Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
2751- BetA,    Betulinic acid inhibits proliferation and triggers apoptosis in human breast cancer cells by modulating ER (α/β) and p53
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, ER-α36↓,
2752- BetA,    Betulinic acid: a natural product with anticancer activity
- Review, Var, NA
selectivity↑, ChemoSen↑, RadioS↑, MMP↓, cl‑Casp3↑, Cyt‑c↑, ROS↑, NF-kB↑, TOP1↓,
2753- BetA,    Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells
- in-vitro, Cerv, HeLa
PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,
2754- BetA,    Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
- in-vitro, Pca, LNCaP
VEGF↓, survivin↓, Sp1/3/4↓, Casp↑, PARP↑, survivin↓, angioG↓,
2756- BetA,    Betulinic acid inhibits growth of hepatoma cells through activating the NCOA4-mediated ferritinophagy pathway
- in-vitro, HCC, HUH7 - in-vitro, HCC, H1299
TumCP↓, ROS↑, antiOx↓, TumCG↓, TumCMig↓, NRF2↓, GPx4↓, HO-1↓, NCOA4↑, FTH1↓, Ferritin↑, Ferroptosis↑, GSH↓, MDA↓,
4273- BetA,    Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats
- in-vivo, NA, NA
*neuroP↑, *BDNF↑, *ROS↓, *Inflam↓, *cognitive↑,
943- BetA,    Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,
8- BetA,    Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
- in-vitro, PC, HaCaT - in-vitro, Pca, PANC1
HH↓, Gli1↓, PTCH1↓, Bcl-2↓,
5557- betaCar,    The Effect of Beta-Carotene on Cognitive Function: A Systematic Review
- Review, Nor, NA
*antiOx↑, *cognitive↑, *Dose↝, *eff↑,
5565- betaCar,    β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
- Study, AD, NA
*Risk↓, *memory↑, *Aβ↓,
5558- betaCar,    Re-remembering the influence of randomized β-carotene on cognitive decline
- Analysis, AD, NA
*cognitive↑,
5559- betaCar,    Low blood carotenoid status in dementia and mild cognitive impairment: A systematic review and meta-analysis
- Review, AD, NA
*antiOx↑, *cognitive↑, *Risk↓,
5560- betaCar,    β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *Aβ↓,
5561- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *cognitive↑, *BBB↑, *lipid-P↓, *eff↑,
5562- betaCar,    Association of Dietary α-Carotene and β-Carotene Intake with Low Cognitive Performance in Older Adults: A Cross-Sectional Study from the National Health and Nutrition Examination Survey
- Study, AD, NA
*cognitive↑, Risk↓,
5563- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease
- Review, AD, NA
*BBB↑, *lipid-P↓, *eff↑, *cognitive↑,
5564- betaCar,    β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *cognitive↑,
1566- betaCar,  Lyco,    Antioxidant and pro-oxidant effects of lycopene in comparison with beta-carotene on oxidant-induced damage in Hs68 cells
- in-vitro, Nor, HS68
*ROS↑, *ROS⇅, *Dose?,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *Hcy/homoC↓, *TNF-α↓, *other↝, *memory↑,
3986- betaCar,  VitC,    Editorial: Impact of Diet on Learning, Memory and Cognition
- Review, AD, NA
*Risk↓, *neuroP↑,
3987- betaCar,  Lyco,    Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection
- Trial, AD, NA
*eff↑,
3988- betaCar,  Lut,  Zeax,    Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables
- Trial, AD, NA
*eff↑, *eff↑, *eff↑,
3989- betaCar,    Dietary factors that affect the bioavailability of carotenoids
*BioAv↑, *BioAv↑,
4083- betaCar,    Significance of vitamin A to brain function, behavior and learning
- Review, AD, NA
*cognitive↑, *memory?,
4082- betaCar,    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis
- Study, AD, NA
*cognitive↑, *BACE↓, *memory↑,
4081- betaCar,    Vitamin A supplementation and risk of skeletal fracture
- Study, NA, NA
BMD↓,
4080- betaCar,    Vitamin A and Alzheimer's disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *Aβ↓,
4078- betaCar,  VitC,  VitB6,    Impact of Diet on Learning, Memory and Cognition
- Review, AD, NA
*neuroP↑, *antiOx↑, *cognitive↑,
5518- BEV,  Chemo,    Bevacizumab
- Review, Var, NA - Review, AMD, NA
Dose↝, other↑, VEGF↓, eff↑, Half-Life↑,
5517- BEV,    Exploring the Immunological Mechanisms Underlying the Anti-vascular Endothelial Growth Factor Activity in Tumors
- Review, Var, NA
VEGF↓, Imm↑, eff↑,
5516- BEV,  immuno,  Chemo,    Targeting vascular normalization: a promising strategy to improve immune–vascular crosstalk in cancer immunotherapy
- Review, Var, NA
OS↑, eff↑,
5515- BEV,    Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro.
- Review, Var, NA
VEGF↓, TumCP↓, tumCV↓, TumCMig↓,
5594- BEV,  immuno,    Serum VEGF-A as a biomarker for the addition of bevacizumab to chemo-immunotherapy in metastatic NSCLC
- Human, NSCLC, NA
eff↑,
5595- BEV,  Chemo,    Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
- Human, CRC, NA
OS↑,
5596- BEV,    Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
- Study, GBM, NA
QoL↑, OS∅,
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, eff↑,
5729- BF,    Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling
- in-vitro, Lung, NA
TumCCA↑, Apoptosis↑, TumCG↓, EGFR↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓,
5723- BF,    Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A
- Study, NA, NA
other↝,
5724- BF,    A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice
- vitro+vivo, Lung, A549
Apoptosis↑, Casp3↑, cl‑PARP↑,
5725- BF,  TMZ,    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide
- in-vitro, GBM, NA
TumCG↓, TumCP↓, CSCs↓, cl‑Casp3↑, PARP↑, Telomerase↓, eff↑,
5726- BF,    Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
- Review, neuroblastoma, SK-N-BE
Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,
5727- BF,    Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221
- in-vitro, OS, U2OS
TumCP↓, Apoptosis↑, ROS↑, miR-221↓,
5728- BF,    Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2↝, p‑VEGFR2/KDR/Flk1↓, EGFR↓, Akt↓, NF-kB↓, p44↓,
5721- BF,    Bufalin Suppresses Triple-Negative Breast Cancer Stem Cell Growth by Inhibiting the Wnt/β-Catenin Signaling Pathway
- in-vitro, BC, NA
CSCs↓, TumCCA↑, cMyc↓, cycD1/CCND1↓, CDK4↓, MMP↓, Casp↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, SOX2↓, Wnt↓, β-catenin/ZEB1↓, EGFR↓,
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,
5730- BF,    Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1
- in-vitro, BC, MCF7 - in-vitro, Lung, A549
other↝, TumCP↓,
5719- BF,    Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway
- in-vitro, Lung, NA
TumCP↓, Hippo↓, YAP/TEAD↓,
5718- BF,    Bufalin inhibits CYP3A4 activity in vitro and in vivo
- in-vivo, Nor, NA
CYP3A4↓, Apoptosis↑, AntiTum↑,
5717- BF,  Chemo,  GEM,    Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas
- Trial, Var, NA
OS∅,
5716- BF,    Pilot Study of Huachansu in Patients with Hepatocellular Carcinoma, Non-Small Cell Lung Cancer, or Pancreatic Cancer
- Trial, NSCLC, NA - Trial, PC, NA - Trial, HCC, NA
Dose↝, toxicity↓, other↓, QoL↑, OS?,

Showing Research Papers: 1451 to 1500 of 7372
Prev Page 30 of 148 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7372

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↓, 1,   MDA↓, 1,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   ETC↓, 1,   MMP↓, 4,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cav1↑, 1,   cMyc↓, 2,   CYP3A4↓, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PDK1↓, 1,   p‑PDK1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 7,   mt-Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 2,   BAX↝, 2,   Bcl-2↓, 3,   Bcl-2↝, 2,   Casp↑, 2,   Casp3↑, 2,   Casp3↝, 1,   cl‑Casp3↑, 3,   proCasp3↑, 1,   Casp9↑, 1,   proCasp9↑, 1,   Cyt‑c↑, 1,   Cyt‑c↝, 1,   Ferroptosis↑, 1,   Hippo↓, 1,   Mcl-1↓, 1,   p27↑, 1,   survivin↓, 3,   Telomerase↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 2,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 2,   PARP↝, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↝, 1,   P21↑, 1,   P21↝, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 2,   Gli1↓, 1,   HH↓, 1,   mTOR↓, 1,   Nanog↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   PTCH1↓, 1,   SOX2↓, 1,   STAT3↓, 1,   TOP1↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

ER-α36↓, 1,   Ki-67↓, 1,   miR-221↓, 1,   p44↓, 1,   TumCMig↓, 3,   TumCP↓, 8,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 3,   VEGF↓, 5,   p‑VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↝, 1,   Imm↑, 1,   NF-kB↓, 1,   NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 6,   Half-Life↑, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↓, 1,   EGFR↓, 3,   Ferritin↑, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS?, 1,   OS↑, 2,   OS∅, 2,   QoL↑, 2,   Risk↓, 1,   toxicity↓, 1,  
Total Targets: 118

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   lipid-P↓, 2,   ROS↓, 2,   ROS↑, 1,   ROS⇅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   Dose?, 1,   Dose↝, 1,   eff↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 15,   memory?, 1,   memory↑, 3,   neuroP↑, 3,   Risk↓, 3,  
Total Targets: 24

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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