| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 4527- | MAG, | Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway |
| - | in-vitro, | ESCC, | TE1 | - | in-vitro, | ESCC, | Eca109 | - | vitro+vivo, | SCC, | KYSE150 |
| 4526- | MAG, | HNK, | Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis |
| - | Review, | Var, | NA |
| 9283- | Maqui, | Hydroethanolic Extracts of the Aristotelia Chilensis (Maqui) Berry Reduces Cellular Viability and Invasiveness in the Endometrial Cancer Cell Line Ishikawa |
| - | in-vitro, | Endo, | NA |
| 8561- | Matr, | Matrine triggers colon cancer cell apoptosis and G0/G1 cell cycle arrest via mediation of microRNA-22 |
| - | in-vitro, | Colon, | SW480 | - | in-vitro, | CRC, | SW-620 |
| 8563- | Matr, | Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition |
| - | in-vitro, | BC, | MDA-MB-231 |
| 8569- | Matr, | Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway |
| - | vitro+vivo, | Cerv, | NA |
| 8575- | Matr, | Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3 |
| - | in-vitro, | GC, | SGC-7901 |
| 8533- | Matr, | Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | 95D |
| 8538- | Matr, | Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling |
| - | in-vitro, | BC, | MDA-MB-231 | - | ex-vivo, | BC, | MDA-MB-231 |
| 8537- | Matr, | Matrine restrains the development of colorectal cancer through regulating the AGRN/Wnt/β-catenin pathway |
| - | vitro+vivo, | CRC, | NA |
| 8536- | Matr, | Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway |
| - | vitro+vivo, | BC, | 4T1 | - | in-vitro, | BC, | MCF7 |
| 8534- | Matr, | Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Nor, | MRC-5 |
| 8532- | Matr, | Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells |
| - | in-vitro, | NSCLC, | NA |
| 8527- | Matr, | Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2 |
| - | in-vitro, | AML, | K562 |
| 8544- | Matr, | Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential |
| - | Review, | BC, | NA |
| 8560- | Matr, | Matrine: A Promising Natural Product With Various Pharmacological Activities |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA | - | Review, | Var, | NA |
| 8555- | Matr, | Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review |
| - | Review, | Var, | NA |
| 8554- | Matr, | Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation |
| - | in-vitro, | PC, | Capan1 | - | in-vitro, | PC, | MIA PaCa-2 |
| 8553- | Matr, | Research progress on the pharmacological effects of matrine |
| - | Review, | Nor, | NA |
| 8547- | Matr, | Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies |
| - | Review, | Var, | NA |
| 8546- | Matr, | Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice |
| - | in-vivo, | Stroke, | NA |
| 8543- | Matr, | Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway |
| - | in-vitro, | RPE/RB, | Y79 |
| 8923- | MBS, | Novel molecular, cytotoxical, and immunological study on promising and selective anticancer activity of Mung bean sprouts |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Liver, | HepG2 |
| 8626- | MBZ, | The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells |
| - | in-vitro, | Lung, | NA |
| 8627- | MBZ, | Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death |
| - | in-vitro, | CRC, | HT-29 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 8628- | MBZ, | Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer |
| - | vitro+vivo, | Lung, | A549 | - | in-vitro, | Lung, | H460 |
| 8632- | MBZ, | Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo |
| - | vitro+vivo, | Lung, | NA |
| 8634- | MBZ, | Rad, | Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer |
| - | vitro+vivo, | BC, | MCF7 | - | in-vitro, | BC, | T47D | - | in-vitro, | BC, | MDA-MB-231 |
| 8641- | MBZ, | ONC201, | The therapeutic potential of repurposed mebendazole, alone and in synergistic combination with ONC201, in the treatment of diffuse midline glioma |
| - | in-vitro, | GBM, | NA |
| 8642- | MBZ, | In vitro and in vivo anticancer activity of mebendazole in colon cancer: a promising drug repositioning |
| - | vitro+vivo, | CRC, | HT-29 | - | NA, | NA, | MCF10 |
| 8643- | MBZ, | Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | 4T1 | - | in-vitro, | BC, | SUM159 |
| 8655- | MBZ, | Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells |
| - | in-vitro, | Melanoma, | NA |
| 8653- | MBZ, | Cisplatin, | Anthelmintic mebendazole enhances cisplatin's effect on suppressing cell proliferation and promotes differentiation of head and neck squamous cell carcinoma (HNSCC) |
| - | in-vitro, | HNSCC, | CAL27 | - | in-vitro, | HNSCC, | SCC-154 |
| 8651- | MBZ, | Rad, | Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma |
| - | in-vitro, | Var, | NA |
| 8650- | MBZ, | Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells |
| - | in-vitro, | Var, | NA |
| 8649- | MBZ, | Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01) |
| - | in-vitro, | GC, | AGP01 |
| 8647- | MBZ, | The Antihelminthic Drug, Mebendazole, Induces Apoptosis in Adult T-Cell Leukemia/Lymphoma Cancer Cells: In-Vitro Trial |
| - | in-vitro, | ALL, | NA |
| 8789- | mCHEMO, | Predictive Biomarkers of Metronomic Chemotherapy Response in Solid Tumors: Chasing an Elusive Signal |
| - | Review, | Var, | NA |
| 8821- | MCP, | Rad, | Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 8817- | MCP, | CPT-11, | Newly Obtained Apple Pectin as an Adjunct to Irinotecan Therapy of Colorectal Cancer Reducing E. coli Adherence and β-Glucuronidase Activity |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | Colon, | Caco-2 |
| 8715- | MeJa, | Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-453 | - | in-vitro, | BC, | MCF-10AT |
| 8717- | MeJa, | Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer |
| - | in-vitro, | NSCLC, | A549 | - | in-vitro, | Lung, | Calu-1 | - | in-vitro, | Lung, | H157 | - | in-vitro, | Lung, | H1792 |
| 8721- | MeJa, | Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells |
| - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | LN229 |
| 8718- | MeJa, | Methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via ROS production in A549 cells |
| - | in-vitro, | Lung, | A549 |
| 8751- | MeSA, | PacT, | Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 8753- | MeSA, | Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis |
| - | vitro+vivo, | GBM, | U251 | - | in-vitro, | GBM, | U87MG |
| 8741- | MeSA, | In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention |
| - | vitro+vivo, | Var, | NA |
| 8749- | MeSA, | etoposide, | Methylseleninic acid enhances the effect of etoposide to inhibit prostate cancer growth in vivo |
| - | in-vivo, | Pca, | NA |
| 8744- | MeSA, | Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells |
| - | in-vitro, | Pca, | DU145 |
| 8743- | MeSA, | PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:14 State#:% Dir#:%
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