| 1230- | CA, | Caff, | Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | MDA-MB-231 | - | Human, | NA, | NA |
| 1207- | CA, | PacT, | Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Cerv, | HeLa |
| 1651- | CA, | PBG, | Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer |
| - | Review, | Var, | NA |
| 1652- | CA, | Caffeic Acid and Diseases—Mechanisms of Action |
| - | Review, | Var, | NA |
| - | in-vitro, | Cerv, | SiHa |
| 1646- | CA, | Caffeic acid: a brief overview of its presence, metabolism, and bioactivity |
| - | Review, | Nor, | NA |
| 1650- | CA, | Adjuvant Properties of Caffeic Acid in Cancer Treatment |
| - | Review, | Var, | NA |
| 1297- | CA, | Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes |
| - | in-vitro, | Ovarian, | OV7 |
| 5752- | CA, | Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma |
| - | Review, | HCC, | NA |
| 5756- | CA, | Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights |
| - | vitro+vivo, | AD, | NA |
| 5755- | CA, | Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture |
| - | Review, | Nor, | NA |
| 5753- | CA, | QC, | MEL, | Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction |
| - | in-vivo, | Colon, | Caco-2 |
| 5751- | CA, | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| - | Review, | Var, | NA |
| 5750- | CA, | Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells |
| - | in-vitro, | MM, | NA |
| 5748- | CA, | Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties |
| - | in-vitro, | Var, | NA |
| 5747- | CA, | Caffeic Acid Enhances Anticancer Drug-induced Apoptosis in Acid-adapted HCT116 Colon Cancer Cells |
| - | in-vitro, | CRC, | NA |
| 5746- | CA, | Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | LNCaP |
| 5749- | CA, | Z, | Rad, | Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice |
| - | vitro+vivo, | BC, | MCF-7 | - | NA, | Liver, | HepG2 |
| 5774- | CA, | CAPE, | Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition |
| - | NA, | BC, | MCF-7 |
| 4268- | Caff, | Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects |
| - | Study, | NA, | NA |
| 4267- | Caff, | Caffeine‐mediated BDNF release regulates long‐term synaptic plasticity through activation of IRS2 signaling |
| - | in-vivo, | NA, | NA |
| 1206- | Caff, | Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices |
| - | in-vitro, | NA, | NA | - | ex-vivo, | NA, | NA |
| 1205- | Caff, | immuno, | Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody |
| - | in-vivo, | Melanoma, | B16-F10 |
| 1653- | Caff, | Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study |
| - | Review, | Melanoma, | NA |
| 4161- | Caff, | Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats |
| - | in-vivo, | AD, | NA |
| 5775- | Calc, | Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study |
| - | Study, | CRC, | NA |
| 5776- | Calc, | Calcium |
| - | Review, | Var, | NA |
| 5777- | Calc, | Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies |
| - | Study, | CRC, | NA |
| 5778- | Calc, | VitD3, | Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies |
| - | Study, | CRC, | NA |
| 5779- | Calc, | Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials |
| - | Study, | CRC, | NA |
| 5212- | CAP, | PI, | Chemo, | Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin |
| - | in-vitro, | Colon, | Caco-2 |
| 5204- | CAP, | Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways |
| - | in-vitro, | Colon, | SW480 | - | in-vitro, | Colon, | CT26 |
| 5203- | CAP, | Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells |
| - | in-vitro, | OS, | KB |
| 5202- | CAP, | Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways |
| - | vitro+vivo, | Bladder, | 5637 | - | in-vitro, | Bladder, | T24/HTB-9 |
| 5201- | CAP, | Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells |
| - | NA, | HCC, | HepG2 |
| 5198- | CAP, | Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines |
| - | in-vitro, | CRC, | LoVo | - | in-vitro, | CRC, | Colo320 |
| 5199- | CAP, | Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation |
| - | vitro+vivo, | AML, | NA |
| 5200- | CAP, | Capsaicin Induces Apoptosis in Human Small Cell Lung Cancer via the TRPV6 Receptor and the Calpain Pathway |
| - | in-vitro, | Lung, | NA |
| 3854- | CAP, | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice |
| - | in-vivo, | AD, | NA |
| 3855- | CAP, | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice |
| - | in-vivo, | AD, | NA |
| 2394- | CAP, | Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction |
| - | in-vitro, | Nor, | GES-1 |
| 2347- | CAP, | Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis |
| - | in-vivo, | Nor, | NA | - | in-vitro, | Nor, | RAW264.7 |
| 2348- | CAP, | Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry |
| - | Analysis, | Nor, | NA |
| 2349- | CAP, | The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease |
| - | in-vivo, | AD, | NA |
| 2652- | CAP, | Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence |
| - | Review, | Var, | NA |
| 1261- | CAP, | Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression |
| - | in-vitro, | ESCC, | KYSE150 |
| 1263- | CAP, | Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression |
| - | in-vitro, | ESCC, | Eca109 |
| 1259- | CAP, | Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells |
| - | in-vitro, | Lung, | H1299 | - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H23 | - | in-vitro, | Lung, | H2009 |
| 1264- | CAP, | Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells |
| - | in-vitro, | HCC, | NA |
| 1262- | CAP, | Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway |
| - | vitro+vivo, | BC, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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