Glycolysis Cancer Research Results

Glycolysis, Glycolysis: Click to Expand ⟱
Source:
Type:
Glycolysis is a metabolic pathway that converts glucose into pyruvate, producing a small amount of ATP (energy) in the process. It is a fundamental process for cellular energy production and occurs in the cytoplasm of cells. In normal cells, glycolysis is tightly regulated and is followed by aerobic respiration in the presence of oxygen, which allows for the efficient production of ATP.
In cancer cells, however, glycolysis is often upregulated, even in the presence of oxygen. This phenomenon is known as the Warburg Mutations in oncogenes (like MYC) and tumor suppressor genes (like TP53) can alter metabolic pathways, promoting glycolysis and other anabolic processes that support cell growth.effect.
Acidosis: The increased production of lactate from glycolysis can lead to an acidic microenvironment, which may promote tumor invasion and suppress immune responses.

Glycolysis is a hallmark of malignancy transformation in solid tumor, and LDH is the key enzyme involved in glycolysis.

Pathways:
-GLUTs, HK2, PFK, PK, PKM2, LDH, LDHA, PI3K/AKT/mTOR, AMPK, HIF-1a, c-MYC, p53, SIRT6, HSP90α, GAPDH, HBT, PPP, Lactate Metabolism, ALDO

Natural products targeting glycolytic signaling pathways https://pmc.ncbi.nlm.nih.gov/articles/PMC9631946/
Alkaloids:
-Berberine, Worenine, Sinomenine, NK007, Tetrandrine, N-methylhermeanthidine chloride, Dauricine, Oxymatrine, Matrine, Cryptolepine

Flavonoids: -Oroxyline A, Apigenin, Kaempferol, Quercetin, Wogonin, Baicalein, Chrysin, Genistein, Cardamonin, Phloretin, Morusin, Bavachinin, 4-O-methylalpinumisofavone, Glabridin, Icaritin, LicA, Naringin, IVT, Proanthocyanidin B2, Scutellarin, Hesperidin, Silibinin, Catechin, EGCG, EGC, Xanthohumol.

Non-flavonoid phenolic compounds:
Curcumin, Resveratrol, Gossypol, Tannic acid.

Terpenoids:
-Cantharidin, Dihydroartemisinin, Oleanolic acid, Jolkinolide B, Cynaropicrin, Ursolic Acid, Triptolie, Oridonin, Micheliolide, Betulinic Acid, Beta-escin, Limonin, Bruceine D, Prosapogenin A (PSA), Oleuropein, Dioscin.

Quinones:
-Thymoquinone, Lapachoi, Tan IIA, Emodine, Rhein, Shikonin, Hypericin

Others:
-Perillyl alcohol, HCA, Melatonin, Sulforaphane, Vitamin D3, Mycoepoxydiene, Methyl jasmonate, CK, Phsyciosporin, Gliotoxin, Graviola, Ginsenoside, Beta-Carotene.
Scientific Papers found: Click to Expand⟱
934- Gallo,    Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase
- Analysis, NA, NA
LDH↓, Glycolysis↓, Apoptosis↑,
5206- Gallo,    Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
- in-vitro, Var, NA
LDHA↓, Glycolysis↓, TumCP↓,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
7286- GGB,    Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
Hif1a↓, Glycolysis↓, OXPHOS↑, ROS↑, Apoptosis↑, toxicity↓, PDKs↓, HK2↓, LDHA↓, PFKFB2↓, PKM2↓, eff↑,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
7297- GlaB,    H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma
- vitro+vivo, GBM, NA
TumCG↓, Glycolysis↑, lactateProd↑, Warburg↑, eff↑, Gli1↓,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, Asthma, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
7503- H2S,    Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
- Review, Var, NA
DNArepair↑, CBS↑, 3MST/MPST↑, ETC↑, ATP↑, Glycolysis↑, ACLY↑,
2400- HCAs,    The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis
- in-vitro, CRC, NA - in-vivo, CRC, NA
PKM2↓, Glycolysis↓, TumCG↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1↓, Apoptosis↑, LDHA↓,
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, BioAv↑, BioAv↑, BioAv↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7793- ISQ,    Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,
2178- itraC,    Itraconazole inhibits tumor growth via CEBPB-mediated glycolysis in colorectal cancer
- in-vivo, CRC, HCT116
TumCG↓, Glycolysis↓, CEBPB?, ENO1↓, LDHA↓, PKM2↓, GAPDH↓, ECAR↓, OCR↓,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
2390- KaempF,    Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis
- in-vitro, CRC, HCT8
eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓,
2453- LE,    The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
- Review, Var, NA
HK2↓, PI3K↓, Akt↓, TumCP↓, Glycolysis↓,
986- LT,  doxoR,    Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells
- in-vitro, BC, 4T1 - in-vitro, BC, MCF7
SOD↓, Catalase↓, Glycolysis↓,
2929- LT,    Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention
- in-vitro, Ovarian, NA
HK2↓, Myc↓, Glycolysis↓,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1/CCND1↓, P21↑, Hif1a↓, Glycolysis↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
995- MEL,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
2374- MET,    Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions
- in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231
eff↑, Apoptosis↑, Glycolysis↓, PKM2↓, mTOR↓, PARP↓,
2384- MET,    Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication
- in-vitro, Thyroid, BCPAP - in-vivo, NA, NA - in-vitro, Thyroid, TPC-1
Glycolysis↓, OXPHOS↑, tumCV↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, TumCCA↑, LDHA↓, PKM2↓, IDH1↑, TumCG↓,
994- MET,    Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy
- in-vitro, Var, NA
Glycolysis↓, HK2↓, ATP↓, AMPK↑, P53↑, Warburg↓, Apoptosis↑,
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
2247- MF,    Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis
- in-vivo, Nor, NA
*Glycolysis↓, *LDHB↑, *NAD↑, *ATP↑, *antiOx↑, *ROS↑, *YAP/TEAD↑, *PGC-1α↑, *TCA↑, *FAO↑, *OXPHOS↑,
2245- MF,    Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis
- in-vitro, Nor, NIH-3T3
Warburg↓, Hif1a↓, *Hif1a∅, Glycolysis↓, *lactateProd↓, *ADP:ATP↓, Pyruv↓, ADP:ATP↓, *PPP↓, *mt-ROS↑, *ROS↓, RPM↑, *ECAR↓,
2244- MF,    Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer
- Review, Var, NA
RPM↑, Glycolysis∅, ROS↑, ChemoSen↑, RadioS↑, selectivity↑,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,
968- OA,    Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MBT-2
Hif1a↓, SIRT3↑, SOD2↑, GlucoseCon↓, Glycolysis↓, TumCG↓,
991- OA,    Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
- in-vivo, NA, NA - in-vivo, Nor, NA
*Glycolysis↓, *GlucoseCon↓, *lactateProd↓, *ECAR↓, *HK2↓, *PFK↓, *PKM2↓, *LDHA↓,
2396- PACs,    PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- in-vitro, HCC, HCCLM3 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2 - in-vitro, Nor, L02
TumCP↓, TumCCA↓, Apoptosis↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, HK2↓, PFK↓, OXPHOS↑, ChemoSen↑, HSP90↓, Hif1a↓,
2421- PB,    Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
- in-vitro, HCC, HCCLM3 - in-vivo, NA, NA - in-vitro, HCC, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vitro, Nor, L02
Glycolysis↓, Apoptosis↑, TumCP↓, lactateProd↓, GlucoseCon↓, HK2↓, ChemoSen↑, *toxicity↓, cMyc↓, PFK1↓, LDHA↓, cMyc↓, ChemoSen↑,

Showing Research Papers: 151 to 200 of 288
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 288

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   Catalase↓, 2,   Catalase↑, 1,   compI↓, 1,   Ferroptosis↑, 1,   i-Iron↑, 1,   NRF2↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 8,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   ROS↓, 1,   ROS↑, 19,   ROS⇅, 1,   RPM↑, 2,   SIRT3↑, 1,   SOD↓, 2,   SOD2↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ATP↓, 10,   ATP↑, 2,   compIII↓, 1,   ETC↓, 1,   ETC↑, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 3,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 5,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 2,   ACLY↑, 1,   ALDOA↓, 1,   AMPK↑, 5,   CAIX↓, 1,   cMyc↓, 4,   ECAR↓, 5,   ENO1↓, 2,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↑, 1,   GlucoseCon↓, 9,   GlucoseCon↑, 2,   GlutaM↓, 1,   Glycolysis↓, 40,   Glycolysis↑, 2,   Glycolysis∅, 1,   HK2↓, 10,   IDH1↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDH↓, 3,   LDHA↓, 11,   MCT4↓, 2,   NADPH↓, 1,   PDH↓, 1,   PDH↑, 1,   PDK1↓, 2,   PDKs↓, 1,   PFK↓, 2,   PFK1↓, 2,   PFKFB2↓, 1,   PKM2↓, 9,   Pyruv↓, 2,   Pyruv↑, 1,   STK11/LKB1↑, 1,   TCA↑, 1,   Warburg↓, 5,   Warburg↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   p‑Akt↓, 1,   Apoptosis↑, 17,   BAX↑, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 4,   proCasp3↓, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Cyt‑c↝, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↑, 2,   MAPK↑, 1,   Mcl-1↓, 1,   MCT1↓, 1,   MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↑, 1,   p38↓, 1,   p38↑, 3,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

mt-DNAdam↑, 1,   DNArepair↑, 1,   P53↑, 2,   PARP↓, 1,   cl‑PARP↑, 1,   proPARP↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   Cyc↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPB?, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 1,   Gli1↓, 2,   p‑GSK‐3β↓, 1,   HH↓, 1,   IGF-1↓, 1,   miR-34a↑, 1,   mTOR↓, 5,   NOTCH↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   PTCH1↓, 1,   Shh↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT5↓, 1,   TumCG↓, 12,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   Slug↓, 1,   TumCA↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 9,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 8,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT3↓, 1,   GLUT4↓, 3,   NHE1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 1,   IκB↑, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 7,   BioAv↝, 2,   ChemoSen↑, 5,   Dose↝, 2,   eff↓, 2,   eff↑, 7,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   LDH↓, 3,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   neuroP↑, 2,   OS↑, 1,   toxicity↓, 2,   TumVol↓, 1,  
Total Targets: 207

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

FFA/NEFA↓, 1,   IRes↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   mt-antiOx↑, 1,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 2,   GPx1↑, 2,   GPx4↑, 2,   HO-1↑, 1,   MFN1↑, 1,   MFN2↑, 1,   NQO1↑, 1,   NRF2↑, 1,   OPA1↑, 1,   OXPHOS↓, 3,   OXPHOS↑, 3,   ROS↓, 10,   ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ATP↑, 3,   DRP1/DNM1L↓, 1,   ETC↑, 1,   mitResp↓, 1,   MMP↑, 2,   MMP↝, 1,   OCR↑, 1,   PGC-1α↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   BMAL1↑, 1,   ECAR↓, 4,   FAO↑, 2,   FASN↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 4,   Glycolysis↑, 3,   Glycolysis↝, 1,   HK2↓, 1,   HK2↑, 2,   lactateProd↓, 2,   LDHA↓, 1,   LDHB↑, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↑, 1,   PDKs↑, 1,   PFK↓, 1,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 3,   PPARα↑, 1,   PPP↓, 1,   SIRT1↑, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

Hippo↑, 1,   MAPK↓, 1,   Pyro↓, 1,   YAP/TEAD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   CXCL12↑, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a∅, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 2,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   PAR-2↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 99

Scientific Paper Hit Count for: Glycolysis, Glycolysis
19 Shikonin
14 3-bromopyruvate
12 Citric Acid
12 Dichloroacetate
11 Baicalein
11 Sulforaphane (mainly Broccoli)
9 Resveratrol
8 EGCG (Epigallocatechin Gallate)
8 Quercetin
7 Berberine
7 Metformin
7 Propolis -bee glue
7 Magnetic Fields
6 Artemisinin
6 Curcumin
6 Vitamin C (Ascorbic Acid)
5 Alpha-Lipoic-Acid
5 Apigenin (mainly Parsley)
5 Ashwagandha(Withaferin A)
5 Betulinic acid
5 Diclofenac
4 Chrysin
4 Chemotherapy
4 Emodin
4 Galloflavin
4 Honokiol
4 Methylene blue
4 Ursolic acid
4 Vitamin D3
3 2-DeoxyGlucose
3 5-fluorouracil
3 Capsaicin
3 Chlorogenic acid
3 Cinnamon
3 diet FMD Fasting Mimicking Diet
3 Isoliquiritigenin
3 Piperlongumine
3 Silymarin (Milk Thistle) silibinin
2 Radiotherapy/Radiation
2 DTS(dibenzyl trisulphide) from Anamu
2 Brucea javanica
2 salinomycin
2 Ellagic acid
2 Fenbendazole
2 Luteolin
2 Melatonin
2 Oroxylin-A
2 Phenylbutyrate
2 Rosmarinic acid
2 Thymoquinone
2 Wogonin
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 tamoxifen
1 Baicalin
1 Boron
1 Boswellia (frankincense)
1 brusatol
1 Caffeic acid
1 Carnosine
1 Celecoxib
1 Celastrol
1 Cichoric acid / Chicoric acid
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 nicotinamide adenine dinucleotide
1 Spermidine
1 Dichloroacetophenone(2,2-)
1 Bortezomib
1 Deguelin
1 diet Methionine-Restricted Diet
1 Dandelion Root
1 Piperine
1 Eugenol
1 Ferulic acid
1 flavonoids
1 Ginkgolide B
1 Ginseng
1 Glabrescione B
1 Gossypol/AT-101
1 Hydrogen Gas
1 hydrogen sulfide
1 Hydroxycinnamic-acid
1 Inositol
1 isoquercitrin
1 itraconazole
1 Ivermectin
1 Kaempferol
1 lambertianic acid
1 Licorice
1 doxorubicin
1 Lycopene
1 Mushroom Chaga
1 Niclosamide (Niclocide)
1 Nimbolide
1 Proanthocyanidins
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Rutin
1 Docetaxel
1 VitK3,menadione
1 Cisplatin
1 triptolide
1 Tumor Treating Fields
1 Selenite (Sodium)
1 Arsenic trioxide
1 Vitamin K2
1 β‐Elemene
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:129  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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