Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, NA, NA
COX2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1/ABCC1↓, *5HT↑, *GABA↑, *eff↑,
5650- BNL,    Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model
- in-vivo, Nor, NA
*P-gp↓, *NF-kB↑, *eff↓, *Dose↝,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp↓, eff↑, other↝,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
5654- BNL,    Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↝, other↝,
5655- BNL,    Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations
- in-vivo, Nor, NA
*BioAv↝, BioAv↓, BioAv↑,
5657- BNL,    Enhancing effect and safety assessment of borneol on the oral absorption of sub-100 nm PLGA nanoparticles
- in-vivo, Nor, NA
*toxicity↓, *EPR↑, *other↑,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5659- BNL,    Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis
- Review, Var, NA
BBB↑, P-gp↓, MDR1↓, HIST1H3B?,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
5661- BNL,    A clinical and mechanistic study of topical borneol‐induced analgesia
- Trial, Nor, NA
*Pain↓,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE↓, *cognitive↑, *BioAv↑, memory↑, P-gp↓, BioEnh↑,
5664- BNL,    Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration
- in-vivo, Nor, NA
*BioAv↑, eff↑,
5665- BNL,    Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies
- in-vivo, Nor, NA
*BBB↑, eff↑,
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5670- BNL,    Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol
- Review, Stroke, NA
*TNF-α↓, *NF-kB↓, IL1β↓, MDA↓, BioEnh↑, BBB↑,
5671- BNL,    (+)-Borneol inhibits the generation of reactive oxygen species and neutrophil extracellular traps induced by phorbol-12-myristate-13-acetate
- in-vitro, Nor, NA
*ROS↓,
5672- Bor,    A comparative review of the pharmacokinetics of boric acid in rodents and humans
- in-vivo, Nor, NA
*Half-Life↝,
5673- Bor,    Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice
- in-vivo, Nor, NA
HRAS↓, Hif1a↓, Akt↓, PTEN↓,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
4271- Bor,    Effects of Boron on Learning and Behavioral Disorders in Rat Autism Model Induced by Intracerebroventricular Propionic Acid
- in-vivo, NA, NA
*BDNF↝,
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
4621- Bor,    Boron
- Review, BPH, NA
*other↝, Risk↑, *Dose↑,
4625- Bor,    Boron and Inflammation
- Review, Arthritis, NA - Review, ostP, NA
*Risk↓, *eff↑, *SOD↑, *NF-kB↓, *Risk↓, *CRP↓, *TNF-α↓, *Wound Healing↑,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
4623- Bor,    Proteomic insights into the anti-cancer mechanisms of boron-based compounds in prostate cancer
- Review, Pca, NA
AntiCan↑,
4622- Bor,    Boron Level in the Prostate of the Normal Human: A Systematic Review
- Review, BPH, NA
Dose↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
697- Bor,    Boron-containing compounds as preventive and chemotherapeutic agents for cancer
- Review, NA, NA
serineP↓, NADHdeh↓, Apoptosis↑,
698- Bor,    Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats
- in-vitro, NA, NA
SAM-e↑,
699- Bor,    Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways
- in-vivo, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *Sema3A/PlexinA1↑,
700- Bor,    Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis
- Analysis, NA, NA
SAM-e↝,
701- Bor,    Dietary boron intake and prostate cancer risk
- Analysis, NA, NA
Risk↓,
702- Bor,  GEN,  SeMet,  Rad,    Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
- Analysis, NA, NA
Risk↓, TumCMig↓, Bcl-2↓,
703- Bor,    Boron intake and prostate cancer risk
- Analysis, NA, NA
Risk∅,
704- Bor,    Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid
- in-vitro, Pca, NA
PSA↓,
705- Bor,    Boric acid inhibits human prostate cancer cell proliferation
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
TumCP↓,
754- Bor,  HRT,    Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women
- Analysis, NA, NA
Risk↓,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
740- Bor,    Anti-cancer effect of boron derivatives on small-cell lung cancer
- in-vitro, Lung, DMS114 - in-vitro, Nor, MRC-5
Apoptosis↑, TumCCA↑, P53↑, Casp3↑, *toxicity↓,
741- Bor,    Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MOB1↓, PD-L1↑, p‑YAP/TEAD↝, IFN-γ↓, sFasL↑, Perforin↓, GranA↓, GranB↓, GNLY↓, PD-1↑,

Showing Research Papers: 1551 to 1600 of 7372
Prev Page 32 of 148 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7372

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   MDA↓, 1,   MDA↑, 1,   NADHdeh↓, 1,   ROS↑, 6,   ROS⇅, 1,   SAM-e↑, 1,   SAM-e↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   Histones↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↑, 8,   mt-Apoptosis↑, 1,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 5,   Casp↑, 1,   Casp3↑, 7,   Casp7↑, 3,   Casp8↑, 1,   Casp9↑, 3,   Ferroptosis↑, 1,   GranA↓, 1,   GranB↓, 1,   MAPK↓, 2,   Perforin↓, 1,   sFasL↑, 1,   p‑YAP/TEAD↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 6,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   DNAdam↑, 3,   HIST1H3B?, 1,   P53↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

Cyc↓, 1,   cycD1/CCND1↓, 1,   cycE1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EIF4E↓, 3,   ERK↓, 1,   HDAC↓, 1,   HRAS↓, 1,   IGF-1↓, 2,   mTORC1↓, 3,   PI3K↓, 1,   PTEN↓, 1,   STAT3↓, 2,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

MOB1↓, 1,   PCBP1↓, 1,   serineP↓, 1,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EPR↑, 2,   HIF-1↓, 1,   Hif1a↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   P-gp↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   GNLY↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   JAK1↓, 1,   NF-kB↓, 2,   PD-1↑, 1,   PD-L1↑, 1,   PSA↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioEnh↑, 5,   ChemoSen↑, 7,   Dose↝, 2,   eff↓, 1,   eff↑, 5,   MDR1↓, 2,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   PD-L1↑, 1,   PSA↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   memory↑, 1,   Risk↓, 8,   Risk↑, 1,   Risk∅, 1,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 1,  
Total Targets: 98

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   lipid-P↑, 1,   MDA↓, 2,   NRF2↑, 1,   ROS↓, 5,   SAM-e↑, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CYP3A4↓, 1,   NAD↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   MMP9↓, 1,   Sema3A/PlexinA1↑, 1,   serineP↓, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 2,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   P-gp↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 5,   JAK2↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   TNF-α↓, 5,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 1,   BDNF↝, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 1,   BioEnh↑, 2,   Dose↑, 4,   Dose↝, 3,   eff↓, 1,   eff↑, 10,   Half-Life↝, 4,   MRP1/ABCC1↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 2,   memory↓, 1,   memory↑, 2,   motorD↓, 1,   neuroP↑, 5,   Pain↓, 1,   Risk↓, 3,   toxicity↓, 3,   toxicity⇅, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 83

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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