BDNF Cancer Research Results

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱
Source:
Type:
Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.
Scientific Papers found: Click to Expand⟱
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
8487- MF,    The effect of repetitive transcranial magnetic stimulation on immediate and long-term cognitive functions in Alzheimer's dementia and mild cognitive impairment: a meta-analysis
- Review, AD, NA
*cognitive↑, *Dose↝, *Dose↝, *BDNF↑, *neuroP↑,
3737- MF,    The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats
- in-vivo, AD, NA
*memory↑, *BDNF↑, *BBB↑,
4150- MF,    Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice
- in-vitro, Nor, NA
*BDNF↑, *VEGF↑,
4146- MF,    Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neurons
- in-vivo, AD, NA
*BDNF↑, *ERK↑,
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
4119- MF,    Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature review
- Review, AD, NA
*cognitive↑, *memory↑, *motorD↑, *eff↑, *eff↑, *Dose↝, *Dose↝, *Dose↝, *BDNF↑, *Aβ↓, *eff↑,
4149- MF,    Pulsed Electro-Magnetic Field (PEMF) Effect on Bone Healing in Animal Models: A Review of Its Efficacy Related to Different Type of Damage
- Review, Nor, NA
*other↑, *BDNF↑, *BMPs↑, *BMD↑,
4148- MF,    Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients
- Human, Stroke, NA
*neuroP↑, *BDNF↑, *Dose↝,
4118- MF,    Effects of transcranial magnetic stimulation on neurobiological changes in Alzheimer's disease
- Review, AD, NA
*cognitive↑, *BDNF↑, *neuroP↑, *memory↑, *ROS↓, *antiOx↑, *Aβ↓, *eff↑,
3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *5HT↑, *cFos↑, *Aβ↓, *memory↑, *BDNF↑, *Ach↑, *AChE↓, *cognitive↑, *BDNF↑, *NGF↑, *β-catenin/ZEB1↑, *p‑Akt↓, *mTOR↓, *MMP1↓, *MMP9↓, *MMP-10↓, *TIMP1↑, *TIMP2↑,
8467- Mg,    Magnesium L-Threonate Reduces Hippocampal Amyloid-β Load without Cognitive Improvement in a PTU-induced Hypothyroidism Model in Young Rats
- in-vivo, AD, NA
*cognitive∅, *BDNF↑, *Aβ42↓,
4169- Mg,    Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala
- in-vivo, Nor, NA
*BDNF↑, *memory↑,
4168- Mg,    Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway
- in-vivo, Nor, NA
*BDNF↑,
8666- MLT,    Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial
- Trial, BC, NA
other↝, cognitive↑, memory↑, Verbal↑, neuroP↑, BDNF↓, TrkB↓, chemoP↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
4226- MO,    The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model
- in-vivo, AD, NA
*neuroP↑, *Mood↑, *BDNF↑, *AChE↓, *MDA↓,
8613- MO,    Unraveling the Effects of Melissa officinalis L. on Cognition and Sleep Quality: A Narrative Review
- Review, AD, NA
*Sleep↑, *Mood↑, *Synergy↑, *QoL↑, *cognitive↑, *ROS↓, *NRF2↑, *HO-1↑, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MDA↓, *Catalase↑, *SOD↑, *BDNF↑, *Dose↝,
8908- MO,    Water Extracts of Moringa oleifera Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *GPx↑, *Catalase↑, *SOD↑, *Bcl-2↓, *BAX↓, *Casp3↓, *BDNF↑, *p‑Akt↑, *p‑CREB↑, *neuroP↑,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
8872- MOR,    Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *MDA↓, *NO↓, *GSH↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *BDNF↑, *antiOx↑, *NeuroI↓, *memory↑,
8888- MOR,    Morin improves learning and memory in healthy adult mice
- in-vivo, AD, NA
*Dose↝, *memory↑, *BDNF↑, *PSD95↑, *memory↑, *BioAv↝,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
8962- mushLions,    Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models
- Review, AD, NA
*NRF2↑, *antiOx↑, *Inflam↓, *neuroG↑, *cognitive↑, *Mood↑, *NGF↑, *BDNF↑, *IL6↓, *TNF-α↓, *neuroP↑, *Ingr↑, *Dose↝, *Learn↑, *memory↑,
8946- mushLions,    Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study
- Trial, AD, NA
*Dose?, *cognitive↑, *Calcium↑, *APOE4↑, *ALB↑, *HemoG↑, *BDNF↑, *ADC↓, *neuroP↑,
8949- mushLions,    Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
- Trial, Obesity, NA
*antiD↑, *ANXi↓, *Sleep↑, *proBDNF↑, *Ingr↝, *Ingr↝, *Dose↝,
8957- mushLions,    Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
- Review, Nor, NA
*neuroP↑, *AntiTum↑, *antiOx↑, TumCP↓, *Inflam↓, TumCI↓, Casp↑, *GutMicro↑, *proBDNF↑, *BDNF↑, *Mood↑, *antiD↑, *ANXi↓, *Sleep↑, *cognitive↑, *Imm↑, *NGF↑, *AChE↓, *toxicity↓,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, *cognitive↑, *cognitive∅, *BBB↑, *NGF↑, *BDNF↑, *NO↓, *memory↑, *Aβ↓,
4160- NAD,    The biochemical pathways of central nervous system neural degeneration in niacin deficiency
- Review, Nor, NA
*BDNF↑, *TrkB↑,
4224- NarG,    The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
- in-vivo, Obesity, NA - NA, AD, NA
*memory↑, *Mood↑, *CREB↑, *BDNF↑, *AChE↓, *cognitive↑, *neuroP↑,
4223- NarG,    Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
- in-vivo, Stroke, NA
*neuroG↑, *BDNF↑, *motorD↑,
4225- NarG,    Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury
- in-vivo, AD, NA
*motorD↑, *BDNF↑, *VEGF↑, *Bax:Bcl2↓, *Casp3↓, *Apoptosis↓, *eff↑,
8435- OM,  Aroma,    Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study
- in-vivo, AD, NA
*Dose?, *antiOx↑, *BDNF↑, *cognitive↑, *AntiViral↑, *AChE↝, *TumMeta↓, *TumCG↓, *Ingr↝, *DNAdam↓, *ROS↓, *MDA↓, *memory↑,
4156- PB,    The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain
- in-vivo, AD, NA
*BDNF↑, *CREB↑,
4219- PBG,    Propolis Increases Brain Derived Neurotrophic Factor Expression in the Prefrontal Cortex of Rat Stress Model
- in-vivo, AD, NA
*BDNF↑,
4218- PBG,    The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells
- in-vitro, Nor, SH-SY5Y - in-vitro, AD, NA
*cognitive↑, *ROS↓, *BDNF↑, *neuroP↑, *antiOx↑,
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *Aβ↓, *p‑tau↓, *autophagy↓, *GSK‐3β↓, *NeuroI↓, *iNOS↓, *COX2/PTGS2↓, *BDNF↑, *MEF2D↑, *cognitive↑, *memory↑,
4222- PI,    Potential of piperine for neuroprotection in sepsis-associated encephalopathy
- in-vivo, Sepsis, NA
*MMP9↓, *BDNF↑, *memory↑, *neuroP↑,
4221- PI,    Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells
- in-vitro, AD, NA
*Mood↑, *BDNF↑,
4220- PI,    Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- in-vivo, AD, NA - in-vivo, MS, NA
*memory↑, *iNOS↓, *NRF2↑, *HO-1↑, *TAC↑, *TNF-α↓, *IL1β↓, *NF-kB↓, *IL10↑, *FOXP3↑, *BDNF↑, other↑,
7517- Poly,    Modulation of neurotrophic signaling pathways by polyphenols
- Review, Nor, NA
*NRF2↑, *HO-1↑, *NGF↑, *BDNF↑, *neuroP↑, p‑CREB↑,
4170- ProBio,  PB,    Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine
- in-vivo, Nor, NA
*BDNF↑, *GutMicro↑,
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4162- QC,    Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
- in-vivo, Stroke, NA
*neuroP↑, *BDNF↑, *TrkB↑, *p‑Akt↑,
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
*Inflam↓, *COX2/PTGS2↓, *5LO↓, *antiOx↑, *BioAv↝, *GPx↑, *SOD↑, *Ach↑, *4-HNE↓, *CREB↑, *BDNF↑, *ROS↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, Nor, NA
*SIRT1↑, *BDNF↑, *PSD95↑, *memory↑,
4153- RES,    Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
4154- RES,    Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,

Showing Research Papers: 151 to 200 of 245
Prev Page 4 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 245

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 2,   Catalase↑, 1,   GSH↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 6,   ROS⇅, 2,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 8,   BAX↑, 1,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Casp↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   FADD↑, 1,   Mcl-1↓, 1,   MOMP↑, 1,   PUMA↑, 1,   TNFR 1↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Akt2↓, 1,   CaMKII ↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 4,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   FOXO1↑, 1,   miR-34a↓, 1,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 3,   P53↓, 2,   PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   CSCs↓, 1,   Ki-67↓, 3,   NOTCH1↓, 1,   NOTCH1↑, 1,   TumCG↓, 6,   TumCP↓, 7,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 3,   Fibronectin↓, 1,   LAMs↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   MMP9↑, 1,   Slug↓, 2,   Snail↓, 1,   TET1↑, 1,   TRIB3↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 3,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   PD-1↓, 1,   PSA↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↝, 2,   CBR1↓, 1,   ChemoSen↑, 8,   CYP1A1↓, 1,   Dose↝, 3,   eff↑, 2,   Half-Life↓, 1,   Half-Life↑, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 4,   Synergy?, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   PSA↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Verbal↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cardioP↑, 1,   chemoP↑, 3,   cognitive↑, 3,   memory↑, 2,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 63,   ARE↑, 5,   Bil↑, 1,   Catalase↓, 1,   Catalase↑, 26,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 20,   GPx4↑, 2,   GSH↑, 31,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 25,   Iron↓, 2,   Keap1↝, 1,   lipid-P↓, 23,   lipid-P↑, 1,   MDA↓, 31,   MDA↑, 1,   MPO↓, 2,   MPOD↑, 1,   NOX↓, 2,   NQO1↑, 6,   Nrf1↑, 2,   NRF2↑, 47,   ONOO↓, 1,   ROS?, 1,   ROS↓, 86,   mt-ROS?, 1,   SOD↓, 2,   SOD↑, 39,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 6,   OCR↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 5,   adiP↑, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 8,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 1,   FABP4↓, 1,   glucose↓, 2,   GSK‐3β↓, 12,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   LDL↓, 7,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   PFK↓, 1,   SIRT1↑, 15,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 19,   ASC↓, 1,   BAX↓, 12,   Bax:Bcl2↓, 5,   Bcl-2↓, 2,   Bcl-2↑, 10,   Casp1↓, 1,   Casp3↓, 22,   Casp3↑, 1,   cl‑Casp3↓, 3,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 2,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 11,   Akt↝, 2,   p‑Akt↓, 4,   p‑Akt↑, 6,   p‑AKT1↑, 1,   AMPKα↑, 1,   CREB↓, 2,   CREB↑, 26,   CREB∅, 1,   p‑CREB↑, 13,   ERK↑, 10,   p‑ERK↓, 1,   p‑ERK↑, 1,   IκB↓, 1,   IκB↑, 1,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 4,   p‑p70S6↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 9,   PI3K↝, 1,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   PTP1B↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cJun↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC↑, 1,   HDAC2↓, 3,   MEF2D↑, 1,   other↓, 3,   other↑, 6,   other↝, 1,   SOX2↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 3,   PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   PARP↓, 1,   PARP1↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   Ki-67↑, 2,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↑, 2,   Nestin↑, 1,   neuroG↑, 6,   NOTCH1↑, 1,   TumCG↓, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↝, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 1,   MUC1↑, 1,   TG2/TGase↓, 2,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumMeta↓, 1,   TXNIP↓, 2,   uPA↑, 1,   β-catenin/ZEB1↑, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   NO↓, 12,   NO↑, 1,   VCAM-1↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 24,   BBB↝, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 8,   OCLN↑, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 3,   COX2/PTGS2↓, 18,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 2,   IL10↑, 6,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 33,   IL23↓, 2,   IL33↓, 1,   IL4↑, 2,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   IL8↓, 6,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 71,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 8,   NF-kB↓, 36,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NLRP3↓, 11,   PAF↓, 1,   PGE2↓, 6,   RAGE↓, 1,   TLR1↓, 1,   TLR4↓, 6,   TNF-α↓, 49,   TRAF6↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 11,   Ach↑, 11,   AChE↓, 32,   AChE↑, 1,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↓, 4,   BDNF↑, 233,   BDNF⇅, 1,   BDNF↝, 1,   BDNF∅, 8,   proBDNF↑, 2,   BrainVol↑, 1,   ChAT↑, 3,   GABA↓, 1,   GABA↑, 4,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOB↓, 2,   NGF↑, 13,   PSD95↑, 14,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 2,   TrkB↓, 1,   TrkB↑, 25,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APOE4↑, 1,   APP↓, 6,   Aβ↓, 41,   Aβ↑, 1,   Aβ42↓, 4,   BACE/β-secretase↓, 15,   PSEN1/PS1↓, 1,   tau↓, 6,   p‑tau↓, 15,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

END↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 11,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   Dose?, 4,   Dose↑, 3,   Dose↝, 22,   eff↑, 17,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ADC↓, 1,   ALAT↓, 5,   ALB↑, 1,   AST↓, 6,   Bil↑, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   BP∅, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 2,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 2,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 5,   antiCG↑, 1,   antiD↑, 2,   AntiDiabetic↑, 6,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   ANXi↓, 2,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 91,   cognitive∅, 3,   hepatoP↑, 15,   Learn↑, 10,   memory↑, 82,   Mood↑, 21,   motorD↑, 10,   neuroP↑, 108,   NP/CIPN↓, 1,   Obesity↓, 6,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 6,   Stress↓, 1,   Stroke↓, 4,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 6,   Diar↓, 2,   GutMicro↑, 12,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 5,  
Total Targets: 411

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor
11 Exercise
10 Hydrogen Gas
10 Magnetic Fields
7 Lycopene
6 Curcumin
6 Sulforaphane (mainly Broccoli)
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Silymarin (Milk Thistle) silibinin
6 Vitamin D3
5 Apigenin (mainly Parsley)
5 Luteolin
5 Zinc
4 Ellagic acid
4 Ginseng
4 Honokiol
4 Huperzine A/Huperzia serrata
4 isoorientin
4 L-Theanine
4 Resveratrol
3 Aromatherapy
3 Carnosic acid
3 Caffeine
3 Cysteamine
3 Ferulic acid
3 Ginkgolide B
3 Magnesium
3 Morin
3 Naringin
3 Piperine
3 Urolithin
2 flavonoids
2 Baicalin
2 Berberine
2 Bacopa monnieri
2 Boron
2 Boswellia (frankincense)
2 Centella asiatica / Gotu kola → asiaticoside
2 Choline
2 Folic Acid, Vit B9
2 Chrysin
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Crocetin
2 Docosahexaenoic Acid
2 diet Short Term Fasting
2 Eugenol
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Hyperoside
2 Kaempferol
2 Mung Bean Sprouts
2 Lutein
2 Zeaxanthin
2 Magnolol
2 Melatonin
2 Moringa oleifera
2 Phenylbutyrate
2 Propolis -bee glue
2 Quercetin
2 Sesame seeds and Oil
2 Taurine
2 Thymoquinone
2 Ursolic acid
1 Annona atemoya Leaf Extract
1 isoquercitrin
1 Rutin
1 Anthocyanins
1 Alpha-Lipoic-Acid
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Artemisinin
1 Astaxanthin
1 Baicalein
1 Beta-Caryophyllene
1 Betulinic acid
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Carnosine
1 chitosan
1 Vitamin B12
1 Vitamin B2,Riboflavin
1 Echinacea
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 dietMediterranean
1 2-DeoxyGlucose
1 Calorie Restriction Mimetics
1 Diindolylmethane
1 Indole-3-carbinol
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Phosphatidylserine
1 Fisetin
1 Formononetin
1 Flaxseed/Linseed
1 Gallic acid
1 Galantamine
1 Bifidobacterium animalis subsp. lactis GCL2505
1 Isoliquiritigenin
1 Isothiocyanates
1 Licochalcone A
1 Lecithin
1 SDG/lignans
1 Matrine
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Marjoram (Origanum majorana)
1 Protocatechuic acid
1 Polyphenols
1 probiotics
1 Pterostilbene
1 Salvia officinalis
1 Rosmarinic acid
1 Selenium
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Safflower yellow
1 Turmerones
1 Vitamin B6,pyridoxine
1 Vitamin E
1 Vitamin K2
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1356  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page