AChE Cancer Research Results

AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA
-Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage
-AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss
-adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended

- Natural AChE inhibitors paper
Scientific Papers found: Click to Expand⟱
8616- MO,  RosA,    Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L
- Study, AD, NA
*AChE↓, *Ingr↝,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,
3843- MO,    Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway
- in-vivo, AD, NA
*memory↑, *ROS↓, *Ach↑, *AChE↓,
3840- MO,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3838- MO,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
3835- MO,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE/β-secretase↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
8957- mushLions,    Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
- Review, Nor, NA
*neuroP↑, *AntiTum↑, *antiOx↑, TumCP↓, *Inflam↓, TumCI↓, Casp↑, *GutMicro↑, *proBDNF↑, *BDNF↑, *Mood↑, *antiD↑, *ANXi↓, *Sleep↑, *cognitive↑, *Imm↑, *NGF↑, *AChE↓, *toxicity↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, AD, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, AD, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE/β-secretase↓,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
3759- NarG,  RT,  CGA,  RosA,    Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease
- Review, AD, NA
*AChE↓, *other↓, *other↓,
4224- NarG,    The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
- in-vivo, Obesity, NA - NA, AD, NA
*memory↑, *Mood↑, *CREB↑, *BDNF↑, *AChE↓, *cognitive↑, *neuroP↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
8435- OM,  Aroma,    Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study
- in-vivo, AD, NA
*Dose?, *antiOx↑, *BDNF↑, *cognitive↑, *AntiViral↑, *AChE↝, *TumMeta↓, *TumCG↓, *Ingr↝, *DNAdam↓, *ROS↓, *MDA↓, *memory↑,
8436- OM,    Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study
- in-vivo, AD, NA
*Dose↝, *Ingr↝, *neuroP↑, *IL6↓, *NO↓, *TNF-α↓, *Inflam↓, *ROS↓, *cognitive↑, *COX2/PTGS2↓, *AChE↓, *GFAP↓,
8437- OM,    Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model
- in-vivo, AD, NA
*Ingr↝, *memory↑, *AChE↓, *ROS↓,
8440- OM,    Free radical scavenging and antiacetylcholinesterase activities of Origanum majorana L. essential oil
- in-vitro, AD, NA
*Ingr↝, *H2O2↓, *lipid-P↓, *AChE↓, *antiOx↑,
8452- OM,    Sweet Marjoram: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities
- Review, Nor, NA
*hepatoP↑, *cardioP↑, *AntiAg↑, *GastroP↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *TumMeta↓, *AntiTum↑, *AChE↓, *Ingr↝, *antiOx↑, Apoptosis↑, P53↑, Bcl-2↓, E-cadherin↑, MMP2↓, MMP9↓, TumMeta↓, *NO↓, *lipid-P↓,
8451- Oreg,    A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
- in-vivo, AD, NA
*Learn↑, *memory↑, *AChE↓, *ROS↓, *COX2/PTGS2↓, *iNOS↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
8988- PCorn,    A Randomized Controlled Trial on the Safety and Cognitive Benefits of a Novel Functional Drink from a Purple Waxy Corn Byproduct in Peri- and Postmenopausal Women
- Trial, Nor, NA
*Dose?, *motorD↑, *memory↑, *ROS↓, *AChE↓, *Ingr↝,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3599- PI,    Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *neuroP↑, *lipid-P↓, *AChE↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3632- RosA,  CA,  QC,    Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer's Disease
- Review, AD, NA
*AChE↓,
3623- RosA,    Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes
- in-vitro, AD, NA
*AChE↓,
3622- RosA,    Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats
- in-vivo, Diabetic, NA
*lipid-P↓, *AChE↓,
3755- RosA,  CUR,    Development of Acetylcholinesterase (AChE) Inhibitor
- Study, AD, NA
*AChE↓, *antiOx↑, *Inflam↓,
3757- RosA,  Sage,  Cro,  NarG,  Caff  Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
- Review, AD, NA
AChE↓,
3645- Sage,  RosA,    Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family
- Study, AD, NA
*AChE↓, *AChE↓,
3643- Sage,    Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery
- Human, Nor, NA
*cognitive↑, *AChE↓,
3641- Sage,    Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer's Disease
- Review, AD, NA
*cognitive↑, *memory↑, *AChE↓,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
4085- Se,    Role of micronutrients in Alzheimer's disease: Review of available evidence
- Review, AD, NA
*AChE↓, *BChE↓, *antiOx↑, *memory↑, *cognitive↑,
6058- SeNPs,  RES,  QC,  CAR,    Engineered nanoplatforms for brain-targeted co-delivery of phytochemicals in Alzheimer's disease: Rational design, blood-brain barrier penetration, and multi-target therapeutic synergy
- Review, AD, NA
*DDS↑, *cognitive↑, *Aβ↓, *tau↓, *Inflam↓, *antiOx↑, *CompStab↑, *CompStab↑, *neuroP↑, *BioAv↑, *AChE↓,
6055- SeNPs,  CUR,  RES,    Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems
- Review, AD, NA
*DDS↑, *Dose↝, *p‑Akt↑, *GSK‐3β↓, *NF-kB↓, *BBB↑, *AChE↓,
6046- SeNPs,  CGA,    Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles
- Study, AD, NA
*AChE↓, *BChE↓, *Aβ↓, *eff↑, *BBB↑, *Dose↝, *IronCh↑, *antiOx↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
3943- Shank,    Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach
- Review, AD, NA
*neuroP↑, *memory↑, *other↝, *AChE↓, *MAOA↓, *MAOB↓, *TrkB↓, *tau↓, *APP↓, *ROS↓, *Mood↑,
3945- Shank,    Novel insights on acetylcholinesterase inhibition by Convolvuluspluricaulis, scopolamine and their combination in zebrafish
- in-vivo, AD, NA
*AChE↓,
3946- Shank,    Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *antiOx↑, *GSR↑, *SOD↑, *GSH↑, *Inflam↓, *ROS↓, *lipid-P↓, *cardioP↑,
3947- Shank,    Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila model
- in-vivo, AD, NA
*OS↑, *antiOx↑, *ROS↓, *AChE↑, *neuroP↑, *memory↑,
3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, *ChAT↑, *NGF↑, *CDK5↓, *neuroP↑, *MDA↓,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,

Showing Research Papers: 151 to 200 of 221
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 221

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   Catalase↑, 1,   GSH↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 3,   HO-1↝, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 3,   ROS↑, 7,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 1,   SOD↑, 2,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   mitResp↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 1,   ATP↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 13,   Bak↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-2↑, 1,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 3,   Casp↝, 1,   Casp1↑, 1,   Casp3↓, 2,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp8↑, 4,   Casp9↑, 8,   cl‑Casp9↑, 1,   proCasp9↓, 1,   Cyt‑c↑, 5,   DR5↑, 1,   Fas↑, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p‑p38↑, 1,   TumCD↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 10,   Akt↑, 1,   p‑Akt↓, 2,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 4,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 1,   JAK↓, 1,   MAPK↑, 2,   mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PKCδ↓, 2,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cMyc↓, 3,   FOXO1↑, 1,   HATs↓, 1,   miR-34a↑, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 9,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 2,   PCNA↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 2,   CDK6↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 4,   Ki-67↓, 1,   mitA↑, 1,   P21↑, 3,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs?, 1,   CSCs↓, 1,   FGF↓, 1,   Ki-67↓, 1,   NOTCH↓, 1,   TumCG↓, 7,   TumCG↑, 1,   TumCP↓, 11,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   EMT↓, 3,   EMT↝, 1,   FAK↓, 2,   LAMs↓, 1,   MMP2↓, 7,   MMP7↓, 1,   MMP9↓, 7,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 2,   Snail↓, 1,   TIMP2↑, 2,   TumCI↓, 4,   TumCMig↓, 7,   TumMeta↓, 6,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 6,   VEGF↓, 8,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL12↓, 1,   IL2↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   NLRP3↓, 1,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↓, 1,   AChE↓, 4,   AChE↑, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 10,   CYP1A1↓, 1,   DDS↑, 1,   Dose↝, 3,   eff↑, 3,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 4,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 4,   EGFR↑, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   NOS2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 222

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 99,   ARE↑, 3,   Catalase↓, 1,   Catalase↑, 40,   GPx↑, 30,   GPx4↑, 3,   GSH↑, 48,   GSR↓, 1,   GSR↑, 5,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 8,   H2O2↓, 5,   HDL↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 32,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 2,   Iron↝, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 47,   lipid-P↑, 1,   MDA↓, 41,   MDA↑, 2,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 44,   ONOO↓, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 118,   ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↓, 3,   SOD↑, 60,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 6,   Thiols↑, 2,   TOS↓, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 10,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 6,   ACC↑, 1,   ALAT↓, 4,   ALAT∅, 1,   AMPK↑, 7,   ATP↑, 8,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 4,   GSK‐3β↓, 18,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   LDL↓, 9,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   SIRT1↑, 5,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 14,   BAD↓, 1,   BAX↓, 9,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 8,   Casp↓, 2,   Casp3↓, 16,   Casp9↓, 3,   Cyt‑c↓, 3,   Fas↓, 1,   Ferroptosis↓, 3,   iNOS↓, 19,   iNOS↑, 1,   necrosis↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 15,   p‑Akt↓, 3,   p‑Akt↑, 3,   AMPKα↑, 1,   CREB↑, 5,   p‑CREB↑, 3,   ERK↓, 1,   ERK↑, 3,   p‑ERK↓, 1,   HER2/EBBR2↓, 1,   IKKα↓, 1,   JNK↓, 4,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 6,   p‑mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 11,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PTP1B↓, 2,   STAT3↓, 1,   STEP↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HATs↓, 1,   HDAC↓, 1,   HDAC↑, 1,   other?, 1,   other↓, 18,   other↑, 4,   other↝, 7,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 3,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↑, 1,   Choline↑, 1,   HH↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 5,   AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   CD31/PECAM-1↑, 1,   Hif1a↓, 1,   NO↓, 19,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 33,   BBB↝, 2,   GastroP↑, 6,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 14,   MMP↝, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 2,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 6,   IL12↓, 2,   IL17↓, 4,   IL18↓, 1,   IL1β↓, 30,   IL1β↑, 1,   IL2↓, 1,   IL23↓, 3,   IL33↓, 1,   IL4↓, 1,   IL4↑, 3,   IL6↓, 21,   IL6↑, 2,   IL8↓, 3,   Imm↑, 6,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 97,   Inflam↑, 2,   IRF3↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MyD88↓, 2,   NeuroI↓, 6,   NF-kB↓, 36,   NF-kB↑, 1,   NLRP3↓, 6,   PGE2↓, 5,   RAGE↓, 1,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 43,   TRAF6↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 7,   Ach?, 1,   Ach↑, 22,   AChE↓, 210,   AChE↑, 3,   AChE↝, 2,   AChE∅, 5,   ADAM10↑, 2,   BChE?, 1,   BChE↓, 36,   BChE∅, 1,   BDNF↓, 1,   BDNF↑, 34,   proBDNF↑, 1,   ChAT↑, 12,   ChE↓, 1,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 11,   MAOA↝, 1,   MAOB↓, 8,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN3↓, 1,   TrkB↓, 1,   TrkB↑, 7,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 4,   APP↓, 10,   Aβ↓, 69,   Aβ↑, 1,   Aβ42↓, 6,   BACE/β-secretase↓, 29,   BACE/β-secretase↝, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↓, 1,   QPCT/QC↓, 1,   tau↓, 15,   p‑tau↓, 22,   XO↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   ERβ/ESR2↑, 1,   GR↑, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 31,   BioAv⇅, 1,   BioAv↝, 11,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   DDS↑, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 28,   eff↑, 22,   eff↝, 1,   eff∅, 1,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALAT∅, 1,   ALP↓, 3,   AST↓, 5,   AST∅, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 6,   creat↓, 2,   CRP↓, 4,   Ferritin↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 21,   IL6↑, 2,   IRes↓, 1,   IRes↝, 1,   LDH↓, 6,   NOS2↓, 3,   RAGE↓, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 8,   antiCG↑, 1,   antiD↑, 1,   AntiDiabetic↑, 15,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 2,   ANXi↓, 1,   cardioP↑, 30,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 92,   cognitive∅, 2,   hepatoP↓, 1,   hepatoP↑, 23,   Learn↑, 10,   memory↑, 91,   Mood?, 1,   Mood↑, 8,   motorD↑, 12,   Mucositis↓, 1,   neuroP↑, 125,   NP/CIPN↓, 2,   Obesity↓, 10,   OS↑, 3,   Pain↓, 6,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 1,   Sleep↑, 5,   Strength↑, 2,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 19,   toxicity↑, 1,   toxicity∅, 2,   Weight↓, 1,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 7,   AntiViral↑, 6,   Bacteria↓, 13,   Diar↓, 3,   GutMicro↑, 12,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 10,  
Total Targets: 450

Scientific Paper Hit Count for: AChE, acetylcholinesterase
18 Curcumin
12 Chlorogenic acid
11 Huperzine A/Huperzia serrata
11 Rosmarinic acid
10 Crocetin
9 Ferulic acid
8 Thymoquinone
7 Berberine
7 Mung Bean Sprouts
7 Vitexin
7 Moringa oleifera
6 Quercetin
6 Caffeic acid
6 Salvia officinalis
6 Marjoram (Origanum majorana)
5 Aromatherapy
5 Luteolin
5 Carvacrol
5 Centella asiatica / Gotu kola → asiaticoside
5 Isovitexin
5 Shankhpushpi
4 EGCG (Epigallocatechin Gallate)
4 α-Bisabolol / Chamomile oil
4 Selenium NanoParticles
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Boswellia (frankincense)
3 Galantamine
3 Resveratrol
3 Magnolol
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Naringin
2 Alpha-Lipoic-Acid
2 Angelica archangelica / Garden Angelica
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Boron
2 Rutin
2 D-limonene
2 flavonoids
2 Garcinol
2 Ginkgo biloba
2 Lemon Balm/Melissa officinalis
2 Geraniol
2 Honokiol
2 Hyperoside
2 Kaempferol
2 Licochalcone A
2 Lycopene
2 Matrine
2 Turmerones
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chrysin
1 Chyawanprash
1 Cinnamon
1 Citicoline, CDP-Choline
1 Radiotherapy/Radiation
1 Vitamin E
1 Ginger/6-Shogaol/Gingerol
1 Capsaicin
1 Rivastigmine
1 Diindolylmethane
1 Indole-3-carbinol
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Protocatechuic acid
1 Emodin
1 Formononetin
1 Gallic acid
1 Gamma-aminobutyric acid
1 isoorientin
1 isoquercitrin
1 Lactoferrin/Talactoferrin
1 MCT oil
1 Magnetic Field Rotating
1 Magnetic Fields
1 Melatonin
1 Morin
1 Zeolite
1 Methylsulfonylmethane
1 Myricetin
1 Nimbolide
1 Oregano
1 Propolis -bee glue
1 Purple Corn / Purple Maize
1 Carnosic acid
1 Caffeine
1 Selenium
1 Sesame seeds and Oil
1 Chemotherapy
1 Safflower yellow
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vanillic Acid
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1329  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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