MMP9 Cancer Research Results

MMP9, MMP9: Click to Expand ⟱

Source: HalifaxProj(suppress)

Type:

Matrix metalloproteinase-9 (MMP-9) is an enzyme that plays a significant role in the degradation of extracellular matrix components.
MMP-9 facilitates the breakdown of the extracellular matrix, which can enable cancer cells to invade surrounding tissues and spread to distant sites (metastasis).
Elevated levels of MMP-9 have been associated with poor prognosis in several cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.

Scientific Papers found: Click to Expand⟱

8847-

DIM,

Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells

-

in-vitro,

BC,

NA

eff?, MMP2↓, MMP9↓, RAS↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, EGFR↓,

8845-

DIM,

I3C,

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

-

Review,

Var,

NA

*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,

8841-

DIM,

3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis

-

in-vitro,

Liver,

Hep3B

-

in-vitro,

Liver,

HUH7

TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,

6271-

DL,

D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells

-

in-vitro,

Colon,

SW480

100μg/ml

-

in-vitro,

Colon,

HT-29

TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,

6273-

DL,

D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways

-

in-vitro,

Colon,

Caco-2

DOX showing IC50 values of 18.6 and 6.4 µM, respectively.

Caco-2 cells were treated with D-limonene or doxorubicin (DOX) for 24 h.

-

in-vitro,

Nor,

HEK293

-

in-vitro,

Colon,

HCT116

ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,

6285-

DL,

Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

MCF7

VEGF↓, *STAT3↓, TumCP↓, TumMeta↓, p‑STAT3↓, MMP9↓, SHP1↑, angioG↓,

6329-

DRE,

VitA,RetA,

Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells

-

in-vitro,

BC,

MCF7

 IC50 values for dandelion extract and ATRA were 1.69 mg/ml and 48 μM, respectively

-

in-vitro,

BC,

MDA-MB-231

MMP9↓, IL1β↓, P53↑, KAI1/CD82↑, Synergy↑,

6348-

DRE,

New prospects in oncotherapy: bioactive compounds from Taraxacum officinale

-

Review,

Var,

NA

Ingr↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,

6350-

DRE,

Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study

-

Review,

Var,

NA

AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,

6317-

DRE,

The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells

-

in-vitro,

Melanoma,

A375

Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,

6365-

DRE,

AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND

-

Review,

Var,

NA

*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,

6360-

DRE,

Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma

-

in-vitro,

ESCC,

KYSE450

-

in-vitro,

ESCC,

Eca109

TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,

4832-

EA,

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

-

Review,

Var,

NA

*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,

1605-

EA,

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

-

Review,

Var,

NA

*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,

1621-

EA,

The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art

-

Review,

Var,

NA

AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,

1620-

EA,

Rad,

Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study

-

in-vitro,

Liver,

HepG2

ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,

27-

EA,

Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice

-

in-vivo,

PC,

PANC1

 PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA

HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,

3238-

EGCG,

Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications

-

Review,

Var,

NA

Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,

3201-

EGCG,

Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential

-

Review,

Var,

NA

*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,

3212-

EGCG,

EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells

-

in-vitro,

Lung,

A549

-

in-vivo,

Lung,

NCIH23

NRF2⇅, ChemoSen↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,

2994-

EGCG,

Nano-Engineered Epigallocatechin Gallate (EGCG) Delivery Systems: Overcoming Bioavailability Barriers to Unlock Clinical Potential in Cancer Therapy

-

Review,

Var,

NA

BioAv↓, NF-kB↓, Casp↑, MMP9↑, Sp1/3/4↑,

639-

EGCG,

Immunomodulatory Effects of Green Tea Catechins and Their Ring Fission Metabolites in a Tumor Microenvironment Perspective

-

Review,

Var,

NA

TIMP3↑, MMP2↓, MMP9↓,

689-

EGCG,

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9

-

vitro+vivo,

Bladder,

SW780

25–100 μM

Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,

6820-

EMD,

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

-

Review,

Nor,

NA

-

Review,

Arthritis,

NA

-

Review,

AD,

NA

*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,

6814-

EMD,

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

-

Review,

Nor,

NA

AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓, *antiAll↑,

1322-

EMD,

The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers

-

Review,

Var,

NA

7.22 μg/mL

Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,

6388-

Eug,

Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review

-

Review,

Var,

NA

Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,

6335-

Eug,

Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells

-

in-vitro,

Nor,

NA

*H2O2↓, *ROS↓, *lipid-P↓, MMP9↓, TIMP1↓, *ROS↓, *antiOx↑,

6325-

Eug,

Anticancer Properties of Eugenol: A Review

-

Review,

Var,

NA

*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,

6332-

Eug,

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

SkBr3

TumCP↓, MMP2↓, MMP9↓, TIMP1↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑,

6331-

Eug,

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition

-

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,

6330-

Eug,

Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement

-

Review,

Var,

NA

TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,

6846-

EVO,

Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway

-

in-vitro,

CRC,

HT29

-

in-vitro,

CRC,

HCT116

TumCP↓, TumCI↓, TumCCA↑, PI3K↓, AKT1↓, P53↑, Bcl-2↓, BAX↑, Apoptosis↑, p‑Casp9↑, E-cadherin↑, N-cadherin↓, MMP9↓, CSCs↓, EGFR↓, PDGFRA↓, Dose↝, TumCG↓,

1057-

EVO,

Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion

-

in-vitro,

Var,

NA

NF-kB↓, TNF-α↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2/BIRC3↓, cFLIP↓, Bfl-1↓,

6870-

FA,

Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial

-

Trial,

AD,

NA

*Dose↝, *cognitive↑, *Hcy/homoC↓, *MMP9↓, *Risk↓,

6881-

FA,

Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight

-

Review,

Var,

NA

ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,

7513-

FA,

Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP

-

in-vitro,

Thyroid,

NA

 150 μM

cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,

7511-

FA,

The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells

-

in-vitro,

Cerv,

HeLa

FA (0.5, 1.0, 1.5, 2.0 mM)

-

in-vitro,

Cerv,

CaSki

MMP9↓, TumCCA↑, P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, LC3II↓, Beclin-1/ATG6↓, ATG5↓, TumCP↓, TumCI↓, MMP9↓,

7510-

FA,

Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability

-

in-vitro,

Lung,

H1299

*antiOx↑, ROS↑, H2O2↑, TumCP↓, TumCMig↓, MMP2↓, MMP9↓,

1656-

FA,

Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

-

Review,

Var,

NA

tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,

6915-

FIS,

SRF,

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma

-

in-vitro,

Melanoma,

NA

EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,

5392-

FIS,

AsP,

Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging

-

in-vivo,

Nor,

NA

eff↑, *antiOx↑, *MMP9↓, *TNF-α↓, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAge↑, *Inflam↓, *JNK↓,

2847-

FIS,

Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells

-

in-vitro,

CCA,

NA

tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,

2850-

FIS,

Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways

-

in-vitro,

BC,

MCF7

TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,

2858-

FIS,

Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines

-

in-vitro,

BC,

4T1

HO-1↑, NRF2↑, MMP2↓, MMP9↓,

2845-

FIS,

Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy

-

Review,

Var,

NA

PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,

2824-

FIS,

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,

2825-

FIS,

Exploring the molecular targets of dietary flavonoid fisetin in cancer

-

Review,

Var,

NA

*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,

2828-

FIS,

Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review

-

Review,

Var,

NA

*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,

2829-

FIS,

Fisetin: An anticancer perspective

-

Review,

Var,

NA

TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,

Showing Research Papers: 151 to 200 of 448
Prev Page 4 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 448

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3, antiOx↑, 10, antiOx⇅, 1, Catalase↓, 5, Catalase↑, 3, Copper↓, 1, Copper↑, 1, frataxin↑, 1, GPx↓, 2, GPx↑, 4, GPx4↓, 6, GSH↓, 23, GSH↑, 5, GSR↑, 2, GSTs↓, 1, GSTs↑, 2, H2O2↓, 1, H2O2↑, 5, HO-1↓, 9, HO-1↑, 14, HO-2↓, 1, Iron↑, 3, Keap1↓, 1, lipid-P?, 1, lipid-P↓, 4, lipid-P↑, 13, MDA↓, 5, MDA↑, 5, MPO↓, 1, NOX4↓, 1, NQO1↓, 1, NQO1↑, 3, NRF2↓, 13, NRF2↑, 16, NRF2⇅, 1, NRF2↝, 1, p‑NRF2↓, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, RNS↑, 1, ROS?, 2, ROS↓, 26, ROS↑, 170, ROS⇅, 7, ROS∅, 1, i-ROS↓, 2, i-ROS↑, 2, mt-ROS↑, 1, SOD↓, 6, SOD↑, 7, SOD1↓, 1, SOD1↑, 2, SOD2↓, 1, SOD2↑, 3, TBARS↑, 1, Thiols↓, 1, Trx1↑, 1, TrxR↓, 7, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, IronCh↑, 2, Tf↓, 1, TfR1/CD71↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2, Bfl-1↓, 1, CDC2↓, 7, CDC25↓, 10, compI↓, 1, compIII↓, 1, compV↓, 1, EGF↓, 5, ETC↓, 3, mitResp↓, 1, mitResp↑, 1, MKK7↓, 1, mtDam↑, 8, OCR↓, 3, mt-OXPHOS↓, 1, PDH↝, 1, PINK1↑, 1, SIRT3↓, 2, SIRT3↑, 3,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3, 5LO↓, 6, ACADS/SCAD↓, 1, ACC↑, 1, ALAT↓, 6, ALAT↝, 1, AMPK↓, 2, AMPK↑, 20, AMPK↝, 1, p‑AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 13, mt-ATP↓, 1, CAIX/CA9↑, 1, ECAR↓, 1, ECAR↝, 1, ENO1↓, 1, FABP4↑, 1, FASN↓, 3, FASN↑, 1, GAPDH↓, 2, GLO-I↓, 1, glucoNG↓, 1, glucose↓, 1, GlucoseCon↓, 9, GlutMet↓, 2, Glycolysis↓, 23, GSK‐3β↓, 11, GSK‐3β↑, 2, p‑GSK‐3β↓, 3, HK1↓, 1, HK2↓, 11, lactateProd↓, 9, LDHA↓, 6, LDL↓, 1, lipidLev↓, 1, NADPH↓, 3, NADPH↑, 3, O-Glc↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 7, p‑PDK1 / PDPK1↓, 1, PDK3↑, 1, PFK↓, 1, PIP3↑, 1, PKM2↓, 8, PKM2↑, 1, PLA2↓, 1, p‑S6↓, 1, SIRT1↓, 6, SIRT1↑, 9, SIRT2↑, 1, SREBP1/SREBF1↓, 2, SREBP2↓, 1, Warburg↓, 4,

Cell Death(tgid=5) ⓘ

AIF↑, 10, APAF1↑, 4, Apoptosis?, 1, Apoptosis↓, 4, Apoptosis↑, 143, ASC↑, 1, ASK1↑, 1, BAD↓, 3, BAD↑, 5, Bak↑, 5, BAX↓, 2, BAX↑, 94, BAX⇅, 1, BAX↝, 1, Bax:Bcl2↑, 22, Bcl-2↓, 104, Bcl-2↑, 3, Bcl-xL↓, 35, BID↓, 2, BID↑, 6, p‑BID↓, 1, BIM↑, 5, BNIP3↑, 3, BNIP3↝, 1, Casp↓, 1, Casp↑, 25, Casp∅, 1, cl‑Casp↑, 1, Casp1↓, 1, Casp1↑, 1, Casp12?, 1, Casp12↑, 2, Casp2↑, 1, Casp3↓, 5, Casp3↑, 114, Casp3∅, 1, cl‑Casp3↑, 15, proCasp3↑, 1, Casp6↑, 1, Casp7↑, 12, cl‑Casp7↑, 1, Casp8↑, 29, Casp8∅, 1, cl‑Casp8↑, 4, proCasp8↑, 2, Casp9↓, 1, Casp9↑, 76, p‑Casp9↑, 1, cl‑Casp9↑, 8, proCasp9↓, 1, proCasp9↑, 1, cFLIP↓, 4, Cyt‑c↓, 1, Cyt‑c↑, 62, mt-Cyt‑c↓, 1, Diablo↑, 12, DR5↑, 22, Endon↑, 2, FADD↑, 4, Fap1↓, 1, Fas↓, 1, Fas↑, 20, FasL↓, 1, FasL↑, 8, FasL⇅, 1, Ferroptosis↑, 7, GranB/GZMB↝, 1, GSDME↑, 1, HEY1↓, 2, IAP1↓, 16, IAP2/BIRC3↓, 6, ICAD↓, 1, ICD↑, 1, iNOS↓, 19, Mcl-1?, 1, Mcl-1↓, 27, p‑Mcl-1↓, 1, MDM2↓, 9, MDM2↑, 1, MOMP↑, 2, Necroptosis↑, 1, necrosis↑, 2, NOXA↑, 3, p38↓, 13, p38↑, 13, p‑p38↓, 4, p‑p38↑, 4, p‑p38↝, 1, Perforin↝, 1, PUMA↓, 1, PUMA↑, 6, Pyro↑, 4, RIP1↑, 1, RIP3↑, 1, survivin↓, 53, TNFR 1↑, 1, TRAIL↑, 3, TRAILR↑, 2, TumCD↓, 1, TumCD↑, 7, XIAP↓, 26, XIAP↑, 1, YAP/TEAD↓, 5,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 134, Akt↑, 4, p‑Akt↓, 43, AKT1↓, 2, Akt2↓, 1, CaMKII ↓, 1, CIP2A↓, 2, CK2↓, 4, cMET↓, 2, p‑cMET↓, 1, cSrc↓, 3, EGFR↓, 34, p‑EGFR↓, 3, ERK↓, 53, ERK↑, 8, p‑ERK↓, 23, p‑ERK↑, 1, p‑ERK↝, 1, FGFR1↓, 3, FGFR2↓, 1, FOXD3↑, 2, HER2/EBBR2↓, 13, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 2, Hippo↑, 1, IGF-1R↓, 6, IGFR↓, 1, IKKα↓, 10, IKKα↝, 1, p‑IKKα↓, 2, IκB↓, 1, p‑IκB↓, 3, p‑IκB↑, 1, JAK↓, 6, p‑JAK↓, 1, JAK1↓, 4, p‑JAK1↓, 1, JAK2↓, 17, p‑JAK2↓, 3, p‑JAK3↓, 1, JNK↓, 12, JNK↑, 18, p‑JNK↓, 5, p‑JNK↑, 2, p‑JNK↝, 1, p‑MAP2K1/MEK1↓, 1, MAPK↓, 35, MAPK↑, 13, p‑MAPK↓, 2, MARK4↓, 2, MEK↓, 5, p‑MEK↓, 2, MKK4↓, 1, mTOR↓, 67, mTOR↝, 1, p‑mTOR↓, 11, mTORC2↓, 2, mTORC2↑, 1, p70S6↓, 1, P70S6K↓, 2, p‑P70S6K↓, 1, p‑P90RSK↑, 1, PDGFR-BB↓, 1, p‑PDGFR-BB↓, 1, PDGFRA↓, 1, PI3K↓, 106, PI3K↑, 1, p‑PI3K↓, 8, p‑PI3K↑, 1, PI3K/Akt↓, 4, PKA↓, 2, PKCδ↓, 14, p‑PKCδ↓, 1, PTEN↓, 1, PTEN↑, 29, Raf↓, 5, e-Raf↓, 1, c-Raf↓, 1, RAS↓, 12, p‑S6K↓, 1, SHP1↑, 2, Sp1/3/4↓, 12, Sp1/3/4↑, 1, Src↓, 2, p‑Src↓, 1, STAT↓, 4, p‑STAT2↓, 1, STAT3↓, 76, STAT3↑, 3, p‑STAT3↓, 13, p‑STAT3↑, 3, STAT5↓, 3, STAT6↓, 2, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↓, 1, ATF4↑, 6, ATF4↝, 1, CBP↓, 1, cJun↓, 8, cJun↑, 1, p‑cJun↓, 1, cMyc↓, 40, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 6, DNMTs↓, 7, EZH2↓, 6, FOXM1↓, 4, FOXO↑, 3, FOXO1↓, 3, FOXO1↑, 1, FOXO3↓, 3, FOXO3↑, 8, FOXO3↝, 1, p‑FOXO3↓, 1, FOXO4↓, 2, FOXO4↑, 1, H3↑, 1, ac‑H3↓, 1, ac‑H3↑, 2, H4↑, 1, ac‑H4↓, 1, ac‑H4↑, 2, HATs↓, 7, HATs↑, 1, HDAC↓, 18, HDAC1↓, 5, HDAC10↓, 1, HDAC2↓, 3, HDAC3↓, 2, HDAC4↓, 1, HDAC6↓, 2, HDAC8↓, 1, HES1↓, 3, JPT1/HN1↓, 1, LINC01116↓, 1, Matr↓, 1, miR-106b↓, 1, miR-107↑, 2, miR-10b-5p↓, 1, miR-126↓, 1, miR-133a-3p↑, 1, miR-139-5p↑, 2, miR-149↑, 1, miR-155↓, 5, miR-155↑, 1, miR-17↓, 1, miR-182-5p↓, 1, miR-194↑, 1, miR-195↑, 1, miR-200b↑, 2, miR-200c↓, 1, miR-203↑, 1, miR-21↓, 8, miR-21↑, 2, miR-210↑, 1, miR-221↓, 1, miR-224↓, 2, miR-25-5p↑, 1, miR-27a-3p↓, 1, miR-27a-3p↑, 1, miR-301a-3p↓, 1, miR-340↓, 2, miR-34a↑, 5, miR-34b-5p↑, 1, miR-384↑, 2, miR-422a↑, 2, miR-592↑, 1, MTA2↓, 1, Myc↓, 5, n-MYC↓, 2, NDRG1↑, 1, OCT4↓, 15, other↓, 3, other↑, 1, other↝, 4, other∅, 1, PAX2↓, 1, PhotoS↑, 1, SOX2↓, 11, SOX4↓, 2, SOX4↑, 1, SOX9?, 1, SOX9↓, 2, SOX9↑, 1, TCF-4↓, 2, tumCV↓, 28, ZBTB10↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 17, eIF2α↓, 1, p‑eIF2α↑, 3, ER Stress↓, 1, ER Stress↑, 33, Erlin1↑, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 12, GRP78/BiP↝, 1, HSF1↓, 1, HSP27↓, 4, HSP27↝, 1, HSP70/HSPA5↓, 7, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSP90↓, 11, HSPs↓, 1, IRE1↑, 5, PDI↑, 1, PERK↑, 3, Proteasome↓, 1, SERPINH1/HSP47↓, 1, UPR↓, 1, UPR↑, 4, XBP-1↓, 1, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1, ATG5↑, 2, ATG7↑, 1, Beclin-1/ATG6↓, 5, Beclin-1/ATG6↑, 10, CTSB↓, 2, CTSD↓, 2, CTSK↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3A↑, 1, LC3B↓, 1, LC3B-II↓, 1, LC3B-II↑, 4, LC3II↓, 3, LC3II↑, 8, LC3s↓, 1, LC3s↑, 1, p62↓, 6, p62↑, 2, PARK2↑, 1, TumAuto↓, 1, TumAuto↑, 31, TumAuto⇅, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1, ATM↑, 2, BRCA1↓, 1, BRCA1↑, 1, p‑BRCA1↑, 1, BRCA2↑, 1, DFF45↓, 2, DNAdam↓, 3, DNAdam↑, 40, DNArepair↓, 2, DNArepair↑, 1, ERCC1↓, 1, ERCC3↑, 1, hTERT/TERT↓, 11, MGMT↓, 1, p16↑, 4, P53?, 2, P53↓, 2, P53↑, 75, P53↝, 1, p‑P53↑, 1, PARP↓, 2, PARP↑, 16, cl‑PARP↓, 1, cl‑PARP↑, 50, PARP1↑, 1, PCNA↓, 24, POLD1↓, 1, SIRT6↓, 2, SIRT6↑, 1, Telomerase↓, 14, TOP1↓, 7, TOP2↓, 6, TOP2↑, 2, TP53↑, 3, TRF2↓, 1, UHRF1↓, 1, XRCC1↓, 1, γH2AX↓, 1, γH2AX↑, 8, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 11, p‑CDK1↓, 1, CDK1/2/5/9↓, 1, CDK2↓, 40, CDK2↑, 3, CDK4↓, 51, CDK4↑, 1, p‑CDK4↓, 1, CDK4/6↓, 1, CDK6↓, 24, CDK6↑, 1, CDK8↓, 1, CDKN1C/p57↓, 1, CDKN1C/p57↑, 1, CHK1↓, 3, p‑CHK1↑, 1, Chk2↓, 2, Cyc↓, 2, cycA1/CCNA1↓, 9, cycA1/CCNA1↑, 2, CycB/CCNB1↓, 19, CycB/CCNB1↑, 1, cycD1/CCND1↓, 85, cycD1/CCND1↑, 1, p‑cycD1/CCND1↓, 1, CycD3↓, 3, cycE/CCNE↓, 23, E2Fs↓, 5, GADD45A↑, 1, Ki-67↓, 28, MAD↓, 1, P21↓, 4, P21↑, 55, p27/CDKN1B↓, 2, p27/CDKN1B↑, 21, pRB↓, 2, pRB↑, 1, p‑pRB↓, 1, RB1↓, 1, RB1↑, 2, p‑RB1↓, 5, Securin↓, 1, TumCCA?, 1, TumCCA↓, 10, TumCCA↑, 148,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, ALDH↓, 6, ALDH1A1↓, 3, BMP2↓, 2, BMPs↑, 1, CD133↓, 10, CD133↑, 1, CD24↓, 4, CD34↓, 1, cFos↓, 8, p‑cFos↓, 1, cMYB↓, 1, CSCs↓, 38, CSCs↑, 1, Diff↓, 1, Diff↑, 3, EIF4E↓, 1, FGF↓, 3, FGF↑, 1, Gli↓, 2, Gli1↓, 9, HH↓, 8, IGF-1↓, 9, IGF-2↓, 1, IGFBP3↓, 1, IGFBP3↑, 2, JAG1↓, 1, Jun↓, 1, Ki-67↓, 28, Let-7↑, 6, LRP6↓, 1, p‑LRP6↓, 1, mTORC1↓, 4, p‑mTORC1↓, 1, Nanog↓, 11, Nestin↓, 2, NICD↓, 1, NOTCH↓, 19, NOTCH1↓, 12, NOTCH1↑, 3, NOTCH1↝, 1, NOTCH2↓, 1, NOTCH3↓, 2, p300↓, 2, Piezo1↑, 1, PTCH1↓, 2, Shh↓, 7, Smo↓, 3, STAT1↓, 1, p‑STAT1↓, 1, Sufu↓, 1, TAZ↓, 1, TOPflash↓, 1, TumCG↓, 67, TumCG↑, 2, TumCP?, 1, TumCP↓, 127, TumCP↑, 2, tyrosinase↓, 2, URGCP/URG4↓, 1, Wnt↓, 42, Wnt/(β-catenin)↓, 5, ZFX↓, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg?, 1, AntiAg↓, 1, AntiAg↑, 2, AP-1↓, 20, AP-1↝, 1, ATPase↓, 1, AXL↓, 2, CA↓, 3, Ca+2↓, 1, Ca+2↑, 32, Ca+2↝, 1, i-Ca+2?, 1, i-Ca+2↑, 1, CAFs/TAFs↓, 2, cal2↓, 1, CCN2/CTGF↓, 2, Cdc42↑, 1, Cofilin↓, 1, COL1A1↓, 1, COL3A1↓, 1, DLC1↑, 1, E-cadherin↓, 13, E-cadherin↑, 69, EMMPRIN↓, 1, EMT↓, 101, EMT↑, 3, EpCAM↓, 4, F-actin↓, 2, FAK↓, 22, FAK↑, 2, p‑FAK↓, 5, fascin↓, 1, Fibronectin↓, 8, GIT1↓, 1, GLI2↓, 2, IQGAP3↓, 1, ITGA1∅, 1, ITGA5↓, 3, ITGA5∅, 1, ITGB1↓, 4, ITGB1∅, 1, ITGB3↓, 1, ITGB3∅, 1, ITGB4∅, 1, KAI1/CD82↑, 1, LAMs↓, 1, LIMK2↓, 1, MALAT1↓, 1, MET↓, 1, MMP-10↓, 2, MMP1↓, 13, MMP11↓, 1, MMP13↓, 8, MMP14↓, 1, MMP16↓, 3, MMP2?, 2, MMP2↓, 260, MMP2↑, 2, MMP2⇅, 1, MMP2↝, 1, MMP2∅, 1, MMP3↓, 15, MMP7↓, 16, MMP7∅, 1, MMP9?, 2, MMP9↓, 399, MMP9↑, 9, MMP9⇅, 1, MMP9↝, 1, MMP9∅, 1, pro‑MMP9↓, 1, MMPs↓, 27, MTA1↓, 1, MUC4↓, 2, N-cadherin↓, 46, NCAM↓, 1, PAI-1/SERPINE1↓, 1, PAK1↓, 2, PDGF↓, 7, Rac1↓, 1, RECK↑, 1, Rho↓, 6, ROCK1↓, 7, ROCK1↑, 1, Sharpin↓, 1, Slug?, 1, Slug↓, 20, Smad1↓, 1, Smad1↑, 1, SMAD2↓, 1, p‑SMAD2↓, 2, SMAD3↓, 2, SMAD3↑, 1, p‑SMAD3↓, 2, SMAD4↓, 2, Snail?, 2, Snail↓, 37, Snail↑, 1, STAC2↓, 1, TET1↓, 1, TET1↑, 3, TGF-β↓, 21, TGF-β↑, 2, TGF-β1↓, 1, TIMP1↓, 7, TIMP1↑, 23, TIMP2↓, 5, TIMP2↑, 17, TIMP3↑, 2, TSP-1↑, 3, TumCA↓, 7, TumCA↑, 1, TumCI↓, 135, TumCI↑, 2, TumCMig↓, 126, TumCMig↑, 1, TumMeta↓, 94, TumMeta↑, 6, TumPF↓, 1, Twist↓, 28, Twist↑, 1, uPA↓, 40, uPAR↓, 7, Vim?, 1, Vim↓, 59, Zeb1↓, 18, ZEB2↓, 3, ZEB2↑, 1, α-SMA↓, 4, α-SMA↑, 1, α-tubulin↑, 3, β-catenin/ZEB1↓, 49, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 97, angioG↑, 1, angioS↑, 1, CCN1/CYR61↓, 1, CD31/PECAM-1↓, 3, ECM/TCF↓, 1, Endoglin↑, 1, eNOS↓, 3, HIF-1↓, 4, Hif1a↓, 57, Hif1a↑, 2, Hif1a↝, 1, LOX1↓, 1, NO↓, 7, NO↑, 1, PHDs↓, 1, TXA2↓, 1, VCAM-1↓, 4, VEGF↓, 148, VEGF↑, 1, VEGFR1↓, 5, VEGFR2/KDR/Flk1↓, 19,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 1, CLDN1↓, 2, CLDN2↓, 1, EPR↑, 5, EPR↝, 1, GLUT1↓, 9, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 1, MMP↓, 75, MMP↑, 1, MMP∅, 1, MPT↑, 5, NHE1↓, 2, TRPM7↓, 1, TRPV1↑, 3, ZO-1↑, 4,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD4+↓, 1, CD4+↑, 1, CD44↓, 15, CD8+↑, 1, p‑cDC2↓, 1, COX1↓, 5, COX2/PTGS2↓, 107, COX2/PTGS2↑, 2, COX2/PTGS2↝, 1, CXCL1↓, 1, CXCL12↓, 2, CXCL16↓, 1, CXCR2↓, 2, CXCR4↓, 23, CXCR4↑, 1, DR4↑, 8, FOXP3↓, 2, FOXP3↑, 1, Gal-3↓, 1, HMGB1↓, 4, ICAM-1↓, 12, IFN-γ↓, 2, IFN-γ↑, 2, Igs↑, 1, IL-1Ra↑, 1, IL1↓, 7, IL1↑, 2, IL10↓, 6, IL10↑, 3, IL12↓, 4, IL12↑, 1, IL17↓, 1, IL18↓, 2, IL18↑, 1, IL1R2↑, 1, IL1RL1/ST2↑, 1, IL1α↓, 2, IL1β↓, 15, IL1β↑, 2, IL2↓, 4, IL2↑, 4, IL22↓, 1, IL23↓, 1, IL33↑, 1, IL4↓, 2, IL4↑, 2, IL6↓, 53, IL6↑, 1, IL8↓, 13, IL8↑, 2, Imm↑, 2, Imm↝, 3, Inflam↓, 27, IRAK1↓, 1, M2 MC↓, 2, MCP1/CCL2↓, 7, MIP2↓, 1, mPGES-1↓, 2, NF-kB?, 1, NF-kB↓, 168, NF-kB↑, 1, NF-kB↝, 1, p‑NF-kB↓, 2, p‑NF-kB↑, 1, NK cell↑, 3, NLRP3↓, 3, NLRP3↑, 2, p50↓, 3, p65↓, 11, p65↑, 1, p‑p65↓, 3, PD-1↓, 2, PD-L1↓, 8, PD-L1↑, 1, PGE2↓, 25, PSA↓, 5, PSA∅, 1, RAGE↓, 1, T-Cell↑, 1, Th1 response↑, 2, TLR2↓, 1, TLR4↓, 3, TLR4↝, 1, TNF-α↓, 34, TNF-α↑, 7, TNF-α∅, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1, TRAF1↓, 1, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, PTN↓, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1, AhR↑, 1, AhR↓, 1, AR↓, 12, AR↑, 1, CYP19↓, 1, ER-α36↓, 2, ER(estro)↓, 1, ERα/ESR1↓, 1, FGF21↓, 1, GR↑, 1, PPARα↓, 2, PPARα↑, 1, PPARα↝, 1, cl‑PPARα↓, 1, PPARγ↓, 3, PPARγ↑, 8, RANKL↓, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 40, BioAv↑, 41, BioAv↝, 10, BioEnh↑, 2, CBR1↓, 1, ChemoSen↓, 2, ChemoSen↑, 122, CompStab↓, 1, CompStab↝, 2, CYP1A1↓, 3, CYP1A1↑, 2, CYP1A2↓, 1, CYP1B1↑, 1, DDS↑, 1, Dose?, 3, Dose↓, 3, Dose↑, 6, Dose↝, 36, Dose∅, 9, eff?, 1, eff↓, 17, eff↑, 62, eff↝, 10, GSTA1↑, 1, Half-Life↓, 9, Half-Life↑, 4, Half-Life↝, 9, Half-Life∅, 1, MDR1↓, 7, MRP1/ABCC1↓, 3, MRP1/ABCC1↝, 1, P-gp/ABCB1↓, 17, P-gp/ABCB1⇅, 1, P450↓, 1, RadioS↑, 37, selectivity?, 2, selectivity↑, 45, selectivity∅, 1, Synergy↑, 88, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 6, ALAT↝, 1, ALP↓, 2, ALP↝, 1, AR↓, 12, AR↑, 1, ascitic↓, 2, AST↓, 4, AST↝, 1, BRCA1↓, 1, BRCA1↑, 1, p‑BRCA1↑, 1, CA125↓, 1, CRP↓, 3, E6↓, 2, E7↓, 2, EGFR↓, 34, p‑EGFR↓, 3, ERα/ESR1↓, 1, EZH2↓, 6, Ferritin↓, 1, FOXM1↓, 4, HER2/EBBR2↓, 13, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 11, IL6↓, 53, IL6↑, 1, LDH↓, 3, LDH↑, 4, Myc↓, 5, PD-L1↓, 8, PD-L1↑, 1, PSA↓, 5, PSA∅, 1, RAGE↓, 1, TP53↑, 3,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 40, AntiCan?, 1, antiCG↓, 1, antiD↑, 1, AntiDiabetic↑, 2, antiNeop↑, 3, AntiTum↓, 1, AntiTum↑, 19, cachexia↓, 2, cardioP↑, 8, CardioT↑, 2, chemoP?, 1, chemoP↑, 16, chemoPv↑, 18, ChemoSideEff↓, 4, cognitive↑, 2, hepatoP↓, 1, hepatoP↑, 8, neuroP↑, 5, OS↑, 7, Pin1↓, 1, QoL↑, 2, radioP↑, 7, Remission↑, 1, RenoP↑, 5, Risk↓, 4, toxicity↓, 13, toxicity↑, 5, toxicity↝, 6, toxicity∅, 1, TumVol↓, 16, TumVol∅, 1, TumW↓, 5, TumW∅, 1, Weight↑, 1, Weight∅, 1, Wound Healing↓, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 3, GutMicro↝, 1, Sepsis↓, 3,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 1037

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5, antiOx↑, 77, ARE↑, 1, Catalase↑, 31, Copper↓, 1, GPx↓, 1, GPx↑, 25, GPx1↑, 1, GPx3↑, 1, GPx4↑, 1, GSH↑, 28, GSR↓, 1, GSR↑, 6, GSTs↑, 11, H2O2↓, 5, H2O2∅, 1, HDL↓, 1, HDL↑, 2, HO-1↑, 20, hyperG↝, 1, Iron↓, 2, i-Iron↓, 1, Keap1↓, 1, lipid-P↓, 18, mt-lipid-P↓, 1, MDA↓, 22, MPO↓, 3, MPO↑, 1, NADH↓, 1, NQO1↑, 3, Nrf1↑, 1, NRF2?, 1, NRF2↑, 30, Prx↑, 2, RNS↓, 4, ROS?, 2, ROS↓, 86, SOD↑, 40, SOD1↑, 6, SOD2↑, 3, TAC↑, 1, TrxR↑, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4, Mets↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1, mtDam↓, 1, PGC-1α↓, 1, PGC-1α↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↑, 1, 5LO↓, 3, ALAT↓, 8, AMPK↑, 8, ATP↑, 1, cAMP↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, glucose↑, 1, GlucoseCon↑, 2, GlutMet↑, 1, GSK‐3β↓, 4, GSK‐3β↑, 1, LDL↓, 3, NAD↑, 1, NADH:NAD↑, 1, SIRT1↑, 11,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4, ASC?, 1, BAD↓, 1, BAX↓, 7, Bcl-2↓, 1, Bcl-2↑, 1, Bcl-xL↑, 1, Casp1↓, 1, Casp3?, 1, Casp3↓, 7, Casp3∅, 1, cl‑Casp3↓, 1, cl‑Casp8↓, 1, Casp9↓, 2, Cyt‑c↓, 3, Cyt‑c∅, 2, Ferroptosis↓, 1, iNOS↓, 14, iNOS↑, 1, necrosis↓, 1, p38↓, 1, p38↑, 2, Pyro?, 1, RIP1↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 5, p‑Akt↓, 2, p‑Akt↑, 2, AKT1↓, 1, CREB↑, 1, p‑CREB↑, 1, ERK↓, 1, ERK↑, 4, p‑ERK↑, 1, IGF-1R↓, 1, JAK↓, 1, JAK2↑, 1, JNK↓, 3, JNK↑, 1, p‑JNK↓, 1, p‑LIMK1↑, 1, MAPK↓, 9, MAPK↑, 4, mTOR↓, 1, mTOR↑, 2, PDGFR-BB↓, 1, PI3K↓, 1, PI3K↑, 5, PKA↑, 1, PKCδ↑, 3, PP2A↑, 1, PTEN↓, 2, PTEN↑, 1, Src↓, 1, STAT↓, 1, STAT3↓, 4, STAT3↑, 2, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3, cJun↓, 1, cMyc↓, 1, p‑cMyc↑, 1, FOXO↑, 1, HDAC↓, 1, HOTAIR↑, 1, other↓, 4, other↑, 5, other↝, 7, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, ER Stress↓, 1, GRP78/BiP↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 7, HSP70/HSPA5↝, 1, HSPs↑, 1, IRE1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1, DNAdam↓, 2, p16↓, 1, P53↓, 2, PCNA↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 2, cycE/CCNE↓, 1, E2Fs↑, 2, P21↓, 1, RB1↓, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, cFos↑, 1, Diff↑, 1, IGF-1↑, 2, neuroG↑, 3, TumCP↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 10, AP-1↓, 4, Ca+2↓, 1, Ca+2↑, 1, Ca+2↝, 1, Cartilage↑, 1, p‑Cofilin↑, 1, COL1↑, 1, EMT↑, 1, LAMs↑, 1, p‑MLC2/MYL9↑, 1, MMP-10↓, 1, MMP1↓, 2, MMP2↓, 7, MMP2↑, 2, MMP3↓, 3, MMP9↓, 32, MMP9↑, 6, MMPs↓, 2, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1, ROCK1↑, 1, Smad1↑, 1, SMAD3↓, 1, TGF-β↓, 4, TGF-β↑, 2, TGF-β1↓, 1, TIMP1↓, 2, TIMP1↑, 2, TIMP2↑, 2, TregCell↑, 1, TumCI↓, 1, TumMeta↓, 1, α-SMA↓, 5, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, angioG↑, 3, CD31/PECAM-1↓, 1, eNOS↑, 2, HIF-1↓, 1, Hif1a↓, 1, Hif1a↑, 1, LOX1↓, 1, NO↓, 15, NO↑, 4, VCAM-1↓, 5, VEGF↓, 3, VEGF↑, 6, p‑VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2, BBB↑, 14, BBB∅, 2, CLDN1↝, 1, GastroP↑, 2, GLUT1↑, 1, GLUT2↑, 1, GLUT3↑, 1, GLUT4↑, 3, MMP↑, 10, MMP∅, 1, MUC19↓, 1, MUC2↓, 1, TJ↑, 1, TRPM7↓, 1, ZO-1↝, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1, CD4+↑, 1, COX1↓, 4, COX2/PTGS2↓, 34, CXCR4↓, 1, Eos↓, 1, HMGB1↓, 2, ICAM-1↓, 3, IFN-γ↓, 1, IFN-γ↑, 1, IL1↓, 3, IL10↓, 1, IL10↑, 5, IL12↓, 3, IL17↓, 3, IL18↓, 2, IL1β↓, 25, IL2↑, 2, IL23↓, 1, IL4↓, 2, IL4↑, 2, IL5↓, 2, IL6↓, 31, IL8↓, 7, Imm↑, 12, Inflam↓, 85, Inflam↑, 2, IRF3↓, 1, MCP1/CCL2↓, 3, MyD88↓, 1, NeuroI↓, 1, NF-kB↓, 45, NK cell↑, 1, NLRP3↓, 6, NLRP3↑, 1, p65↓, 1, PGE2↓, 14, PGE2↑, 3, RAGE↓, 1, SOCS-3↓, 1, Th1 response↓, 1, Th2↑, 2, TLR2↓, 3, TLR4↓, 6, TNF-α↓, 32, TRIF↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2, Ach↑, 1, AChE↓, 12, AChE↑, 1, BChE↓, 1, BDNF↑, 9, GABA↑, 3, NGF↑, 2, PSD95↑, 1, SNAP25↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3, Aβ↓, 15, BACE/β-secretase↓, 5, tau↓, 1, p‑tau↓, 1, β-Amyloid↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1, CYP19↓, 1, PPARγ↓, 1, PPARγ↑, 4,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 28, BioAv↑, 25, BioAv↝, 19, BioEnh↑, 1, CompStab↑, 1, CYP1A1↑, 1, CYP1A2↑, 1, CYP2E1↓, 1, Dose⇅, 1, Dose↝, 8, eff↓, 2, eff↑, 17, eff↝, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↝, 6, Half-Life∅, 1, P-gp/ABCB1↓, 1, P450↓, 3, Synergy↑, 5,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8, ALP↓, 3, AST↓, 11, BMD↑, 1, BP↓, 2, BP↝, 1, p‑BRCA1↑, 1, CRP↓, 5, Hcy/homoC↓, 1, IL6↓, 31, LDH↓, 4, LDH↑, 1, NOS2↓, 2, RAGE↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 4, antiAll↑, 14, AntiArt↑, 7, AntiCan↓, 1, AntiCan↑, 16, antiCG↑, 1, AntiDiabetic↓, 1, AntiDiabetic↑, 15, antiPs↑, 1, AntiTum↑, 5, cardioP↑, 27, CardioT↓, 1, chemoP↑, 4, chemoPv↑, 3, cognitive↓, 1, cognitive↑, 17, diuretic↑, 3, hepatoP↓, 1, hepatoP↑, 24, Learn↑, 2, memory↑, 18, motorD↑, 4, Mucositis↓, 1, neuroP↓, 2, neuroP↑, 61, Obesity↓, 4, OS↑, 1, Pain↓, 6, QoL↑, 1, radioP↑, 2, RenoP↑, 5, Risk↓, 1, Stroke↓, 5, toxicity↓, 20, toxicity↑, 1, toxicity↝, 6, toxicity∅, 3, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2, AntiFungal↓, 1, AntiFungal↑, 2, AntiP↑, 1, AntiViral↑, 7, Bacteria↓, 19, Diar↓, 1, GutMicro↑, 4, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,
Total Targets: 379

Scientific Paper Hit Count for: MMP9, MMP9

19 Resveratrol
15 Fisetin
13 Curcumin
12 Thymoquinone
11 Matrine
11 Sulforaphane (mainly Broccoli)
9 Apigenin (mainly Parsley)
9 Baicalein
9 Berberine
9 Quercetin
9 Luteolin
9 Lycopene
8 Garcinol
8 Magnetic Fields
7 Boswellia (frankincense)
7 Propolis -bee glue
7 Capsaicin
7 Magnolol
7 Morin
6 Silver-NanoParticles
6 Alpha-Lipoic-Acid
6 Artemisinin
6 Caffeic acid
6 Chrysin
6 Diindolylmethane
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Honokiol
6 Kaempferol
6 Rosmarinic acid
5 Melatonin
5 Betulinic acid
5 Ellagic acid
5 Ferulic acid
5 Formononetin
5 Gambogic Acid
5 Nimbolide
5 Piperine
4 Cisplatin
4 Cucurbitacin
4 Pterostilbene
4 Silymarin (Milk Thistle) silibinin
4 Shikonin
4 Urolithin
3 Ascorbyl Palmitate
3 Celastrol
3 Hydroxycinnamic-acid
3 D-limonene
3 Emodin
3 phytic acid, Inositol hexakisphosphate
3 Magnetic Field Rotating
3 Phenethyl isothiocyanate
3 Piperlongumine
2 1,8-Cineole
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Paclitaxel/Taxol
2 alpha Linolenic acid
2 Radiotherapy/Radiation
2 Ashwagandha(Withaferin A)
2 Baicalin
2 Berbamine
2 Biochanin A
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Chlorogenic acid
2 chitosan
2 Cinnamon
2 Crocetin
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Evodiamine
2 tamoxifen
2 Fucoidan
2 Ginkgolic acids
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Grapeseed extract
2 Proanthocyanidins
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Inositol
2 Ivermectin
2 Juglone
2 Licorice
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Marjoram (Origanum majorana)
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Isovitexin
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Chemotherapy
1 Brucea javanica
1 brusatol
1 Bacopa monnieri
1 borneol
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Centella asiatica / Gotu kola → asiaticoside
1 Selenium NanoParticles
1 Carvone
1 Cyclopamine
1 Cysteamine
1 Vitamin A, Retinoic Acid
1 Folic Acid, Vit B9
1 Bortezomib
1 Flaxseed/Linseed
1 Gallic acid
1 Ginkgo biloba
1 Geraniol
1 Ginkgetin
1 Hops (Humulus lupulus)
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 isoorientin
1 Plumbagin
1 Lactobacillus
1 Licochalcone A
1 Methylglyoxal
1 Methylsulfonylmethane
1 Myricetin
1 Niclosamide (Niclocide)
1 Propyl gallate
1 temozolomide
1 Polyphenols
1 Parthenolide
1 Sanguinarine
1 Sesame seeds and Oil
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Turmerones
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:203  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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