p‑pRB↓, 4,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 2,   TumCCA?, 2,   TumCCA↓, 2,   TumCCA↑, 61,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 1,   BMP2↓, 1,   BMPs↑, 2,   CD133↓, 6,   CD133↑, 1,   CD34↓, 1,   cFos↓, 8,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 15,   Diff↓, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli1↓, 4,   HH↓, 1,   IGF-1↓, 7,   p‑IGF-1↓, 1,   IGFBP3↑, 3,   Jun↓, 1,   Ki-67↓, 14,   Let-7↓, 1,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 8,   NOTCH1↓, 7,   NOTCH1↑, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 5,   Smo↓, 3,   STAT1↓, 2,   TumCG↓, 33,   TumCP↓, 44,   p‑TumCP↓, 1,   Wnt↓, 25,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 7,   AP-1↝, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 10,   Ca+2↝, 2,   cal2↑, 1,   Cdc42↓, 2,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 32,   F-actin↓, 1,   FAK↓, 9,   p‑FAK↓, 1,   Fibronectin↓, 3,   GLI2↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MET↓, 4,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 5,   MMP13↓, 1,   MMP17↓, 1,   MMP2↓, 33,   MMP2↝, 1,   MMP3↓, 5,   MMP7↓, 6,   MMP9↓, 37,   MMPs↓, 15,   MUC1↑, 1,   N-cadherin↓, 13,   NCAM↑, 1,   p44↓, 1,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 2,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 7,   Smad1↓, 1,   SMAD3↓, 1,   Snail↓, 16,   TET1↑, 1,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↑, 2,   TIMP2↑, 6,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 1,   TumCI↓, 36,   TumCMig↓, 29,   TumMeta↓, 29,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 4,   Vim↓, 16,   Vim↑, 1,   Zeb1↓, 7,   α-SMA↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 22,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 31,   CD31/PECAM-1↓, 3,   ECM/TCF↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 30,   Hypoxia↓, 1,   LOX1↓, 2,   NO↓, 3,   NO↑, 2,   NO↝, 1,   VEGF↓, 51,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 9,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   CLDN1↓, 2,   CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 5,   GLUT4↓, 2,   MMP↓, 29,   MMP↑, 1,   NHE1↓, 2,   TRPM7↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 5,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 41,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 3,   FOXP3↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IL1↓, 6,   IL10↓, 3,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 1,   IL5↓, 1,   IL6↓, 16,   IL6↝, 1,   IL8↓, 5,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 12,   IRAK1↓, 2,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 71,   NF-kB↑, 2,   NF-kB↝, 1,   NLRP3↓, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-1↝, 1,   PD-L1↓, 6,   PGE2↓, 14,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 1,   T-Cell↑, 1,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 2,   TNF-α↓, 14,   TNF-α↑, 2,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AhR↓, 1,   AhR↓, 1,   AR↓, 7,   AR↝, 1,   ER(estro)↓, 1,   FGF21↓, 2,   PPARα↓, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↑, 1,   RANKL↓, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 9,   BioAv↑, 8,   BioAv↝, 7,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↑, 44,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 15,   Dose∅, 2,   eff?, 1,   eff↓, 8,   eff↑, 20,   eff↝, 6,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 4,   P-gp/ABCB1↓, 5,   P450↓, 5,   P450↝, 1,   RadioS↑, 19,   selectivity?, 1,   selectivity↑, 17,   selectivity↝, 1,   Synergy↓, 1,   Synergy↑, 36,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 7,   AR↝, 1,   BloodF⇅, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CEA↓, 2,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 152,   EGFR↑, 2,   EGFR↝, 2,   p‑EGFR↓, 10,   EZH2↓, 4,   FOXM1↓, 4,   HER2/EBBR2↓, 16,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 16,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 13,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 5,   chemoP↓, 1,   chemoP↑, 8,   chemoPv↑, 8,   hepatoP↑, 2,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 5,   QoL↑, 4,   RenoP↑, 2,   Risk↓, 6,   toxicity↓, 4,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 3,   TumW↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 1,  
Total Targets: 738

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↑, 23,   Catalase↑, 12,   GPx↑, 6,   GPx1↑, 1,   GSH↑, 11,   GSR↑, 2,   GSTs↑, 4,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 9,   MDA↓, 3,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 11,   ROS↓, 26,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 10,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

HSP60/HSPD1↓, 1,   Insulin↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 2,   AMPK↑, 1,   ATP↑, 2,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   LDL↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 5,   Cyt‑c↓, 1,   iNOS↓, 5,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   AKT1↓, 1,   Akt2↓, 1,   p‑CREB↑, 1,   EGFR↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   IKKα↓, 1,   IKKα↑, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 2,   PI3K↓, 2,   PI3K↑, 3,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   MLC2/MYL9↝, 1,   MMP13↓, 1,   p‑Rac1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 3,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 3,   MUC5AC↓, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX2/PTGS2↓, 8,   COX2/PTGS2↑, 1,   IL10↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 6,   IL6↓, 8,   IL6↑, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 25,   pol-M2 MC↑, 1,   NF-kB↓, 8,   NLRP3↓, 2,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 6,   BChE↓, 2,   BDNF↑, 1,   ChAT↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   DHT↓, 1,   Estro↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 12,   BioAv↝, 5,   BioEnh↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↝, 4,   eff↑, 2,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 2,   AST↓, 4,   BMD↑, 1,   creat↓, 1,   CRP↓, 2,   EGFR↓, 3,   hs-CRP↓, 1,   IL6↓, 8,   IL6↑, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 4,   AntiDiabetic↑, 4,   antiPs↑, 1,   cardioP↓, 1,   cardioP↑, 9,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 8,   memory↑, 5,   motorD↑, 2,   Mucositis↓, 1,   neuroP↑, 25,   Obesity↓, 4,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   Stroke↓, 3,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 5,   GutMicro↑, 8,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 195

Scientific Paper Hit Count for: EGFR, Epidermal Growth Factor Receptor
14 Fisetin
12 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Honokiol
6 Shikonin
5 Silymarin (Milk Thistle) silibinin
4 almonertinib
4 Berberine
4 Sulforaphane (mainly Broccoli)
4 Resveratrol
3 Artemisinin
3 Bufalin/Huachansu
3 brusatol
3 gefitinib, erlotinib
3 Diindolylmethane
3 Gallic acid
3 Luteolin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Betulinic acid
2 Brucea javanica
2 cetuximab
2 chaetocin
2 Docetaxel
2 Ursolic acid
2 Formononetin
2 Flaxseed/Linseed
2 Graviola
2 Phenethyl isothiocyanate
2 Licochalcone A
2 Lycopene
2 Magnetic Fields
2 Nimbolide
2 Piperlongumine
1 Astragalus
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Aloe anthraquinones
1 Biochanin A
1 Chemotherapy
1 Boron
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 Chrysin
1 Crocetin
1 Photodynamic Therapy
1 Radiotherapy/Radiation
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Indole-3-carbinol
1 Dandelion Root
1 Ellagic acid
1 Piperine
1 Evodiamine
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 HydroxyTyrosol
1 Hyperoside
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 itraconazole
1 Kaempferol
1 L-Theanine
1 Lapatinib
1 Licorice
1 Magnolol
1 Matrine
1 mebendazole
1 Moringa oleifera
1 Morin
1 doxorubicin
1 Myricetin
1 Naringin
1 Niclosamide (Niclocide)
1 Propranolol
1 Gold NanoParticles
1 Rosmarinic acid
1 Gemcitabine (Gemzar)
1 statins
1 Citric Acid
1 Thymoquinone
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:94  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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