Ferroptosis Cancer Research Results

Ferroptosis, Ferroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Type of programmed cell death dependent on iron.
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS).
The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis.
Scientific Papers found: Click to Expand⟱
3023- RosA,    Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis
- in-vivo, Sepsis, NA
*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,
3024- RosA,    rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice
- in-vivo, Sepsis, NA
*Ferroptosis↓, *GRP78/BiP↓, *PERK↓, *ATF4↓, *Sepsis↓, *GSH↑, *SOD↑, *Catalase↑,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Ferroptosis↑, CSCs↓, NF-kB↓, GSR↓, GSH↑, Iron↑,
5000- Sal,    Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- vitro+vivo, BC, NA
CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
5039- SAS,    Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer
- vitro+vivo, BC, NA
xCT/SLC7A11↓, ROS↑, GSH↓, Ferroptosis↑, TumCG↓, toxicity↓, lipid-P↑,
4712- Se,    Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
- Review, Var, NA
selenoP↑, Ferroptosis↑, lipid-P↑,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2200- SK,    Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis
- in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, 8505C
NF-kB↓, GPx4↓, TrxR1↓, PKM2↓, GLUT1↓, Glycolysis↓, Ferroptosis↑, GlucoseCon↓, lactateProd↓, ROS↑,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
2202- SK,    Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
- in-vitro, Var, NA
Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
1068- SM,    Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA - Human, BC, NA
TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, Synergy↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
1002- SSE,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
Apoptosis↑, Ferroptosis↑, DNMT1↓, TET1↑, TumCCA↑, cl‑PARP↑, cl‑Casp3↑, Cyt‑c↑, BIM↑, NOXA↑, Apoptosis↑, ROS↑, ER Stress↑, UPR↑,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT/SLC7A11↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5094- SSE,  Matr,    Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
- vitro+vivo, Nor, NRK52E
*GPx4↑, *xCT/SLC7A11↑, *GSH↑, *RenoP↝, *Ferroptosis↓,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT/SLC7A11↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4732- SSE,    Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
- in-vivo, Autism, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *other↝,
4718- SSE,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,
1221- Z,    Unexpected zinc dependency of ferroptosis: what is in a name?
- Analysis, Nor, NA
*Ferroptosis↑, *ROS↑, *lipid-P↑,

Showing Research Papers: 151 to 186 of 186
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 186

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 1,   Catalase↓, 1,   Fenton↑, 9,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 6,   GPx4↓, 74,   GPx4↑, 3,   GPx4↝, 1,   GPx4∅, 1,   GSH↓, 55,   GSH↑, 1,   GSH↝, 1,   i-GSH↓, 1,   GSH/GSSG↓, 6,   GSR↓, 1,   H2O2↑, 2,   HO-1↓, 5,   HO-1↑, 13,   HO-1↝, 1,   Iron↓, 2,   Iron↑, 49,   Iron↝, 3,   i-Iron↓, 1,   i-Iron↑, 9,   c-Iron↑, 1,   Keap1↓, 3,   Keap1↑, 2,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 58,   MDA↓, 2,   MDA↑, 32,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NRF2↓, 23,   NRF2↑, 12,   NRF2↝, 1,   RNS↑, 1,   ROS↓, 2,   ROS↑, 113,   ROS↝, 1,   mt-ROS↑, 1,   selenoP↑, 1,   SOD↓, 4,   SOD1↑, 1,   TBARS↑, 1,   Trx↓, 1,   TrxR↓, 2,   TrxR1↓, 1,   xCT/SLC7A11↓, 22,   xCT/SLC7A11↑, 1,   xCT/SLC7A11∅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 4,   Ferritin↑, 2,   FPN↝, 1,   FTH1↓, 6,   FTH1↑, 1,   FTL↑, 2,   IronCh↑, 2,   LIP↑, 1,   Mets↑, 1,   NCOA4↑, 4,   NCOA4↝, 1,   STEAP3↑, 1,   Tf↓, 1,   Tf↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 1,   CDC25↝, 1,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   ETC↓, 3,   MCU↓, 1,   Mortalin↓, 1,   mtDam↑, 9,   OXPHOS↓, 3,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 7,   ACSL4↝, 1,   ACSL4∅, 1,   ACSL5↑, 2,   ALDOA↓, 1,   AMPK↑, 11,   p‑AMPK↑, 1,   ATP↓, 8,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 7,   GSK‐3β↓, 2,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 2,   MCT4↓, 1,   NADPH↓, 2,   PDK1 / PDPK1↓, 1,   PFKP↓, 1,   PKM2↓, 3,   PKM2↑, 1,   Pyruv↓, 1,   SAT1↑, 1,   SCD1↓, 2,   SIRT1↓, 1,   SIRT1↑, 2,   SLC1A5↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Apoptosis↑, 40,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 9,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 8,   Casp3↑, 6,   cl‑Casp3↑, 7,   cl‑Casp3∅, 1,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 2,   Cupro↑, 1,   Cyt‑c↑, 7,   DR5↑, 2,   Fas↑, 1,   FasL↓, 1,   Ferroptosis↓, 5,   Ferroptosis↑, 147,   GranB/GZMB↝, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 2,   MOMP↑, 2,   necrosis↑, 2,   NOXA↑, 1,   oncosis↑, 1,   p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   Pyro↑, 4,   survivin↓, 4,   TumCD↓, 1,   TumCD↑, 5,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 20,   p‑Akt↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ?, 1,   CaMKII ↓, 1,   cMET↓, 2,   EGFR↓, 2,   ERK↓, 5,   ERK↑, 2,   p‑ERK↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 5,   MAPK↑, 5,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   mTOR↓, 15,   mTOR↑, 3,   p‑mTOR↓, 1,   OR13G1?, 1,   P70S6K↑, 1,   PI3K↓, 14,   p‑PI3K↓, 2,   PTEN↑, 3,   RET↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 10,   STAT3↑, 1,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 3,   ATFs↑, 1,   cMyc↓, 4,   DLEU1↓, 1,   DNMT1↓, 1,   DNMT1↑, 1,   DNMTs↓, 1,   FOXO1↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGF2BP3/IMP3/KOC↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-21↓, 2,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   miR-592↑, 1,   OCT4↓, 2,   other?, 1,   other↓, 2,   other↑, 3,   other↝, 4,   SOX2↓, 1,   SOX4↓, 2,   tumCV↓, 16,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 10,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 4,   OTUB2↓, 1,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3II↑, 3,   LC3s↑, 1,   lysoMP↑, 1,   p62↓, 3,   p62↑, 2,   p‑p62↑, 1,   TumAuto↑, 21,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   DNAdam↑, 8,   DNArepair↓, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   HR↓, 1,   p16↑, 2,   P53↓, 2,   P53↑, 13,   PARP↑, 2,   cl‑PARP↑, 3,   cl‑PARP∅, 1,   PCNA↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   Telomerase↓, 1,   TOP2↑, 1,   TP53↑, 1,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK1↝, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↑, 1,   CDK7↓, 1,   CHK1↝, 1,   p‑CHK1↑, 2,   p‑Chk2↑, 1,   CycB/CCNB1↓, 3,   CycB/CCNB1↑, 1,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↑, 1,   cycE1↓, 1,   Ki-67↓, 6,   mitA↑, 1,   P21↑, 2,   p27/CDKN1B↑, 2,   TumCCA↑, 35,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Axin2↑, 1,   CD133↓, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 6,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 1,   FOSL1↑, 1,   GDF15↓, 1,   Ki-67↓, 6,   mTORC1↓, 1,   Nanog↓, 3,   NOTCH↓, 3,   NOTCH1↓, 2,   Piezo1↑, 2,   TumCG↓, 33,   TumCP?, 1,   TumCP↓, 46,   TumCP↑, 4,   TumCP⇅, 1,   Wnt↓, 10,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AP-1↓, 2,   ASAP2↓, 1,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 4,   E-cadherin↑, 4,   EMT↓, 14,   ITGB1↑, 1,   MALAT1↓, 1,   MMP16↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP9↓, 6,   MMPs↓, 3,   MUC1-C↓, 1,   N-cadherin↓, 4,   NCAM↑, 1,   PCBP1↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   T-cadherin↑, 1,   TET1↑, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCI↓, 21,   TumCI↑, 1,   TumCMig↓, 19,   TumCMig↑, 1,   TumMeta↓, 10,   TumMeta↑, 1,   TumPF↓, 2,   uPA↓, 3,   Vim↓, 5,   β-catenin/ZEB1↓, 8,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 12,   angioG↑, 1,   ECM/TCF↓, 1,   EGR1↓, 1,   Hif1a↓, 13,   Hif1a↑, 1,   NO↓, 2,   REL↑, 1,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CD36/FAT↑, 1,   EPR↑, 1,   GLUT1↓, 3,   GLUT4↓, 2,   MMP↓, 16,   MPT↑, 2,   OATPs↓, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   DR4↑, 1,   Eos↑, 1,   FOXP3↓, 1,   HLA↑, 1,   HMGB1↓, 3,   IL1↓, 2,   IL12↑, 1,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 7,   Imm↝, 1,   Inflam↓, 3,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 15,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↑, 1,   PD-L1↓, 4,   PGE2↓, 1,   TCF7/TCF1↓, 1,   TLR1↑, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 1,   AR↝, 1,   CYP24A1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 4,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 46,   CompStab↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 12,   Dose∅, 1,   eff↓, 17,   eff↑, 24,   eff↝, 2,   Half-Life↓, 4,   MDR1↓, 3,   P-gp/ABCB1↓, 1,   RadioS↑, 7,   RadioS↝, 1,   selectivity↑, 13,   Synergy↑, 19,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   AR↝, 1,   BMD↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 2,   Ferritin↓, 4,   Ferritin↑, 2,   IL6↓, 1,   LDH↓, 1,   PD-L1↓, 4,   RBM3↑, 1,   TP53↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 10,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 5,   chemoP↑, 4,   hepatoP↑, 1,   OS↑, 3,   QoL↑, 1,   radioP↑, 2,   Risk↓, 2,   toxicity↓, 3,   toxicity↑, 2,   toxicity↝, 1,   TumVol↓, 7,   TumW↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 495

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 1,   antiOx↑, 14,   Catalase↑, 5,   Fenton↓, 1,   GPx↑, 4,   GPx4↓, 2,   GPx4↑, 15,   GPx4∅, 1,   GSH↓, 2,   GSH↑, 10,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 9,   HO-1↝, 1,   HO-1∅, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   lipid-P↓, 8,   lipid-P↑, 3,   MDA↓, 9,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 21,   NRF2∅, 1,   ROS↓, 22,   ROS↑, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↓, 1,   SOD↓, 1,   SOD↑, 12,   TAC↑, 3,   TBARS↓, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↓, 1,   FTH1↑, 1,   IronCh↑, 3,   NCOA4↝, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,   mtDam↓, 4,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACSL4↓, 5,   ACSL4∅, 1,   ALAT↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   ATP↑, 2,   FAO↓, 1,   GlucoseCon↑, 1,   GSK‐3β↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 8,   Apoptosis↑, 1,   BAX↓, 4,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 2,   Casp3↓, 4,   Casp3↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 32,   Ferroptosis↑, 4,   iNOS↓, 2,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   ERK↓, 1,   JNK↓, 4,   MAPK↓, 4,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↑, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 1,   DNMT1↓, 1,   DNMTs↓, 1,   FOXO3↑, 1,   KLF4↑, 1,   other↓, 2,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,   GRP78/BiP↓, 3,   IRE1↓, 2,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   neuroG↑, 1,   TumCG↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Cartilage↑, 1,   MMP9↓, 1,   NFAT↓, 1,   ROCK1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↑, 1,   NO↓, 2,   TXA2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN4↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   MMP↑, 3,   OCLN↑, 1,   TJ↑, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 5,   IL6↓, 5,   Inflam↓, 19,   NeuroI↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 4,   Aβ42↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 4,   ChemoSen↑, 1,   Dose?, 3,   eff↓, 1,   eff↑, 5,   selectivity↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   anemia↓, 1,   AST↓, 1,   BloodF↑, 1,   BP↓, 1,   BUN↓, 2,   creat↓, 2,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 5,   IRes↝, 1,   LDH↑, 1,   RAGE↓, 1,   RBC↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 7,   chemoP↑, 3,   cognitive↑, 5,   hepatoP↓, 1,   hepatoP↑, 3,   Learn↑, 2,   memory↑, 4,   motorD↑, 1,   neuroP↑, 10,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 6,   RenoP↝, 1,   Risk↓, 1,   Strength↑, 1,   Stroke↓, 4,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 3,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 222

Scientific Paper Hit Count for: Ferroptosis, Ferroptosis
19 Artemisinin
8 Matrine
8 Shikonin
8 Selenite (Sodium)
7 Luteolin
7 Cisplatin
7 erastin
7 Curcumin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Copper and Cu NanoParticles
4 Sulfasalazine
4 Honokiol
4 Kaempferol
3 doxorubicin
3 Boron
3 immunotherapy
3 Docosahexaenoic Acid
3 Isoliquiritigenin
3 Phenethyl isothiocyanate
3 Sulforaphane (mainly Broccoli)
3 Licochalcone A
3 Piperlongumine
3 Rosmarinic acid
3 salinomycin
2 Andrographis
2 Berberine
2 Betulinic acid
2 brusatol
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Disulfiram
2 Formononetin
2 Gambogic Acid
2 Ginkgo biloba
2 Ginkgetin
2 Hyperoside
2 isoquercitrin
2 Juglone
2 Lactoferrin/Talactoferrin
2 Magnetic Fields
2 Magnetic Field Rotating
2 Vitamin C (Ascorbic Acid)
2 Morin
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 5-fluorouracil
1 Docetaxel
1 Astaxanthin
1 Radiotherapy/Radiation
1 Atorvastatin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Carvacrol
1 Celastrol
1 Vitamin K2
1 Crocetin
1 Cucurbitacin
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Dipyridamole
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 ferumoxytol
1 Gallic acid
1 Hydrogen Gas
1 HydroxyTyrosol
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Lactobacillus
1 MCT oil
1 magnetic nanoparticles
1 Zeolite
1 Myricetin
1 nicotinamide adenine dinucleotide
1 Orlistat
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Psoralidin
1 Quercetin
1 Resveratrol
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitexin
1 Isovitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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