Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4277- BM,    Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri
- in-vivo, NA, NA
*BDNF↑, *p‑CREB↑,
3694- BM,    Use of Bacopa monnieri in the Treatment of Dementia Due to Alzheimer Disease: Systematic Review of Randomized Controlled Trials
- Review, AD, NA
*cognitive∅, *other↑,
3693- BM,    Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE↓, *Inflam↓, *ROS↓, *antiOx↑,
3698- BM,    Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
- in-vivo, AD, NA
*lipid-P↓, *ROS↓, *neuroP↑,
3695- BM,    Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans
- in-vitro, AD, HT22
*OS↑, *mt-ROS↓, *ROS↓, *neuroP↑, *ER Stress↓,
3696- BM,    Discovery of Molecular Networks of Neuroprotection Conferred by Brahmi Extract in Aβ42-Induced Toxicity Model of Drosophila melanogaster Using a Quantitative Proteomic Approach
- in-vivo, NA, NA
*neuroP↑, *memory↑,
3697- BM,    Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies
- Review, AD, NA
*ROS↓, *cognitive↑, *memory↑, *BBB↑, *P-gp↓, *CYP3A2↓,
3692- BM,    Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Aβ↓, *cognitive↑,
3691- BM,    Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial
- Study, Nor, NA
*cognitive↑, *memory↑, *BP∅,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
5684- BML,    Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway
- in-vitro, Cerv, HeLa
ROS↑, Apoptosis↑, P53↑, TumCMig↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1↑, IL2↓, IL4↓, IFN-γ↓, COX2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5679- BML,    Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro
- in-vitro, Melanoma, SK-MEL-28
CD44↓,
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,
5677- BML,    Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
- in-vitro, Melanoma, A431 - in-vitro, Melanoma, A375
TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5676- BML,    Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake
- in-vivo, NA, NA
Half-Life↝, Dose↝, Dose↝,
5681- BML,    Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review
- Review, Var, NA
Inflam↓, chemoP↑,
5682- BML,    A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study
- Human, Var, NA
Dose↝, toxicity↝, eff↑,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, NA, NA
COX2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1↓, *5HT↑, *GABA↑, *eff↑,
5650- BNL,    Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model
- in-vivo, Nor, NA
*P-gp↓, *NF-kB↑, *eff↓, *Dose↝,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp↓, eff↑, other↝,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
5654- BNL,    Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↝, other↝,
5655- BNL,    Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations
- in-vivo, Nor, NA
*BioAv↝, BioAv↓, BioAv↑,
5657- BNL,    Enhancing effect and safety assessment of borneol on the oral absorption of sub-100 nm PLGA nanoparticles
- in-vivo, Nor, NA
*toxicity↓, *EPR↑, *other↑,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5659- BNL,    Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis
- Review, Var, NA
BBB↑, P-gp↓, MDR1↓, HIST1H3B?,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
5661- BNL,    A clinical and mechanistic study of topical borneol‐induced analgesia
- Trial, Nor, NA
*Pain↓,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE↓, *cognitive↑, *BioAv↑, memory↑, P-gp↓, BioEnh↑,
5664- BNL,    Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration
- in-vivo, Nor, NA
*BioAv↑, eff↑,
5665- BNL,    Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies
- in-vivo, Nor, NA
*BBB↑, eff↑,
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5670- BNL,    Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol
- Review, Stroke, NA
*TNF-α↓, *NF-kB↓, IL1β↓, MDA↓, BioEnh↑, BBB↑,
5671- BNL,    (+)-Borneol inhibits the generation of reactive oxygen species and neutrophil extracellular traps induced by phorbol-12-myristate-13-acetate
- in-vitro, Nor, NA
*ROS↓,
5672- Bor,    A comparative review of the pharmacokinetics of boric acid in rodents and humans
- in-vivo, Nor, NA
*Half-Life↝,
5673- Bor,    Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice
- in-vivo, Nor, NA
HRAS↓, Hif1a↓, Akt↓, PTEN↓,
3518- Bor,    Boron Report
- Review, Var, NA - Review, AD, NA
Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,
3514- Bor,  CUR,    Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta
- in-vivo, AD, NA
*DNAdam↓, *MDA↓, *AChE↓, *neuroP↑, *ROS↓, *NO↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α↓, *iNOS↓, *NF-kB↓,

Showing Research Papers: 1451 to 1500 of 5798
Prev Page 30 of 116 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5798

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↓, 2,   HO-1↓, 1,   lipid-P↓, 1,   MDA↓, 2,   ROS↑, 10,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   Histones↑, 1,  

Cell Death ⓘ

Akt↓, 4,   APAF1↑, 1,   Apoptosis↑, 8,   mt-Apoptosis↑, 1,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 4,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 6,   Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   Cyt‑c↓, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 3,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 2,   Beclin-1↑, 3,   LC3I↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   ATR↑, 1,   DNAdam↑, 4,   HIST1H3B?, 1,   P53↑, 5,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   cycE1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 2,   EIF4E↓, 3,   ERK↓, 2,   HRAS↓, 1,   IGF-1↓, 1,   mTORC1↓, 3,   PI3K↓, 1,   PTEN↓, 1,   STAT3↓, 2,   TumCG↓, 2,  

Migration ⓘ

serineP↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Endoglin↑, 1,   EPR↑, 2,   Hif1a↓, 4,  

Barriers & Transport ⓘ

BBB↑, 6,   P-gp↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IFN-γ↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 2,   JAK1↓, 1,   NF-kB↓, 4,   PSA↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioEnh↑, 5,   ChemoSen↑, 8,   Dose↝, 4,   eff↓, 1,   eff↑, 5,   Half-Life↝, 1,   MDR1↓, 2,   RadioS↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   chemoP↑, 1,   memory↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 2,   TumVol↓, 3,   TumW↓, 1,  
Total Targets: 101

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 2,   Keap1↓, 1,   lipid-P↓, 3,   MDA↓, 4,   NRF2↑, 1,   ROS↓, 10,   mt-ROS↓, 1,   SOD↑, 4,   TOS↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   p‑CREB↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp3↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

5LO↓, 2,   COL1↑, 1,   MMP9↓, 1,   TGF-β↑, 1,   ZO-1↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   EPR↑, 2,   NO↓, 2,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 6,   P-gp↓, 5,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 1,   IL1β↓, 3,   IL6↓, 3,   Inflam↓, 6,   JAK2↓, 1,   MIP‑1α↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 4,   TNF-α↑, 1,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 2,   BDNF↑, 1,   ChAT↑, 1,   GABA↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 4,   BACE↓, 2,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 1,   BioEnh↑, 2,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 7,   Half-Life↝, 4,   MRP1↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BMD↑, 1,   BP↓, 1,   BP∅, 1,   Calcium↑, 1,   IL6↓, 3,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 7,   cognitive∅, 1,   hepatoP↑, 2,   memory↑, 4,   neuroP↑, 9,   OS↑, 1,   Pain↓, 2,   toxicity↓, 2,   toxicity⇅, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,   Diar↓, 1,  
Total Targets: 94

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page