JNK Cancer Research Results

JNK, c-Jun N-terminal kinase (JNK): Click to Expand ⟱
Source:
Type:
JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function. Janus signaling promotes cancer cell survival.
JNK, or c-Jun N-terminal kinase, is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis (programmed cell death). JNK is activated in response to various stress signals, such as UV radiation, oxidative stress, and inflammatory cytokines.
JNK activation can promote apoptosis in cancer cells, acting as a tumor suppressor. However, in other contexts, it can promote cell survival and proliferation, contributing to tumor progression.

JNK is often unregulated in cancers, leading to increased cancer cell proliferation, survival, and resistance to apoptosis. This activation is typically associated with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2/PTGS2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3278- Lyco,    Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells
- in-vitro, Colon, SW480
TNF-α↓, IL1β↓, IL6↓, iNOS↓, COX2/PTGS2↓, PGE2↓, NO↓, NF-kB↓, JNK↓, Inflam↓, MPO↓,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2/PTGS2↓,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
486- MF,    mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes
- in-vitro, Nor, HaCaT
*mTOR↑, *PI3K↑, *Akt↑, *p‑ERK↑, *other↑, *p‑JNK↑, *p‑P70S6K↑,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8775- MSM,    Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells
- Review, Colon, HCT116
*AntiArt↑, *ROS↓, tumCV↓, Apoptosis↑, PARP↑, Casp3↑, p‑JNK↑, eff↝, *toxicity↓, ChemoSen↑, TumCP↓,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,
2062- PB,    Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway
- in-vitro, Lung, H460 - in-vitro, Lung, H1792 - in-vitro, Lung, A549 - in-vitro, Lung, SK-LU-1 - in-vitro, Nor, HBE4-E6/E7
JNK↓, ERK↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4943- PEITC,    Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation
- in-vitro, Ovarian, OVCAR-3
TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,
5184- PEITC,    Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
- vitro+vivo, AML, U937
Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2949- PL,    Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
1940- PL,    Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,
2005- PLB,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
1986- PTL,    Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide
- in-vitro, Var, NA
JNK↑, ROS↑, eff↓, NF-kB↓, Trx↓,
3919- PTS,    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *SIRT1∅, *PPARα↑, *SOD2↑, *JNK↓, *p‑tau↓,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, Nor, HepG2
*Inflam↓, *UPR↓, *GRP58↓, *XBP-1↓, *ER Stress↓, *antiOx↑, TNF-α↓, p‑eIF2α↓, p‑IRE1↓, p‑JNK↓, CHOP/DDIT3↓,
3366- QC,    Quercetin Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis by Inhibiting the Glucose Regulatory Protein 78 Activation
- in-vivo, IBD, NA
*Apoptosis↓, *Inflam↓, *ROS↓, *ER Stress↓, *TNF-α↓, *MPO↓, *p‑JNK↓, *Casp12↓, *GRP78/BiP↓, *antiOx↑, *NF-kB↓,
3372- QC,  FIS,  KAE,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2/PTGS2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3077- RES,    Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways
- in-vitro, Chon, HTB94
MMP2↓, MMP9↓, SOX9↑, MMPs↓, p‑p38↑, p‑JNK↓, NF-kB↓, HO-1↓,
3017- RosA,  Per,    Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells
- in-vitro, Lung, A549
TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,
3021- RosA,    Rosmarinic acid ameliorates septic-associated mortality and lung injury in mice via GRP78/IRE1α/JNK pathway
- in-vivo, Sepsis, NA
*eff↑, *SOD↑, *MDA↓, *GRP78/BiP↓, *IRE1↓, *JNK↓, *Sepsis↓,
3023- RosA,    Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis
- in-vivo, Sepsis, NA
*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,

Showing Research Papers: 151 to 200 of 226
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 226

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   antiOx⇅, 1,   Catalase↓, 4,   Catalase↑, 1,   Fenton↑, 5,   GPx↓, 3,   GPx4↓, 4,   GSH↓, 15,   GSH↑, 1,   GSH/GSSG↓, 2,   GSR↓, 1,   GSTs↓, 1,   H2O2↑, 3,   HNE↑, 1,   HO-1↓, 5,   HO-1↑, 8,   Iron↓, 1,   Iron↑, 3,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 6,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 3,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 10,   NRF2↑, 9,   NRF2↝, 1,   Prx↓, 1,   ROS?, 2,   ROS↓, 8,   ROS↑, 109,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   m-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 6,   SOD↑, 1,   SOD1↓, 2,   SOD2↓, 3,   Trx↓, 4,   Trx1↓, 2,   TrxR↓, 4,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 3,   CDC25↓, 4,   CDC25↑, 1,   CS↓, 1,   ETC↓, 2,   mitResp↓, 2,   mtDam↑, 5,   OXPHOS↓, 2,   PDH↓, 1,   PDH↑, 1,   PGC-1α↑, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALDOA↓, 1,   ALDOB↑, 1,   AMPK↓, 1,   AMPK↑, 12,   ATP↓, 8,   ATP↑, 1,   CAIX/CA9↑, 1,   ENO1↓, 1,   ENO3↑, 1,   FAO↑, 1,   FASN↓, 4,   FBP1↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   GlucoseCon↓, 6,   glut↓, 1,   GlutaM↓, 1,   Glycolysis↓, 10,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   HK2↓, 5,   HK3↑, 1,   lactateProd↓, 7,   lactateProd↑, 1,   LDHA↓, 3,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↑, 1,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFK1↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM2↓, 6,   PKM2↑, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 9,   AIF↝, 1,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 88,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 2,   BAD↑, 4,   BAX↑, 47,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 9,   Bcl-2↓, 49,   Bcl-2↑, 2,   Bcl-2↝, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 13,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BNIP3↝, 1,   Casp↑, 13,   Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 66,   Casp3↝, 1,   cl‑Casp3↑, 11,   proCasp3↑, 1,   Casp6↑, 2,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 20,   cl‑Casp8↑, 3,   Casp9↑, 45,   cl‑Casp9↑, 4,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 45,   Cyt‑c↝, 2,   Diablo↑, 3,   DR5↑, 16,   Endon↑, 2,   FADD↑, 1,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 13,   FasL↓, 1,   FasL↑, 7,   Ferroptosis↑, 4,   GranB/GZMB↝, 1,   GRP58↓, 1,   GSDMD↑, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 8,   Mcl-1↓, 13,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 2,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 4,   p‑p38↑, 15,   p‑p38↝, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 1,   Pyro↑, 3,   RIP1↓, 2,   RIP3↓, 1,   survivin↓, 24,   TRAIL↑, 2,   TumCD↑, 10,   TumCD∅, 1,   XIAP↓, 11,   YAP/TEAD↓, 2,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 56,   Akt↑, 2,   Akt↝, 2,   p‑Akt↓, 8,   p‑Akt↑, 2,   AKT1↓, 1,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 2,   CREB↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 11,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 33,   ERK↑, 15,   ERK↝, 1,   p‑ERK↓, 15,   p‑ERK↑, 9,   p‑ERK⇅, 1,   p‑ERK↝, 1,   HER2/EBBR2↓, 4,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 3,   IKKα↝, 1,   p‑IKKα↓, 1,   IR↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 1,   JAK2↓, 3,   JNK↓, 30,   JNK↑, 104,   JNK↝, 3,   p‑JNK↓, 13,   p‑JNK↑, 24,   p‑JNK↝, 1,   cl‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 16,   MAPK↑, 18,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 5,   MEK↓, 2,   MEK↑, 1,   p‑MEK↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 23,   mTOR↝, 1,   p70S6↓, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 4,   PAK↓, 1,   PHKG1↑, 1,   PI3K↓, 40,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 2,   PIK3CA↓, 1,   p‑PIK3R1↓, 1,   PKCδ↓, 6,   p‑PKCδ↓, 1,   PPP2R1A↑, 1,   PTEN↓, 1,   PTEN↑, 8,   PTEN↝, 1,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 2,   Sp1/3/4↓, 6,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 26,   STAT3↑, 1,   p‑STAT3↓, 3,   STAT4↓, 1,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↓, 1,   ATF4↑, 3,   CBP↓, 1,   cJun↓, 3,   cJun↑, 3,   p‑cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 9,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 3,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   H3K4↓, 1,   H3K9↓, 1,   H4↓, 1,   H4↑, 2,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC2↓, 1,   HMTs↓, 3,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-218↑, 1,   Myc↓, 1,   Myc↑, 1,   MYCN↓, 1,   OCT4↓, 5,   other?, 1,   other↓, 3,   other↑, 2,   other↝, 2,   SOX2↓, 3,   SOX4↓, 2,   SOX9↓, 1,   SOX9↑, 1,   SUV39H↓, 1,   tumCV↓, 21,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 15,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↓, 3,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 31,   GRP78/BiP↓, 3,   GRP78/BiP↑, 7,   GRP94↑, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   HSPs↓, 2,   HSPs↑, 1,   IRE1↑, 4,   p‑IRE1↓, 1,   PERK↑, 4,   p‑PERK↓, 1,   UPR↑, 7,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5,   ATG7↑, 3,   Beclin-1/ATG6↑, 10,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 8,   p62↓, 1,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 21,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 22,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 2,   p16↑, 2,   P53↓, 2,   P53↑, 34,   P53↝, 1,   p‑P53↑, 2,   PARP↓, 2,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   cl‑PARP1↑, 1,   PCNA↓, 11,   SAPK↑, 1,   Telomerase↓, 5,   TOP1↓, 3,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 16,   CDK4↓, 17,   p‑CDK4↓, 1,   CDK6↓, 7,   CDK6↑, 2,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 23,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 2,   Ki-67↓, 9,   P21?, 1,   P21↓, 2,   P21↑, 30,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 11,   pRB↑, 1,   p‑pRB↓, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 65,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2,   ALDH1A1↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 2,   cFos↓, 2,   cFos↑, 1,   p‑cFos↓, 1,   CSCs↓, 12,   Diff↓, 1,   FGF↓, 1,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 2,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 9,   mTORC1↓, 3,   Nanog↓, 5,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 4,   NOTCH1↓, 6,   NOTCH3↓, 3,   p300↓, 1,   Shh↓, 1,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 28,   TumCG↑, 1,   TumCP↓, 47,   TumCP↑, 1,   TumCP∅, 1,   Wnt↓, 13,   Wnt/(β-catenin)↓, 2,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 2,   AP-1↓, 9,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 3,   Ca+2↓, 1,   Ca+2↑, 20,   i-Ca+2?, 1,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 8,   EMMPRIN↓, 1,   EMT↓, 20,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 11,   fascin↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 22,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 4,   MMP9↓, 38,   MMPs↓, 10,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin↓, 8,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 2,   ROCK1↑, 1,   Slug↓, 2,   Smad1↝, 1,   Snail?, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 7,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 2,   TIMP2↑, 5,   TRIB3↑, 1,   TumCI↓, 20,   TumCMig↓, 19,   TumMeta↓, 22,   TumMeta↑, 1,   TumPF↓, 1,   Twist↓, 4,   Tyro3↓, 1,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 6,   Vim↑, 1,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 16,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   angioG↑, 1,   CD31/PECAM-1↓, 2,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 17,   Hif1a↑, 3,   NO↓, 3,   NO↑, 2,   VEGF↓, 34,   VEGF↝, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 47,   MMP↑, 1,   MPT↑, 1,   TRPM7↓, 2,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   p‑cDC2↓, 1,   COX2/PTGS2↓, 25,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCR4↓, 7,   DR4↑, 4,   FOXP3↓, 1,   FOXP3↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 13,   IL6↑, 1,   IL6↝, 1,   IL8↓, 5,   Imm↑, 3,   Imm↝, 2,   Inflam↓, 15,   M2 MC↓, 2,   MCP1/CCL2↓, 2,   NF-kB↓, 58,   NF-kB↑, 1,   NF-kB↝, 3,   p‑NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 1,   p65↓, 6,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 7,   PSA↓, 2,   PSA↝, 1,   RAGE↓, 1,   T-Cell↑, 3,   Th1 response↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 11,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 8,   AR↝, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 9,   BioAv↑, 17,   BioAv↝, 2,   chemoR↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 47,   CompStab↓, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A2↓, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↝, 21,   Dose∅, 2,   eff↓, 31,   eff↑, 32,   eff↝, 4,   eff∅, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 5,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 17,   selectivity?, 2,   selectivity↑, 29,   selectivity∅, 1,   Synergy↑, 30,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 8,   AR↝, 1,   BMD↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   EGFR↓, 11,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 2,   IL6↓, 13,   IL6↑, 1,   IL6↝, 1,   LDH↓, 2,   LDH↑, 2,   Myc↓, 1,   Myc↑, 1,   NSE↓, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   PSA↝, 1,   RAGE↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   antiNeop↑, 1,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 11,   chemoPv↑, 10,   ChemoSideEff↓, 2,   cognitive?, 1,   cognitive↑, 2,   hepatoP↑, 4,   neuroP↑, 6,   NP/CIPN↓, 1,   OS↑, 4,   PFS↑, 1,   QoL↑, 2,   radioP↑, 5,   RenoP↑, 2,   Risk↓, 3,   toxicity?, 1,   toxicity↓, 1,   toxicity∅, 1,   TumVol↓, 7,   TumW↓, 3,   Weight↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,   Diar↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 744

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 34,   ARE↑, 2,   Bil↑, 1,   Catalase↓, 1,   Catalase↑, 24,   Fenton↓, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 16,   GPx1↑, 1,   GPx4↑, 4,   GSH↑, 23,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 6,   H2O2↓, 1,   H2O2↑, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 16,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 2,   lipid-P↓, 15,   MDA↓, 18,   MPO↓, 4,   NOX↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 26,   RNS↓, 1,   ROS↓, 51,   ROS↑, 2,   ROS∅, 1,   SOD↓, 1,   SOD↑, 30,   SOD1↑, 2,   SOD2↑, 1,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↑, 1,   mtDam↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 6,   AMPK↑, 8,   p‑AMPK↑, 1,   ATP↑, 1,   cAMP↑, 2,   FABP4↓, 1,   glucose↓, 1,   glucose↝, 2,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 1,   NADPH↓, 2,   SIRT1↑, 2,   SIRT1∅, 1,  

Cell Death(tgid=5) ⓘ

APAF1↓, 1,   Apoptosis↓, 10,   ASK1↓, 1,   BAX↓, 7,   BAX↑, 1,   Bax:Bcl2↝, 1,   Bcl-2↓, 1,   Bcl-2↑, 5,   Casp↓, 1,   Casp12↓, 2,   Casp3↓, 9,   Casp3∅, 2,   cl‑Casp3↓, 1,   Casp6↓, 1,   Casp9↓, 7,   Casp9∅, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 2,   Fas↓, 1,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   GRP58↓, 1,   iNOS↓, 12,   iNOS↑, 3,   necrosis↓, 1,   p38↓, 12,   p‑p38↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 5,   Akt↝, 1,   p‑Akt↑, 2,   CREB↑, 1,   ERK↓, 9,   ERK↑, 5,   p‑ERK↓, 3,   p‑ERK↑, 3,   HGF/c-Met↑, 1,   p‑IKKα↓, 2,   p‑IκB↓, 1,   JNK↓, 30,   JNK↑, 4,   p‑JNK↓, 13,   p‑JNK↑, 4,   MAPK↓, 12,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 2,   MEK↓, 1,   p‑MKK4↑, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 2,   p‑P70S6K↑, 1,   PI3K↓, 1,   PI3K↑, 2,   p‑PI3K↑, 1,   PKCδ↓, 1,   STAT3↝, 1,   STAT4↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   other↓, 1,   other↑, 4,   other↝, 7,   RUNX2∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 2,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   IRE1↓, 3,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 3,   PARP∅, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   neuroG↑, 1,   STAT1↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 3,   ARG1/2↑, 1,   Ca+2↓, 2,   Ca+2↝, 1,   COL1∅, 1,   EMT↑, 1,   heparanase↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 5,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↑, 1,   TumCI↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 2,   Hif1a↓, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 4,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 6,   BBB↝, 1,   BBB∅, 2,   CLDN4↑, 1,   GLUT2↑, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 7,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OCLN↑, 1,   TJ↑, 2,   TRPC1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CCL11↓, 1,   CD4+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 18,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL1↓, 2,   IL10↑, 5,   IL12↓, 1,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 21,   IL4↓, 3,   IL4↑, 1,   IL6↓, 23,   IL8↓, 3,   Imm↑, 5,   Inflam?, 1,   Inflam↓, 50,   IRF3↓, 1,   LPS↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 2,   NeuroI↓, 1,   Neut↓, 1,   NF-kB↓, 30,   p‑NF-kB↓, 2,   NLRP3↓, 6,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 5,   PGE2↑, 1,   RAGE↓, 1,   Th1 response↓, 2,   Th17↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 7,   TLR4∅, 1,   TNF-α↓, 30,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 8,   BChE↓, 2,   BDNF↑, 7,   BDNF∅, 1,   ChAT↑, 1,   NGF↑, 1,   PSD95↑, 2,   SNAP25↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 11,   Aβ42↓, 1,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 7,   BioAv↝, 9,   Dose?, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 6,   eff↑, 7,   eff↝, 1,   GSTA1↑, 2,   Half-Life↝, 5,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   ALP∅, 1,   AST↓, 6,   BG↓, 2,   Bil↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 3,   IL6↓, 23,   LDH↓, 3,   LDH↑, 1,   OCN∅, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 5,   AntiArt↑, 3,   AntiCan↑, 4,   AntiDiabetic↓, 1,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 12,   CardioT↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 15,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 16,   Learn↑, 2,   memory↑, 13,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 37,   Obesity↓, 1,   Pain↓, 2,   radioP↑, 4,   RenoP↑, 5,   Strength↑, 1,   Stroke↓, 4,   toxicity?, 1,   toxicity↓, 10,   toxicity↝, 2,   toxicity∅, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 4,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 3,  
Total Targets: 350

Scientific Paper Hit Count for: JNK, c-Jun N-terminal kinase (JNK)
9 Berberine
9 Curcumin
9 Luteolin
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Apigenin (mainly Parsley)
6 Shikonin
6 Thymoquinone
5 Silver-NanoParticles
5 Allicin (mainly Garlic)
5 Capsaicin
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Baicalein
4 Chlorogenic acid
4 Chrysin
4 Copper and Cu NanoParticles
4 Disulfiram
4 Gambogic Acid
4 Kaempferol
4 Licochalcone A
4 Magnolol
4 Magnetic Fields
4 Piperlongumine
3 Radiotherapy/Radiation
3 Cisplatin
3 Artemisinin
3 Betulinic acid
3 Carvacrol
3 chaetocin
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 isoorientin
3 Lycopene
3 Melatonin
3 Propolis -bee glue
3 Phenethyl isothiocyanate
3 Quercetin
2 Astragalus
2 Vitamin C (Ascorbic Acid)
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 brusatol
2 Thymol-Thymus vulgaris
2 Celastrol
2 Ursolic acid
2 Ferulic acid
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Juglone
2 Magnetic Field Rotating
2 Phenylbutyrate
2 Plumbagin
2 Resveratrol
2 Vitamin K2
1 1,8-Cineole
1 Camptothecin
1 Anethole/trans-Anethole
1 Berbamine
1 Bromelain
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Crocetin
1 Cucurbitacin
1 Sulforaphane (mainly Broccoli)
1 Dihydrocaffeic Acid
1 Bicalutamide
1 Cynaropicrin
1 Dandelion Root
1 Emodin
1 Eugenol
1 5-fluorouracil
1 Evodiamine
1 Ascorbyl Palmitate
1 Garcinol
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginkgetin
1 Graviola
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Linalool
1 Matrine
1 Morin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Parthenolide
1 Pterostilbene
1 Perilla
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:168  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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