Synergy Cancer Research Results

Synergy, Synergy: Click to Expand ⟱
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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
1866- DCA,  MET,  BTZ,    Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner
- in-vivo, NA, NA
Synergy↑, TumCG↓, Hif1a↓, PDH↑, lactateProd↓, TumVol↓, TumW↓, Glycolysis↑, neuroP↑,
1885- DCA,    Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
SMCT1∅, eff↓, eff↑, Synergy↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
6706- DFC,  MET,    Frontiers | Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells
- in-vitro, AML, U937
lactateProd↓, TumCP↓, Synergy↑, Glycolysis↓,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, Synergy↑, Synergy↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
TumCP↑, angioG↓, CD8+↑, GutMicro↑, Synergy↑,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, Synergy↑, HO-1↓, DNAdam↑, Synergy↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, Synergy↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
2268- dietMet,    Methionine dependency and cancer treatment
- Review, Var, NA
ChemoSen↑, *eff↑, selectivity↑, Synergy↑,
2264- dietMet,    Methionine restriction for cancer therapy: From preclinical studies to clinical trials
- Review, Var, NA
TumCP↓, *ROS?, ChemoSen↑, RadioS↑, Synergy↑, ROS↑, selectivity↑, TS↓, eff↑,
5191- dietMet,    Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
- in-vitro, Colon, HT29
ChemoSen↑, RadioS↑, Ferroptosis↑, Synergy↑, eff↑, GSH↓, eff↓,
4984- Dipy,  ATV,    Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
- in-vitro, AML, NA
Synergy↑, Apoptosis↑, selectivity↑, TumCG↓, HMG-CoA↓, HMGCR↑,
4983- Dipy,  ATV,    Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one
- Review, Var, NA
HMG-CoA↓, AntiTum↓, Synergy↑,
6730- Dipy,  ASA,    Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
- vitro+vivo, CRC, NA
*AntiThr↑, Synergy↑, ER Stress↑, UPR↑, *AntiAg↑, *COX1↓, Risk↓, TumCG↓, Apoptosis↑, HMG-CoA↓, *Inflam↓, *antiOx↓,
5386- docx,  AsP,    Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
- vitro+vivo, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Pca, PC3
Dose↝, ROS↑, eff↑, Synergy↑,
6329- DRE,  VitA,RetA,    Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MMP9↓, IL1β↓, P53↑, KAI1/CD82↑, Synergy↑,
6326- DRE,  MT/VAE,    Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy
- in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, Apoptosis↑, MMP↓, TumCI↓, TumCMig↓, Synergy↑,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, Synergy↑, Half-Life↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, Synergy↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, Synergy↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, Synergy↑, CSCs↓, Dose↝, Half-Life↑,
4915- DSF,  Cu,    Disulfiram: A novel repurposed drug for cancer therapy
- Review, Var, NA
ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, Synergy↑, selectivity↑, Proteasome?,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
6614- Ech,    Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice
- in-vivo, Var, NA
*Imm↑, *AntiAge↑, OS↑, NK cell↑, PGE2↓, 5LO↓, COX2/PTGS2↓, Dose↝, Synergy↑,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, Synergy↑, NRF2↑, HO-1↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2/PTGS2↓, NOS2↓, ac‑H3↑, ac‑H4↑, Synergy↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, Synergy↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
5047- erastin,    The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- in-vitro, Ovarian, NA
xCT/SLC7A11↓, GSH↓, Ferroptosis↑, ChemoSen↑, Synergy↑,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
Synergy↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *Synergy↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, Synergy↑, Synergy↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
4143- Ex,    Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, *Synergy↑, *other↓, *eff↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
6962- FA,  VitB12,    Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design
- Trial, AD, NA
*Hcy/homoC↝, *IL6↓, *TNF-α↓, *MCP1/CCL2↝, *Synergy↑, *cognitive↑, *Inflam↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
6861- FBZ,    Fenbendazole pharmacokinetics, metabolism, and potentiation in horses
- in-vivo, Nor, NA
*BioAv↑, *Synergy↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp/ABCB1∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, Synergy↑, Dose↝, TumCG↓,
6858- FBZ,    Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells
- in-vitro, Lung, A549
Synergy↑, mt-ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, PARP↑, TumCCA↑, cycA1/CCNA1↓, cycE/CCNE↓,
2498- FBZ,    Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins
- in-vivo, lymphoma, NA
eff↓, Synergy↑, TumVol↓, antiOx↑, Hif1a↓,
2494- FBZ,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, Synergy↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, Synergy↑,
6893- Fer,  VitC,    MRI Detection and Therapeutic Enhancement of Ferumoxytol Internalization in Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, U118MG
Synergy↑, i-Iron↑, AntiCan↑, ROS↓, H2O2↑,

Showing Research Papers: 151 to 200 of 415
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 415

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   AURKB↓, 1,   CBR1↓, 1,   CD47↓, 1,   CLDN7↑, 1,   compV↓, 1,   ERCC3↑, 1,   H3K9↓, 3,   IRes↓, 1,   KAI1/CD82↑, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-224↓, 1,   miR-375↑, 1,   miR-422a↑, 1,   MMP16↓, 1,   MYCN↑, 1,   NA↑, 2,   OGFr↑, 1,   OLIG2↓, 1,   ORR↑, 1,   PFS↓, 1,   PFS↑, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,   PTN↓, 1,   RBC↑, 1,   SUV39H↓, 3,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 2,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 14,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GPx4↑, 1,   GSH↓, 20,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HK1↓, 1,   HO-1↓, 3,   HO-1↑, 10,   hyperG↓, 1,   ICD↑, 2,   Iron↑, 5,   i-Iron↑, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 4,   OXPHOS↝, 2,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 18,   ROS↑, 174,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 4,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 1,   compIII↓, 1,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 2,   MEK↓, 5,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 56,   MMP↑, 3,   Mortalin↓, 1,   MPT↑, 4,   mtDam↑, 10,   OCR↓, 2,   OCR↑, 2,   PGC-1α↑, 1,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 12,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 3,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   ALAT↑, 1,   AMP↑, 1,   AMPK↑, 17,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 23,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   FGF21↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 33,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 16,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDH↓, 10,   p‑LDH↓, 1,   LDHA↓, 6,   LDL↓, 3,   lipoGen↓, 2,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PDKs↓, 10,   PFK↓, 2,   PFK2?, 1,   PFKFB2↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 11,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 2,   SREBP2↓, 2,   STK11/LKB1↑, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 10,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 119,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 59,   BAX↝, 2,   Bax:Bcl2↑, 16,   Bcl-2↓, 67,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 77,   cl‑Casp3↑, 11,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 8,   cl‑Casp8↑, 2,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   proCasp9↑, 2,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 35,   Diablo↑, 4,   DR4↑, 5,   DR5↑, 14,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 14,   GSDME-N↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 10,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 6,   iNOS↑, 2,   JNK↓, 3,   JNK↑, 9,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 5,   MAPK↝, 1,   p‑MAPK↓, 1,   Mcl-1↓, 16,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 2,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 7,   p38↓, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 3,   Pyro↑, 3,   survivin↓, 24,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 2,   TumCD↑, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 67,   Akt↑, 11,   p‑Akt↓, 17,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 7,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 3,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 3,   HATs↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 3,   pRB↓, 1,   p‑pRB↓, 2,   sonoS↑, 2,   tumCV?, 1,   tumCV↓, 31,   tumCV↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 34,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 9,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 4,   UPR↑, 9,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 9,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 32,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DNA-PK↑, 2,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 35,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 35,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 27,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 41,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 3,   P21↑, 21,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 87,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 7,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 35,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 6,   EMT↓, 47,   EMT↑, 2,   ERK↓, 13,   ERK↑, 5,   ERK↝, 1,   p‑ERK↓, 11,   FGF↓, 1,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 19,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 6,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   mTOR↓, 41,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 9,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 7,   p300↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 51,   PI3K↑, 4,   p‑PI3K↓, 3,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 11,   RAS↓, 6,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 2,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 41,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 71,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 22,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 5,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 13,   CAFs/TAFs↓, 1,   cal2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD11b↑, 2,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   Cofilin↓, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 25,   ER-α36↓, 2,   FAK↓, 5,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 17,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 3,   MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 40,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 49,   MMP9↑, 2,   MMPs↓, 19,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 16,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 5,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 3,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 13,   SOX4↓, 2,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 51,   TumCMig↓, 36,   TumCMig↑, 1,   TumCP?, 1,   TumCP↓, 69,   TumCP↑, 2,   TumMeta↓, 36,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   VEGFR1↓, 1,   Vim?, 1,   Vim↓, 19,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 53,   angioG↑, 2,   ATF4↓, 1,   ATF4↑, 7,   ECM/TCF↓, 1,   EGFR↓, 19,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 34,   Hif1a↑, 1,   Hypoxia↓, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 2,   p‑PDGFR-BB↓, 1,   VEGF↓, 58,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   P-gp/ABCB1∅, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 21,   IL8↓, 5,   Imm↑, 16,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 19,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 7,   M2 MC↓, 3,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 65,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 9,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 19,   PSA↓, 5,   PSA∅, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 15,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10,   CDK6↓, 8,   CDK6↑, 4,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 19,   BioAv↑, 33,   BioAv↝, 13,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 137,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 9,   Dose↝, 50,   Dose∅, 15,   eff↓, 32,   eff↑, 87,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 45,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 434,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALAT↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 19,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 3,   GutMicro↑, 6,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 10,   IL6↓, 21,   Ki-67↓, 17,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 10,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 5,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 32,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 17,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 19,   chemoPv↑, 7,   ChemoSideEff↓, 11,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 3,   OS↑, 30,   PDE4↓, 1,   Pin1↓, 2,   QoL↑, 7,   QoL∅, 1,   radioP↑, 7,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 20,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 17,   TumW↓, 8,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 7,   Sepsis↓, 2,  
Total Targets: 887

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 6,   compII↑, 1,   diuretic↑, 2,   NA↑, 1,   NeuroI↓, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   Stress↓, 1,   Stroke↓, 3,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 65,   Catalase↑, 26,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 3,   GPx↑, 20,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 20,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 23,   MDA↓, 19,   MDA↑, 1,   MPO↓, 4,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 38,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 73,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 35,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 2,   ATP↓, 1,   ATP↑, 7,   ATP↝, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 5,   mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 8,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 3,   LDL↓, 6,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GADD34↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 10,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 2,   AKT1↓, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 14,   other↝, 8,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 3,   ERK↑, 2,   GH↑, 1,   GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,   TumCG∅, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 8,   AP-1↓, 3,   APP↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   Ki-67↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   MUC1↑, 1,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 2,   serineP↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   VCAM-1↓, 4,   ZO-1↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   ATF4↓, 2,   EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 12,   BBB↝, 1,   GastroP↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 20,   IL2↓, 2,   IL33↓, 1,   IL4↓, 2,   IL6?, 1,   IL6↓, 32,   IL8↓, 3,   Imm↓, 1,   Imm↑, 7,   Inflam↓, 86,   Inflam↑, 2,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   PGE2↓, 8,   PSA↓, 2,   TLR2↓, 2,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 38,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 2,   NGF↑, 1,   tau↓, 6,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 16,   BACE/β-secretase↓, 7,   NLRP3↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   DHT↓, 1,   Leptin↓, 1,   testos↓, 1,   testos↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 45,   BioAv⇅, 2,   BioAv↝, 15,   BioEnh↑, 3,   ChemoSen↑, 1,   Dose↑, 4,   Dose↝, 25,   eff↓, 1,   eff↑, 15,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 73,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   ALP↓, 2,   AST↓, 13,   BloodF↑, 2,   BMD↑, 3,   BMPs↑, 1,   BP↓, 7,   BP↝, 1,   Calcium↑, 1,   creat↓, 2,   CRP↓, 6,   EGFR↓, 1,   GutMicro↑, 14,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 32,   Ki-67↓, 1,   LDH↓, 3,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 2,   RAGE↓, 2,   Urea↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   antiAll↑, 5,   AntiArt↑, 4,   AntiCan↑, 10,   AntiDiabetic↑, 13,   AntiP↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 31,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 24,   cognitive↝, 1,   hepatoP↑, 24,   memory↑, 20,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 55,   Obesity↓, 8,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 10,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 1,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 2,   IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 383

Scientific Paper Hit Count for: Synergy, Synergy
23 Curcumin
15 Vitamin C (Ascorbic Acid)
14 Quercetin
13 Chrysin
12 Sulforaphane (mainly Broccoli)
12 Dichloroacetate
11 Metformin
11 Lycopene
10 EGCG (Epigallocatechin Gallate)
9 Chemotherapy
9 Resveratrol
8 Silver-NanoParticles
8 Artemisinin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Atorvastatin
7 Berberine
7 immunotherapy
6 Radiotherapy/Radiation
6 Hyperthermia
6 Magnetic Fields
6 Apigenin (mainly Parsley)
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Inositol
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Melatonin
5 Dipyridamole
5 Carvacrol
5 diet FMD Fasting Mimicking Diet
5 Fenbendazole
5 Formononetin
5 Gambogic Acid
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 Rosmarinic acid
4 3-bromopyruvate
4 Auranofin
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 salinomycin
4 diet Methionine-Restricted Diet
4 Dandelion Root
4 Disulfiram
4 Hydrogen Gas
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chaetocin
3 chitosan
3 5-fluorouracil
3 Copper and Cu NanoParticles
3 Piperine
3 Emodin
3 Eugenol
3 Genistein (soy isoflavone)
3 Honokiol
3 Ivermectin
3 Juglone
3 Kaempferol
3 Luteolin
3 Matrine
3 Terpinen-4-ol / Tea Tree Oil
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Trichostatin A
2 Allicin (mainly Garlic)
2 Andrographis
2 isoquercitrin
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 hydroxychloroquine
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 Vitamin A, Retinoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 Fucoidan
2 Gallic acid
2 Cisplatin
2 Gamma-aminobutyric acid
2 doxorubicin
2 Ginkgetin
2 Gossypol/AT-101
2 HydroxyCitric Acid
2 Spermidine
2 Lecithin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Shikonin
2 Selenite (Sodium)
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anti-oxidants
1 Acer okamotoanum
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Trastuzumab
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Ascorbyl Palmitate
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Beta-Caryophyllene
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 Arsenic trioxide
1 olaparib/LYNPARZA
1 Galloflavin
1 verapamil
1 Garcinol
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginkgolide B
1 Gold NanoParticles
1 Calorie Restriction Mimetics
1 iodine
1 Inulin Prebiotic
1 isoorientin
1 itraconazole
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 lambertianic acid
1 Lapatinib
1 low dose naltrexone
1 Licorice
1 Linalool
1 Vitamin E
1 Magnolol
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Marjoram (Origanum majorana)
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 statins
1 triptolide
1 Turmerones
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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