RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
Source:
Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
6906- FIS,  Rad,    Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models
- in-vivo, CRC, CT26 - in-vivo, CRC, HCT116
antiOx↑, Inflam↓, angioG↓, TumCI↓, TumCP↓, TumCG↓, RadioS↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6905- FIS,    Fisetin overcomes non-targetability of mutated KRAS induced YB-1 signaling in colorectal cancer cells and improves radiosensitivity by blocking repair of radiation-induced DNA double-strand breaks
- in-vitro, CRC, NA
RadioS↑,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7016- Fuc,    Therapies from Fucoidan: New Developments
- Review, Var, NA
*Bacteria↓, *BioAv↓, *Dose↝, *GutMicro↑, PD-1↝, ROS⇅, cl‑Casp↑, cl‑PARP↑, RadioS↑, *radioP↑, *neuroP↑, *Aβ↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7127- Ge-132,    Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents
- vitro+vivo, Var, NA
eff↑, BioAv↑, RadioS↑,
7100- Geld,  Rad,    Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin
- in-vitro, Var, NA
HSP90↓, Akt↓, RadioS↑, selectivity↑,
7099- Geld,    Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation
- in-vitro, CRC, DLD1
RadioS↑, EF-1α↓, Akt↓, HSP90↓,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7119- GEO2,    Germanium oxide enhances the radiosensitivity of cells
- in-vitro, Nor, CHO K1
RadioS↑, ROS↑, eff↓, DNAdam↓, Catalase∅, GSTs∅,
7287- GGB,  Rad,    Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, TumCMig↓, RadioS↑, TumCCA↑, PI3K↓, p‑Akt↓, PDK1 / PDPK1↓,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
4420- GoldNP,  Rad,    Computational modeling and experimental synthesis of BSA-coated bimetallic theranostic MnO₂-Au@curcumin nanoplatform for synergistic radiochemotherapy of breast cancer
- in-vitro, BC, 4T1
RadioS↑,
7306- GoldNP,  Rad,    Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma
- in-vivo, SCC, NA
Synergy↑, RadioS↑,
7305- GoldNP,  Rad,    The use of gold nanoparticles to enhance radiotherapy in mice
- in-vivo, Var, NA
Dose↝, selectivity↑, toxicity↝, RadioS↑,
1901- GoldNP,  Rad,    The role of thioredoxin reductase in gold nanoparticle radiosensitization effects
- in-vitro, Lung, A549
MMP↓, ROS↑, RadioS↑, TrxR↓,
3526- GoldNP,  Rad,    Advances in nanoparticle-based radiotherapy for cancer treatment
- Review, Var, NA
RadioS↑, EPR↑, ROS↑, TumCCA↑,
7319- Gos,    BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides
- in-vitro, PC, NA
eff↑, Ca+2↑, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, RadioS↑,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2896- HNK,    Honokiol inhibits hypoxia-inducible factor-1 pathway
- in-vivo, Colon, CT26
Hif1a↓, RadioS↑,
4522- HNK,  MAG,    Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth
- in-vitro, HNSCC, FaDu
AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,
7651- HPT,  Rad,    Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner
- in-vitro, Var, NA
RadioS↑, DNArepair↓, Dose↑,
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7619- HPT,    The role of hyperthermia in the treatment of tumor
- Review, Var, NA
Imm↑, RadioS↑, ChemoSen↑, EPR↑,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7620- HPT,    Hyperthermia and radiotherapy: physiological basis for a synergistic effect
- Review, Var, NA
RadioS↑, DNArepair↓, Hypoxia↓, CSCs↓, Imm↑, pH↝, HSPs↑, ROS↑, eff↑,
7577- HPT,  Rad,    Randomized trial of hyperthermia and radiation for superficial tumors
- Trial, Var, NA
RadioS↑, eff↑, Dose↝,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
- Analysis, Var, NA
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
7574- HPT,  Oxy,    Improvement of tumor oxygenation by mild hyperthermia
- Review, Var, NA
Hypoxia↓, OCR↓, RadioS↑, Synergy↑, Dose↝,
7573- HPT,  Rad,    Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies
- vitro+vivo, Var, NA
RadioS↑, BRCA2↓,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7571- HPT,    Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
- vitro+vivo, Var, NA
BRCA2↓, eff↑, RadioS↑,
7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, Var, NA
BRCA2↓, selectivity↑, RadioS↑, eff↝,
7627- HPT,  Rad,    Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients
- Trial, BC, NA
CR↑, OS↑, *toxicity↝, RadioS↑,
7623- HPT,  Rad,    Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i
- Review, Var, NA
BRCA2↓, RadioS↑, eff↑,
5053- HPT,  Rad,  Chemo,    Association of elevated reactive oxygen species and hyperthermia induced radiosensitivity in cancer stem-like cells
- in-vitro, Var, NA
CSCs↓, TumCP↓, ROS↑, RadioS↑,
7549- HYP,  Rad,    Study on the mechanism of hyperoside in affecting the biological progression and radiosensitivity of esophageal carcinoma by modulating the STAT3/AKT/ERK pathway
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE150
TumCP↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, RadioS↑, p‑STAT3↓, p‑Akt↓, p‑ERK↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,

Showing Research Papers: 151 to 200 of 314
Prev Page 4 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 314

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 6,   Catalase↑, 1,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 4,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 4,   GSH↓, 25,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 2,   GSTs↝, 1,   GSTs∅, 1,   H2O2↓, 2,   H2O2↑, 4,   HO-1↓, 9,   HO-1↑, 4,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 2,   i-Iron↑, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 1,   MDA↑, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 14,   NRF2↑, 11,   NRF2∅, 1,   Prx↓, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 163,   ROS⇅, 5,   ROS↝, 1,   mt-ROS↑, 3,   RPM↑, 1,   SOD↓, 7,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 3,   TrxR↓, 12,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   CDC2↓, 2,   CDC25↓, 1,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   Insulin↓, 4,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 3,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 6,   p‑PDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↑, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK↑, 16,   ATP↓, 10,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 2,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycolysis↓, 26,   Glycolysis↝, 1,   Glycolysis∅, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK2↓, 11,   HMG-CoA↓, 2,   lactateProd↓, 9,   LDHA↓, 4,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   MethCyc↓, 1,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PDKs↑, 1,   PFK↓, 4,   PKM2↓, 9,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 2,   SIRT1↓, 4,   SIRT1↑, 5,   SIRT2↓, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 2,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 102,   ASC↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 34,   Bax:Bcl2↑, 11,   Bcl-2↓, 41,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 2,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 17,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 45,   cl‑Casp3↑, 10,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 5,   Casp8↑, 11,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 29,   cl‑Casp9↑, 5,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   Diablo↑, 3,   DR5↑, 7,   Fas↑, 7,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GSDME↑, 1,   IAP1↓, 3,   IAP2/BIRC3↑, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 8,   MDM2↓, 5,   p‑MDM2↓, 1,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 4,   Pyro↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 15,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 12,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 2,   p‑Akt↓, 13,   AMPKα↑, 1,   BRAF↓, 1,   p‑CaMKII ↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 2,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   EGFR↑, 2,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 4,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 2,   IκB↓, 2,   IκB↑, 1,   JAK↓, 1,   JAK↝, 1,   JAK1↓, 4,   JAK2↓, 8,   JNK↓, 2,   JNK↑, 12,   p‑JNK↑, 2,   MAPK↓, 16,   MAPK↑, 6,   MEK↓, 3,   mTOR↓, 36,   mTOR↑, 1,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 1,   P90RSK↓, 2,   PAK↓, 1,   PI3K↓, 38,   PI3K↑, 2,   p‑PI3K↓, 2,   PI3K/mTOR/ETS2↓, 1,   PIK3CA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 3,   RAS↓, 6,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 27,   STAT3↑, 1,   p‑STAT3↓, 9,   STAT6↓, 2,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 6,   ATF4↝, 1,   cJun↓, 5,   cMyc↓, 15,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 2,   H4↓, 1,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC8↓, 1,   miR-143↑, 1,   miR-21↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 4,   Myc↑, 1,   n-MYC↓, 2,   OCT4↓, 2,   other↓, 1,   other↑, 5,   other↝, 8,   PhotoS↑, 5,   Prot↓, 1,   sonoS↑, 2,   SOX2↓, 4,   SOX4↑, 1,   TCF-4↓, 2,   tumCV↓, 17,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 25,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP72↑, 1,   HSP90↓, 8,   HSPs↑, 2,   IRE1↑, 3,   PERK↑, 4,   Proteasome?, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   LC3s↓, 1,   lysoMP↑, 1,   p62↓, 2,   p62↑, 2,   TumAuto↓, 2,   TumAuto↑, 21,   TumAuto↝, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA2↓, 5,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 4,   DNAdam↑, 51,   DNArepair↓, 8,   DNArepair↑, 1,   hTERT/TERT↓, 8,   P53↓, 1,   P53↑, 35,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 8,   cl‑PARP↑, 21,   PCNA↓, 5,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 6,   TOP2↓, 4,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 8,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 14,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 12,   CDK6↑, 1,   CDK8↓, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 26,   cycE/CCNE↓, 9,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 4,   P21↓, 2,   P21↑, 26,   p27/CDKN1B↑, 14,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 2,   TubPol↓, 1,   TumCCA↓, 4,   TumCCA↑, 82,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   CD133↓, 2,   CD34↓, 1,   cFos↓, 5,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 28,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 5,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 5,   IGF-1↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 9,   NOTCH1↓, 3,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 6,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 46,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 61,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 19,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 16,   Ca+2↝, 1,   i-Ca+2↑, 1,   Cav1↓, 1,   Cdc42↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 37,   EMT↝, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   Furin↓, 1,   IQGAP3↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   KRAS↓, 1,   MALAT1↓, 4,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 32,   MMP7↓, 5,   MMP9↓, 33,   MMP9↑, 1,   MMPs↓, 8,   MUC4↓, 1,   N-cadherin↓, 10,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 1,   Rac1↓, 3,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   Snail↓, 8,   TET1↑, 2,   TGF-β↓, 8,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   TumCA↓, 1,   TumCI↓, 33,   TumCMig↓, 27,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 27,   TumMeta↑, 1,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 6,   Vim?, 1,   Vim↓, 13,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 26,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 48,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 32,   Hif1a↑, 1,   Hypoxia↓, 7,   LOX1↓, 1,   NO↓, 1,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 46,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   CellMemb↑, 2,   CLDN1↓, 1,   CLDN2↓, 1,   CLDN2↑, 1,   EPR↑, 5,   EPR↝, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 41,   MMP↑, 2,   MPT↑, 3,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↝, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 7,   CD8+↑, 1,   p‑cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 3,   CXCR4↓, 5,   DCells↑, 1,   DR4↑, 1,   FOXP3↓, 2,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 10,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL6↓, 17,   IL8↓, 4,   IL8↑, 1,   Imm↑, 19,   Inflam↓, 21,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 74,   NF-kB↑, 5,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 3,   p65↓, 4,   p65↑, 1,   p‑p65↓, 2,   PD-1↓, 3,   PD-1↝, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PGE2↓, 10,   PSA↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   TLR4↓, 2,   TNF-α↓, 10,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↝, 3,   e-pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AKR1C3/17β-HSD5/PGF Synthase↓, 1,   AR↓, 7,   ER-α36↓, 2,   ER(estro)↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 30,   BioAv↝, 8,   BioEnh↑, 1,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 5,   ChemoSen↑, 153,   ChemoSen⇅, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 4,   CompStab↝, 2,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 4,   Dose↓, 2,   Dose↑, 9,   Dose↝, 36,   Dose∅, 8,   eff↓, 27,   eff↑, 85,   eff⇅, 1,   eff↝, 10,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 9,   Half-Life↑, 3,   Half-Life↝, 8,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 9,   P450↓, 1,   P450↝, 1,   RadioS?, 3,   RadioS↓, 6,   RadioS↑, 304,   RadioS↝, 2,   RadioS∅, 2,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 64,   Synergy↑, 72,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALAT↑, 1,   ALP↓, 1,   AR↓, 7,   AST↓, 2,   AST↑, 1,   BG↓, 2,   BloodF↑, 4,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CEA↓, 3,   CRP↓, 1,   EGFR↓, 14,   EGFR↑, 2,   EZH2↓, 1,   Ferritin↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 8,   IL6↓, 17,   KRAS↓, 1,   LDH↓, 5,   LDH↑, 1,   LDH↝, 1,   Myc↓, 4,   Myc↑, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 23,   antiNeop↑, 1,   AntiTum↑, 13,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 2,   chemoP↑, 20,   chemoPv↑, 7,   ChemoSideEff↓, 6,   CR↑, 1,   fatigue↓, 2,   hepatoP↑, 3,   hepatoP↝, 1,   LC↑, 1,   Mucositis↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   OS↑, 20,   OS∅, 2,   Pain↓, 3,   PFS↓, 1,   PFS∅, 1,   QoL↑, 5,   QoL∅, 1,   radioP↑, 17,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 13,   Risk↑, 1,   Risk∅, 1,   Sleep↑, 1,   toxicity↓, 23,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 5,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 2,   GutMicro↝, 2,   Sepsis↓, 1,  
Total Targets: 777

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 22,   Catalase↑, 12,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 17,   GSH/GSSG↑, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 5,   Keap1↓, 1,   Keap1↑, 1,   ox-Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 6,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 12,   ROS?, 1,   ROS↓, 34,   ROS↑, 2,   ROS↝, 1,   ROS∅, 2,   SOD↓, 1,   SOD↑, 13,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   OCR↑, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 3,   ATP↑, 2,   glucose↓, 1,   GlucoseCon↑, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↑, 1,   NADPH↑, 1,   NADPH∅, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↓, 2,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   JNK↓, 1,   MAPK↓, 1,   PI3K↓, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p300↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Cartilage↑, 1,   FAK↑, 1,   MMP13↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   HIF-1↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 6,   IL2↓, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 28,   NF-kB↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   GR↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 13,   BioAv↑, 10,   BioAv↝, 4,   BioEnh↑, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 7,   eff↑, 4,   eff↝, 1,   GSTA1↓, 1,   Half-Life↓, 2,   Half-Life↝, 4,   Half-Life∅, 1,   RadioS↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AST↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 7,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 6,   AntiTum↓, 1,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 6,   cognitive↑, 4,   hepatoP↑, 8,   memory↑, 4,   motorD↑, 2,   neuroP↑, 18,   Obesity↓, 2,   Pain↓, 2,   radioP↑, 8,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 1,   toxicity?, 1,   toxicity↓, 15,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 5,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 3,   Inf↓, 1,  
Total Targets: 175

Scientific Paper Hit Count for: RadioS, RadioSensitizer
93 Radiotherapy/Radiation
19 Curcumin
18 Hyperthermia
11 Silver-NanoParticles
9 Fisetin
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
7 Magnetic Fields
6 Chemotherapy
6 Cisplatin
6 Berberine
6 salinomycin
6 diet Methionine-Restricted Diet
6 Ellagic acid
5 Copper and Cu NanoParticles
5 Dichloroacetate
5 Disulfiram
5 Gold NanoParticles
5 mebendazole
5 Melatonin
5 Thymoquinone
4 Atorvastatin
4 Chrysin
4 Honokiol
4 Oxygen, Hyperbaric
4 Luteolin
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
4 Selenium NanoParticles
4 Selenite (Sodium)
3 Selenium
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 brusatol
3 Crocetin
3 Eugenol
3 diet FMD Fasting Mimicking Diet
3 Ferulic acid
3 Gambogic Acid
3 Kaempferol
3 Quercetin
3 Metformin
3 Piperlongumine
3 Parthenolide
3 Sulfasalazine
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Anti-oxidants
2 Vitamin C (Ascorbic Acid)
2 Astaxanthin
2 Beta-Caryophyllene
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 diet Short Term Fasting
2 Diindolylmethane
2 immunotherapy
2 EGCG (Epigallocatechin Gallate)
2 Geldanamycin
2 Gossypol/AT-101
2 Magnolol
2 Methyl Jasmonate
2 methylseleninic acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Vitamin A, Retinoic Acid
1 Artemisinin
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diclofenac
1 Electrical Pulses
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Ginkgolide B
1 Ginkgetin
1 Hydroxycinnamic-acid
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoflavones
1 low dose naltrexone
1 Lycopene
1 Mung Bean Sprouts
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methylglyoxal
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 doxorubicin
1 Oxaliplatin
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page