| Source: HalifaxProj(inhibit) |
| Type: |
| Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts. IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth. IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin. |
| 3201- | EGCG, | Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential |
| - | Review, | NA, | NA |
| 3594- | EGCG, | Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells |
| - | in-vitro, | AD, | HMC1 |
| 6784- | EGCG, | Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health |
| - | Review, | Nor, | NA |
| - | in-vitro, | GBM, | U87MG |
| 1503- | EGCG, | Epigenetic targets of bioactive dietary components for cancer prevention and therapy |
| - | Review, | NA, | NA |
| 6814- | EMD, | Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics |
| - | Review, | Nor, | NA |
| 6818- | EMD, | Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer's Disease-Like Features in Rats |
| - | in-vivo, | AD, | NA |
| 6819- | EMD, | Recent advances in the therapeutic potential of emodin for human health |
| - | Review, | Nor, | NA |
| 7045- | EMD, | TSG, | Synergic effects and possible mechanism of emodin and stilbene glycosides on colorectal cancer |
| - | vitro+vivo, | CRC, | NA |
| 5487- | EP, | High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas |
| - | in-vivo, | GBM, | NA |
| 6792- | EPA, | Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico |
| - | Trial, | HNSCC, | NA |
| 6381- | Eug, | Biological Properties and Prospects for the Application of Eugenol—A Review |
| - | Review, | Var, | NA |
| 6388- | Eug, | Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review |
| - | Review, | Var, | NA |
| 6325- | Eug, | Anticancer Properties of Eugenol: A Review |
| - | Review, | Var, | NA |
| 6323- | Eug, | Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects |
| - | Review, | Var, | NA | - | Review, | Arthritis, | NA |
| 6330- | Eug, | Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement |
| - | Review, | Var, | NA |
| 5055- | Ex, | Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes |
| - | Review, | Var, | NA |
| 3714- | FA, | Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review |
| - | Review, | AD, | NA |
| 6871- | FA, | Sesame, | Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation |
| - | in-vivo, | Nor, | NA |
| 6885- | FA, | Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways |
| - | in-vivo, | Nor, | NA |
| - | Trial, | AD, | NA |
| 6951- | FA, | Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI |
| - | Trial, | AD, | NA |
| 6954- | FA, | Folic acid as a potential therapeutic agent for Alzheimer's disease: Effects on inflammatory cytokines, amyloid deposition, and neurotransmitter metabolism |
| - | Trial, | AD, | NA |
| 6919- | FIS, | Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells |
| 2861- | FIS, | The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress |
| - | Review, | Nor, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 2841- | FIS, | Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer |
| - | in-vitro, | Nor, | RAW264.7 | - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | Hep3B | - | in-vitro, | Liver, | HUH7 |
| 2843- | FIS, | Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential |
| - | Review, | Var, | NA |
| 6981- | Form, | Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | PSA, | NA |
| 6995- | Form, | Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia |
| - | Review, | Nor, | BV2 |
| 7035- | GA, | Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway |
| - | in-vitro, | IBD, | Caco-2 |
| 7028- | GA, | Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases |
| - | Review, | Nor, | NA |
| 7080- | GABA, | The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention |
| - | Review, | AD, | NA |
| 7052- | Gallo, | Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment |
| - | in-vivo, | Colon, | SW48 |
| 7067- | GamB, | Gambogic Acid and Its Role in Chronic Diseases |
| - | Review, | Var, | NA |
| 805- | GAR, | Cisplatin, | PacT, | Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells |
| - | Review, | NA, | NA |
| 7212- | GBE, | The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 7117- | Ge-132, | Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts |
| - | in-vitro, | Nor, | NA |
| 7130- | Ge-132, | Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer |
| - | Trial, | BC, | NA |
| 6570- | Ger, | Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells |
| - | in-vitro, | Thyroid, | TPC-1 |
| 7140- | GI, | Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes |
| - | Review, | Var, | NA |
| 7260- | Gink, | Ginkgetin: A natural biflavone with versatile pharmacological activities |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA | - | Review, | AD, | NA |
| 4003- | Gins, | Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences |
| - | Review, | adrenal, | NA |
| 4511- | GLA, | Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 3768- | H2, | Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial |
| - | Trial, | AD, | NA |
| 3770- | H2, | Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3772- | H2, | Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis |
| - | in-vivo, | AD, | NA |
| 3773- | H2, | Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases |
| - | Review, | Park, | NA |
| 3787- | H2, | Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis |
| - | Review, | AD, | NA |
| 3766- | H2, | The role of hydrogen in Alzheimer′s disease |
| - | Review, | AD, | NA |
| 4346- | H2, | Medical Application of Hydrogen in Hematological Diseases |
| - | Review, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:158 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid