Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1260- CAP,    Capsaicin inhibits in vitro and in vivo angiogenesis
- vitro+vivo, NA, NA
VEGF↓, angioG↓, TumCCA↑, cycD1/CCND1↓, Akt↓,
1265- CAP,    Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver
- in-vivo, CRC, NA
GutMicro↓, Risk↑,
1518- CAP,    Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo
- in-vitro, CRC, HCT116
ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24/HTB-9
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
2013- CAP,    Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, P53↑, P21↑, BAX↑, PSA↓, AR↓, NF-kB↓, Proteasome↓, TumVol↓, eff∅,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
2017- CAP,    Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease
- Review, Var, NA
RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
2020- CAP,    Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale
- Review, Var, NA
AntiTum↑, selectivity↑, TRPV1↑, MMP↓, Ca+2↑, ER Stress↑, angioG↓, Casp3?, cl‑PARP↑, selectivity↑, ROS↑, *ROS∅, selectivity↑,
4266- CAP,    Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord
- in-vivo, NA, NA
*BDNF↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5769- CAPE,    Caffeic Acid Phenethyl Ester Inhibits the Proliferation of HEp2 Cells by Regulating Stat3/Plk1 Pathway and Inducing S Phase Arrest
- in-vitro, Laryn, HEp2
tumCV↓, STAT3↓, TumCCA↑,
5770- CAPE,    Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B
- in-vitro, Nor, NA
*NF-kB↓, *Imm↑, *Inflam↓,
5771- CAPE,  PBG,    Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
- in-vitro, HNSCC, NA
MMP↓, Casp3↑, survivin↓, XIAP↓,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5773- CAPE,    Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B
- NA, HCC, SK-HEP-1
TumCI↓, MMP2↓, MMP9↓, NF-kB↓, TumMeta↓,
5767- CAPE,    Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer
- Review, Oral, NA
TumCP↓, tumCV↓, TumMeta↓, Akt↓, NF-kB↓, MMPs↓, EGFR↓, COX2↓, TumCCA?,
5766- CAPE,    A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model
- in-vivo, Nor, NA
*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,
5765- CAPE,    Absorption properties and effects of caffeic acid phenethyl ester and its p-nitro-derivative on P-glycoprotein in Caco-2 cells and rats
- vitro+vivo, Colon, Caco-2
P-gp↓,
5764- CAPE,    Caffeic Acid Phenethyl Ester (CAPE), Derived from a Honeybee Product Propolis, Exhibits a Diversity of Anti-tumor Effects in Preclinical Models of Human Breast Cancer
- vitro+vivo, BC, MCF-7 - NA, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, NF-kB↓, MDR1↓, VEGF↓, angioG↓,
5763- CAPE,    Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
- NA, HCC, NA
*antiOx↑, *neuroP↑, NF-kB↓, TumCG↓, TumMeta↓, MMPs↓, P53↑, ChemoSen↑,
5762- CAPE,    Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy
- in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
ChemoSen↓, Apoptosis↑,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
5760- CAPE,    Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCG↓, TumCCA↑,
5759- CAPE,    CAPE is a potent and a specific inhibitor of NF-kappa B activation and this may provide the molecular basis for its multiple immunomodulatory and antiinflammatory activities.
- Study, Nor, NA
*NF-kB↓,
5758- CAPE,  PBG,    Caffeic acid phenethyl ester and therapeutic potentials
- Review, Var, NA
*antiOx↑, *Inflam↓, ChemoSen↑, chemoP↑, COX1↓, COX2↓, selectivity↑, NF-kB↓, RadioS↑, *ROS↓, *lipid-P↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
5754- CAPE,  Rad,    The radiosensitizing effect of Caffeic Acid Phenethyl Ester in breast cancer is dependent on p53 status
- in-vivo, BC, MDA-MB-231
tumCV↓, eff⇅, RadioS↑, OS↑,
1082- CAR,    Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression
- in-vitro, lymphoma, U937
COX2↓, PPARα↑, PPARγ↑,
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,
1287- CAR,    Carvacrol induces apoptosis in human breast cancer cells via Bcl-2/CytC signaling pathway
- in-vitro, BC, HCC1937
TumCP↓, TumCCA↑, Apoptosis↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↓,
3876- Carno,  Ex,    Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin
- in-vivo, AD, NA
*cognitive↑, *neuroP↑,
3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, *CREB↑, *BDNF↑, *NGF↑, *antiOx↑, *ROS↓,
3874- Carno,    Effects of zinc and carnosine on aggregation kinetics of Amyloid-β40 peptide
- Review, AD, NA
*Aβ↓, *IronCh↑,
3877- Carno,    Carnosine, diabetes and Alzheimer's disease
- Review, AD, NA
*toxicity∅, *antiOx↑, IronCh↑,
3878- Carno,    Safety and Efficacy Evaluation of Carnosine, An Endogenous Neuroprotective Agent for Ischemic Stroke
- in-vivo, Stroke, NA
*toxicity∅, *antiOx↑, *neuroP↑, *IronCh↑, *ROS↓,
3879- Carno,    Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults
- Human, AD, NA
*memory↑, *cognitive↑,
3873- Carno,    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
- in-vivo, AD, NA
*ROS↓, *IronCh↑, *Aβ↓, *AntiAge↑, *lipid-P↓, *cognitive↑, *memory∅,
3871- Carno,    Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper
- Review, NA, NA
*ROS↓, *NO↓, *Inflam↓,
3870- Carno,    Could carnosine or related structures suppress Alzheimer's disease?
- Review, AD, NA
*IronCh↑, *Aβ↓, *ROS↓, *Vim↓,
3880- Carno,    EFFECT OF ANSERINE/CARNOSINE SUPPLEMENTATION ON THE PREVENTION OF ALZHEIMER'S DISEASE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT
- Trial, AD, NA
*cognitive↑, *other↑,
3881- Carno,    The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis
- Review, AD, NA
*cognitive↑,
3872- Carno,    Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
- in-vitro, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *neuroP↑, *ROS↓, *NO↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
603- Catechins,    Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
- in-vitro, NA, HL-60
ROS↑, DNAdam↑, H2O2↑,
939- Catechins,  5-FU,    Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil
- vitro+vivo, GC, SNU620
lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,

Showing Research Papers: 1751 to 1800 of 5806
Prev Page 36 of 117 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5806

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   compI↓, 1,   ENOX2↓, 1,   ENOX2↑, 1,   GPx↓, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   ROS↑, 8,   mt-ROS↑, 1,   SOD↓, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   compIII↓, 1,   MMP↓, 7,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 2,   CREB↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↓, 2,  

Cell Death ⓘ

Akt↓, 6,   p‑Akt↓, 1,   Apoptosis↑, 6,   Bak↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   BIM↑, 1,   Casp3?, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 4,   Fap1↓, 1,   iNOS↓, 1,   JNK↑, 2,   proApCas↑, 1,   Proteasome↓, 1,   survivin↓, 1,   TRPV1↑, 4,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 5,   ac‑P53↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   FOXO↑, 1,   mTOR↓, 2,   mTOR↑, 1,   PI3K↓, 3,   Src↓, 1,   STAT3↓, 1,   p‑STAT3↑, 1,   TumCG↓, 5,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   ATPase↓, 1,   Ca+2↑, 4,   i-Ca+2?, 1,   COL1↓, 1,   COL4↓, 1,   E-cadherin↑, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP9↓, 3,   MMPs↓, 2,   N-cadherin↓, 1,   p‑pax↓, 1,   Snail↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCMig↑, 1,   TumCP↓, 4,   TumCP↑, 1,   TumMeta↓, 4,   Vim↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 2,   EPR↑, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 4,   NF-kB↓, 10,   PD-1↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 5,   Dose?, 1,   Dose↝, 1,   Dose∅, 3,   eff↓, 2,   eff↑, 9,   eff⇅, 1,   eff∅, 1,   Half-Life∅, 1,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 2,   GutMicro↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 4,   chemoP↑, 1,   chemoPv↑, 2,   OS↑, 1,   RenoP↑, 1,   Risk↑, 1,   TumVol↓, 1,  
Total Targets: 143

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   GSH↑, 2,   GSR↑, 1,   HNE↓, 1,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 2,   NOX4↓, 1,   NRF2↑, 2,   ROS↓, 10,   ROS∅, 2,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Bax:Bcl2↓, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   Cyt‑c∅, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↑, 1,   PI3K↑, 1,  

Migration ⓘ

5LO↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 7,   Inflam↑, 1,   NF-kB↓, 6,   p65↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 2,   GABA↝, 1,   NGF↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 5,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 1,   cognitive↑, 5,   memory↑, 2,   memory∅, 1,   neuroP↑, 6,   toxicity↓, 1,   toxicity∅, 3,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 56

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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