iNOS Cancer Research Results

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3372- QC,  FIS,  KAE,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2/PTGS2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE/β-secretase↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2/PTGS2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, Var, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
*SIRT1↑, *NLRP3↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *PKM2↓, *HO-1↑, *ROS↓, *NO↓, *MDA↓, *antiOx↑, *COX2/PTGS2↓, *HMGB1↓, *iNOS↓, *NF-kB↓,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, Var, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
*VEGF↑, *iNOS↑, *NF-kB↑, *Sp1/3/4↑, *cardioP↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2/PTGS2↓, *NF-kB↓, *iNOS↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
7830- SA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *NeuroI↓, *iNOS↓, *3-NT↓, *Ach↑, *ChAT↑, *Dose↝, *neuroP↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3659- SFN,    Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
- in-vitro, AD, NA
*NRF2↑, *ROS↓, *MDA↓, *SOD↑, *IL1β↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *Inflam↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1478- SFN,  acet,    Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells
- in-vitro, Nor, NA
Synergy↑, NO↓, iNOS↓, COX2/PTGS2↓, IL1β↓, ROS↓,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, Nor, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3320- SIL,    Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action
- Review, AD, NA
*hepatoP↑, *neuroP↑, *ROS↓, *β-Amyloid↓, *Inflam↓, *Aβ↓, *NF-kB↓, *TNF-α↓, *LTA/TNF-β↓, *iNOS↓, *NO↓, *COX2/PTGS2↓,
3331- SIL,    The clinical anti-inflammatory effects and underlying mechanisms of silymarin
- Review, Nor, NA
*Inflam↓, *NF-kB↓, *NLRP3↓, *COX2/PTGS2↓, *iNOS↓, *neuroP↑, *p‑ERK↓, *p38↓, *MAPK↓, *EGFR↓, *ROS↓, *lipid-P?, *5LO↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2/PTGS2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3329- SIL,    iNOS_expression_in_the_brain_and_Gills_of_the_hypoxic-reoxygenated_rainbow_trout_Oncorhynchus_mykis">Silymarin regulates the HIF-1 and iNOS expression in the brain and Gills of the hypoxic-reoxygenated rainbow trout (Oncorhynchus mykis)
- in-vivo, Nor, NA
*NO↓, *MDA↓, *TAC↑, *Hif1a↓, *iNOS↓,
3328- SIL,    Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB
- in-vivo, BPH, NA
*NF-kB↓, *Hif1a↓, *PTEN↑, *Weight↓, *NO↓, *IL6↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓,
3325- SIL,    Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG1/2↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
5339- TFdiG,    Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line
- in-vitro, CRC, HCT116
eff↑, TumCCA↑, Inflam↓, COX2/PTGS2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,
5336- TFdiG,    Theaflavin-3,3′-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways
- in-vivo, Nor, NA
*IL6↓, *TNF-α↓, *iNOS↓, *PGE1↓, *ROS↓, *Inflam↓, *PI3K↓, *Akt↓, *NF-kB↓, *MAPK↓, *Cartilage↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, Nor, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓, *antiAll?,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, CompStab↝, TumCG↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
634- VitC,    Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
- Analysis, Sepsis, NA
other↓, iNOS↓, eNOS↑,
2277- VitK2,    Vitamin K2 suppresses rotenone-induced microglial activation in vitro
- in-vitro, Nor, BV2 - NA, AD, NA - NA, Park, NA
*p38↓, *ROS↓, *Casp1↓, *MMP↑, *NF-kB↓, *IL1β↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*ALB↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2/PTGS2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

Showing Research Papers: 151 to 198 of 198
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 198

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 9,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 4,   HO-1↑, 6,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 4,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 11,   ROS↓, 12,   ROS↑, 50,   ROS⇅, 4,   SOD↑, 6,   SOD2↓, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compIV↓, 1,   EGF↓, 1,   mitResp↓, 1,   MKK7↓, 2,   mtDam↑, 4,   OCR↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   ACSL4↑, 1,   ALAT↓, 1,   ALAT↝, 1,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↓, 3,   ECAR↝, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↑, 40,   BAD↓, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 24,   Bax:Bcl2↑, 3,   Bcl-2↓, 30,   Bcl-xL↓, 7,   BID↓, 1,   BID↑, 3,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 31,   cl‑Casp3↑, 3,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 20,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 18,   Diablo↑, 3,   DR5↑, 6,   Endon↑, 1,   Fap1↓, 1,   Fas↑, 6,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 3,   ICAD↓, 1,   iNOS↓, 55,   iNOS↑, 3,   Mcl-1↓, 7,   MDM2↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 2,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 14,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 2,   XIAP↓, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 2,   p‑Akt↓, 8,   cMET↓, 2,   EGFR↓, 7,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 5,   GRB2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 4,   JNK↑, 4,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 3,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   p‑mTOR↓, 2,   P70S6K↓, 3,   PI3K↓, 23,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PKA↓, 1,   PKCδ↓, 4,   PTEN↑, 7,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   CBP↓, 1,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 7,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC1↓, 3,   HDAC6↓, 1,   HDAC8↓, 1,   Matr↓, 1,   miR-125b↓, 1,   miR-21↓, 1,   miR-34a↓, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 3,   other↓, 3,   other↑, 4,   other↝, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 12,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   HSP90↑, 1,   HSPs↓, 1,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 4,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   ERCC1↓, 1,   hTERT/TERT↓, 3,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 28,   P53↝, 1,   PARP↓, 2,   PARP↑, 6,   cl‑PARP↑, 9,   PARP1↑, 1,   PCNA↓, 7,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 1,   TP53↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK4↓, 9,   CDK4/6↓, 1,   CDK6↓, 6,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   Chk2↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 25,   cycE/CCNE↓, 6,   cycE/CCNE↑, 2,   E2Fs↓, 2,   E2Fs↑, 1,   Ki-67↓, 5,   P21↓, 3,   P21↑, 16,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 36,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 8,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   Ki-67↓, 5,   mTORC1↓, 1,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 3,   NOTCH1↓, 6,   NOTCH1↑, 1,   p300↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 11,   TumCG↑, 1,   TumCP↓, 27,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 3,   ASAP2↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 2,   i-Ca+2?, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 9,   EpCAM↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   Fibronectin↓, 2,   ITGA5↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MMP-10↓, 2,   MMP1↓, 1,   MMP2↓, 19,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 29,   MMPs↓, 10,   N-cadherin↓, 8,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 4,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 4,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 17,   TumCMig↓, 21,   TumMeta↓, 16,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 4,   Vim↓, 9,   Zeb1↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 2,   HIF-1↓, 1,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 8,   VCAM-1↓, 1,   VEGF↓, 29,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   CLDN2↓, 1,   MMP↓, 19,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 46,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 5,   CXCR4↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 6,   IL1↓, 5,   IL10↓, 7,   IL12↓, 2,   IL1β↓, 12,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL4↓, 2,   IL6↓, 22,   IL8↓, 7,   Imm↑, 3,   Inflam↓, 15,   LRIG1↑, 1,   M1↓, 1,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 43,   NF-kB↑, 5,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 3,   PD-L1↓, 2,   PGE2↓, 8,   PSA↓, 2,   RAGE↓, 1,   TLR4↓, 4,   TNF-α↓, 24,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 2,   PPARα↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 20,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1B1↑, 1,   Dose↑, 2,   Dose↝, 8,   Dose∅, 7,   eff↓, 2,   eff↑, 19,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↑, 7,   selectivity↑, 9,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   BP↓, 1,   BRCA1↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 4,   i-LDH↓, 1,   Myc↓, 2,   PD-L1↓, 2,   PSA↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 13,   antiNeop↑, 1,   AntiTum↑, 4,   cardioP↑, 3,   chemoP?, 1,   chemoP↑, 9,   chemoPv↑, 6,   ChemoSideEff↓, 1,   cognitive?, 1,   cognitive↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   OS↑, 2,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 523

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

3-NT↓, 1,   antiOx↓, 4,   antiOx↑, 62,   ARE↑, 2,   Bil↑, 2,   Catalase↑, 35,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 23,   GSH↑, 44,   GSR↓, 2,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 3,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 40,   HO-1⇅, 1,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 5,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 35,   MDA↓, 44,   MPO↓, 10,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 9,   NRF2↓, 1,   NRF2↑, 56,   Prx↑, 2,   RNS↓, 5,   ROS↓, 106,   ROS↑, 2,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 58,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 5,   Trx↑, 2,   Trx1↑, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 2,   mtDam↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 11,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 2,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   GSK‐3β↓, 5,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NADPH↑, 1,   PKM2↓, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 18,   BAX↓, 12,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 6,   Casp1↓, 3,   Casp3↓, 15,   Casp3↑, 1,   Casp3∅, 2,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 8,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 2,   Fas↓, 3,   Ferroptosis↓, 1,   iNOS↓, 138,   iNOS↑, 6,   necrosis↓, 2,   p38↓, 7,   p38↑, 1,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 7,   AMPKα↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 7,   ERK↑, 3,   p‑ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   p‑JAK1↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 2,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 3,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKA↑, 1,   PKCδ?, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RIP1↓, 1,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3?, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 2,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 1,   HDAC↓, 2,   HDAC↑, 1,   MEF2D↑, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 2,   other↝, 4,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   ER Stress↓, 5,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 7,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 4,   PARP∅, 1,   cl‑PARP↓, 1,   Telomerase↓, 2,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↓, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 2,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 4,   AP-1↓, 3,   ARG1/2↑, 2,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 4,   COL1↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 4,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 6,   MMPs↓, 3,   MMPs↑, 1,   MUC1↑, 2,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TXNIP↓, 2,   uPA↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 4,   NO↓, 42,   NO↑, 1,   VCAM-1↓, 6,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 15,   BBB↝, 2,   BBB∅, 2,   CLDN1↑, 3,   CLDN3↑, 1,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   memfluid↑, 1,   MMP↑, 10,   MMP∅, 1,   MUC2↑, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↑, 2,   TJ↑, 2,   VGSC↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 92,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 8,   IL1↓, 6,   IL10↓, 5,   IL10↑, 6,   IL12↓, 4,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 62,   IL1β↑, 1,   IL2↓, 7,   IL4↓, 3,   IL4↑, 2,   IL6↓, 70,   IL6↑, 2,   IL8↓, 7,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↓, 2,   Inflam↓, 97,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 2,   LTA/TNF-β↓, 1,   MCP1/CCL2↓, 5,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 3,   NeuroI↓, 5,   NF-kB↓, 78,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 15,   p65↓, 2,   p‑p65↓, 1,   PGE1↓, 1,   PGE2↓, 28,   PGE2↑, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 15,   TNF-α↓, 89,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 3,   AChE↓, 20,   AChE↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 7,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 4,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 2,   NGF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   BACE/β-secretase↓, 10,   tau↓, 5,   p‑tau↓, 5,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   GR↑, 1,   PPARα↑, 3,   PPARγ↓, 1,   PPARγ↑, 6,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 24,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↑, 2,   Dose↝, 14,   eff↓, 1,   eff↑, 12,   eff↝, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 7,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALB↑, 1,   AST↓, 12,   BG↓, 1,   Bil↑, 2,   BMD↑, 1,   BP↓, 4,   colonLen↑, 1,   creat↓, 3,   CRP↓, 3,   EGFR↓, 1,   IL6↓, 70,   IL6↑, 2,   LDH↓, 6,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll?, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 7,   antiCG↑, 1,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 24,   chemoP↑, 4,   chemoPv↑, 1,   cognitive↑, 32,   cognitive↝, 1,   hepatoP↓, 2,   hepatoP↑, 25,   Learn↑, 2,   memory↑, 33,   motorD↑, 4,   neuroP↑, 73,   NP/CIPN↓, 1,   Obesity↓, 4,   Pain↓, 8,   radioP↑, 6,   RenoP↑, 12,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 7,   Diar↓, 2,   GutMicro↑, 14,   Inf↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 446

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
11 Silymarin (Milk Thistle) silibinin
9 Quercetin
7 Curcumin
7 Thymoquinone
6 Magnetic Fields
5 Baicalein
5 Propolis -bee glue
4 Alpha-Lipoic-Acid
4 Beta-Caryophyllene
4 Ferulic acid
4 isoorientin
4 Luteolin
4 Lycopene
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 α-Bisabolol / Chamomile oil
3 Cichoric acid / Chicoric acid
3 Fisetin
3 Licorice
3 Pterostilbene
3 Rutin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Artemisinin
2 Benzyl isothiocyanate
2 Phenethyl isothiocyanate
2 Boron
2 buckwheat sprouts
2 Caffeic acid
2 Carnosic acid
2 Capsaicin
2 Chrysin
2 Echinacea
2 Crocetin
2 EGCG (Epigallocatechin Gallate)
2 Eugenol
2 Gambogic Acid
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Isovitexin
2 Kaempferol
2 Magnolol
2 Melatonin
2 Mung Bean Sprouts
2 Rosmarinic acid
2 Shikonin
2 Aflavin-3,3′-digallate
2 Vitamin K2
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Cisplatin
1 Biochanin A
1 xanthohumol
1 Allyl isothiocyanate
1 Bromelain
1 Boswellia (frankincense)
1 Beetroot
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Carvacrol
1 Celastrol
1 Chlorogenic acid
1 Chocolate
1 Lecithin
1 Dichloroacetate
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Emodin
1 Formononetin
1 Gamma-aminobutyric acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Grapeseed extract
1 Siegesbeckia glabrescens
1 Hops (Humulus lupulus)
1 Hyperoside
1 Vitexin
1 Licochalcone A
1 Lutein
1 MBE, Maqui berry
1 Magnetic Field Rotating
1 Moringin
1 Moringa oleifera
1 Morin
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Piperlongumine
1 Sinapic acid
1 acetaminophen
1 Taurine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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