ROS Cancer Research Results

ROS, Reactive Oxygen Species: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
Reactive oxygen species (ROS) are highly reactive molecules that contain oxygen and can lead to oxidative stress in cells. They play a dual role in cancer biology, acting as both promoters and suppressors of cancer.
ROS can cause oxidative damage to DNA, leading to mutations that may contribute to cancer initiation and progression. So normally you want to inhibit ROS to prevent cell mutations.
However excessive ROS can induce apoptosis (programmed cell death) in cancer cells, potentially limiting tumor growth. Chemotherapy typically raises ROS.
-mitochondria is the main source of reactive oxygen species (ROS) (and the ETC is heavily related)
ROS Homeostasis in Cancer Cells and Its Potential as a Therapeutic Target

"Reactive oxygen species (ROS) are two electron reduction products of oxygen, including superoxide anion, hydrogen peroxide, hydroxyl radical, lipid peroxides, protein peroxides and peroxides formed in nucleic acids 1. They are maintained in a dynamic balance by a series of reduction-oxidation (redox) reactions in biological systems and act as signaling molecules to drive cellular regulatory pathways."
"During different stages of cancer formation, abnormal ROS levels play paradoxical roles in cell growth and death 8. A physiological concentration of ROS that maintained in equilibrium is necessary for normal cell survival. Ectopic ROS accumulation promotes cell proliferation and consequently induces malignant transformation of normal cells by initiating pathological conversion of physiological signaling networks. Excessive ROS levels lead to cell death by damaging cellular components, including proteins, lipid bilayers, and chromosomes. Therefore, both scavenging abnormally elevated ROS to prevent early neoplasia and facilitating ROS production to specifically kill cancer cells are promising anticancer therapeutic strategies, in spite of their contradictoriness and complexity."
"ROS are the collection of derivatives of molecular oxygen that occur in biology, which can be categorized into two types, free radicals and non-radical species. The non-radical species are hydrogen peroxide (H 2O 2 ), organic hydroperoxides (ROOH), singlet molecular oxygen ( 1 O 2 ), electronically excited carbonyl, ozone (O3 ), hypochlorous acid (HOCl, and hypobromous acid HOBr). Free radical species are super-oxide anion radical (O 2•−), hydroxyl radical (•OH), peroxyl radical (ROO•) and alkoxyl radical (RO•) [130]. Any imbalance of ROS can lead to adverse effects. H2 O 2 and O 2 •− are the main redox signalling agents. The cellular concentration of H2 O 2 is about 10−8 M, which is almost a thousand times more than that of O2 •−".
"Radicals are molecules with an odd number of electrons in the outer shell [393,394]. A pair of radicals can be formed by breaking a chemical bond or electron transfer between two molecules."

Recent investigations have documented that polyphenols with good antioxidant activity may exhibit pro-oxidant activity in the presence of copper ions, which can induce apoptosis in various cancer cell lines but not in normal cells. "We have shown that such cell growth inhibition by polyphenols in cancer cells is reversed by copper-specific sequestering agent neocuproine to a significant extent whereas iron and zinc chelators are relatively ineffective, thus confirming the role of endogenous copper in the cytotoxic action of polyphenols against cancer cells. Therefore, this mechanism of mobilization of endogenous copper." > Ions could be one of the important mechanisms for the cytotoxic action of plant polyphenols against cancer cells and is possibly a common mechanism for all plant polyphenols. In fact, similar results obtained with four different polyphenolic compounds in this study, namely apigenin, luteolin, EGCG, and resveratrol, strengthen this idea.
Interestingly, the normal breast epithelial MCF10A cells have earlier been shown to possess no detectable copper as opposed to breast cancer cells [24], which may explain their resistance to polyphenols apigenin- and luteolin-induced growth inhibition as observed here (Fig. 1). We have earlier proposed [25] that this preferential cytotoxicity of plant polyphenols toward cancer cells is explained by the observation made several years earlier, which showed that copper levels in cancer cells are significantly elevated in various malignancies. Thus, because of higher intracellular copper levels in cancer cells, it may be predicted that the cytotoxic concentrations of polyphenols required would be lower in these cells as compared to normal cells."

Majority of ROS are produced as a by-product of oxidative phosphorylation, high levels of ROS are detected in almost all cancers.
-It is well established that during ER stress, cytosolic calcium released from the ER is taken up by the mitochondrion to stimulate ROS overgeneration and the release of cytochrome c, both of which lead to apoptosis.

Note: Products that may raise ROS can be found using this database, by:
Filtering on the target of ROS, and selecting the Effect Direction of ↑

Targets to raise ROS (to kill cancer cells):
• NADPH oxidases (NOX): NOX enzymes are involved in the production of ROS.
    -Targeting NOX enzymes can increase ROS levels and induce cancer cell death.
    -eNOX2 inhibition leads to a high NADH/NAD⁺ ratio which can lead to increased ROS
• Mitochondrial complex I: Inhibiting can increase ROS production
• P53: Activating p53 can increase ROS levels(by inducing the expression of pro-oxidant genes)
• Nrf2 inhibition: regulates the expression of antioxidant genes. Inhibiting Nrf2 can increase ROS levels
• Glutathione (GSH): an antioxidant. Depleting GSH can increase ROS levels
• Catalase: Catalase converts H2O2 into H2O+O. Inhibiting catalase can increase ROS levels
• SOD1: converts superoxide into hydrogen peroxide. Inhibiting SOD1 can increase ROS levels
• PI3K/AKT pathway: regulates cell survival and metabolism. Inhibiting can increase ROS levels
• HIF-1α inhibition: regulates genes involved in metabolism and angiogenesis. Inhibiting HIF-1α can increase ROS
• Glycolysis: Inhibiting glycolysis can increase ROS levels • Fatty acid oxidation: Cancer cells often rely on fatty acid oxidation for energy production.
-Inhibiting fatty acid oxidation can increase ROS levels
• ER stress: Endoplasmic reticulum (ER) stress can increase ROS levels
• Autophagy: process by which cells recycle damaged organelles and proteins.
-Inhibiting autophagy can increase ROS levels and induce cancer cell death.
• KEAP1/Nrf2 pathway: regulates the expression of antioxidant genes.
    -Inhibiting KEAP1 or activating Nrf2 can increase ROS levels and induce cancer cell death.
• DJ-1: regulates the expression of antioxidant genes. Inhibiting DJ-1 can increase ROS levels
• PARK2: regulates the expression of antioxidant genes. Inhibiting PARK2 can increase ROS levels
• SIRT1 inhibition:regulates the expression of antioxidant genes. Inhibiting SIRT1 can increase ROS levels
• AMPK activation: regulates energy metabolism and can increase ROS levels when activated.
• mTOR inhibition: regulates cell growth and metabolism. Inhibiting mTOR can increase ROS levels
• HSP90 inhibition: regulates protein folding and can increase ROS levels when inhibited.
• Proteasome: degrades damaged proteins. Inhibiting the proteasome can increase ROS levels
• Lipid peroxidation: a process by which lipids are oxidized, leading to the production of ROS.
    -Increasing lipid peroxidation can increase ROS levels
• Ferroptosis: form of cell death that is regulated by iron and lipid peroxidation.
    -Increasing ferroptosis can increase ROS levels
• Mitochondrial permeability transition pore (mPTP): regulates mitochondrial permeability.
    -Opening the mPTP can increase ROS levels
• BCL-2 family proteins: regulate apoptosis and can increase ROS levels when inhibited.
• Caspase-independent cell death: a form of cell death that is regulated by ROS.
    -Increasing caspase-independent cell death can increase ROS levels
• DNA damage response: regulates the repair of DNA damage. Increasing DNA damage can increase ROS
• Epigenetic regulation: process by which gene expression is regulated.
    -Increasing epigenetic regulation can increase ROS levels

-PKM2, but not PKM1, can be inhibited by direct oxidation of cysteine 358 as an adaptive response to increased intracellular reactive oxygen species (ROS)

ProOxidant Strategy:(inhibit the Mevalonate Pathway (likely will also inhibit GPx)
-HydroxyCitrate (HCA) found as supplement online and typically used in a dose of about 1.5g/day or more
-Atorvastatin typically 40-80mg/day, -Dipyridamole typically 200mg 2x/day Combined effect research
-Lycopene typically 100mg/day range (note debatable as it mainly lowers NRF2)

Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy 
ROS-Inducing Interventions in Cancer — Canonical + Mechanistic Reference
-generated from AI and Cancer database
ROS rating:  +++ strong | ++ moderate | + weak | ± mixed | 0 none
NRF2:        ↓ suppressed | ↑ activated | ± mixed | 0 none
Conditions:  [D] dose  [Fe] metal  [M] metabolic  [O₂] oxygen
             [L] light [F] formulation [T] tumor-type [C] combination




Item ROS↑ NRF2 Condition Mechanism Class Remarks 



ROS">Piperlongumine
+++ ↓ [D][T] ROS-dominant






ROS">Shikonin
+++↓/±[D][T]ROS-dominant






ROS">Vitamin K3 (menadione)
+++↓[D]ROS-dominant






ROS">Copper (ionic / nano)
+++↓[Fe][F]ROS-dominant






ROS">Sodium Selenite
+++↓[D]ROS-dominant






ROS">Juglone
+++↓[D]ROS-dominant






ROS">Auranofin
+++↓[D]ROS-dominant






ROS">Photodynamic Therapy (PDT)
+++0[L][O₂]ROS-dominant






ROS">Radiotherapy / Radiation
+++0[O₂]ROS-dominant






ROS">Doxorubicin
+++↓[D]ROS-dominant






ROS">Cisplatin
++↓[D][T]ROS-dominant






ROS">Salinomycin
++↓[D][T]ROS-dominant






ROS">Artemisinin / DHA
++↓[Fe][T]ROS-dominant






ROS">Sulfasalazine
++↓[C][T]ROS-dominant






ROS">FMD / fasting
++↓[M][C][O₂]ROS-dominant






ROS">Vitamin C (pharmacologic)
++↓[Fe][D]ROS-dominant






ROS">Silver nanoparticles
++±[F][D]ROS-dominant






ROS">Gambogic acid
++↓[D][T]ROS-dominant






ROS">Parthenolide
++↓[D][T]ROS-dominant






ROS">Plumbagin
++↓[D]ROS-dominant






ROS">Allicin
++↓[D]ROS-dominant






ROS">Ashwagandha (Withaferin A)
++↓[D][T]ROS-dominant






ROS">Berberine
++↓[D][M]ROS-dominant






ROS">PEITC
++↓[D][C]ROS-dominant






ROS">Methionine restriction
+↓[M][C][T]ROS-secondary






ROS">DCA
+±[M][T]ROS-secondary






ROS">Capsaicin
+±[D][T]ROS-secondary






ROS">Galloflavin
+0[D]ROS-secondary






ROS">Piperine
+±[D][F]ROS-secondary






ROS">Propyl gallate
+↓[D]ROS-secondary






ROS">Scoulerine
+?[D][T]ROS-secondary






ROS">Thymoquinone
±±[D][T]Dual redox






ROS">Emodin
±±[D][T]Dual redox






ROS">Alpha-lipoic acid (ALA)
±↑[D][M]NRF2-dominant






ROS">Curcumin
±↑/↓[D][F]NRF2-dominant






ROS">EGCG
±↑/↓[D][O₂]NRF2-dominant






ROS">Quercetin
±↑/↓[D][Fe]NRF2-dominant






ROS">Resveratrol
±↑[D][M]NRF2-dominant






ROS">Sulforaphane
±↑↑[D]NRF2-dominant






ROS">Lycopene
0↑—Antioxidant






ROS">Rosmarinic acid
0↑—Antioxidant






ROS">Citrate
00—Neutral


Scientific Papers found: Click to Expand⟱
2287- AgNPs,    Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
- in-vitro, Nor, HUVECs
*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,
2286- AgNPs,    ROS_localization_after_the_silver_nanoparticles_exposure_depending_on_particle_size">Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size
- in-vitro, Nor, 3T3
*eff↑, *mt-ROS↑, *eff↑,
2836- AgNPs,  Gluc,    Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells
- in-vitro, Cerv, HeLa
eff↝, TumCCA↑, eff↑, eff↑, ROS↑, GSH↓, SOD↓, lipid-P↑, LDH↑,
2835- AgNPs,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2538- AgNPs,  SDT,  Z,    Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
- Study, Var, NA - vitro+vivo, NA, NA
ROS↑, eff↑, eff↑, TumCP↓, toxicity↓,
252- Ajoene,    Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB
- in-vitro, AML, HL-60
H2O2↑, NF-kB↑, ROS↑,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
5167- AL,    The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
- in-vitro, Nor, 3T3 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, CRC, HT-29
Thiols↓, tumCV↓, TumCP↓, GSH↓, GSSG↑, ROS↑,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
254- AL,    Allicin and Cancer Hallmarks
- Review, Var, NA
NRF2⇅, BAX↑, Bcl-2↓, Fas↑, MMP↓, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Casp12↑, GSH↓, TumCCA↑, ROS↑, antiOx↓,
257- AL,  Cisplatin,    Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors
- in-vitro, NSCLC, A549
ROS↑, HIF-1↓, E-cadherin↑, N-cadherin↓, antiOx↓, Dose↝,
231- AL,    Molecular Docking Studies with Garlic Phytochemical Constituents to Inhibit the Human EGFR Protein for Lung Cancer Therapy
- Analysis, Lung, NA
EGFR↓, ROS↑,
239- AL,    Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways
- in-vitro, GC, SGC-7901
Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, NA, NA
GSH↓, Bacteria↓, LDL↓, ROS↑, NRF2↑, cognitive↑, memory↑, BP↓, RNS↓,
235- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
233- AL,  5-FU,    Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway
- in-vivo, Liver, NA
ROS↑, MMP↓, Casp3↑, PARP↑, Bcl-2↓,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,
2648- AL,    Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
- in-vitro, OS, SaOS2 - in-vivo, OS, NA
ROS↑, TumCG↓, TumAuto↑, Wnt↓, β-catenin/ZEB1↓, MALAT1↓,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
2656- AL,    Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
- in-vitro, Park, PC12
*antiOx↑, *Apoptosis↓, *LDH↓, ROS↓, *lipid-P↓, *mtDam↓, *MMP↓, *Cyt‑c↓, *ATP∅, *Ca+2↝, *neuroP↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
3270- ALA,    Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis
- Trial, AD, NA
*cognitive↑, *other↝, *neuroP↑, *IronCh↑, *ROS↓, *GSH↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
3433- ALA,    Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
- in-vitro, Nor, NA
*ROS↓, *Apoptosis↓, *Hif1a↑, *FOXO1↑, *FOXO3↑, *ATM↑, *SIRT1↑, *SIRT3↑, *CD34↑,
3434- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, PI3K↓, p‑Akt↓, p‑P70S6K↓, mTOR↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, LDHA↓, Glycolysis↓, ChemoSen↑,
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF7
ChemoSen↑, PI3K↓, Akt↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, Glycolysis↓, CSCs↓, IGF-1R↓, Furin↓, RadioS↑,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, Nor, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3440- ALA,    Protective effects of alpha lipoic acid (ALA) are mediated by hormetic mechanisms
- Review, AD, NA
*ROS↓, *neuroP↑, *Aβ↓, *cardioP?,
3442- ALA,    α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B - in-vitro, Nor, 3T3
tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
3447- ALA,    Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells
- in-vitro, AD, SH-SY5Y
*ATP↑, *MMP↑, *ROS↓, *GlucoseCon↑, *GSH↑, *neuroP↑, *cognitive↑, *Ach↑, *Inflam↓, *Aβ↓, OXPHOS↓,
3448- ALA,    Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line
- in-vitro, Nor, NA
*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,

Showing Research Papers: 151 to 200 of 2969
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2969

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 6,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 15,   antiOx↑, 48,   antiOx⇅, 4,   ARE↓, 1,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 39,   Catalase↑, 27,   Catalase∅, 2,   Ceru↓, 1,   Copper↓, 1,   Copper↑, 1,   CoQ10↝, 1,   cystine↓, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 36,   frataxin↑, 1,   GCLM↓, 1,   GCLM↑, 2,   GPx↓, 18,   GPx↑, 20,   GPx1↓, 4,   GPx1⇅, 1,   GPx1∅, 1,   GPx4↓, 71,   GPx4↑, 2,   GSH?, 1,   GSH↓, 228,   GSH↑, 26,   GSH⇅, 2,   GSH∅, 3,   i-GSH↓, 1,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 24,   GSR↓, 7,   GSR↑, 5,   GSS↑, 1,   GSSG↓, 1,   GSSG↑, 7,   ox-GSSG↑, 1,   GSTs↓, 5,   GSTs↑, 7,   GSTs↝, 1,   GSTs∅, 1,   H2O2?, 1,   H2O2↓, 5,   H2O2↑, 52,   i-H2O2↓, 1,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HNE↑, 1,   HO-1↓, 33,   HO-1↑, 51,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   HO-2↑, 1,   hyperG↓, 1,   Iron↓, 5,   Iron↑, 49,   Iron↝, 2,   Iron∅, 1,   i-Iron↓, 2,   i-Iron↑, 10,   c-Iron↑, 1,   Keap1↓, 5,   Keap1↑, 5,   Keap1↝, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 18,   lipid-P↑, 96,   lipid-P↝, 1,   MDA?, 1,   MDA↓, 11,   MDA↑, 52,   i-MDA↑, 4,   MGO↑, 1,   Mich↑, 1,   MPO↓, 1,   NADH↓, 4,   mt-NADH↓, 1,   NADPH/NADP+↓, 2,   NFE2L2↑, 1,   NOX↓, 2,   NOX↑, 1,   NOX2↑, 1,   NOX4↓, 2,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 8,   NQO1↑, 9,   Nrf1↑, 1,   NRF2↓, 85,   NRF2↑, 84,   NRF2⇅, 2,   NRF2↝, 2,   NRF2∅, 3,   p‑NRF2↓, 1,   p‑NRF2↑, 2,   OSI↑, 1,   p66Shc↓, 1,   p66Shc↑, 1,   PAO↑, 1,   Prx↓, 5,   Prx↑, 1,   Prx3↑, 1,   Prx4↓, 1,   Prx4↑, 1,   Prx6↑, 2,   PrxI↓, 1,   PrxI∅, 1,   ox-PrxI↑, 1,   PrxII↓, 2,   PrxII↑, 1,   PrxII∅, 1,   PYCR1↓, 1,   RNS↓, 2,   RNS↑, 5,   ROS?, 9,   ROS↓, 161,   ROS↑, 1786,   ROS⇅, 43,   ROS↝, 14,   ROS∅, 13,   i-ROS?, 1,   i-ROS↓, 2,   i-ROS↑, 8,   m-ROS↑, 1,   mt-ROS↓, 3,   mt-ROS↑, 53,   RPM↑, 3,   SAM-e↝, 1,   selenoP↓, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 50,   SOD↑, 33,   SOD∅, 1,   mt-SOD↑, 1,   SOD1↓, 5,   SOD1↑, 4,   SOD2↓, 16,   SOD2↑, 9,   ac‑SOD2↓, 1,   T-SOD↓, 1,   TAC↓, 5,   TAC↑, 2,   TBARS↑, 4,   Thiols↓, 10,   i-Thiols↓, 1,   TKT↓, 1,   TKT↝, 1,   TOS↑, 1,   Trx↓, 21,   Trx↑, 2,   Trx1↓, 8,   Trx1↑, 2,   ox-Trx1↑, 2,   Trx2↓, 3,   TrxR↓, 55,   TrxR↑, 2,   TrxR1?, 1,   TrxR1↓, 20,   TrxR1↑, 1,   mt-TrxR1↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 26,   xCT/SLC7A11↑, 2,   xCT/SLC7A11∅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

ATOX1↝, 1,   Ferritin↓, 8,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 7,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 8,   LIP↑, 1,   Mets↑, 1,   NCOA4↑, 4,   NCOA4↝, 1,   Tf↓, 2,   Tf↑, 2,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 2,   ADP:ATP↑, 4,   BCR-ABL↓, 1,   CDC2↓, 11,   CDC25↓, 26,   CDC25↑, 2,   CDC25↝, 1,   compI↓, 13,   compI↑, 1,   compII↓, 4,   compII↑, 1,   compIII↓, 4,   compIII↑, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 7,   ETC?, 1,   ETC↓, 25,   ETC↝, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 1,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 5,   MCU↓, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 25,   mitResp↑, 4,   MKK7↓, 1,   Mortalin↓, 1,   mRET↑, 1,   mtDam↓, 3,   mtDam↑, 121,   OCR↓, 25,   OCR↑, 9,   mt-OCR↓, 1,   OXPHOS↓, 23,   OXPHOS↑, 18,   OXPHOS⇅, 1,   OXPHOS↝, 3,   OXPHOS∅, 1,   mt-OXPHOS↓, 4,   mt-OXPHOS↑, 2,   PDH↓, 6,   PDH↑, 7,   PDH↝, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 6,   SDH↓, 3,   SDH↑, 1,   SIRT3↓, 3,   SIRT3↑, 8,   SSBP1↑, 1,   TrxR2↓, 1,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 7,   5LO↓, 10,   6PGD↓, 1,   ACC↓, 2,   ACC↑, 4,   p‑ACC↑, 1,   ACLY↓, 5,   p‑ACLY↓, 1,   ACSL4↑, 4,   ACSL4↝, 1,   ACSL4∅, 1,   adiP↑, 1,   ALAT↓, 12,   ALAT↑, 1,   ALAT↝, 1,   ALAT∅, 1,   ALDOA↓, 3,   ALDOB↑, 1,   AminoA↓, 1,   AMP↓, 1,   AMP↑, 3,   AMPK↓, 4,   AMPK↑, 68,   p‑AMPK↑, 10,   p‑AMT/GCST/T-protein↑, 1,   ANXA7↑, 2,   ATP↓, 111,   ATP↑, 4,   ATP↝, 1,   ATP∅, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   ATP:AMP↓, 1,   BHB↑, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CholSyn↓, 1,   citrate↓, 2,   CPT1A↓, 1,   CRM↑, 3,   DHCR24↑, 1,   DHODH↓, 2,   ECAR↓, 11,   ECAR↝, 1,   ECAR∅, 1,   ENO1↓, 4,   ENO3↑, 1,   FABP4↑, 1,   FAO↓, 2,   FASN↓, 14,   FASN↑, 1,   FBP1↑, 1,   FBPase↑, 1,   FDG↓, 2,   G6PD↓, 4,   G6PD∅, 1,   GAPDH↓, 7,   GDH↓, 1,   GLO-I↓, 3,   GLS↓, 2,   glucoNG↓, 2,   glucoNG↑, 1,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↓, 45,   GlucoseCon↑, 4,   GlucoseCon∅, 2,   glut↓, 2,   GlutaM↓, 2,   GlutMet↓, 2,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 129,   Glycolysis↑, 2,   Glycolysis↝, 1,   Glycolysis∅, 1,   GSK‐3β↓, 19,   GSK‐3β↑, 13,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 13,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HAGH/GLO2↓, 1,   Histones↑, 2,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 57,   HK2↑, 2,   HK2∅, 1,   HK3↑, 1,   HMG-CoA↓, 2,   HMGCS2↑, 1,   IDH1↓, 1,   IDO1↓, 1,   KeyT↑, 1,   lact/pyru↓, 1,   lactateProd↓, 50,   lactateProd↑, 6,   lactateProd∅, 2,   LDHA↓, 29,   LDHA↑, 1,   LDHA∅, 1,   LDL↓, 5,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 4,   NAD↓, 6,   NAD↑, 2,   NAD↝, 1,   NADH:NAD↓, 1,   NADPH↓, 17,   NADPH↑, 8,   NADPH↝, 1,   PCK1↓, 2,   PCK1↑, 1,   PDHA1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 22,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PDKs↓, 11,   PDKs↑, 1,   PFK↓, 9,   PFK1↓, 4,   PFK1↑, 1,   PFK2?, 1,   PFKP↓, 3,   PGK1↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM2↓, 42,   PKM2↑, 2,   p‑PKM2↓, 1,   PLA2↓, 1,   polyA↓, 1,   PPP↓, 5,   PPP↑, 1,   Pyrim↓, 1,   Pyruv↓, 4,   Pyruv↑, 1,   R5P↝, 1,   RNR↓, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 18,   SIRT1↑, 21,   SIRT2↓, 2,   SIRT2↑, 1,   SLC1A5↓, 1,   SLC25A1↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   SSAT↑, 1,   TCA?, 1,   TCA↓, 10,   TCA↑, 3,   TCA↝, 1,   TS↓, 3,   Warburg↓, 31,   Warburg↑, 1,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 39,   AIF↝, 1,   APAF1↑, 11,   Apoptosis?, 7,   Apoptosis↓, 26,   Apoptosis↑, 836,   Apoptosis↝, 1,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 10,   ASC↓, 1,   ASC↑, 2,   ASK1↑, 5,   p‑ASK1↑, 1,   BAD↓, 4,   BAD↑, 29,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 28,   BAX↓, 14,   BAX↑, 356,   BAX⇅, 2,   BAX↝, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 79,   Bcl-2↓, 376,   Bcl-2↑, 8,   Bcl-2↝, 1,   Bcl-2∅, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 75,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 20,   p‑BID↓, 1,   cl‑BID↑, 3,   BIM↑, 19,   BNIP3?, 2,   BNIP3↑, 4,   BNIP3↝, 2,   BOK↑, 1,   Casp↓, 3,   Casp↑, 122,   Casp↝, 1,   cl‑Casp↑, 3,   proCasp↑, 1,   Casp1↓, 3,   Casp1↑, 3,   cl‑Casp1↑, 2,   Casp10↑, 3,   Casp10∅, 1,   Casp12?, 1,   Casp12↑, 10,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   pro‑Casp12↓, 1,   Casp2↑, 3,   Casp3?, 3,   Casp3↓, 10,   Casp3↑, 451,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp3↑, 100,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 4,   proCasp3↑, 6,   pro‑Casp3↑, 1,   CASP4↑, 2,   Casp6↓, 1,   Casp6↑, 4,   Casp7↑, 50,   cl‑Casp7↑, 5,   Casp8↓, 3,   Casp8↑, 99,   Casp8∅, 3,   cl‑Casp8↑, 14,   proCasp8↑, 2,   Casp9?, 1,   Casp9↓, 3,   Casp9↑, 255,   Casp9∅, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 43,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 13,   Cupro↑, 3,   Cyt‑c↓, 5,   Cyt‑c↑, 280,   Cyt‑c↝, 4,   Cyt‑c?, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 16,   DIDO1/DIO-1↑, 1,   DR5↓, 1,   DR5↑, 61,   DR5∅, 1,   Endon↑, 4,   FADD↑, 13,   FADD∅, 1,   Fap1↓, 2,   Fas↓, 2,   Fas↑, 42,   FasL↑, 19,   Ferroptosis↓, 4,   Ferroptosis↑, 105,   GranB/GZMB↝, 1,   GRP58↓, 2,   GSDMD↑, 4,   cl‑GSDMD↑, 1,   GSDME↑, 2,   cl‑GSDME↑, 2,   GSDME-N↑, 2,   HEY1↓, 1,   IAP1↓, 19,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICD↑, 7,   iNOS↓, 32,   iNOS↑, 3,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 46,   Mcl-1↑, 2,   p‑Mcl-1↓, 1,   MDM2↓, 21,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 5,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 12,   NAIP↓, 1,   Necroptosis↑, 18,   necrosis↑, 19,   NOXA↑, 7,   oncosis↑, 2,   p38↓, 17,   p38↑, 54,   p‑p38↓, 4,   p‑p38↑, 17,   Paraptosis↑, 6,   PDCD4↑, 1,   Perforin↝, 1,   proApCas↑, 1,   PUMA↓, 2,   PUMA↑, 14,   PUMA⇅, 1,   PUMA↝, 1,   Pyro↑, 17,   RIP1↓, 4,   RIP1↑, 5,   p‑RIP1↑, 1,   RIP3↓, 1,   RIP3↑, 8,   p‑RIP3↑, 3,   survivin↓, 108,   TNFR 1↑, 2,   TRAIL↑, 13,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD?, 1,   TumCD↓, 4,   TumCD↑, 107,   TumCD∅, 2,   TUNEL↑, 1,   XIAP↓, 50,   XIAP↑, 2,   YAP/TEAD↓, 9,   YAP/TEAD↑, 2,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 316,   Akt↑, 16,   Akt↝, 2,   p‑Akt↓, 84,   p‑Akt↑, 2,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 7,   BCAP↓, 1,   BRAF↝, 1,   CaMKII ↓, 4,   CaMKII ↑, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 3,   CK2↓, 9,   cMET↓, 6,   p‑cMET↑, 2,   CREB↓, 1,   cSrc↓, 4,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 68,   EGFR↑, 2,   EGFR↝, 2,   p‑EGFR↓, 4,   ERK↓, 105,   ERK↑, 27,   ERK↝, 1,   p‑ERK↓, 27,   p‑ERK↑, 9,   p‑ERK⇅, 1,   p‑ERK↝, 1,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HCAR2↑, 3,   HER2/EBBR2↓, 21,   HGF/c-Met↓, 3,   Hippo↓, 1,   Hippo↑, 1,   Hippo↝, 1,   IGF-1R↓, 10,   IGF-1R↑, 1,   p‑IGF-1R↓, 1,   IGFR↓, 1,   IKKα↓, 8,   IKKα↑, 4,   p‑IKKα↓, 1,   IκB↓, 3,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 13,   JAK↝, 1,   p‑JAK↓, 1,   JAK1?, 1,   JAK1↓, 12,   JAK1↑, 2,   p‑JAK1↓, 1,   JAK2↓, 26,   p‑JAK2↓, 4,   JNK↓, 11,   JNK↑, 81,   JNK↝, 2,   p‑JNK↓, 5,   p‑JNK↑, 13,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 69,   MAPK↑, 52,   MAPK↝, 5,   p‑MAPK↓, 4,   p‑MAPK↑, 8,   MARK4↓, 3,   MEK↓, 7,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 2,   MKP2↓, 2,   Mst1↑, 1,   mTOR↓, 178,   mTOR↑, 9,   mTOR⇅, 1,   mTOR↝, 2,   p‑mTOR↓, 26,   p‑mTOR↑, 1,   mTORC2↓, 5,   mTORC2↑, 1,   p42↑, 1,   p‑p42↓, 1,   p‑p42↑, 1,   p70S6↓, 5,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 11,   P70S6K↑, 1,   p‑P70S6K↓, 3,   p85S6K↓, 1,   P90RSK↓, 2,   PDGFR-BB↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K↓, 214,   PI3K↑, 11,   PI3K↝, 3,   p‑PI3K↓, 15,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3K/Akt⇅, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 3,   p‑PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 6,   PKCδ↓, 19,   PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 3,   PTEN↑, 55,   PTEN↝, 2,   PTK2B / PYK2↓, 1,   PTP1B↓, 1,   Raf↓, 8,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 22,   RAS↑, 1,   RET↓, 1,   p‑S6K↓, 3,   SHP1↑, 2,   Sp1/3/4↓, 30,   Src↓, 5,   p‑Src↓, 2,   STAT↓, 9,   p‑STAT↓, 1,   STAT3↓, 161,   STAT3↑, 8,   STAT3⇅, 1,   STAT3↝, 1,   p‑STAT3↓, 35,   p‑STAT3↑, 3,   mt-STAT3↓, 1,   STAT5↓, 5,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 2,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 3,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF2↓, 3,   ATF3↓, 1,   ATF3↑, 4,   ATF4↓, 1,   ATF4↑, 31,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 2,   ChrMod↝, 1,   cJun↓, 13,   cJun↑, 7,   p‑cJun↑, 2,   cMyc↓, 84,   cMyc↑, 3,   p‑cMyc↑, 1,   CREBBP↓, 1,   DLEU1↓, 1,   DNMT1↓, 17,   DNMT1↑, 1,   DNMT3A↓, 4,   DNMT3B↓, 1,   DNMTs↓, 12,   DNMTs⇅, 1,   EZH2↓, 8,   FOXM1↓, 10,   FOXO↓, 1,   FOXO↑, 5,   FOXO1↓, 5,   FOXO1↑, 5,   FOXO3↓, 7,   FOXO3↑, 15,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↓, 2,   FOXO4↑, 3,   H3↓, 4,   H3↑, 2,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 3,   H3K9↓, 1,   H4↓, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 2,   HATs⇅, 1,   HDAC↓, 57,   HDAC⇅, 1,   HDAC1↓, 15,   HDAC10↑, 1,   HDAC2↓, 8,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 4,   HMTs↓, 3,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-125b↓, 1,   miR-130a↓, 1,   miR-139-5p↑, 2,   miR-148a↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-19b↓, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 14,   miR-21↑, 1,   miR-210↓, 1,   miR-218↑, 1,   miR-22↑, 2,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 3,   miR-34a↑, 7,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-486↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 10,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 22,   other?, 3,   other↓, 16,   other↑, 33,   other⇅, 1,   other↝, 52,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 6,   RUNX2↓, 1,   Set9↑, 1,   SETBP1↓, 1,   Shc↓, 1,   sonoS↑, 4,   SOX2↓, 20,   SOX4↓, 4,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 3,   SUMO↓, 1,   SUV39H↓, 5,   TCF-4↓, 3,   TET3↑, 1,   TFE3↑, 2,   tumCV?, 3,   tumCV↓, 259,   tumCV↑, 5,   tumCV∅, 4,   USF1↑, 1,   UTF1↑, 1,   YMcells↓, 1,   ZBTB10↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 5,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 80,   CHOP/DDIT3↝, 1,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   COX17↝, 1,   CRT↑, 1,   i-CRT↓, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 4,   eIF2α↑, 18,   p‑eIF2α↓, 1,   p‑eIF2α↑, 12,   p‑eIF2α↝, 1,   ER Stress↓, 6,   ER Stress↑, 182,   ER Stress↝, 1,   Erlin1↑, 1,   ERStress↑, 2,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 43,   GRP78/BiP↝, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 10,   HSP70/HSPA5↑, 16,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 24,   HSP90↑, 3,   HSPs↓, 2,   HSPs↑, 3,   HTRA↓, 1,   IRE1↑, 9,   NQO2↑, 1,   PDI↑, 3,   PERK↓, 1,   PERK↑, 23,   p‑PERK↑, 3,   p‑PERK↝, 1,   Proteasome?, 1,   Proteasome↓, 3,   PSMB5↓, 1,   UPR↓, 1,   UPR↑, 30,   XBP-1↓, 2,   XBP-1↑, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 18,   ATG7↑, 6,   autoF↓, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 7,   Beclin-1/ATG6↑, 43,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LAMP1?, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 11,   LC3A↑, 3,   LC3B↑, 10,   LC3B-II↑, 9,   LC3I↑, 2,   LC3II↓, 2,   LC3II↑, 34,   LC3s↓, 1,   LC3s↑, 5,   LC3s↝, 1,   lysoMP↑, 2,   LysoPr↑, 1,   lysosome↝, 1,   MitoP↓, 1,   MitoP↑, 5,   p62↓, 26,   p62↑, 19,   PARK2↑, 6,   RUBCN↓, 1,   SESN2↑, 4,   TFEB↑, 1,   TumAuto↓, 7,   TumAuto↑, 173,   TumAuto⇅, 2,   TumAuto↝, 1,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 11,   p‑ATM↑, 3,   ATR↑, 2,   p‑ATR↑, 1,   BRCA1↓, 4,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 2,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 3,   DNA-PK↑, 5,   DNAdam↓, 8,   DNAdam↑, 261,   mt-DNAdam↑, 2,   DNArepair↓, 10,   DNArepair↑, 3,   ERCC3↑, 1,   m-FAM72A↓, 1,   FEN1↓, 2,   G9a↓, 1,   HR↓, 2,   hTERT/TERT↓, 19,   Ku70/XRCC6↓, 1,   MGMT↓, 3,   p16↑, 8,   P53?, 2,   P53↓, 11,   P53↑, 260,   P53↝, 7,   P53∅, 1,   p‑P53↓, 2,   p‑P53↑, 14,   ac‑P53↑, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 11,   PARP↑, 51,   PARP∅, 1,   p‑PARP↑, 3,   cl‑PARP↓, 5,   cl‑PARP↑, 191,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 5,   PCNA↓, 57,   POLD1↓, 1,   RAD51↓, 3,   RAD51↑, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 26,   TOP1?, 1,   TOP1↓, 18,   TOP1↝, 1,   TOP1∅, 1,   TOP2↓, 10,   TOP2↑, 1,   TP53↓, 3,   TP53↑, 5,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 27,   γH2AX↝, 1,   p‑γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CDK1↓, 33,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK2↓, 68,   CDK2↑, 5,   CDK4↓, 80,   CDK4↑, 5,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 28,   CDK6↑, 7,   CDK6∅, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   cellSen↑, 2,   CHK1↓, 5,   CHK1↑, 2,   CHK1↝, 1,   p‑CHK1↑, 3,   Chk2↓, 4,   Chk2↑, 6,   p‑Chk2↑, 2,   Cyc↓, 5,   Cyc↝, 1,   cycA1/CCNA1↓, 21,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 49,   CycB/CCNB1↑, 9,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 162,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 1,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   CycD3↑, 1,   cycE/CCNE↓, 38,   cycE/CCNE↑, 3,   cycE1↓, 3,   cycF↑, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 6,   Ki-67↓, 58,   Ki-67↑, 1,   MAD↓, 1,   mitA↓, 1,   mitA↑, 4,   p19↑, 1,   P21?, 2,   P21↓, 10,   P21↑, 159,   P21↝, 1,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 58,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 5,   RB1↑, 3,   p‑RB1↓, 8,   RRM2↓, 1,   Securin↓, 2,   TAp63α↑, 1,   TumCCA?, 4,   TumCCA↓, 14,   TumCCA↑, 599,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 3,   ALDH↓, 17,   ALDH1A1↓, 3,   ALDH1A3↓, 1,   Axin2↑, 1,   BMI1↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 3,   CD133↓, 15,   CD133↑, 1,   CD24↓, 4,   CD34↓, 2,   cFos↓, 12,   cFos↑, 2,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 101,   CSCs↑, 3,   CSCsMark↓, 2,   Diff↓, 1,   Diff↑, 13,   EIF4E↓, 3,   EP4/PTGER4↑, 1,   FGF↓, 4,   FOSL1↑, 1,   Gli↓, 1,   Gli1↓, 11,   HH↓, 8,   HMGCR↓, 2,   IGF-1?, 1,   IGF-1↓, 19,   IGF-2↓, 1,   IGF-2↑, 1,   IGFBP1↑, 2,   IGFBP3↓, 1,   IGFBP3↑, 5,   IGFBP7↑, 1,   JAG1↓, 1,   Jun↓, 2,   p‑Jun↓, 1,   p‑Jun↑, 1,   Ki-67↓, 58,   Ki-67↑, 1,   Let-7↓, 1,   Let-7↑, 3,   LRP6↓, 1,   mTORC1↓, 16,   p‑mTORC1↓, 1,   Nanog↓, 22,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 29,   NOTCH↑, 1,   NOTCH1↓, 23,   NOTCH1↑, 4,   NOTCH3↓, 4,   p300↓, 2,   Piezo1↑, 2,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   STAT1↑, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TumCG?, 3,   TumCG↓, 319,   TumCG↑, 8,   TumCP?, 2,   TumCP↓, 463,   TumCP↑, 12,   TumCP⇅, 1,   tyrosinase↓, 2,   Wnt?, 1,   Wnt↓, 74,   Wnt↑, 2,   Wnt↝, 1,   Wnt/(β-catenin)↓, 11,   Wnt/(β-catenin)↑, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   Alix/AIP‑1↓, 3,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 20,   AP-1↑, 2,   AP-1↝, 1,   APC↑, 2,   ASAP2↓, 1,   ATPase↓, 2,   ATPase↑, 1,   AXL↓, 3,   BACH1↓, 1,   BACH1↑, 1,   CA↓, 2,   Ca+2↓, 12,   Ca+2↑, 125,   Ca+2↝, 9,   i-Ca+2?, 1,   i-Ca+2↑, 8,   CAFs/TAFs↓, 3,   cal2↓, 1,   cal2↑, 3,   CD11b↑, 1,   Cdc42↓, 3,   Cdc42↑, 1,   Chl↑, 1,   i-Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 79,   EMT?, 1,   EMT↓, 151,   EMT↑, 4,   EMT↝, 1,   EpCAM↓, 4,   F-actin↓, 3,   FAK↓, 30,   FAK↑, 1,   p‑FAK↓, 7,   fascin↓, 1,   Fibronectin↓, 6,   FOSB↑, 1,   Furin↓, 3,   GIT1↓, 1,   GLI2↓, 3,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB1↑, 1,   ITGB3↓, 2,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 3,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↓, 1,   LRP1↑, 1,   MALAT1↓, 6,   MET↓, 4,   MET↑, 1,   p‑MET↓, 2,   MMP-10↓, 3,   MMP1↓, 11,   MMP13↓, 7,   MMP15↓, 1,   MMP16↓, 2,   MMP2?, 1,   MMP2↓, 173,   MMP2↑, 1,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 11,   MMP7↓, 19,   MMP7∅, 1,   MMP9?, 1,   MMP9↓, 193,   MMP9↑, 5,   MMP9:TIMP1↓, 1,   MMPs↓, 70,   MTA1↓, 1,   MUC1↑, 1,   MUC4↓, 4,   N-cadherin↓, 54,   N-cadherin↑, 1,   NCAM↑, 1,   NFAT↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   PAK1↓, 4,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 8,   Rac1↓, 4,   RECK↑, 1,   Rho↓, 8,   Rho↑, 1,   Rho↝, 1,   ROCK1↓, 7,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 18,   Smad1↓, 2,   Smad1↑, 3,   SMAD2↓, 3,   p‑SMAD2↓, 1,   SMAD3↓, 4,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↓, 3,   SMAD4↑, 1,   p‑SMAD4↓, 1,   Snail?, 2,   Snail↓, 43,   STAC2↓, 1,   T-cadherin↓, 1,   T-cadherin↑, 1,   talin↓, 1,   TET1?, 1,   TET1↓, 1,   TET1↑, 10,   TGF-β↓, 31,   TGF-β↑, 4,   TGF-β1↓, 2,   THBS1↓, 1,   TIMP1↓, 4,   TIMP1↑, 18,   TIMP2↓, 5,   TIMP2↑, 20,   TIMP3↑, 1,   TRIB3↑, 3,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 6,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 183,   TumCI↑, 2,   TumCMig↓, 215,   TumCMig↑, 3,   TumCMig⇅, 1,   TumMeta↓, 160,   TumMeta↑, 11,   TumPF↓, 3,   Twist↓, 32,   TXNIP↑, 4,   Tyro3↓, 1,   uPA↓, 33,   uPA↝, 1,   uPAR↓, 3,   Vim?, 1,   Vim↓, 67,   Vim↑, 1,   Zeb1↓, 21,   Zeb1↑, 1,   ZEB2↓, 4,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 89,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 213,   angioG↑, 7,   CD31/PECAM-1↓, 3,   ECM/TCF↓, 2,   EGR1↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 14,   HIF-1↑, 2,   Hif1a↓, 148,   Hif1a↑, 10,   Hif1a↝, 2,   Hypoxia↓, 5,   Hypoxia↑, 1,   LOX1↓, 3,   NO↓, 12,   NO↑, 17,   NO↝, 1,   PHDs↓, 1,   REL↑, 1,   VCAM-1↓, 3,   VEGF↓, 198,   VEGF↑, 4,   VEGF↝, 1,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 26,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 17,   BBB↝, 1,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 9,   CLDN1↓, 6,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 2,   CTR1↝, 1,   CX43/GJA1↓, 1,   EPR↓, 1,   EPR↑, 23,   EPR↝, 1,   GLUT1↓, 39,   GLUT1↑, 4,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3↑, 2,   GLUT4↓, 7,   IBI↑, 1,   KCNH2/hERG↓, 1,   LAT↓, 1,   MMP?, 2,   MMP↓, 529,   MMP↑, 15,   MMP↝, 4,   MMP∅, 3,   MPT↓, 1,   MPT↑, 24,   NHE1↓, 5,   OCLN↑, 1,   SLC12A5↓, 1,   SMCT1∅, 1,   sonoP↑, 1,   SVCT-2↝, 1,   SVCT-2∅, 2,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↓, 1,   TRPV1↑, 11,   TRPV1↝, 1,   TRPV2↑, 1,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD14↑, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 7,   CD44↓, 24,   CD47↓, 2,   CD8+↑, 12,   cDC2↓, 5,   cGAS–STING↑, 2,   COX1↓, 5,   COX1↑, 1,   COX2/PTGS2↓, 158,   COX2/PTGS2↑, 7,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL1↓, 1,   CXCL12↓, 3,   CXCL16↓, 1,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DCells↑, 3,   DR4↑, 15,   DR4∅, 2,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 3,   Gal-3↓, 2,   Gal1↑, 1,   HCAR1↓, 1,   HCAR2↑, 3,   HLA-I/II↑, 1,   HMGB1↓, 6,   i-HMGB1↓, 1,   ICAM-1↓, 10,   IFN-γ↓, 9,   IFN-γ↑, 4,   Igs↓, 1,   Igs↑, 2,   IL1↓, 11,   IL1↑, 4,   IL10↓, 9,   IL10↑, 3,   IL12↓, 3,   IL12↑, 3,   IL17↓, 1,   IL18↓, 1,   IL18↑, 1,   IL1β↓, 38,   IL1β↑, 6,   IL2↓, 6,   IL2↑, 6,   IL33↑, 1,   IL4↓, 5,   IL4↑, 1,   IL6↓, 90,   IL6↑, 3,   IL6↝, 1,   IL8↓, 20,   IL8↑, 4,   Imm↑, 41,   Imm↝, 5,   INF-γ↝, 1,   Inflam↓, 86,   Inflam↑, 1,   Inflam↝, 1,   IRAK1↓, 2,   LRIG1↑, 1,   M1↑, 1,   pol-M1↑, 1,   M2 MC↓, 5,   M2 MC↑, 1,   pol-M2 MC↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 8,   MCT1↓, 5,   MIP2↓, 2,   NAF1↓, 3,   Neut↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 333,   NF-kB↑, 19,   NF-kB↝, 2,   p‑NF-kB↓, 4,   p‑NF-kB↑, 3,   NK cell↑, 19,   NK cell⇅, 1,   NLRP3↓, 13,   NLRP3↑, 7,   NOD1↓, 1,   p50↓, 3,   p65↓, 18,   p65↑, 1,   p‑p65↓, 5,   ac‑p65↓, 1,   PD-1↓, 4,   PD-1↝, 1,   PD-L1↓, 20,   PD-L1↑, 4,   PGD2↓, 1,   PGE1↓, 1,   PGE2↓, 34,   PSA↓, 18,   PSA↝, 1,   RAGE↓, 2,   RAGE↑, 1,   RANTES?, 1,   Resistin↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↑, 8,   T-Cell↝, 1,   TCF↓, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   TLR1↑, 1,   TLR2↓, 2,   TLR4↓, 11,   TLR4↝, 1,   TNF-α↓, 73,   TNF-α↑, 15,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 5,   Treg lymp↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GFAP↓, 2,   pH↓, 3,   pH↑, 2,   pH↝, 3,   i-pH↓, 2,   i-pH↑, 1,   TAMS↝, 1,   Temp∅, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↑, 1,   MAOA↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   PRNP↑, 1,   PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↓, 2,   AKR1C3/17β-HSD5/PGF Synthase↓, 1,   AR↓, 34,   AR↑, 1,   AR↝, 1,   COMT↓, 1,   CYP19↓, 1,   ER-α36↓, 7,   ER(estro)↓, 3,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   FGF21↓, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↓, 1,   PPARα↑, 2,   cl‑PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 9,   PPARγ↝, 1,   RANKL↓, 2,   SRC3↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 2,   ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 94,   BioAv↑, 102,   BioAv↝, 30,   BioEnh?, 1,   BioEnh↑, 10,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 6,   ChemoSen↑, 451,   ChemoSen⇅, 2,   ChemoSen↝, 1,   ChemoSen∅, 4,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 8,   CompStab↝, 2,   CYP1A1↓, 7,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 4,   DDS↑, 5,   Dose?, 13,   Dose↓, 10,   Dose↑, 32,   Dose⇅, 4,   Dose↝, 167,   Dose∅, 44,   DrugR↓, 1,   eff?, 2,   eff↓, 360,   eff↑, 359,   eff⇅, 1,   eff↝, 51,   eff∅, 5,   GSTA1↓, 3,   GSTA1↑, 2,   GSTP1/GSTπ↓, 3,   GSTZ1↝, 1,   Half-Life?, 1,   Half-Life↓, 25,   Half-Life↑, 7,   Half-Life↝, 26,   Half-Life∅, 2,   MDR1↓, 15,   MRP1/ABCC1↓, 5,   MRP1/ABCC1↑, 1,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 44,   P-gp/ABCB1↑, 2,   P-gp/ABCB1⇅, 1,   P450↓, 8,   P450↝, 1,   RadioS?, 1,   RadioS↓, 3,   RadioS↑, 170,   RadioS↝, 2,   selectivity?, 4,   selectivity↓, 6,   selectivity↑, 382,   selectivity↝, 2,   selectivity∅, 4,   Synergy↑, 269,   Synergy↝, 1,   TET2↓, 1,   TET2↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 12,   ALAT↑, 1,   ALAT↝, 1,   ALAT∅, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 34,   AR↑, 1,   AR↝, 1,   AST↓, 7,   AST↑, 1,   AST↝, 1,   AST∅, 1,   BG↓, 6,   BloodF↑, 3,   BMD↑, 3,   BP↓, 3,   BRAF↝, 1,   BRCA1↓, 4,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BUN↓, 2,   CEA↓, 2,   creat↓, 3,   CRP↓, 5,   E6↓, 5,   E7↓, 5,   EGFR↓, 68,   EGFR↑, 2,   EGFR↝, 2,   p‑EGFR↓, 4,   ERα/ESR1↓, 3,   EZH2↓, 8,   Ferritin↓, 8,   Ferritin↑, 1,   FOXM1↓, 10,   HER2/EBBR2↓, 21,   hTERT/TERT↓, 19,   IL6↓, 90,   IL6↑, 3,   IL6↝, 1,   IRes↓, 1,   KeyT↑, 1,   KRAS↓, 3,   LDH?, 1,   LDH↓, 26,   LDH↑, 13,   LDH↝, 3,   e-LDH↑, 1,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 10,   Myc↑, 1,   NLR↓, 1,   NOS2↓, 2,   NOS2↑, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 20,   PD-L1↑, 4,   PSA↓, 18,   PSA↝, 1,   RAGE↓, 2,   RAGE↑, 1,   RBC↑, 1,   RBM3↑, 1,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 5,   TRIB3↑, 3,   Tumccf↓, 1,   Urea↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 4,   AntiCan↑, 184,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 8,   AntiTum↓, 2,   AntiTum↑, 80,   AntiTum∅, 1,   Appetite↑, 2,   BowelM↑, 2,   breath↑, 1,   cachexia↓, 4,   cardioP↑, 25,   CardioT↓, 2,   CardioT↑, 1,   CardioT↝, 1,   chemoP↓, 1,   chemoP↑, 87,   chemoPv↑, 58,   ChemoSideEff↓, 20,   cognitive?, 1,   cognitive↑, 6,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↓, 3,   hepatoP↑, 28,   K17↓, 1,   LC↑, 1,   memory↑, 1,   motorD↑, 1,   Mucositis↓, 2,   neuroP↓, 1,   neuroP↑, 28,   NKG2D↑, 1,   NP/CIPN↓, 3,   NP/CIPN↑, 1,   Obesity↓, 2,   OS↓, 2,   OS↑, 63,   OS⇅, 1,   OS∅, 2,   Pain↓, 8,   PFS↓, 1,   PFS↑, 1,   PFS∅, 1,   Pin1↓, 2,   QoL↑, 19,   QoL∅, 1,   radioP↑, 34,   Remission↑, 6,   RenoP↑, 23,   Risk↓, 48,   Risk↑, 2,   Sleep↑, 3,   Strength↑, 2,   toxicity?, 1,   toxicity↓, 54,   toxicity↑, 12,   toxicity⇅, 1,   toxicity↝, 30,   toxicity∅, 11,   TumVol↓, 70,   TumVol↑, 1,   TumW↓, 30,   Weight↓, 1,   Weight↑, 6,   Weight∅, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiP↑, 3,   AntiViral↑, 1,   Bacteria↓, 9,   GutMicro↑, 15,   GutMicro↝, 3,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 4,   Ingr↝, 4,  
Total Targets: 1874

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 6,   antiOx?, 2,   antiOx↓, 24,   antiOx↑, 475,   mt-antiOx↑, 1,   ARE↓, 1,   ARE↑, 12,   ARE↝, 1,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 7,   Catalase↑, 222,   Catalase↝, 1,   Copper↓, 2,   DPPH↓, 1,   DUOX1↓, 1,   Fenton↓, 7,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 6,   GPx↑, 160,   GPx1↑, 9,   GPx4↓, 2,   GPx4↑, 13,   GPx4∅, 1,   GSH↓, 11,   GSH↑, 249,   GSH⇅, 1,   GSH/GSSG↑, 3,   GSR↓, 3,   GSR↑, 29,   GSS↑, 2,   GSSG↓, 4,   GSSG∅, 1,   GSTs↓, 4,   GSTs↑, 41,   H2O2↓, 20,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 15,   HDL∅, 1,   HNE↓, 3,   HNE↑, 1,   HO-1?, 1,   HO-1↓, 7,   HO-1↑, 190,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↓, 2,   hyperG↝, 1,   Iron↓, 11,   Iron↑, 2,   Iron↝, 2,   i-Iron↓, 3,   i-Iron↑, 1,   Keap1↓, 18,   Keap1↑, 2,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 197,   lipid-P↑, 7,   mt-lipid-P↓, 1,   MDA↓, 204,   MDA↑, 8,   MPO↓, 29,   MPO↑, 2,   NADH↓, 1,   NFE2L2↓, 1,   NOX↓, 5,   NOX2↓, 2,   NOX4↓, 11,   NQO1↑, 48,   NQO1↝, 2,   Nrf1↓, 1,   Nrf1↑, 6,   NRF2?, 1,   NRF2↓, 12,   NRF2↑, 320,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 2,   p‑NRF2↑, 2,   Prx↓, 1,   Prx↑, 6,   Prx4∅, 1,   RNS↓, 13,   ROMO1↑, 1,   ROS?, 9,   ROS↓, 1113,   ROS↑, 59,   ROS⇅, 13,   ROS↝, 3,   ROS∅, 26,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 12,   mt-ROS↑, 4,   RPM↑, 1,   RPM↝, 1,   selenoP↑, 16,   SOD?, 1,   SOD↓, 10,   SOD↑, 311,   SOD↝, 1,   mt-SOD↑, 1,   SOD1↓, 2,   SOD1↑, 17,   SOD2↑, 18,   TAC↑, 39,   TAC∅, 1,   TBARS↓, 11,   TBARS↑, 1,   Thiols↑, 5,   TOS↓, 2,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↓, 1,   TrxR↑, 4,   TrxR1↑, 3,   UCPs↑, 2,   UCPs↝, 1,   uricA↓, 5,   VitC↑, 8,   VitE↓, 1,   VitE↑, 5,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 2,   FPN↑, 1,   FTH1↓, 1,   FTH1↑, 2,   FTL↓, 1,   IronCh↓, 1,   IronCh↑, 41,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 4,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   compI↓, 2,   compI↑, 3,   compII↑, 2,   compIII↓, 1,   compIII↑, 2,   compIV↑, 3,   compV↑, 1,   DRP1/DNM1L↓, 5,   DRP1/DNM1L↑, 2,   p‑DRP1/DNM1L↝, 1,   EGF↓, 1,   ETC↓, 4,   ETC↑, 4,   ETC↝, 2,   FIS1↓, 5,   FIS1↑, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   Insulin↑, 5,   MFN1↓, 1,   MFN1↑, 1,   MFN1↝, 1,   MFN2↓, 2,   MFN2↑, 5,   MFN2↝, 1,   mitResp↓, 1,   mitResp↑, 11,   mtDam↓, 29,   mtDam↑, 1,   NGB↑, 1,   OCR↓, 2,   OCR↑, 8,   mt-OCR↑, 1,   OPA1↓, 2,   OPA1↑, 2,   OXPHOS↓, 3,   OXPHOS↑, 5,   PDH↑, 1,   PGC-1α↑, 22,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 3,   SIRT3↑, 14,   TFAM↑, 4,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 7,   15-LOX/ALOX15↓, 1,   5LO↓, 18,   ACADS/SCAD↑, 1,   ACC↓, 2,   ACC↑, 2,   mt-ACC⇅, 1,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 4,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 69,   ALAT↑, 1,   ALDOA↑, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 55,   AMPK⇅, 1,   p‑AMPK↑, 4,   ATP↓, 5,   ATP↑, 47,   ATP∅, 1,   mt-ATP↑, 1,   BMAL1↑, 1,   Buty↑, 1,   cAMP↑, 7,   CPT1A↑, 1,   CRM↑, 5,   cytoP450↓, 1,   DGAT1↓, 1,   DHA↑, 1,   ECAR↓, 3,   ECAR↑, 1,   FABP4↓, 1,   FAM↑, 1,   FAO↓, 1,   FAO↑, 6,   FASN↓, 7,   FFA/NEFA↓, 2,   G6PD↑, 1,   glucose↓, 18,   glucose↑, 1,   glucose↝, 5,   GlucoseCon↓, 2,   GlucoseCon↑, 17,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 3,   Glycolysis↑, 6,   Glycolysis↝, 2,   GPI↑, 1,   GSK‐3β↓, 35,   GSK‐3β↑, 7,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 5,   H2S↑, 4,   HK2↓, 2,   HK2↑, 6,   HMG-CoA↓, 3,   IDH1↑, 1,   KeyT↝, 1,   lactateProd↓, 2,   LDHA↓, 2,   LDHA↑, 2,   LDHB↑, 1,   LDL↓, 40,   lipidLev↓, 6,   lipoGen↓, 2,   NAD↓, 1,   NAD↑, 6,   NADH:NAD↑, 1,   NADPH↓, 18,   NADPH↑, 12,   NADPH∅, 1,   PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PDKs↑, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PFKL↑, 3,   PFKM↑, 2,   PFKP↑, 1,   PGC1A↑, 1,   PGM1?, 1,   PKM1↑, 2,   PKM2↓, 6,   PKM2↑, 4,   PLA2↓, 2,   PONs↑, 1,   PPP↓, 2,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 61,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 106,   Apoptosis↑, 1,   Apoptosis∅, 1,   ASC?, 1,   ASC↓, 4,   ASK1↓, 1,   BAD↓, 3,   BAX↓, 41,   BAX↑, 7,   Bax:Bcl2↓, 6,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-2↑, 34,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   BNIP3↓, 1,   Casp↓, 4,   Casp1↓, 9,   cl‑Casp1↓, 1,   proCasp1↓, 1,   Casp12↓, 4,   Casp3?, 1,   Casp3↓, 73,   Casp3↑, 8,   Casp3∅, 1,   cl‑Casp3↓, 12,   cl‑Casp3↑, 1,   Casp6↓, 1,   Casp7↓, 1,   Casp8↓, 3,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 2,   Casp9↓, 24,   Casp9↑, 4,   cl‑Casp9↓, 2,   cl‑Casp9↑, 1,   Cyt‑c↓, 16,   Cyt‑c↑, 4,   Cyt‑c∅, 3,   Fas↓, 4,   Fas↑, 2,   Ferroptosis↓, 19,   Ferroptosis↑, 2,   GranB/GZMB↓, 1,   GSDMD↓, 2,   HEY1↑, 1,   iNOS↓, 100,   iNOS↑, 2,   necrosis↓, 3,   p38↓, 15,   p38↑, 3,   p‑p38↓, 11,   Pyro?, 1,   Pyro↓, 4,   RIP1↓, 1,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 20,   Akt↑, 45,   Akt↝, 2,   p‑Akt↓, 5,   p‑Akt↑, 11,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↓, 1,   CREB↑, 13,   p‑CREB↑, 8,   EGFR↓, 2,   ERK↓, 14,   ERK↑, 14,   p‑ERK↓, 7,   p‑ERK↑, 7,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 2,   Hippo↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB?, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 3,   p‑JAK1↓, 1,   JAK2↓, 3,   JAK2↑, 4,   p‑JAK2↓, 2,   JNK↓, 21,   JNK↑, 3,   p‑JNK↓, 10,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 47,   MAPK↑, 6,   MAPK↝, 3,   p‑MAPK?, 1,   p‑MAPK↓, 2,   p‑MEK↓, 1,   p‑MKK4↑, 1,   Mst1↓, 2,   mTOR↓, 17,   mTOR↑, 12,   p‑mTOR↓, 4,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 16,   PI3K↑, 33,   PI3K↝, 1,   p‑PI3K↑, 1,   PKA↑, 3,   PKCδ?, 1,   PKCδ↓, 3,   PKCδ↑, 6,   p‑PKCδ↑, 1,   PP2A↑, 4,   PTEN↓, 4,   PTEN↑, 3,   p‑PTEN↑, 1,   Raf↓, 1,   RAS↓, 2,   STAT↓, 4,   STAT3?, 1,   STAT3↓, 11,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 10,   ATF2↑, 1,   ATF4↓, 5,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 3,   FOXO1↑, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 7,   HATs↓, 1,   HDAC↓, 7,   HDAC↑, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   miR-155↓, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other?, 4,   other↓, 28,   other↑, 44,   other↝, 51,   other∅, 1,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 3,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 15,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 2,   cl‑eIF2α↑, 1,   ER Stress↓, 30,   ER Stress↑, 2,   GRP78/BiP↓, 15,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSF1↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 12,   HSP70/HSPA5↝, 1,   HSP90↓, 2,   HSP90↑, 1,   HSPs↑, 3,   HSPs↝, 1,   IRE1↓, 3,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 3,   p‑PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 4,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↓, 1,   ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3II↓, 2,   LC3II↑, 3,   LC3s↓, 1,   MitoP↑, 5,   p62↓, 5,   p62↑, 5,   PARK2↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 45,   DNAdam↑, 2,   DNAdam∅, 1,   DNArepair↑, 2,   p16↓, 1,   P53↓, 9,   P53↑, 5,   P53↝, 1,   PARP↓, 2,   p‑PARP↓, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 4,   SIRT6↑, 3,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   CDK5↓, 4,   cellSen↝, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 3,   Ki-67↑, 2,   P21↓, 6,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CD34↑, 1,   CEBPA↓, 1,   cFos↓, 1,   cFos↑, 1,   Choline↑, 1,   Diff↑, 4,   Diff↝, 1,   FGF↑, 3,   HH↓, 1,   IGF-1↓, 3,   IGF-1↑, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 3,   Ki-67↑, 2,   Nestin↑, 1,   neuroG↑, 6,   NOTCH↓, 1,   NOTCH↑, 1,   NOTCH1↑, 1,   p300↓, 1,   p‑STAT1↓, 1,   TumCG↓, 2,   TumCP↓, 4,   tyrosinase↓, 2,   Wnt↓, 1,   Wnt↑, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 40,   AP-1↓, 13,   AP-1↑, 1,   ARG1/2↑, 1,   BACH1↓, 1,   Ca+2?, 2,   Ca+2↓, 37,   Ca+2↑, 9,   Ca+2↝, 6,   Ca+2∅, 1,   i-Ca+2↓, 2,   cal2↓, 2,   Cartilage↑, 8,   p‑Cofilin↓, 1,   COL1↓, 5,   COL1↑, 2,   COL3A1↓, 2,   E-cadherin↑, 3,   EMT↓, 4,   EMT↑, 1,   FAK↑, 1,   Fibronectin↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 6,   MMP2↓, 9,   MMP2↑, 3,   MMP3↓, 5,   MMP9↓, 18,   MMP9↑, 2,   MMPs↓, 5,   MMPs↑, 1,   MUC1↑, 2,   N-cadherin↑, 1,   Na+↑, 1,   NFAT↓, 1,   PAI-1/SERPINE1↓, 1,   PDGF↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Sema3A/PlexinA1↑, 1,   p‑Smad1↑, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   p‑SMAD5↑, 1,   Smad7↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 2,   TG2/TGase↓, 1,   TGF-β↓, 15,   TGF-β↑, 7,   TGF-β1↓, 5,   TGF-β1↑, 3,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCMig↑, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 7,   TXNIP↑, 2,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 6,   Vim↑, 1,   α-SMA↓, 12,   α-SMA↑, 1,   α-SMA↝, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↑, 5,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   angioG↑, 13,   CD31/PECAM-1↑, 2,   E-sel↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 5,   p‑eNOS↑, 2,   HIF-1↓, 2,   Hif1a↓, 9,   Hif1a↑, 5,   Hif1a↝, 1,   Hif1a∅, 1,   LOX1↓, 2,   NO↓, 72,   NO↑, 7,   TXA2↓, 1,   VCAM-1↓, 15,   VEGF↓, 10,   VEGF↑, 13,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 5,   BBB↑, 100,   BBB↝, 4,   BBB∅, 3,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN5↑, 1,   CX43/GJA1↑, 1,   GastroP↑, 10,   GLUT1↑, 3,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 10,   memfluid↑, 2,   MMP↓, 14,   MMP↑, 67,   MMP⇅, 1,   MMP↝, 2,   MMP∅, 4,   MPT↑, 1,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 1,   THBD↑, 1,   TJ↓, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPC1↓, 1,   TRPC1↑, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV1↑, 6,   TRPV3↑, 1,   VGCC↝, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   AIM2↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 5,   CD8+↑, 1,   COX1↓, 10,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 154,   COX2/PTGS2↑, 2,   COX2/PTGS2∅, 1,   CXCc↓, 1,   CXCL12↑, 1,   CXCL15↓, 1,   CXCR2↑, 1,   CXCR4↓, 2,   DCells↑, 1,   Eos↓, 2,   FOXP3↑, 1,   GM-CSF↓, 1,   GM-CSF↑, 1,   HCAR2↑, 1,   HMGB1↓, 8,   ICAM-1↓, 14,   IFN-γ↓, 15,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 11,   IL1↑, 1,   IL10↓, 18,   IL10↑, 25,   IL12↓, 8,   IL13↓, 2,   IL17↓, 15,   IL17↑, 1,   IL18↓, 8,   IL1α↓, 1,   IL1β↓, 157,   IL1β↑, 2,   IL2↓, 13,   IL2↑, 3,   IL22↓, 2,   IL23↓, 4,   IL33↓, 2,   IL4↓, 11,   IL4↑, 8,   IL5↓, 4,   IL5↑, 1,   IL6?, 1,   IL6↓, 183,   IL6↑, 5,   IL8↓, 27,   IL8↑, 1,   Imm↓, 1,   Imm↑, 26,   Imm⇅, 2,   Imm↝, 2,   INF-γ↓, 3,   INF-γ↑, 1,   Inflam?, 4,   Inflam↓, 598,   Inflam↑, 8,   Inflam∅, 1,   IP-10/CXCL-10↓, 1,   IP-10/CXCL-10↑, 1,   IRF3↓, 2,   LPS↓, 2,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 21,   MCP1/CCL2↑, 2,   MCT1↓, 1,   MIP2↓, 3,   mPGES-1↓, 1,   MyD88↓, 7,   NeuroI↓, 11,   Neut↓, 2,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 248,   NF-kB↑, 4,   p‑NF-kB↓, 6,   NK cell↑, 2,   NLRP3↓, 66,   NLRP3↑, 4,   NOD1↓, 1,   p65↓, 5,   p‑p65↓, 1,   PAF↓, 2,   PAR-2↓, 1,   PGE1↓, 1,   PGE2↓, 45,   PGE2↑, 2,   RAGE↓, 6,   RANTES↓, 4,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 3,   TLR2↓, 5,   TLR3↓, 1,   TLR4↓, 36,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 245,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TREM-1↓, 1,   TRIF↓, 2,   VitD↑, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   GGT/CD224↓, 1,   pH↑, 1,   pH↝, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 3,   5HT↑, 14,   Ach?, 1,   Ach↑, 27,   AChE↓, 111,   AChE↑, 3,   AChE↝, 2,   AChE∅, 1,   ADAM10↑, 7,   ADAM10↝, 1,   BChE↓, 24,   BDNF↓, 3,   BDNF↑, 79,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 2,   CARTPT↑, 1,   ChAT↑, 17,   ChE↓, 1,   DA↑, 1,   EndoR↑, 1,   GABA↓, 3,   GABA↑, 7,   GABA↝, 1,   MAOA↓, 16,   MAOA↑, 1,   MAOA↝, 1,   MAOB↓, 7,   monoA↓, 1,   monoA↑, 2,   NGF↑, 10,   PSD95↑, 7,   RELN↑, 1,   SNAP25↑, 3,   TPH1↓, 1,   TrkB↓, 1,   TrkB↑, 9,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 10,   APOE4↓, 1,   APP↓, 19,   cl‑APP↓, 1,   cl‑APP↑, 1,   Aβ?, 1,   Aβ↓, 185,   Aβ42↓, 10,   BACE/β-secretase↓, 49,   BACE/β-secretase↝, 1,   IDE↑, 1,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 39,   p‑tau↓, 51,   XO↓, 5,   XO↝, 1,   β-Amyloid↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   AhR↑, 2,   AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   END↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   Estro↓, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 2,   NR1H4↑, 1,   PPARα↑, 9,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 24,   p‑PPARγ↓, 1,   PR↝, 1,   RAAS↓, 1,   testos↑, 1,   testos?, 1,   TSHR↓, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv?, 1,   BioAv↓, 122,   BioAv↑, 161,   BioAv⇅, 3,   BioAv↝, 72,   BioAv∅, 2,   BioEnh↑, 9,   ChemoSen↑, 5,   CompStab↑, 4,   CompStab↝, 4,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 6,   CYP3A2↓, 2,   CYP3A4↓, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 9,   Dose⇅, 3,   Dose↝, 143,   Dose∅, 4,   eff↓, 12,   eff↑, 96,   eff↝, 10,   GSTA1↓, 2,   GSTA1↑, 4,   Half-Life↓, 17,   Half-Life↑, 10,   Half-Life↝, 36,   Half-Life∅, 3,   P-gp/ABCB1↓, 5,   P450↓, 4,   P450↑, 2,   P450↝, 1,   selectivity↑, 6,   Synergy↑, 49,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 69,   ALAT↑, 1,   ALB↑, 3,   ALP↓, 15,   anemia↓, 1,   AST↓, 75,   AST↑, 1,   BG↓, 8,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 11,   BMD↑, 7,   BP↓, 30,   BP↝, 1,   BP∅, 1,   p‑BRCA1↑, 1,   BUN?, 1,   BUN↓, 8,   Calcium↝, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 20,   CRP↓, 19,   EGFR↓, 2,   Ferritin↓, 1,   Ferritin↑, 2,   HbA1c↓, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 183,   IL6↑, 5,   IRes↓, 2,   IRes↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 26,   LDH↑, 3,   NLR↓, 1,   NOS2↓, 5,   RAGE↓, 6,   RBC↑, 1,   SpO2↑, 1,   TC↓, 4,   TG/TAG↓, 7,   TMAO↓, 1,   TMAO↑, 2,   Urea↓, 5,   VitD↑, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 3,   AntiAge↑, 30,   antiAll?, 1,   antiAll↑, 38,   AntiArt↑, 17,   AntiCan↓, 3,   AntiCan↑, 59,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 74,   AntiMyl↑, 2,   antiNeop↑, 1,   antiPs↑, 5,   AntiTum↓, 2,   AntiTum↑, 13,   ANXi↓, 1,   Bone Healing↑, 1,   cardioP?, 3,   cardioP↓, 2,   cardioP↑, 188,   cardioP⇅, 1,   cardioP∅, 1,   CardioT↓, 4,   chemoP↑, 35,   chemoPv↑, 13,   cognitive↓, 5,   cognitive↑, 226,   cognitive↝, 1,   cognitive∅, 1,   cough?, 1,   cytoP↑, 1,   diuretic↑, 6,   fatigue↓, 2,   hepatoP↓, 7,   hepatoP↑, 175,   Learn↑, 17,   memory?, 1,   memory↓, 2,   memory↑, 201,   memory∅, 2,   Mood?, 1,   Mood↑, 7,   motorD↓, 2,   motorD↑, 32,   Mucositis↓, 2,   neuroP?, 2,   neuroP↓, 3,   neuroP↑, 426,   NP/CIPN↓, 3,   Obesity↓, 30,   OS↓, 1,   OS↑, 22,   Pain↓, 17,   PDE4↓, 1,   QoL↑, 4,   radioP↑, 32,   RenoP↓, 1,   RenoP↑, 66,   Risk↓, 16,   Sleep↑, 7,   SoreThr?, 1,   Strength↑, 6,   Stress↓, 4,   Stroke↓, 33,   Stroke↝, 1,   Tinn↓, 1,   toxicity?, 4,   toxicity↓, 149,   toxicity↑, 16,   toxicity⇅, 1,   toxicity↝, 31,   toxicity∅, 37,   Weight↓, 8,   Weight↑, 1,   Weight∅, 1,   Wound Healing↓, 2,   Wound Healing↑, 18,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 30,   AntiFungal↓, 2,   AntiFungal↑, 14,   AntiP↓, 1,   AntiP↑, 7,   AntiViral↑, 27,   Bacteria↓, 67,   Diar↓, 4,   GutMicro↑, 70,   Inf↓, 3,   Sepsis↓, 20,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 3,   Ingr↑, 2,   Ingr↝, 16,   Phen↑, 1,   Poly↑, 1,   QC↑, 1,  
Total Targets: 1144

Scientific Paper Hit Count for: ROS, Reactive Oxygen Species
123 Silver-NanoParticles
99 Curcumin
96 Quercetin
95 Magnetic Fields
75 Thymoquinone
59 Radiotherapy/Radiation
58 Resveratrol
57 Vitamin C (Ascorbic Acid)
55 Shikonin
51 Lycopene
50 Berberine
50 Sulforaphane (mainly Broccoli)
47 Hydrogen Gas
46 Luteolin
45 EGCG (Epigallocatechin Gallate)
43 Baicalein
42 Alpha-Lipoic-Acid
40 Selenite (Sodium)
40 Ashwagandha(Withaferin A)
40 Piperlongumine
39 Selenium NanoParticles
38 Artemisinin
37 Betulinic acid
34 Rosmarinic acid
34 Fisetin
33 Cisplatin
33 doxorubicin
33 Melatonin
33 Capsaicin
32 Silymarin (Milk Thistle) silibinin
29 Chemotherapy
29 Apigenin (mainly Parsley)
29 Propolis -bee glue
29 Honokiol
28 Copper and Cu NanoParticles
27 Magnetic Field Rotating
26 Allicin (mainly Garlic)
26 Emodin
26 Gambogic Acid
25 Phenethyl isothiocyanate
23 Chlorogenic acid
23 Chrysin
23 Juglone
23 Kaempferol
22 Licochalcone A
22 Vitamin K2
21 chitosan
20 Coenzyme Q10
19 isoquercitrin
19 isoorientin
18 Boron
18 Ferulic acid
18 Morin
17 salinomycin
17 Ivermectin
17 Parthenolide
16 Urolithin
15 Caffeic acid
15 chaetocin
15 Crocetin
15 Ellagic acid
15 Eugenol
15 Isoliquiritigenin
15 Phenylbutyrate
14 Photodynamic Therapy
14 Auranofin
14 Boswellia (frankincense)
14 Carnosic acid
14 Carvacrol
14 Selenium
13 5-fluorouracil
13 Dichloroacetate
13 Dandelion Root
13 Gallic acid
13 Isovitexin
13 Magnolol
13 Matrine
13 Moringa oleifera
13 Pterostilbene
12 Graviola
12 HydroxyTyrosol
12 Isobavachalcone
12 Methylene blue
12 VitK3,menadione
11 Astaxanthin
11 Cinnamon
11 Ursolic acid
11 Cynaropicrin
11 Hyperthermia
11 Linalool
11 Piperine
10 Beta-Caryophyllene
10 Bacopa monnieri
10 α-Bisabolol / Chamomile oil
10 Mung Bean Sprouts
10 diet FMD Fasting Mimicking Diet
10 Diindolylmethane
10 Ginkgo biloba
10 Hyperoside
10 Plumbagin
10 Nimbolide
9 SonoDynamic Therapy UltraSound
9 Andrographis
9 D-limonene
9 borneol
9 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
9 Centella asiatica / Gotu kola → asiaticoside
9 Hydroxycinnamic-acid
9 Diclofenac
9 Marjoram (Origanum majorana)
8 3-bromopyruvate
8 Rutin
8 Metformin
8 Disulfiram
8 Electrical Pulses
8 Sulfasalazine
8 Vitexin
8 Magnesium
8 Mushroom Lion’s Mane, Hericium erinaceus
8 Propyl gallate
7 EMF
7 Gold NanoParticles
7 Gemcitabine (Gemzar)
7 Docetaxel
7 immunotherapy
7 Berbamine
7 brusatol
7 Carnosine
7 Celastrol
7 methylseleninic acid
7 diet Methionine-Restricted Diet
7 eicosapentaenoic acid
7 Formononetin
7 Garcinol
7 Ginkgetin
6 2-DeoxyGlucose
6 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
6 Anethole/trans-Anethole
6 Biochanin A
6 Butyrate
6 Chlorophyllin
6 Chocolate
6 Citric Acid
6 Carvone
6 Cynara scolymus/Globe Artichoke/Artichoke Extract
6 Lemongrass Extract/Citral
6 Aflavin-3,3′-digallate
6 Fenbendazole
6 Fucoidan
6 HydroxyCitric Acid
6 Lutein
6 Methyl Jasmonate
6 Methylsulfonylmethane
5 1,8-Cineole
5 Brucea javanica
5 Bromelain
5 erastin
5 buckwheat sprouts
5 Thymol-Thymus vulgaris
5 Cichoric acid / Chicoric acid
5 Vitamin E
5 Spermidine
5 Huperzine A/Huperzia serrata
5 Date Fruit Extract
5 Docosahexaenoic Acid
5 Evodiamine
5 Flaxseed/Linseed
5 Lemon Balm/Melissa officinalis
5 Gossypol/AT-101
5 Inositol
5 Methylglyoxal
5 nicotinamide adenine dinucleotide
4 chemodynamic therapy
4 Zinc
4 Paclitaxel/Taxol
4 Cucurbitacin
4 diet Short Term Fasting
4 Ginkgo biloba-EGb 761
4 SDG/lignans
4 Geraniol
4 Ginkgolide B
4 Ginseng
4 γ-linolenic acid (Borage Oil)
4 Hibiscus sabdariffa
4 lambertianic acid
4 Licorice
4 Lactoferrin/Talactoferrin
4 Myricetin
4 Naringin
4 Taurine
3 5-Aminolevulinic acid
3 Anthocyanins
3 Glucose
3 Aromatherapy
3 temozolomide
3 Black phosphorus
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Catechins
3 Choline
3 methotrexate
3 Dihydrocaffeic Acid
3 Oxygen, Hyperbaric
3 Indole-3-carbinol
3 ferumoxytol
3 flavonoids
3 Shilajit/Fulvic Acid
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 Orlistat
3 phytic acid, Inositol hexakisphosphate
3 Modified Citrus Pectin
3 MCT oil
3 Oleuropein
3 α-Santalol/Sandalwood oil
3 Shankhpushpi
3 Terpinen-4-ol / Tea Tree Oil
3 Turmerones
3 Vitamin B1/Thiamine
2 5-Hydroxytryptophan
2 Astragalus
2 DTS(dibenzyl trisulphide) from Anamu
2 Fennel Oil/Foeniculum vulgare
2 Ascorbyl Palmitate
2 Atorvastatin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 Lapatinib
2 xanthohumol
2 Cannabidiol
2 beta-carotene(VitA)
2 Bufalin/Huachansu
2 Bruteridin(bergamot juice)
2 Bullatacin
2 Cat’s Claw
2 Celecoxib
2 Carica papaya leaf extract
2 Calorie Restriction Mimetics
2 Galantamine
2 CUSP9
2 Folic Acid, Vit B9
2 Galloflavin
2 Salvia officinalis
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 iodine
2 isoflavones
2 Potassium
2 mebendazole
2 Vitamin B3,Niacin
2 Niclosamide (Niclocide)
2 Pachymic acid
2 Sanguinarine
2 Psoralidin
2 Radio Frequency
2 Rauwolfia serpentina/Indian Snakeroot
2 Sesame seeds and Oil
2 Iron
2 Salvia miltiorrhiza
2 triptolide
2 Vitamin D3
1 cetuximab
1 Annona atemoya Leaf Extract
1 Annona atemoya Seed Extract
1 Anzaroot, Astragalus fasciculifolius Bioss
1 entinostat
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Angelica archangelica / Garden Angelica
1 Anti-oxidants
1 Sorafenib (brand name Nexavar)
1 tamoxifen
1 almonertinib
1 epirubicin
1 Ras-selective lethal 3
1 Black Seed Oil/Nigella sativa
1 Lecithin
1 Chyawanprash
1 Aspirin
1 Rivastigmine
1 Cyclopamine
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 diet Fermented Foods
1 diet Ketogenic
1 diet Plant based
1 Echinacea
1 Cannabichromene
1 Exercise
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 hydroxychloroquine
1 verapamil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 hydrogen sulfide
1 Helleborus niger extracts – Christmas Rose
1 Rapamycin
1 Inoscavin A
1 Butein
1 Scopoletin
1 Lactobacillus
1 Lapachol
1 Geldanamycin
1 irinotecan
1 magnetic nanoparticles
1 Mangiferin
1 Mistletoe/Viscum album Extracts
1 L-Theanine
1 Myrrh
1 N-Acetyl-Cysteine
1 No Product/Mechanism Only
1 Oleocanthal
1 Oregano
1 sericin
1 Polyphenols
1 benzo(a)pyrene
1 Rhein
1 Perilla
1 Oxaliplatin
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Silicic Acid
1 Squalene
1 Osimertinib
1 Adagrasib
1 Glutathione
1 statins
1 Safflower yellow
1 Terminalia bellirica
1 Triphala
1 Vanillic Acid
1 Vitamin A, Retinoic Acid
1 Vitamin B12
1 Vitamin B2,Riboflavin
1 Vitamin B5,Pantothenic Acid
1 glucose deprivation
1 Transarterial Chemoembolization
1 probiotics
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:275  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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