IL1β Cancer Research Results

IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2/PTGS2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
6752- DHA,    A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease
- Trial, BC, NA
TNF-α∅, IL1β∅, COX2/PTGS2∅,
6721- DHCA,    Dihydrocaffeic Acid—Is It the Less Known but Equally Valuable Phenolic Acid?
- Review, Nor, NA
*ROS↓, *Inflam↓, *eff↑, *other↝, *IL1β↓, *IL8↓, *TNF-α↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6329- DRE,  VitA,RetA,    Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MMP9↓, IL1β↓, P53↑, KAI1/CD82↑, eff↑,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, eff↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6792- EPA,    Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico
- Trial, HNSCC, NA
Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, QoL↑,
6382- Eug,    Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells
- in-vitro, Cerv, NA
ChemoSen↑, eff↓, Bcl-2↓, COX2/PTGS2↓, IL1β↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6333- Eug,  Cisplatin,  Rad,    Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation
- in-vitro, Cerv, HeLa
TumCP↓, LDH↝, ChemoSen↑, RadioS↑, Casp3↑, BAX↑, Cyt‑c↑, Casp9↑, Bcl-2↓, COX2/PTGS2↓, IL1β↓, ROS↑, NF-kB↓, COX2/PTGS2↓, TumCCA↓, Thiols↓, GSH↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3715- FA,  CUR,  PS,    The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice
- in-vivo, AD, NA
*cognitive↑, *IL1β↓, *Ach↑, *Aβ↓, *p‑tau↓, *BDNF↑, *APP↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
6886- FA,  MTX,    Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *p65↓, *BAX↓, *Casp3↓, *NRF2↑, *HO-1↑, *PPARγ↑, *Inflam↓,
6954- FA,    Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism
- Trial, AD, NA
*Inflam↓, *Aβ↓, *IL1β↓, *IL6↓, *TNF-α↓, *tau↓, *GABA↑, *5HT↑, *Ach↑, *Albumin↑, *HemoG↑, *neuroP↑, *Hcy/homoC↓,
6857- FBZ,    Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway
- vitro+vivo, BC, NA
tumCV↓, Pyro↑, cl‑Casp3↑, GSDME↑, IL1β↑, Glycolysis↓, HK2↓, TumVol↓, TumW↓, toxicity↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2862- FIS,    Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rat
- in-vivo, Diabetic, NA
*BG↓, *NF-kB↓, *IL1β↓, *NO↓, *Insulin↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6988- Form,    Formononetin ameliorates high glucose‑induced endothelial dysfunction by inhibiting the JAK/STAT signaling pathway
- in-vitro, Nor, HUVECs
*JAK2↓, *Casp3↑, *Inflam↓, *IL1β↓, *ICAM-1↓, *AntiDiabetic↑,
6995- Form,    Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia
- Review, Nor, BV2
*TNF-α↓, *IL6↓, *IL1β↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *neuroP↑, *Inflam↓,
7021- Fuc,    Fucoidan Prevents the Progression of Osteoarthritis in Rats
- in-vivo, Arthritis, NA
*Dose↝, *Cartilage↑, *TNF-α↓, *IL1β↓, *MMP1↓,
7003- Fuc,  Chemo,    An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients
IL1β↓, TNF-α↓, Inflam↓,
7035- GA,    Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
- in-vitro, IBD, Caco-2
*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,
7040- GA,    Effects of gallic acid on acrylamide-induced endoplasmic reticulum stress, neuroinflammation and neuronal apoptosis in rats
- Trial, AD, NA
*SOD↑, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TNF-α↓, *IL1β↓, *BAX↓, *Casp3↓, *BDNF↑, *NRF2↑, *HO-1↑,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
7052- Gallo,    Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment
- in-vivo, Colon, SW48
TumCMig↓, TumCI↓, NLRP3↓, LDH↓, Inflam↓, IL6↓, TNF-α↓, IL1β↓,
3723- GBE,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3772- H2,    Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *Inflam↓, *ROS↓, *GutMicro↑, *TNF-α↓, *IL6↓, *IL1β↓, *IL10↓, *Catalase↑, *GSH↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,

Showing Research Papers: 101 to 150 of 297
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 297

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD47↓, 1,   CXCR3↓, 1,   KAI1/CD82↑, 1,   miR-124-3p↓, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GSH↓, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 5,   SOD↑, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   LDH↑, 2,   LDH↝, 1,   SCD1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 4,   BAX↑, 3,   Bcl-2↓, 3,   Casp↝, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   DR4↑, 1,   DR5↑, 1,   GSDME↑, 1,   IAP2/BIRC3↓, 1,   Mcl-1↓, 2,   Pyro↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   P53↑, 4,   P53↝, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   Diff↑, 1,   EP2↓, 1,   ERK↓, 2,   GSK‐3β↑, 1,   HDAC1↓, 1,   HRAS↓, 1,   NOTCH↓, 1,   PI3K↓, 2,   STAT3↓, 2,   TumCG↓, 1,   TumCG↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↓, 1,   Ca+2↑, 1,   CEA↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MMP2↓, 3,   MMP9↓, 2,   MMP9↑, 1,   MMPs↓, 2,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 6,   TumMeta↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↑, 1,   EGFR↓, 1,   Hif1a↓, 3,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   COX2/PTGS2∅, 1,   HMGB1↓, 1,   IL1β↓, 9,   IL1β↑, 4,   IL1β∅, 1,   IL6↓, 3,   IL8↑, 1,   Inflam↓, 3,   NF-kB↓, 7,   NK cell↑, 1,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 4,   TNF-α↑, 3,   TNF-α∅, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 2,   ChemoSen↑, 7,   Dose↝, 5,   eff↓, 1,   eff↑, 5,   eff∅, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

CA125↓, 1,   CEA↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 1,   EZH2↓, 1,   GutMicro↑, 1,   IL6↓, 3,   Ki-67↓, 2,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 2,   LDH↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   chemoP↑, 3,   cognitive↑, 1,   neuroP↑, 1,   NP/CIPN↓, 2,   OS↑, 2,   QoL↑, 3,   radioP↑, 4,   toxicity↓, 1,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 155

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 5,   compII↑, 1,   DA↑, 1,   diuretic↑, 2,   SpO2↑, 1,   Stress↓, 1,   Stroke↓, 4,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   ARE↑, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↑, 13,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 7,   GPx1↑, 1,   GSH↑, 12,   GSTs↑, 2,   HO-1↓, 2,   HO-1↑, 12,   Keap1↝, 1,   lipid-P↓, 8,   MDA↓, 11,   MPO↓, 3,   NOX4↓, 1,   NQO1↑, 2,   NRF2↑, 16,   RNS↓, 2,   ROS↓, 25,   mt-ROS?, 1,   mt-ROS↓, 1,   SIRT3↑, 2,   SOD↓, 1,   SOD↑, 14,   TBARS↓, 2,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 4,   compIII↑, 1,   Insulin↑, 2,   mitResp↑, 1,   MMP↑, 2,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 5,   AMPK↑, 1,   BUN↓, 1,   CREB↓, 1,   glucose↓, 1,   LDL↓, 2,   NADPH↓, 3,   PPARγ↑, 5,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 4,   BAD↓, 1,   BAX↓, 3,   BAX↑, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 10,   Casp3↑, 1,   Casp8↓, 1,   Casp9↓, 4,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 8,   JNK↓, 1,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 2,   p‑MAPK?, 1,   p‑MAPK↓, 1,   p38↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 3,   other↓, 1,   other↑, 1,   other↝, 4,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   FOXO3↑, 1,   HDAC2↓, 1,   mTOR↓, 2,   p‑mTOR↓, 2,   PI3K↓, 1,   PI3K↑, 2,   PTEN↓, 1,   STAT3↑, 2,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 1,   APP↓, 3,   Ca+2↓, 2,   Cartilage↑, 1,   CEA↓, 1,   CLDN1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   MMP1↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   TJ↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TXNIP↓, 1,   VCAM-1↓, 3,   Vim↓, 1,   ZO-1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   eNOS↑, 1,   NO↓, 6,   NO↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 2,   IBI↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 9,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL10↓, 3,   IL10↑, 2,   IL18↓, 2,   IL1β↓, 35,   IL1β↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 21,   IL6↑, 1,   IL8↓, 3,   Imm↑, 3,   Inflam↓, 28,   Inflam↑, 1,   JAK2↓, 1,   JAK2↑, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 14,   p65↓, 1,   PGE2↓, 7,   RANTES↓, 1,   TLR4↓, 4,   TNF-α↓, 33,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 3,   BDNF↑, 6,   BrainVol↑, 1,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 2,   NGF↑, 1,   tau↓, 1,   p‑tau↓, 4,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 10,   BACE/β-secretase↓, 2,   MAOB↓, 1,   NLRP3↓, 7,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 3,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   eff↑, 9,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   Albumin↑, 1,   ALP↓, 1,   AST↓, 5,   BG↓, 1,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 1,   BP↓, 1,   CEA↓, 1,   creat↓, 3,   GutMicro↑, 6,   Hcy/homoC↓, 1,   HemoG↑, 1,   IL6↓, 21,   IL6↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 6,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 5,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 10,   hepatoP↑, 10,   memory↑, 8,   neuroP↑, 19,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 5,   Sleep↑, 1,   toxicity↓, 6,   toxicity↑, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 2,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 249

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
18 Thymoquinone
12 Sulforaphane (mainly Broccoli)
10 Propolis -bee glue
10 Hydrogen Gas
10 Quercetin
8 Curcumin
8 Lycopene
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Alpha-Lipoic-Acid
6 Resveratrol
6 Shikonin
6 Urolithin
5 Silver-NanoParticles
5 Beta-Caryophyllene
5 Chrysin
5 Crocetin
5 Hyperoside
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Berberine
4 Eugenol
4 Ferulic acid
4 Chemotherapy
4 Honokiol
4 Isoliquiritigenin
4 Rosmarinic acid
3 1,8-Cineole
3 α-Bisabolol / Chamomile oil
3 Carvacrol
3 Celastrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorogenic acid
3 Cichoric acid / Chicoric acid
3 Dandelion Root
3 Radiotherapy/Radiation
3 EGCG (Epigallocatechin Gallate)
3 Fisetin
3 Formononetin
3 Gallic acid
3 Luteolin
3 Piperine
3 Rutin
3 Vitamin C (Ascorbic Acid)
2 Allicin (mainly Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalin
2 Betulinic acid
2 borneol
2 Boron
2 Boswellia (frankincense)
2 Butyrate
2 Capsaicin
2 Thymol-Thymus vulgaris
2 Echinacea
2 D-limonene
2 Emodin
2 Cisplatin
2 Phosphatidylserine
2 Fucoidan
2 Ginkgo biloba
2 isoquercitrin
2 5-fluorouracil
2 Melatonin
2 Phenylbutyrate
2 Piperlongumine
2 Pterostilbene
1 Anthocyanins
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 xanthohumol
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Carnosine
1 chitosan
1 Chyawanprash
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dihydrocaffeic Acid
1 Vitamin A, Retinoic Acid
1 eicosapentaenoic acid
1 methotrexate
1 Folic Acid, Vit B9
1 Fenbendazole
1 Gamma-aminobutyric acid
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Linalool
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Naringin
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 Psoralidin
1 Perilla
1 α-Santalol/Sandalwood oil
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 acetaminophen
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
1 Zeaxanthin
1 Lutein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:978  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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