MAPK Cancer Research Results

MAPK, mitogen-activated protein kinase: Click to Expand ⟱
Source: CGL-CS
Type:
Mitogen-activated protein kinases (MAPKs) are a group of proteins involved in transmitting signals from the cell surface to the nucleus, playing a crucial role in various cellular processes, including growth, differentiation, and apoptosis (programmed cell death).

MAPK Pathways: The MAPK family includes several pathways, the most notable being:
1.ERK (Extracellular signal-Regulated Kinase): Often associated with cell proliferation and survival.
2.JNK (c-Jun N-terminal Kinase): Typically involved in stress responses and apoptosis.
3.p38 MAPK: Associated with inflammatory responses and apoptosis.

Inhibitors: Targeting the MAPK pathway has become a strategy in cancer therapy. For example, BRAF inhibitors (like vemurafenib) are used in treating melanoma with BRAF mutations.
Altered Expression Levels:
Overexpression: Many cancers exhibit overexpression of MAPK pathway components, such as RAS, BRAF, and MEK. This overexpression can lead to increased signaling activity, promoting cell proliferation and survival.
Downregulation: In some cases, negative regulators of the MAPK pathway (e.g., MAPK phosphatases) may be downregulated, leading to enhanced MAPK signaling.
The expression levels of MAPK pathway components can serve as biomarkers for cancer diagnosis, prognosis, and treatment response. For example, high levels of phosphorylated ERK (p-ERK) may indicate active MAPK signaling and poor prognosis in certain cancers.

Numerous reports indicate that the MAPK pathway plays a major role in tumor progression and invasion, while inhibition of MAPK signaling reduces invasion.
Scientific Papers found: Click to Expand⟱
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE/β-secretase↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7528- HT,    Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
- in-vitro, AML, Jurkat - in-vitro, AML, HL-60 - in-vitro, NA, 1-
*antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, AntiCan↑, TumCCA↑, PI3K↓, MAPK↑, ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, p‑P53↓,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7548- HYP,    Mechanistic evaluation of hyperoside against non-small cell lung cancer: a combined approach of network pharmacology and in vitro experimental validation
- in-vitro, NSCLC, A549
MMP9↓, cl‑Casp3↑, MAPK↑, EGFR↓, TumCP↓, p38↑, Apoptosis↑, BAX↑, ERK↓, FOXO1↓,
7554- HYP,    Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism
- in-vitro, NSCLC, A549
tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, Synergy↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7862- isoO,    Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia
- in-vitro, Nor, BV2
*Apoptosis↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *TNF-α↓, *MAPK↓, *NF-kB↓, *ROS↓, *NeuroI↓,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
7812- ISQ,    Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway
- vitro+vivo, NPC, CNE1 - in-vitro, NPC, HNE1
tumCV↓, TumCP↓, ROS↑, lipid-P↑, NF-kB↓, MAPK↓, IL1β↓, TumCG↓, lipid-P↓, Ferroptosis↓, eff↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
7900- IVT,    Isovitexin: A Promising Active Compound Found in Nature's Bounty
- in-vivo, Nor, NA
*BioAv↓, *Imm↝, *antiOx↑, *AntiCan↑, *neuroP↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *MAPK↓, *MPO↓, *ROS↓, TumAuto↑, Apoptosis↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8073- KAE,    Kaempferol inhibits oxidative stress-induced ferroptosis via the ROS/P38MAPK pathway to delay intervertebral disc degeneration: a combinatorial study of cell, animal, and transcriptomic evidence
- Review, Nor, NA
*Inflam↓, *antiOx↑, *ROS↓, *MAPK↓, *Ferroptosis↓,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
8206- LCA,    Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
- in-vivo, GC, BGC-823
ROS?, Casp3↑, cl‑PARP↑, eff↓, ERK↑, JNK↑, MAPK↑, AntiP↑, AntiTum↑, TumCP↓, selectivity↑, GSH/GSSG↓, MDA↑, lipid-P↑, PI3K↓, Akt↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8230- LCA,    The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway
- vitro+vivo, Nor, NA
*hepatoP↑, *ROS↓, *TLR4↓, *NF-kB↓, *MAPK↓, *NLRP3↓, *NRF2↑, *Inflam↓, *Pyro↓,
8284- LE,    Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation
- in-vivo, Nor, NA
*Ingr↝, *iNOS↓, *COX2/PTGS2↓, *IκB↓, *p65↓, *ERK↓, *p38↓, *MAPK↓, *PI3K↓, *Akt↓, *NF-kB↓,
8130- LF,    Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways
- in-vitro, HCC, HepG2 - in-vitro, HCC, HepG3 - in-vitro, HCC, SK-HEP-1
Iron↓, TumCP↓, selectivity↑, TumCCA↑, p‑MAPK↑, JNK↑, Apoptosis↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
8317- LIN,    Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
- in-vitro, Liver, HepG2
TumCP↓, TumCCA↑, CDK4↓, cycA1/CCNA1↓, P21↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, cl‑PARP↑, DNAdam↑, RAS↓, Akt↓, mTOR↓, ROS↑, MAPK↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,

Showing Research Papers: 151 to 200 of 311
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 311

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   antiOx⇅, 1,   Catalase↓, 6,   Catalase↑, 3,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GPx4↑, 1,   GSH↓, 21,   GSH↑, 5,   GSH/GSSG↓, 2,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 3,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 10,   Iron↓, 1,   Iron↑, 4,   Iron↝, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 8,   MDA↓, 3,   MDA↑, 6,   MPO↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 8,   NRF2↑, 13,   NRF2↝, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 131,   ROS⇅, 6,   ROS∅, 1,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 6,   SOD↑, 6,   SOD1↓, 1,   SOD2↓, 1,   TAC↓, 1,   TOS↑, 1,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7,   CDC25↓, 7,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 3,   mtDam↑, 9,   OCR↓, 2,   OXPHOS↑, 2,   OXPHOS↝, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   adiP↑, 1,   AMPK?, 1,   AMPK↑, 14,   ATGL/PNPLA2↓, 1,   ATP↓, 9,   ATP↑, 1,   CAIX/CA9↑, 1,   DHODH↓, 1,   ECAR↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 12,   GSK‐3β↓, 3,   GSK‐3β↑, 6,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 3,   LDHA↓, 3,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 2,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PKM2↓, 5,   Pyruv↓, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SREBP2↓, 1,   TCA↓, 2,   TumCM/A↑, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 7,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 118,   mt-Apoptosis↑, 2,   ASC↓, 1,   BAD↑, 6,   Bak↑, 7,   BAX↑, 69,   Bax:Bcl2↑, 10,   Bcl-2↓, 70,   Bcl-xL↓, 14,   BID↓, 1,   BID↑, 6,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 1,   Casp↑, 26,   cl‑Casp↑, 1,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 65,   cl‑Casp3↑, 16,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 3,   Casp8↑, 20,   cl‑Casp8↑, 1,   Casp9↑, 51,   cl‑Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 49,   Diablo↑, 2,   DR5↑, 20,   FADD↑, 2,   Fas↓, 2,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 12,   Mcl-1↑, 1,   MDM2↓, 4,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 2,   p38↓, 6,   p38↑, 30,   p‑p38↓, 2,   p‑p38↑, 5,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 2,   survivin↓, 22,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 6,   XIAP↓, 13,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 91,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 13,   p‑Akt↑, 2,   AKT1↓, 1,   Akt2↓, 2,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 15,   EGFR↑, 1,   p‑EGFR↓, 2,   EphB4↓, 1,   ERK↓, 47,   ERK↑, 14,   ERK↝, 2,   p‑ERK↓, 9,   p‑ERK↑, 3,   p‑ERK⇅, 1,   FGFR1↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 3,   IGF-1R↓, 2,   IKKα↓, 5,   p‑IKKα↓, 2,   IR↓, 1,   JAK↓, 8,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 9,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 4,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 123,   MAPK↑, 75,   MAPK↝, 6,   p‑MAPK↓, 6,   p‑MAPK↑, 12,   MEK↓, 3,   p‑MEK↓, 2,   mTOR↓, 45,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 2,   NRAS↓, 1,   p42↑, 1,   p‑p42↑, 1,   p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 5,   PAK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 80,   PI3K↑, 3,   PI3K↝, 3,   p‑PI3K↓, 3,   PI3K/Akt↓, 3,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 3,   PTEN↑, 9,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 8,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 5,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 5,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 4,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 5,   CBP↓, 1,   cJun↓, 2,   cJun↑, 2,   cMyc↓, 12,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMTs↓, 3,   EZH2↓, 1,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 2,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   H4↓, 1,   H4↑, 2,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 10,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 2,   HDAC8↓, 1,   miR-107↑, 2,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-200b↑, 2,   miR-21↓, 6,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-330-5p↑, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-384↑, 1,   miR-422a↑, 2,   Myc↓, 1,   MYCN↓, 1,   NDRG1↑, 2,   OCT4↓, 3,   other↓, 3,   other↑, 3,   other↝, 2,   Shc↓, 1,   SOX2↓, 6,   SOX4↓, 1,   TCF-4↓, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 22,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 12,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 4,   p‑eIF2α↑, 1,   ER Stress↑, 23,   GRP78/BiP?, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 13,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↓, 1,   LAMP2↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 15,   LC3s↑, 1,   p62↓, 3,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 2,   TumAuto↑, 30,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   DNAdam↑, 34,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 6,   p16↑, 1,   P53↓, 1,   P53↑, 55,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↑, 26,   PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 6,   TOP2↓, 3,   TOP2↑, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 6,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 10,   CDK1↑, 3,   CDK2↓, 21,   CDK2↑, 2,   CDK4↓, 28,   CDK4↑, 2,   CDK6↓, 6,   CDK6↑, 3,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 36,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE/CCNE↑, 1,   E2Fs↓, 1,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   Ki-67↓, 14,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 34,   p27/CDKN1B↑, 17,   p‑pRB↓, 4,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 106,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   Axin2↑, 1,   BMP7/OP1↓, 1,   CD133↓, 4,   CD24↓, 2,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 16,   CSCsMark↓, 2,   Diff↓, 1,   Diff↑, 2,   FGF↓, 2,   FGF↑, 1,   Gli1↓, 1,   IGF-1↓, 9,   IGFBP1↑, 1,   IGFBP3↑, 2,   Jun↓, 2,   Ki-67↓, 14,   Let-7↑, 1,   mTORC1↓, 3,   Nanog↓, 4,   Nestin↓, 1,   NOTCH↓, 12,   NOTCH1↓, 5,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 3,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 31,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 81,   TumCP↑, 3,   TumCP∅, 1,   Wnt↓, 29,   Wnt↝, 1,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 2,   AP-1↓, 8,   AP-1↑, 3,   ATPase↓, 1,   AXL↓, 2,   Ca+2↓, 1,   Ca+2↑, 24,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 20,   EMT↓, 37,   EMT↑, 1,   F-actin↓, 2,   FAK↓, 14,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 2,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB4↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP11↓, 1,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 48,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 54,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 22,   MUC4↓, 1,   N-cadherin↓, 13,   NEDD9↓, 1,   NFAT↑, 1,   p44↑, 1,   p‑p44↑, 1,   PAK1↓, 1,   PDGF↓, 5,   Rac1↓, 2,   Rho↓, 4,   ROCK1↓, 2,   Slug↓, 3,   Smad1↝, 1,   SMAD3↓, 2,   Snail↓, 6,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 1,   TGF-β↓, 13,   TGF-β↑, 2,   TGF-β↝, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 1,   TIMP2↑, 4,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI↓, 46,   TumCMig↓, 36,   TumCMig↑, 1,   TumMeta↓, 44,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 3,   Vim↓, 17,   Vim↑, 1,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 47,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 24,   Hif1a↝, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 48,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 2,   CLDN1↑, 1,   EPR↑, 3,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 54,   MPT↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 5,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD8+↑, 1,   COX2/PTGS2↓, 39,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 3,   IL1↓, 6,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL5↓, 1,   IL6↓, 23,   IL8↓, 6,   Imm↑, 6,   Inflam↓, 21,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MDSCs↓, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 84,   NF-kB↑, 2,   NF-kB↝, 1,   NK cell↑, 5,   NLRP3↓, 4,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 6,   T-Cell↑, 1,   Th1 response↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 18,   TNF-α↑, 2,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 8,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 23,   BioAv↑, 27,   BioAv↝, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 78,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 20,   Dose∅, 2,   DrugR↓, 1,   eff↓, 20,   eff↑, 37,   eff↝, 6,   Half-Life↓, 9,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 11,   P450↓, 1,   RadioS↑, 23,   selectivity↑, 30,   selectivity∅, 1,   Synergy↑, 43,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALB↝, 1,   AR↓, 8,   ascitic↓, 1,   BG↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 15,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 6,   IL6↓, 23,   IRes↓, 1,   LDH↓, 2,   LDH↑, 1,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 6,   TP53↑, 2,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 34,   AntiCan?, 1,   antiCG↓, 1,   AntiDiabetic↑, 2,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 16,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 16,   chemoPv↑, 8,   ChemoSideEff↓, 5,   cognitive↑, 1,   hepatoP↑, 7,   neuroP↑, 6,   OS↑, 7,   Pain↓, 1,   QoL↑, 1,   radioP↑, 5,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 7,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 1,   TumW∅, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 816

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 66,   ARE↑, 3,   Bil↑, 2,   Catalase↑, 32,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 22,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 33,   GSR↓, 1,   GSR↑, 8,   GSTs↓, 1,   GSTs↑, 6,   H2O2↓, 3,   H2O2∅, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1↓, 1,   HO-1↑, 32,   hyperG↝, 1,   Keap1↓, 3,   lipid-P?, 1,   lipid-P↓, 28,   MDA↓, 29,   MPO↓, 5,   NQO1↑, 6,   NRF2↓, 3,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS↓, 82,   ROS↑, 2,   SOD↓, 1,   SOD↑, 45,   SOD1↑, 5,   SOD2↑, 2,   TAC↑, 8,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 4,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT?, 1,   ALAT↓, 5,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 11,   AMPK↝, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 1,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 4,   NADPH↑, 2,   SCFAs↑, 1,   SIRT1↑, 5,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 14,   BAD↓, 1,   BAX↓, 4,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp3?, 1,   Casp3↓, 15,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   Casp8↓, 3,   cl‑Casp8↓, 1,   Casp9↓, 5,   Casp9∅, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 3,   HEY1↑, 1,   iNOS↓, 22,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 7,   p38↑, 4,   p‑p38↓, 5,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 20,   Akt↝, 2,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 2,   EGFR↓, 2,   ERK↓, 8,   ERK↑, 8,   p‑ERK↓, 5,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IGF-1R↑, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 1,   p‑JNK↓, 6,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 70,   MAPK↑, 15,   MAPK↝, 4,   p‑MAPK?, 1,   p‑MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 3,   mTOR↝, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 15,   PI3K↝, 2,   PKA↑, 3,   PKCδ↓, 3,   PKCδ↑, 3,   PP2A↑, 1,   PTEN↓, 4,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   Src↓, 1,   p‑Src↑, 1,   STAT↓, 3,   STAT3↓, 4,   STAT3↝, 1,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   other↓, 2,   other↑, 3,   other↝, 5,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 2,   P53↓, 4,   P53↑, 1,   PARP↓, 1,   PARP∅, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   IGFBP3↑, 1,   Jun↓, 1,   neuroG↑, 3,   NOTCH↑, 1,   STAT1↓, 1,   TumCP↓, 2,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 5,   ARG1/2↑, 1,   Ca+2↓, 4,   Ca+2↑, 2,   Ca+2↝, 1,   Cartilage↑, 3,   COL1↓, 1,   FAK↑, 1,   p‑FAK↑, 1,   Fibrosis↓, 1,   heparanase↑, 1,   MLC2/MYL9↝, 1,   MMP2↓, 2,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 2,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   E-sel↓, 2,   eNOS↑, 2,   Hif1a↓, 1,   NO↓, 15,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB?, 1,   BBB↑, 16,   CLDN1↓, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↑, 8,   MUC19↓, 1,   MUC2↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 29,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↑, 9,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 32,   IL2↓, 1,   IL4↓, 4,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 1,   IL8↓, 7,   Imm↑, 2,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 86,   Inflam↑, 1,   IRF3↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↓, 3,   NeuroI↓, 2,   Neut↓, 1,   NF-kB↓, 70,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 13,   NLRP3↑, 1,   p65↓, 1,   p‑p65↓, 1,   PAF↓, 1,   PGE1↓, 1,   PGE2↓, 13,   RAGE↓, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th17↓, 1,   TLR1↓, 1,   TLR2↓, 3,   TLR4↓, 12,   TLR4↑, 1,   TNF-α↓, 45,   TNF-α↑, 2,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 4,   Ach↑, 2,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 2,   BDNF↑, 9,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 1,   NGF↑, 2,   TPH1↓, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 17,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   IDE↑, 1,   tau↓, 5,   p‑tau↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↓, 3,   PPARγ↑, 4,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25,   BioAv↑, 23,   BioAv↝, 12,   BioEnh↑, 2,   ChemoSen↑, 1,   CYP2D6↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 12,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 4,   P450↓, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 5,   ALP↓, 1,   anemia↓, 1,   AST↓, 5,   Bil↑, 2,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   BP↝, 1,   BUN↓, 1,   CEA↓, 1,   colonLen↑, 1,   CRP↓, 6,   EGFR↓, 2,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 30,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 5,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   RBC↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 8,   antiCG↑, 2,   AntiDiabetic↓, 1,   AntiDiabetic↑, 6,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 23,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 22,   diuretic↑, 2,   hepatoP↓, 1,   hepatoP↑, 22,   memory↑, 21,   motorD↑, 2,   Mucositis↓, 1,   neuroP↑, 59,   Obesity↓, 5,   Pain↓, 2,   radioP↑, 4,   RenoP↑, 7,   Risk↓, 1,   Strength↑, 2,   Stroke↓, 6,   toxicity?, 1,   toxicity↓, 13,   toxicity↝, 6,   toxicity∅, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 7,   Bacteria↓, 8,   Diar↓, 2,   GutMicro↑, 9,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 450

Scientific Paper Hit Count for: MAPK, mitogen-activated protein kinase
13 Quercetin
9 Thymoquinone
8 Allicin (mainly Garlic)
8 Berberine
8 Luteolin
7 Chlorogenic acid
7 Curcumin
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Chrysin
6 Fisetin
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Isovitexin
5 Betulinic acid
5 Propolis -bee glue
5 Emodin
4 Alpha-Lipoic-Acid
4 Cisplatin
4 Baicalein
4 Caffeic acid
4 Carvacrol
4 EGCG (Epigallocatechin Gallate)
4 isoorientin
4 Kaempferol
4 Lycopene
4 Magnolol
4 Resveratrol
3 beta-glucans
3 Boron
3 Copper and Cu NanoParticles
3 Sulforaphane (mainly Broccoli)
3 Piperine
3 Formononetin
3 Fucoidan
3 Gallic acid
3 Gambogic Acid
3 Garcinol
3 Hyperoside
3 Lactoferrin/Talactoferrin
3 Melatonin
3 Urolithin
3 Vitamin K2
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Chemotherapy
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Bromelain
2 Boswellia (frankincense)
2 brusatol
2 Carnosic acid
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Echinacea
2 Cynaropicrin
2 diet FMD Fasting Mimicking Diet
2 Disulfiram
2 Ellagic acid
2 Evodiamine
2 Ferulic acid
2 Flaxseed/Linseed
2 Ginseng
2 Honokiol
2 Isoliquiritigenin
2 Vitexin
2 Juglone
2 Naringin
2 Nimbolide
2 Oxygen, Hyperbaric
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Pterostilbene
2 Rutin
2 salinomycin
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 3-bromopyruvate
1 Silver-NanoParticles
1 Paclitaxel/Taxol
1 DTS(dibenzyl trisulphide) from Anamu
1 Bicarbonate(Sodium)
1 Astaxanthin
1 Baicalin
1 Berbamine
1 Benzyl isothiocyanate
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Mung Bean Sprouts
1 Capsaicin
1 Celastrol
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Deguelin
1 immunotherapy
1 Eurycomanone
1 Eugenol
1 Trastuzumab
1 Ginkgo biloba
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 Isobavachalcone
1 Inositol
1 isoquercitrin
1 Ivermectin
1 L-Theanine
1 Licorice
1 Linalool
1 Methylene blue
1 Photodynamic Therapy
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 Radiotherapy/Radiation
1 Magnetic Field Rotating
1 Magnesium
1 Mangiferin
1 Methylglyoxal
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Orlistat
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phycocyanin
1 Plumbagin
1 Rosmarinic acid
1 buckwheat sprouts
1 Salvia officinalis
1 Oxaliplatin
1 Sanguinarine
1 Selenium
1 Selenium NanoParticles
1 Shikonin
1 Terminalia bellirica
1 5-fluorouracil
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:181  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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