HDAC Cancer Research Results

HDAC, Histone deacetylases: Click to Expand ⟱
Source:
Type:
Enzymes involved in regulating gene expression by removing acetyl groups from histones, the proteins around which DNA is wrapped.
-Many cancers exhibit altered expression levels of HDACs, which can contribute to the dysregulation of genes involved in cell growth, survival, and differentiation.
-HDACs can repress the expression of tumor suppressor genes, leading to uncontrolled cell proliferation and survival. This repression can be a key factor in the development and progression of cancer.
-HDAC inhibitors (HDACi) have been developed and are being investigated for their ability to reactivate silenced genes, induce cell cycle arrest, and promote apoptosis in cancer cells.
-HDAC1, HDAC2): Often overexpressed in various cancers, including breast, prostate, and colorectal cancers. Their overexpression is associated with poor prognosis.
-HDAC4, HDAC5): These may have both oncogenic and tumor-suppressive roles depending on the context and cancer type.
-While HDACs are not classified as traditional oncogenes, their overexpression and activity can contribute to oncogenic processes.
-HDAC inhibitor works by preventing the removal of acetyl groups from histones, thereby modulating gene expression, influencing cell behavior, and potentially reversing aberrant gene silencing seen in various diseases.
-HDAC inhibitors can help reactivate these genes, thereby inhibiting growth and inducing apoptosis in cancer cells.
Scientific Papers found: Click to Expand⟱
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, NA, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3426- TQ,    Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
- in-vitro, BC, MDA-MB-468 - in-vitro, AML, JK
UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,

Showing Research Papers: 151 to 156 of 156
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 156

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   PKM2↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 2,   Bak↑, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-xL↓, 2,   Casp↑, 1,   Casp3↑, 2,   Casp7↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   survivin↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   H4↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CYP1B1↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 1,   G9a↓, 1,   P53↑, 2,   cl‑PARP↑, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   FOXO↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 6,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 2,   Jun↓, 1,   mTOR↓, 2,   NOTCH↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   PTEN↑, 3,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

DLC1↑, 1,   E-cadherin↑, 1,   FAK↓, 2,   Ki-67↓, 2,   MMP9↓, 2,   MMPs↓, 1,   MUC4↓, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 2,   Twist↓, 3,   Vim↓, 1,   Zeb1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   COX2/PTGS2↓, 2,   CXCR4↓, 1,   Inflam↓, 2,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 2,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

B2M↓, 1,   BRCA1↑, 1,   EZH2↓, 1,   Ki-67↓, 2,   Maspin↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   hepatoP↑, 2,   RenoP↑, 1,  
Total Targets: 102

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NAD↑, 1,   SIRT1↑, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CRP↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 27

Scientific Paper Hit Count for: HDAC, Histone deacetylases
34 Sulforaphane (mainly Broccoli)
23 Phenylbutyrate
14 Thymoquinone
12 Butyrate
10 EGCG (Epigallocatechin Gallate)
7 Apigenin (mainly Parsley)
6 Curcumin
4 Chrysin
4 Chemotherapy
4 Luteolin
4 Quercetin
3 Berberine
3 Boron
3 Honokiol
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Atorvastatin
2 Radiotherapy/Radiation
2 Emodin
2 Inulin Prebiotic
2 Cisplatin
2 Propolis -bee glue
2 Phenethyl isothiocyanate
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Andrographis
1 Betulinic acid
1 chaetocin
1 diet FMD Fasting Mimicking Diet
1 Formononetin
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Magnolol
1 Piperlongumine
1 Polyphenols
1 Vorinostat
1 diet Plant based
1 Gemcitabine (Gemzar)
1 Vitamin D3
1 doxorubicin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:140  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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