Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5920- Cats,    Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours
- in-vivo, Melanoma, B16-BL6
eff↑, Ki-67↓, TumCP↓, Apoptosis↑, TumCG↓,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
5922- Cats,    Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB
- in-vitro, AML, THP1
NF-kB↓, AP-1↓, TNF-α↓,
5917- Cats,    Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
- Trial, CRC, NA
Dose↝, *DNArepair↑, toxicity↝, BioAv↝, eff∅,
5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Neut↓, eff↑, Imm↑, Dose↝,
5915- Cats,    Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells
- in-vitro, AML, NA
Apoptosis↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5913- Cats,    Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection
- Review, Nor, NA
*Inflam↓, *NF-kB↓, *DPPH↓, *TNF-α↓, *Imm↑,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
18- CBC/D,    Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli
- vitro+vivo, MB, NA
HH↓, Gli1↓,
17- CBC/D,    CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1
- in-vivo, CRC, NA
HH↓, Gli1↓, BioAv↓, TumCP↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
1199- CBD,    Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis
- in-vivo, Obesity, NA
lipoGen↓,
5820- CBD,    Cannabidiol effects in stem cells: A systematic review
- Review, Var, NA
*other↑, CSCs↓, SOX2↓, other↝,
5812- CBD,    Cannabidiol oil or placebo in advanced cancer-disease progression and survival: a secondary analysis
- Trial, Var, NA
other∅, OS∅, other∅,
5813- CBD,    Pharmacokinetics of Cannabidiol: A Systematic Review and Meta-Regression Analysis
- Review, Var, NA
Dose↝, BioAv↑, BioAv↓, BioAv↑,
5814- CBD,    Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline
- Review, Var, NA
eff↓,
5815- CBD,    Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
- in-vitro, GBM, NA
TRPV2↑, selectivity↑, ChemoSen↑,
5816- CBD,    Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4
- in-vitro, GBM, NA
TRPV2↑, Ca+2↑, MitoP↑, eff↑,
5817- CBD,    COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
- vitro+vivo, Lung, A549
AntiTum⇅, tumCV↓, Apoptosis↑, eff↓, COX2↑, PPARγ↑,
5818- CBD,    Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress
- in-vivo, PC, PANC1
GRP78/BiP↑, ATF4↑, CHOP↑, UPR↑, TumCG↓, ER Stress↑, eff↓,
5819- CBD,    The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence
- Review, Lung, NA
Apoptosis↑, PPARγ↓, mtDam↑, ROS↑, EMT↓, CD8+↑, NK cell↑, ChemoSen↑, ATP↓, glucose↓, Ca+2↑, TRPV2↑,
1081- CBDA,    Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
- in-vitro, BC, MDA-MB-231
COX2↓, Id1↓, SHARP↑,
1105- CEL,    Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
- in-vitro, BC, NA
COX2↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, miR-145↑, TGF-β↓, SMAD3↓,
1054- CEL,    Celecoxib inhibited activation of NF-κB and expression of NF-κB P65 protein in HepG2 cells
- in-vitro, Liver, HepG2
NF-kB↓, p65↓,
955- CEL,    Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells
- in-vitro, RPE, D407
TumCP↓, VEGF↓, Hif1a↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1↓, LDHA↓, GLUT1↓, ECAR↓,
954- CGA,    Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
Hif1a↓, VEGF↓, angioG↓, Akt↓,
1083- CGA,    In Silico Insight the Prediction of Chlorogenic Acid in Coffee through Cyclooxygenase-2 (COX2) Interaction
- Analysis, NA, NA
COX2↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF-7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
1244- CGA,  immuno,    Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody
- in-vivo, NA, NA
PD-L1↓, T-Cell↑, eff↑,
1298- CGA,    Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells
- in-vitro, Lung, A549
Bcl-2↓, BAX↑, Casp3↑, p38↑, JNK↑, Nanog↓, SOX2↓, OCT4↓,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, NA, NA
*LDL↓,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, NA, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
4482- Chit,    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
EPR↑, mtDam↑, ROS↑, Apoptosis↑,
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
MDSCs↓, TregCell↓, IL10↓, NK cell↑,
3699- Chol,    Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study
- Study, AD, NA
*other∅, *cognitive↑,
3700- Chol,    Eggs and Health Special Issue
- Review, Nor, NA
*other↑, *other↑, *Inflam↓, *ROS↓, *antiOx↑, *Iron↑, *cardioP∅,

Showing Research Papers: 1901 to 1950 of 5930
Prev Page 39 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5930

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

TRPV2↑, 3,  

Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↓, 1,   HO-1↑, 1,   MDA↓, 1,   MDA↑, 1,   NRF2↑, 1,   Prx↓, 1,   ROS↑, 7,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 3,   mtDam↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   ECAR↓, 1,   glucose↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   homoC↓, 1,   LDHA↓, 1,   lipoGen↓, 1,   PDK1↓, 1,   PKM2↓, 3,   PPARγ↓, 1,   PPARγ↑, 1,   SHARP↑, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↑, 9,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-xL↑, 1,   cl‑BID↑, 1,   Casp↑, 2,   Casp3↑, 3,   proCasp8↑, 1,   Cyt‑c↑, 1,   FADD↑, 1,   Fas↑, 2,   FasL↑, 1,   iNOS↓, 1,   JNK↑, 2,   cl‑Mcl-1↑, 1,   p38↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

miR-145↑, 1,   other↓, 2,   other↝, 4,   other∅, 2,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↑, 1,   CSCs↓, 1,   EMT↓, 3,   Gli1↓, 2,   HH↓, 2,   Id1↓, 1,   LRP6↓, 1,   p‑LRP6↓, 1,   Nanog↓, 1,   OCT4↓, 1,   SOX2↓, 2,   TumCG↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 2,   E-cadherin↑, 2,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 2,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TregCell↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 6,   TumMeta↓, 2,   Vim↓, 2,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↑, 1,   EPR↑, 3,   Hif1a↓, 3,   Hif1a↑, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   COX2↑, 1,   HMGB1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   M1↓, 1,   MDSCs↓, 1,   Neut↓, 1,   NF-kB↓, 3,   NK cell↑, 2,   p65↓, 1,   PD-L1↓, 1,   T-Cell↑, 1,   TNF-α↓, 3,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↝, 3,   eff↓, 4,   eff↑, 11,   eff↝, 1,   eff∅, 1,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 2,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   AntiTum⇅, 1,   chemoPv↑, 1,   OS↑, 1,   OS∅, 1,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 2,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 145

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   DPPH↓, 1,   Iron↑, 1,   lipid-P↓, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 3,   other↝, 1,   other∅, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   eff?, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

cardioP∅, 1,   cognitive↑, 1,   toxicity↓, 2,   Weight↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 27

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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