HDAC Cancer Research Results

HDAC, Histone deacetylases: Click to Expand ⟱
Source:
Type:
Enzymes involved in regulating gene expression by removing acetyl groups from histones, the proteins around which DNA is wrapped.
-Many cancers exhibit altered expression levels of HDACs, which can contribute to the dysregulation of genes involved in cell growth, survival, and differentiation.
-HDACs can repress the expression of tumor suppressor genes, leading to uncontrolled cell proliferation and survival. This repression can be a key factor in the development and progression of cancer.
-HDAC inhibitors (HDACi) have been developed and are being investigated for their ability to reactivate silenced genes, induce cell cycle arrest, and promote apoptosis in cancer cells.
-HDAC1, HDAC2): Often overexpressed in various cancers, including breast, prostate, and colorectal cancers. Their overexpression is associated with poor prognosis.
-HDAC4, HDAC5): These may have both oncogenic and tumor-suppressive roles depending on the context and cancer type.
-While HDACs are not classified as traditional oncogenes, their overexpression and activity can contribute to oncogenic processes.
-HDAC inhibitor works by preventing the removal of acetyl groups from histones, thereby modulating gene expression, influencing cell behavior, and potentially reversing aberrant gene silencing seen in various diseases.
-HDAC inhibitors can help reactivate these genes, thereby inhibiting growth and inducing apoptosis in cancer cells.
Scientific Papers found: Click to Expand⟱
2105- TQ,    Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation
- in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Hs766t - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, Var, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3426- TQ,    Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
- in-vitro, BC, MDA-MB-468 - in-vitro, AML, JK
UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,

Showing Research Papers: 151 to 158 of 158
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 158

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 1,   i-GSH∅, 1,   GSR↓, 1,   GSS↑, 1,   GSTs↓, 1,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 4,   NRF2↑, 16,   NRF2∅, 1,   ROS?, 1,   ROS↓, 6,   ROS↑, 46,   ROS⇅, 4,   i-ROS?, 1,   mt-ROS↑, 1,   SOD↓, 3,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   Insulin↓, 1,   mtDam↑, 3,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PDH↑, 1,   p‑PDH↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 5,   ATP↓, 4,   ATP↑, 1,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   Histones↝, 1,   HK2↓, 6,   HMG-CoA↓, 2,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 1,   LDL↓, 2,   NADPH↑, 1,   NH3↓, 1,   PA↑, 1,   PDK1 / PDPK1↓, 3,   PKM2↓, 3,   PKM2↑, 1,   RARβ↑, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 38,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 1,   Bak↑, 3,   BAX↑, 22,   BAX⇅, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 27,   Bcl-xL↓, 16,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 29,   Casp3↝, 1,   cl‑Casp3↑, 4,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 4,   Casp8∅, 1,   Casp9↑, 15,   cl‑Casp9↑, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 20,   Cyt‑c↝, 1,   Diablo↑, 3,   DR5↑, 5,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 2,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 4,   Mcl-1↑, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 3,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 16,   TRAIL↑, 2,   TumCD↑, 2,   TUNEL↑, 1,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 19,   p‑Akt↓, 6,   AKT1↓, 1,   AMPKα↑, 1,   CaMKII ↑, 1,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 7,   EGFR↑, 1,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 3,   p‑ERK↑, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 5,   HGF/c-Met↓, 2,   IKKα↓, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 2,   MEK↓, 1,   mTOR↓, 10,   mTOR↑, 1,   mTOR∅, 1,   p‑mTOR↓, 3,   p70S6↓, 1,   PI3K↓, 13,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 9,   p‑PTEN↓, 1,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 1,   RAS↑, 1,   Sp1/3/4↓, 1,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 13,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT3↑, 2,   STAT5↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↑, 2,   cMyc↓, 8,   DNMT1↓, 13,   DNMT3A↓, 11,   DNMTs↓, 25,   DNMTs⇅, 1,   EZH2↓, 6,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 2,   H3↓, 2,   H3↑, 3,   ac‑H3↓, 2,   ac‑H3↑, 13,   ac‑H3↝, 1,   H4↓, 1,   H4↑, 3,   ac‑H4↓, 2,   ac‑H4↑, 9,   HATs↓, 6,   HATs↑, 7,   HATs⇅, 1,   HDAC↓, 140,   HDAC↑, 1,   HDAC⇅, 1,   HDAC∅, 1,   HDAC1↓, 14,   HDAC11↓, 1,   HDAC2↓, 7,   HDAC3↓, 9,   HDAC4↓, 2,   HDAC6↓, 1,   HDAC8↓, 6,   HMTs↓, 3,   HMTs↑, 1,   KLF4↓, 1,   MeCP2↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-22↑, 1,   miR-30a-5p↑, 1,   OCT4↓, 3,   other?, 1,   other↓, 1,   other↝, 3,   PRC2↓, 1,   Prot↓, 1,   SOX2↓, 1,   SOX4↓, 1,   SOX9↓, 1,   SUZ12↓, 1,   TET3↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ChemChap↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 9,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   ac‑HSP90↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   BRCA1↑, 2,   DNAdam↑, 8,   DNArepair↓, 3,   G9a↓, 3,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 2,   P53↑, 16,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 12,   PARP1↑, 1,   PCNA↓, 7,   PCNA↝, 1,   SIRT6↓, 1,   Telomerase↓, 7,   TOP1↓, 1,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 2,   CDK2↓, 8,   CDK2↑, 1,   CDK4↓, 9,   CDK6↓, 3,   CDKN1C/p57↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 15,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   GADD45A↑, 2,   Ki-67↓, 5,   p19↑, 2,   P21?, 1,   P21↑, 26,   p27/CDKN1B↑, 6,   pRB↑, 1,   p‑RB1↓, 2,   TumCCA?, 2,   TumCCA↓, 1,   TumCCA↑, 44,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMI1↓, 2,   BMPs↑, 1,   CD133↓, 3,   CD34↓, 2,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 7,   Diff↑, 3,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   Neurog1↑, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 2,   Shh↓, 2,   Smo↓, 1,   TOPflash↑, 1,   TumCG↓, 23,   TumCP↓, 23,   TumCP⇅, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

67LR↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 5,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 5,   Cav1↓, 1,   Cdc42↓, 1,   CDH1↑, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 11,   EMT?, 1,   EMT↓, 14,   FAK↓, 9,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 17,   proMMP2↓, 1,   MMP7↓, 1,   MMP9↓, 20,   MMPs↓, 13,   MUC4↓, 3,   N-cadherin↓, 5,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   Smad1↑, 1,   Snail↓, 5,   TET1↑, 3,   TGF-β↓, 4,   TGF-β↑, 2,   TIMP1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 11,   TumCMig↓, 11,   TumMeta↓, 14,   TumMeta↑, 1,   Twist↓, 7,   TXNIP↑, 2,   Tyro3↓, 1,   uPA↓, 6,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 6,   α-tubulin↑, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 27,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 3,   CLDN2↓, 1,   GLUT1↓, 4,   MMP?, 1,   MMP↓, 20,   MMP↑, 1,   NHE1↓, 1,   SLC12A5↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD44↓, 5,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 3,   CXCR4↑, 1,   HCAR2↑, 4,   ICAM-1↓, 1,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 1,   IL12↑, 1,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL2↑, 4,   IL6↓, 8,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 5,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   NAF1↓, 1,   NF-kB↓, 31,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 3,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 2,   SOCS1↑, 1,   TLR4↓, 1,   TNF-α↓, 11,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   COMT↑, 1,   CYP11A1↓, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 33,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 2,   eff↓, 9,   eff↑, 24,   eff↝, 4,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   RadioS↑, 8,   selectivity?, 1,   selectivity↑, 26,   Synergy↑, 30,   TET2↓, 1,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 2,   AR↓, 4,   AST↓, 1,   B2M↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   CEA↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 6,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 9,   IL6↓, 8,   LDH↓, 1,   Maspin↑, 2,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RBM3↑, 1,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 4,   CardioT↓, 2,   chemoP↑, 8,   chemoPv↑, 6,   ChemoSideEff↓, 3,   cognitive↑, 1,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 7,   OS↑, 7,   Remission↑, 2,   RenoP↑, 3,   Risk↓, 7,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 7,   TumW↓, 6,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 6,   GutMicro↝, 1,  
Total Targets: 576

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   ARE↑, 1,   Catalase↑, 7,   GPx↑, 4,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 4,   HDL↑, 1,   HO-1↑, 5,   lipid-P↓, 2,   MDA↓, 2,   MPO↑, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 10,   RNS↓, 1,   ROS↓, 26,   ROS↝, 1,   ROS∅, 1,   SAM-e↑, 1,   SOD↑, 7,   SOD1↑, 1,   SOD2↑, 2,   TBARS↓, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   ATP↝, 1,   cytoP450↓, 1,   FABP4↓, 1,   FAO↑, 1,   GSK‐3β↓, 1,   LDL↓, 1,   lipoGen↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NH3↓, 1,   SIRT1↑, 2,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   Casp3↓, 2,   Cyt‑c↓, 1,   IAP1↓, 1,   iNOS↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   AMPKα↑, 1,   CREB↑, 1,   ERK↑, 1,   HCAR2↑, 1,   IGF-1R↓, 1,   IKKα↑, 1,   JAK↓, 1,   JNK↓, 1,   MAPK↓, 1,   PDGFR-BB↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 15,   HDAC↑, 3,   HDAC2↓, 1,   HDAC3↓, 2,   other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ChemChap↑, 2,   ER Stress↓, 2,   HSP27↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AP-1↓, 2,   Ca+2↝, 1,   MMP13↓, 1,   MMP2↓, 1,   p‑Rac1↓, 1,   serineP↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   uPA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↑, 1,   memfluid↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CXCR2↑, 1,   HCAR2↑, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 5,   IL17↓, 3,   IL1β↓, 8,   IL22↓, 1,   IL4↑, 1,   IL6↓, 9,   IL8↓, 3,   Imm↝, 1,   Inflam↓, 20,   Inflam↑, 2,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 11,   PGE2↓, 2,   TNF-α↓, 14,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 2,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 9,   BioAv↑, 11,   BioAv↝, 4,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 5,   GSTA1↑, 1,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   BMD↑, 1,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 9,   LDH↓, 1,   Mag↑, 1,   TMAO↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   antiPs↑, 1,   cardioP↑, 7,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 3,   memory↑, 4,   neuroP↑, 12,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 6,   RenoP↑, 2,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 9,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 2,  
Total Targets: 197

Scientific Paper Hit Count for: HDAC, Histone deacetylases
34 Sulforaphane (mainly Broccoli)
23 Phenylbutyrate
14 Thymoquinone
12 Butyrate
10 EGCG (Epigallocatechin Gallate)
7 Apigenin (mainly Parsley)
6 Curcumin
4 Chrysin
4 Chemotherapy
4 Luteolin
4 Quercetin
3 Berberine
3 Boron
3 Honokiol
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Atorvastatin
2 Radiotherapy/Radiation
2 Emodin
2 Inulin Prebiotic
2 Cisplatin
2 Propolis -bee glue
2 Phenethyl isothiocyanate
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Andrographis
1 Betulinic acid
1 chaetocin
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 Indole-3-carbinol
1 Formononetin
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Kaempferol
1 Magnolol
1 Piperlongumine
1 Polyphenols
1 Vorinostat
1 diet Plant based
1 Gemcitabine (Gemzar)
1 Vitamin D3
1 doxorubicin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:140  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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