Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
5583- BetA,    Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
- vitro+vivo, Var, NA
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
8- BetA,    Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
- in-vitro, PC, HaCaT - in-vitro, Pca, PANC1
HH↓, Gli1↓, PTCH1↓, Bcl-2↓,
2721- BetA,    Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells
- in-vitro, Cerv, HeLa
ROS↑, Dose↝, Bcl-2↓, BAX↑, ER Stress↑,
2716- BetA,    Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment
- Review, Var, NA
AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1 / PDPK1↓,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, Synergy↑,
2732- BetA,  Chemo,    Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
ChemoSen↑, selectivity↑, GRP78/BiP↑, ER Stress↑, PERK↑, Ca+2↑, Cyt‑c↑, BAX↑, Bcl-2↓,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
2743- BetA,    Betulinic acid and the pharmacological effects of tumor suppression
- Review, Var, NA
ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumCCA↑, Sp1/3/4↓, STAT3↓, NF-kB↓, EMT↓, TOP1↓, MAPK↑, p38↑, JNK↑, Casp↑, Bcl-2↓, BAX↑, VEGF↓, LAMs↓,
2746- BetA,    Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, CRC, NA
TumCG↓, BAX↑, Bcl-2↓, ROS↑, MMP↓, TIMP2↑, TumVol↓,
2748- BetA,    Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
- Review, Var, NA
Bcl-2↓, MMP↓, Cyt‑c↑, Casp↑, Diablo↑, AIF↑, angioG↓, BioAv↓, NF-kB↓,
1305- BetA,    Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
- in-vitro, UEC, NA
Apoptosis↑, Bcl-2↓, BAX↑,
1285- BetA,    Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
- in-vitro, Var, NA
Apoptosis↑, Bcl-2↓, cycD1/CCND1↓, BAX↑,
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, Synergy↑,
5726- BF,    Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
- Review, neuroblastoma, SK-N-BE
Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,
5728- BF,    Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2/PTGS2↝, p‑VEGFR2/KDR/Flk1↓, EGFR↓, Akt↓, NF-kB↓, p44↓,
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,
9203- BITC,    Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,
9182- BITC,    Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells
- in-vitro, Oral, NA
AntiCan↑, ROS↑, Ca+2↝, tumCV↓, Casp3↑, Casp9↑, MMP↓, BAX↑, BAD↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, DNAdam↑,
9167- BITC,    Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, CD31/PECAM-1↓, VEGF↓, PCNA↓, CDK4↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
9161- BITC,    Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, NA, MCF10
TumCG↓, TumCCA↑, Apoptosis↑, selectivity↑, CycB/CCNB1↓, CDK1↓, CDC25↓, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, Cyt‑c↑, ROS?, cl‑Casp9↑, cl‑Casp8↑, cl‑Casp3↑,
5688- BJ,    Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes
- vitro+vivo, PC, MIA PaCa-2
TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE/β-secretase↓, TOP2↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, Melanoma, NA
COX2/PTGS2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
702- Bor,  GEN,  SeMet,  Rad,    Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
- Analysis, Pca, NA
Risk↓, TumCMig↓, Bcl-2↓,
742- Bor,    In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
- in-vitro, Thyroid, NA
NOXA↑, APAF1↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, miR-21↓,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
749- Bor,    Comparative effects of boric acid and calcium fructoborate on breast cancer cells
- in-vitro, BC, NA
P53↓, Bcl-2↓, Casp3↑, Apoptosis↑,
750- Bor,    Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis
- in-vitro, CRC, Caco-2
Bcl-2↓, BAX↑, Akt↓, p70S6↓, PTEN↑, TSC2↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, Var, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31/PECAM-1↓, NF-kB↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
1420- Bos,    Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway
- vitro+vivo, GC, BGC-823
TumCP↓, TumCG↓, PTEN↑, BAX↑, Bcl-2↓, p‑Akt↓, COX2/PTGS2↓,
1426- Bos,  CUR,  Chemo,    Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer
- in-vivo, CRC, NA - in-vitro, CRC, HCT116 - in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vitro, RCC, SW-620 - in-vitro, RCC, HT-29 - in-vitro, CRC, Caco-2
miR-34a↑, miR-27a-3p↓, TumCG↓, BAX↑, Bcl-2↓, PARP1↓, TumCCA↑, Apoptosis↑, cMyc↓, CDK4↓, CDK6↓, cycD1/CCND1↓, ChemoSen↑, miR-34a↑, miR-27a-3p↓,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
5697- BRU,    Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
- in-vitro, HNSCC, NA
NRF2↓, STAT3↓, proCasp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, Hif1a↓, cMyc↓, JNK↑, MAPK↑, tumCV↓, ROS∅,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6552- BSB,    Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease
- in-vivo, AD, NA
*TNF-α↓, *Aβ↓, *Casp3↓, *Bcl-2↓, *neuroP↑, *antiOx↑, *Inflam↓, *AntiBio↑, *AChE↓, *BChE↓, Dose↝, Dose↝, Dose↝,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
6559- BSB,    Modulatory effect of α-Bisabolol on induced apoptosis via mitochondrial and NF-κB/Akt/PI3K Signaling pathways in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, TumCP↓, Apoptosis↓, ROS↑, Bcl-2↓, BAX↑, BAD↑, Casp3↑, Casp9↑, Cyt‑c↑, NF-kB↓, p‑PI3K↓, p‑Akt↓,
9263- BTB,    Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Casp3↑, Casp7↑, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, MMP↓, DNAdam↑, Imm↑, angioG↑,

Showing Research Papers: 151 to 200 of 856
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 856

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 4,   antiOx↑, 9,   antiOx⇅, 2,   ARE↓, 1,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 12,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 8,   GPx1↓, 1,   GPx4↓, 8,   GPx4↑, 1,   GSH↓, 51,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HO-1↓, 8,   HO-1↑, 14,   HO-1↝, 1,   Iron↑, 3,   i-Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 9,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   MPO↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 7,   NRF2↓, 20,   NRF2↑, 21,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx6↑, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 4,   ROS↓, 28,   ROS↑, 346,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 4,   mt-ROS↑, 8,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 18,   SOD↑, 14,   SOD1↓, 2,   SOD1↑, 2,   SOD2↓, 6,   SOD2↑, 4,   TAC?, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 3,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 6,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 11,   CDC2↑, 1,   CDC25↓, 17,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 5,   ETC↓, 4,   HSP60/HSPD1↓, 1,   MCU↓, 1,   mitResp↓, 3,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 27,   OCR↓, 6,   OXPHOS↓, 8,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   PHB↑, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   5LO↓, 3,   ACC↑, 4,   p‑ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 26,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 23,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 10,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 3,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 3,   GlucoseCon↓, 7,   GlutaM↓, 1,   GlutMet↓, 2,   Glycolysis↓, 29,   GSK‐3β↓, 12,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 14,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 8,   LDL↓, 3,   lipidLev↓, 1,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 11,   PDKs↓, 1,   PFK↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 12,   PLA2↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   SSAT↑, 1,   TCA?, 1,   TCA↓, 3,   TCA↑, 1,   TS↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   AIF↝, 1,   APAF1↑, 15,   Apoptosis?, 4,   Apoptosis↓, 16,   Apoptosis↑, 426,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 25,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 22,   BAX↓, 11,   BAX↑, 505,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2?, 1,   Bcl-2↓, 764,   Bcl-2↑, 18,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 116,   Bcl-xL↑, 3,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 17,   BIM↓, 1,   BIM↑, 17,   BNIP3?, 2,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 1,   Casp↑, 56,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 4,   Casp10↑, 2,   Casp12?, 1,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 3,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 331,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 93,   proCasp3↓, 3,   proCasp3↑, 3,   Casp6↑, 2,   Casp7?, 1,   Casp7↑, 32,   cl‑Casp7↑, 8,   Casp8↓, 1,   Casp8↑, 67,   cl‑Casp8↑, 14,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 194,   Casp9∅, 1,   p‑Casp9↑, 2,   cl‑Casp9↑, 37,   proCasp9↓, 1,   proCasp9↑, 3,   CellShr↑, 1,   cFLIP↓, 10,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 180,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 8,   DIDO1/DIO-1↑, 1,   DR5↑, 34,   FADD↑, 12,   Fas↓, 2,   Fas↑, 35,   FasL↓, 1,   FasL↑, 18,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   HEY1↓, 2,   IAP1↓, 21,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 17,   iNOS↑, 2,   Mcl-1↓, 64,   MDM2↓, 16,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 8,   NAIP↓, 2,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 8,   p38↓, 7,   p38↑, 32,   p‑p38↓, 7,   p‑p38↑, 13,   Paraptosis↑, 2,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 118,   survivin↑, 1,   survivin↝, 1,   TNFR 1↑, 4,   TRAIL↑, 9,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 29,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 56,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 182,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 70,   p‑Akt↑, 1,   AKT1↓, 6,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   p‑cMET↑, 2,   cSrc↓, 4,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 60,   ERK↑, 17,   p‑ERK↓, 27,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 10,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 5,   JAK1↓, 8,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 5,   JNK↑, 33,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 10,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 20,   MAPK↝, 1,   p‑MAPK↓, 3,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 6,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   Mst1↑, 1,   mTOR↓, 91,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 22,   mTORC2↓, 4,   p‑p42↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 3,   PI3K↓, 130,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 16,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 2,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 3,   PTEN↑, 33,   PTEN↝, 2,   PTPN6↑, 1,   Raf↓, 8,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 6,   STAT3↓, 88,   STAT3↑, 4,   p‑STAT3↓, 22,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 2,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 16,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 56,   cMyc↑, 2,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 7,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 2,   FOXO1↓, 1,   FOXO1↑, 4,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 3,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 26,   HDAC1↓, 9,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 2,   HES1↓, 1,   HOXB-AS1↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 2,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-125b↓, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 3,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 10,   miR-375↓, 1,   miR-375↝, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 7,   n-MYC↓, 2,   NR1D2↓, 1,   OCT4↓, 15,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 9,   PhotoS↑, 3,   Set9↑, 1,   sonoS↑, 2,   SOX2↓, 9,   SOX4↑, 1,   SOX9?, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 3,   tumCV↓, 112,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 36,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 10,   p‑eIF2α↓, 1,   p‑eIF2α↑, 6,   ER Stress↓, 1,   ER Stress↑, 48,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 2,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 11,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 10,   ATG7↑, 4,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 29,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 2,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 3,   LC3II↑, 19,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 11,   p62↑, 5,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↑, 55,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 4,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 3,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 76,   mt-DNAdam↑, 1,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   p16↑, 3,   P53↓, 9,   P53↑, 177,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 10,   PARP↑, 35,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 134,   cl‑PARP∅, 1,   PARP1↓, 2,   PARP1↑, 2,   cl‑PARP1↑, 5,   PCNA↓, 51,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   Telomerase↓, 11,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 5,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 29,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 5,   CDK4↓, 51,   CDK4↑, 2,   CDK4/6↓, 3,   CDK6↓, 21,   CDK6↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 5,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 43,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 143,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   CycD3↓, 5,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 44,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 92,   P21↝, 2,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 40,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↓, 2,   RB1↑, 3,   p‑RB1↓, 2,   cl‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA↓, 8,   TumCCA↑, 289,   WEE1↑, 3,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 3,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 9,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 37,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 20,   HH↓, 17,   HMGCR↓, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 44,   Let-7↑, 2,   MCM2↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 15,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 1,   PCLAF↓, 1,   PTCH1↓, 9,   PTCH2↓, 1,   SAL↑, 1,   Shh↓, 13,   Smo↓, 9,   p‑STAT1↓, 1,   Sufu↑, 1,   TumCG?, 3,   TumCG↓, 147,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 229,   TumCP↑, 4,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 34,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   AP-1↝, 2,   ATPase↓, 2,   AXL↓, 4,   Ca+2↓, 4,   Ca+2↑, 40,   Ca+2↝, 3,   i-Ca+2↑, 1,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 4,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 3,   E-cadherin↓, 8,   E-cadherin↑, 57,   EMT↓, 72,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 3,   Fibronectin↓, 6,   GIT1↓, 1,   GLI2↓, 9,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 4,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 5,   MMP16↓, 1,   MMP2↓, 99,   MMP2↝, 1,   MMP3↓, 9,   MMP7↓, 10,   MMP9↓, 117,   MMPs↓, 32,   MRGPRF↓, 1,   MTA1↓, 2,   MUC4↓, 3,   N-cadherin↓, 37,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 2,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 4,   Rac1↓, 4,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 19,   SMAD2↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↑, 1,   Snail?, 1,   Snail↓, 31,   TET1↑, 2,   TGF-β↓, 16,   TGF-β↑, 3,   TIMP1↓, 3,   TIMP1↑, 10,   TIMP2↓, 2,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 3,   TumCA↑, 1,   TumCI?, 2,   TumCI↓, 102,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 105,   TumCMig↑, 1,   TumMeta↓, 68,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 2,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 41,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 83,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 9,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 57,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 5,   VEGF↓, 125,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 12,   GLUT1↑, 1,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT4↓, 2,   KCNH2/hERG↓, 1,   MMP↓, 198,   MMP↑, 1,   MPT↑, 5,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 12,   CD8+↑, 4,   cDC2↓, 5,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 12,   FOXP3↓, 2,   FOXP3↑, 1,   HCAR2↑, 1,   HLA↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   HMGB1↑, 1,   ICAM-1↓, 13,   IFN-γ↓, 4,   IFN-γ↑, 5,   IL1↓, 7,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 16,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 7,   IL33↑, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 13,   Imm↑, 12,   Imm↝, 1,   Inflam↓, 38,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 175,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 10,   p‑p65↓, 5,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 3,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR4↓, 6,   TLR4↝, 1,   TNF-α↓, 42,   TNF-α↑, 11,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 2,   TRAF1↓, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↑, 1,   AR↓, 16,   AR↝, 1,   ER-α36↓, 2,   ERα/ESR1↓, 2,   ERβ/ESR2↑, 1,   GR↝, 1,   PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 30,   BioAv↑, 33,   BioAv↝, 8,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 144,   ChemoSen↝, 1,   CompStab↑, 3,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 3,   Dose↑, 8,   Dose↝, 65,   Dose∅, 8,   eff↓, 88,   eff↑, 89,   eff↝, 8,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 7,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MDR1↑, 1,   MRP↓, 1,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 18,   P450↓, 2,   RadioS↑, 43,   selectivity↓, 1,   selectivity↑, 108,   Synergy?, 1,   Synergy↑, 99,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 16,   AR↝, 1,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BRAF↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 4,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   LDH?, 1,   LDH↓, 13,   LDH↑, 6,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   PSADT↑, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 3,   AntiCan↑, 61,   AntiCan?, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 2,   AntiTum↑, 34,   cachexia↓, 2,   cardioP↑, 11,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 33,   chemoPv↑, 19,   ChemoSideEff↓, 7,   ChemoSideEff∅, 1,   hepatoP↑, 15,   K17↓, 1,   neuroP↑, 8,   NKG2D↑, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 9,   Pain↓, 2,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 12,   Risk↓, 13,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 1,   toxicity↝, 12,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 43,   TumVol↑, 2,   TumW↓, 22,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 5,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 11,  
Total Targets: 1240

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 90,   ARE↑, 1,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 52,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 38,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 5,   GSTs↓, 1,   GSTs↑, 13,   H2O2↓, 5,   HDL↑, 2,   HO-1?, 2,   HO-1↓, 1,   HO-1↑, 26,   HO-2↓, 1,   Iron↓, 2,   Keap1↓, 5,   Keap1↑, 1,   lipid-P↓, 38,   MDA?, 1,   MDA↓, 39,   MDA↑, 1,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 3,   NRF2?, 1,   NRF2↑, 50,   Prx↑, 1,   RNS↓, 5,   ROS?, 1,   ROS↓, 118,   ROS↑, 3,   ROS∅, 3,   SOD?, 1,   SOD↓, 2,   SOD↑, 69,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 6,   TBARS↓, 4,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 2,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 15,   AMPK↓, 2,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 4,   mt-ATP↑, 1,   GAPDH↑, 1,   glucose↓, 5,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 3,   H2S↑, 2,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NH3↓, 1,   PFK↓, 1,   PLA2↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 31,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 48,   BAX↑, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 12,   Bcl-2↑, 58,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↑, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 35,   Casp3↑, 2,   cl‑Casp3↓, 9,   Casp8↓, 1,   Casp9↓, 10,   cl‑Casp9↓, 4,   Cyt‑c↓, 8,   Cyt‑c↑, 2,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   GSDMD↓, 1,   iNOS↓, 20,   MLKL↓, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 7,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   JAK2↑, 3,   JNK↓, 6,   JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 5,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 9,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 2,   STAT3↑, 6,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 2,   cJun↓, 1,   p‑cJun↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC2↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 3,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   IRE1↓, 2,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 2,   PARK2↑, 3,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 6,   p16↓, 1,   P53↓, 4,   P53↑, 2,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 5,   cal2↓, 2,   Cartilage↑, 1,   E-cadherin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 2,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↑, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 15,   NO↑, 3,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 9,   BBB↝, 2,   BBB∅, 2,   CLDN4↑, 1,   GastroP↑, 5,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 3,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 26,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 5,   IL13↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 31,   IL1β↑, 1,   IL2↓, 1,   IL22↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 38,   IL6↑, 1,   IL8↓, 8,   Imm↓, 1,   Imm↑, 6,   Inflam↓, 108,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 6,   NF-kB↓, 39,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 7,   PGE2↓, 9,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   TLR4↓, 6,   TNF-α↓, 55,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 4,   AChE↓, 21,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 16,   BDNF⇅, 1,   ChAT↑, 3,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 3,   Aβ↓, 18,   Aβ42↓, 3,   BACE/β-secretase↓, 7,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 3,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 3,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 27,   BioAv↑, 34,   BioAv↝, 20,   BioAv∅, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 13,   Dose∅, 1,   eff↓, 4,   eff↑, 9,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 14,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 4,   AST↓, 17,   Bil↓, 1,   BMD↑, 2,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 4,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6↓, 38,   IL6↑, 1,   LDH↓, 8,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 1,   antiAll↑, 12,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 20,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 5,   cognitive↑, 22,   diuretic↑, 3,   hepatoP↓, 2,   hepatoP↑, 33,   Learn↑, 4,   memory↑, 22,   motorD↑, 5,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 70,   Obesity↓, 8,   OS↑, 1,   Pain↓, 3,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 21,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 9,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 12,   Bacteria↓, 20,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 12,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 489

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
32 Silver-NanoParticles
29 Thymoquinone
25 Quercetin
18 Luteolin
17 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Sulforaphane (mainly Broccoli)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Berberine
11 Emodin
11 Honokiol
11 Silymarin (Milk Thistle) silibinin
10 Cisplatin
10 Melatonin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
10 Licochalcone A
10 Matrine
9 Eugenol
9 Gossypol/AT-101
9 Lycopene
8 Capsaicin
8 Graviola
8 Magnolol
8 Morin
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Isoliquiritigenin
7 Juglone
7 Nimbolide
7 Piperlongumine
6 5-fluorouracil
6 Paclitaxel/Taxol
6 Phenethyl isothiocyanate
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Ferulic acid
6 Formononetin
6 Ginkgetin
6 Hibiscus sabdariffa
6 Hyperoside
6 isoorientin
6 Kaempferol
6 lambertianic acid
6 Licorice
5 Astragalus
5 Artemisinin
5 Astaxanthin
5 doxorubicin
5 Benzyl isothiocyanate
5 Boswellia (frankincense)
5 Carnosic acid
5 Cynaropicrin
5 Isobavachalcone
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Rosmarinic acid
5 Urolithin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Photodynamic Therapy
4 Alpha-Lipoic-Acid
4 Isovitexin
4 Metformin
4 Aloe anthraquinones
4 Biochanin A
4 Chemotherapy
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Geraniol
4 Ginkgolide B
4 HydroxyTyrosol
4 Indole-3-carbinol
4 Isorhamnetin
4 isoquercitrin
4 Ivermectin
4 Moringa oleifera
4 Propolis -bee glue
3 3-bromopyruvate
3 Açaí, Euterpe oleracea
3 Gemcitabine (Gemzar)
3 Allyl isothiocyanate
3 immunotherapy
3 Berbamine
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Docetaxel
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Vitexin
3 L-Theanine
3 Laetrile B17 Amygdalin
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Polyphenols
2 Cucurbitacin
2 Electrical Pulses
2 Chlorella (Chlorella vulgaris)
2 Flaxseed/Linseed
2 carboplatin
2 Hydrogen Gas
2 iodine
2 itraconazole
2 Lactobacillus
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 SDG/lignans
2 Linalool
2 Lutein
2 Mangiferin
2 Methylglyoxal
2 Marjoram (Origanum majorana)
2 Propyl gallate
2 Phycocyanin
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 Isothiocyanates
1 selenomethionine
1 Black turtle bean
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Citicoline, CDP-Choline
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Rutin
1 Butein
1 Scopoletin
1 Vitamin C (Ascorbic Acid)
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Sesamin
1 Auranofin
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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