Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱

Source:

Type: pro-survival proteins

The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.

Scientific Papers found: Click to Expand⟱

84-

QC,

Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression

-

in-vitro,

Pca,

PC3

 25, 50, 75, 100 uM

P21↑, cDC2↓, CDK1↓, CycB/CCNB1↓, Casp3↑, Bcl-2↓, Bcl-xL↓, BAX↑, pRB↓, TumCCA↑, Apoptosis↑,

83-

QC,

Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3

-

in-vitro,

Pca,

PC3

 25, 50, 75, 100 uM

Bcl-2↓, Bcl-xL↓, BAX↑, IGFBP3↑,

79-

QC,

Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats

-

in-vivo,

Pca,

NA

 200 mg/kg/3x/week

 rats

GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,

882-

RES,

Resveratrol: A Double-Edged Sword in Health Benefits

-

Review,

Var,

NA

AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,

881-

RES,

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

PC,

PANC1

-

in-vitro,

Pca,

DU145

TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,

3061-

RES,

The Anticancer Effects of Resveratrol: Modulation of Transcription Factors

-

Review,

Var,

NA

AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27/CDKN1B↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,

3003-

RosA,

Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases

-

Review,

Var,

NA

-

Review,

AD,

NA

-

Review,

Park,

NA

*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,

2446-

SFN,

CAP,

The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor

-

in-vitro,

Pca,

LNCaP

10uM

AR↓, Bcl-xL↓, TumCP↓, Glycolysis↓, HK2↓, PKA↓, Hif1a↓, PSA↓, ECAR↓, BioAv↑, BioAv↓, *toxicity↓,

1469-

SFN,

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

Pca,

NA

orthotopically implanted PC-3 tumors

Synergy↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,

3301-

SIL,

Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

-

Review,

Var,

NA

Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,

3293-

SIL,

Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer

-

Review,

Var,

NA

hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,

3288-

SIL,

Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations

-

Review,

Var,

NA

Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,

2230-

SK,

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer

-

in-vitro,

CRC,

HCT116

-

in-vivo,

NA,

NA

TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,

3950-

Taur,

Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes

-

Review,

Diabetic,

NA

-

Review,

Stroke,

NA

-

Review,

AD,

NA

*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,

2353-

TQ,

The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

-

Review,

PC,

NA

BioAv↝, BioAv↑, MUC4↓, PKM2↓, Synergy↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2/PTGS2↓, PGE1↓,

2120-

TQ,

Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3

-

in-vitro,

Melanoma,

A431

ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,

2121-

TQ,

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

MDA-MB-231

p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,

2084-

TQ,

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

-

Review,

Var,

NA

*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,

2085-

TQ,

Anticancer Activities of Nigella Sativa (Black Cumin)

-

Review,

Var,

NA

MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑, *antiAll↑,

2095-

TQ,

Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ChemoSen↑,

2100-

TQ,

Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant

-

Review,

Var,

NA

ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,

2102-

TQ,

A review on therapeutic potential of Nigella sativa: A miracle herb

-

Review,

Var,

NA

angioG↓, NF-kB↓, PPARγ↓, Bcl-2↓, Bcl-xL↓, MUC4↓, cJun↑, p38↑, P21↑, HDAC↓, *radioP↑, hepatoP↑,

2108-

TQ,

Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa

-

Review,

Var,

NA

HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,

4565-

TQ,

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

-

Review,

BC,

NA

Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,

3414-

TQ,

Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells

-

in-vitro,

RCC,

Caki-1

tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,

3422-

TQ,

Thymoquinone, as a Novel Therapeutic Candidate of Cancers

-

Review,

Var,

NA

selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

3423-

TQ,

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics

-

Review,

Var,

NA

AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,

3429-

TQ,

Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells

-

in-vitro,

AML,

NA

-

in-vivo,

NA,

NA

mouse

DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, CompStab↝, TumCG↓,

2411-

UA,

Ursolic acid in health and disease

-

Review,

Var,

NA

Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

1838-

VitK3,

PDT,

Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways

-

in-vitro,

Cerv,

NA

eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

Showing Research Papers: 151 to 180 of 180
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 180

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 1, antiOx⇅, 1, ARE↑, 1, Catalase↓, 2, Catalase↑, 1, Copper↑, 1, frataxin↑, 1, GPx↓, 1, GPx↑, 1, GPx4↓, 1, GSH↓, 9, GSH↑, 2, GSR↑, 1, H2O2↓, 1, H2O2↑, 1, i-H2O2↑, 1, HO-1↓, 4, HO-1↑, 1, HO-2↓, 1, lipid-P↓, 2, lipid-P↑, 4, MDA↑, 2, NRF2↓, 4, NRF2↑, 5, NRF2↝, 1, ROS?, 1, ROS↓, 3, ROS↑, 73, ROS⇅, 2, ROS↝, 1, ROS∅, 1, mt-ROS↑, 3, SAM-e↝, 1, SOD↓, 5, SOD↑, 1, TAC↓, 1, Trx↑, 1, ox-Trx1↑, 1, TrxR↓, 1, TrxR↑, 1, TrxR1↓, 3,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1, CDC2↓, 2, CDC25↓, 7, compI↓, 1, compIII↓, 1, EGF↓, 1, ETC↓, 2, mtDam↑, 7, OCR↓, 2, PHB↑, 1, PINK1↑, 1, SIRT3↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 2, ACC↑, 1, p‑ACC↑, 1, ACLY↓, 1, ALAT↓, 1, AMPK↓, 2, AMPK↑, 7, p‑AMPK↑, 2, ATP↓, 3, ECAR↓, 1, ECAR↝, 1, ENO1↓, 1, FAO↑, 1, FASN↓, 2, FASN↑, 1, FBPase↑, 1, glucoNG↑, 1, GlucoseCon↓, 3, GlutMet↓, 1, Glycolysis↓, 6, GSK‐3β↓, 3, GSK‐3β↑, 2, p‑GSK‐3β↓, 2, HK2↓, 4, lactateProd↓, 3, LDHA↓, 1, LDL↓, 2, lipidLev↓, 1, NAD↝, 1, NADPH↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 5, PFK1↓, 1, PFK2↓, 1, PKM2↓, 3, PLA2↓, 1, p‑S6↓, 1, SIRT1↓, 2, SIRT1↑, 2, TCA↑, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 4, APAF1↑, 6, Apoptosis↓, 4, Apoptosis↑, 71, Apoptosis↝, 1, mt-Apoptosis↑, 1, ASC↑, 1, BAD?, 1, BAD↓, 1, BAD↑, 15, Bak↑, 13, BAX↓, 2, BAX↑, 66, BAX↝, 1, BAX∅, 1, Bax:Bcl2↓, 1, Bax:Bcl2↑, 7, Bcl-2↓, 117, Bcl-2↑, 2, Bcl-2↝, 1, Bcl-2∅, 1, Bcl-xL↓, 166, Bcl-xL↑, 8, Bcl-xL↝, 2, Bcl-xL∅, 1, BID↓, 1, BID↑, 6, cl‑BID↑, 2, BIM↓, 1, BIM↑, 7, BNIP3↑, 1, Casp↑, 19, cl‑Casp↑, 2, Casp1↓, 1, Casp10↑, 1, Casp2↑, 2, Casp3↓, 1, Casp3↑, 72, Casp3↝, 1, cl‑Casp3↑, 16, proCasp3↑, 1, pro‑Casp3↝, 1, Casp6↑, 3, Casp7↑, 4, cl‑Casp7↑, 2, Casp8↑, 17, cl‑Casp8↑, 4, proCasp8↑, 1, Casp9↓, 1, Casp9↑, 48, cl‑Casp9↑, 9, cFLIP↓, 3, Cyt‑c↓, 1, Cyt‑c↑, 42, Cyt‑c↝, 1, Diablo↑, 4, DR5↑, 10, FADD↑, 3, Fas↑, 8, FasL↑, 5, IAP1↓, 19, IAP2/BIRC3↓, 9, IAP2/BIRC3↑, 1, iNOS↓, 6, JWA↑, 1, Mcl-1?, 1, Mcl-1↓, 32, cl‑Mcl-1↑, 1, MDM2↓, 11, MOMP↑, 1, necrosis↑, 1, NOXA↑, 6, p38↓, 1, p38↑, 4, p‑p38↓, 1, p‑p38↑, 3, PUMA↑, 6, survivin↓, 57, survivin↝, 1, TNFR 1↑, 1, TRAIL↑, 2, TRAILR↑, 1, TumCD↑, 5, XIAP?, 1, XIAP↓, 30, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 43, Akt↑, 4, Akt↝, 1, p‑Akt↓, 14, BRAF↝, 1, CaMKII ↓, 1, p‑cMET↑, 1, cSrc↓, 4, EGFR↓, 7, EGFR↝, 1, ERK↓, 12, ERK↑, 1, p‑ERK↓, 7, p‑ERK↑, 2, HCAR2↑, 1, HER2/EBBR2↓, 3, HGF/c-Met↓, 1, Hippo↑, 1, IGF-1R↓, 2, IKKα↓, 6, IKKα↑, 1, p‑IKKα↓, 3, IκB↓, 2, IκB↑, 1, JAK↓, 2, JAK1↓, 4, JAK2↓, 9, p‑JAK2↓, 3, JNK↓, 1, JNK↑, 9, JNK↝, 1, p‑JNK↓, 1, p‑JNK↑, 2, MAP2K1/MEK1↓, 1, MAPK↓, 11, MAPK↑, 1, MAPK↝, 1, p‑MAPK↑, 1, MARK4↓, 1, MEK↓, 2, p‑MEK↓, 3, p‑MEK↑, 1, mTOR↓, 20, mTOR↑, 2, mTOR↝, 1, p‑mTOR↓, 5, NIK↓, 1, p70S6↑, 1, P70S6K↓, 2, p‑P70S6K↓, 1, p‑P90RSK↑, 1, PI3K↓, 28, PI3K↑, 1, PI3K↝, 1, p‑PI3K↓, 3, PI3K/Akt↓, 2, PI3K/Akt↝, 1, PI3k/Akt/mTOR↓, 1, PIAS-3↑, 1, PKA↓, 2, PKCδ↓, 3, PP2A↑, 1, PRAS40↑, 1, PTEN↓, 1, PTEN↑, 13, PTEN↝, 2, Raf↓, 3, RAS↓, 2, RTK-RAS↓, 1, SHP1↓, 1, SHP1↑, 4, Sp1/3/4↓, 3, Src↓, 2, STAT↓, 2, STAT3↓, 35, STAT3↑, 2, p‑STAT3↓, 10, STAT5↓, 2, STK11/LKB1↑, 1, p‑STK11/LKB1↑, 2, THEM4/CTMP↑, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2, ATF4↑, 5, cJun↓, 1, cJun↑, 2, p‑cJun↑, 1, cMyc↓, 21, cMyc↑, 1, DNMT1↓, 3, DNMT3A↓, 1, DNMTs↓, 3, EZH2↓, 2, FOXM1↓, 2, FOXO↑, 1, FOXO1↓, 1, FOXO3↓, 2, FOXO3↑, 2, GATA3↑, 1, H3↓, 2, ac‑H3↑, 1, H3K27ac↓, 1, ac‑H4∅, 1, HATs↓, 1, HATs↑, 1, HDAC↓, 17, HDAC1↓, 4, HDAC10↓, 1, HDAC2↓, 2, HDAC3↓, 2, HDAC4↓, 1, HES1↓, 1, miR-134↑, 1, miR-139-5p↑, 1, miR-155↓, 1, miR-200b↑, 1, miR-205↑, 1, miR-21↓, 2, miR-210↓, 1, miR-34a↑, 2, miR-34b-5p↑, 1, miR-384↑, 1, Myc↓, 2, OCT4↓, 1, other↓, 3, other↝, 1, Prot↓, 1, SOX2↓, 1, SUV39H↓, 1, TCF-4↓, 1, tumCV↓, 22,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↑, 4, eIF2α↓, 1, eIF2α↑, 1, p‑eIF2α↑, 2, ER Stress↑, 10, GRP78/BiP↑, 3, HSF1↓, 1, HSP27↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 1, HSP90↓, 3, IRE1↑, 2, PERK↑, 2, UPR↑, 2, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↓, 1, ATG3↑, 2, ATG5↑, 3, ATG7↑, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 2, p‑Beclin-1/ATG6↑, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3A↑, 1, LC3B-II↑, 1, LC3I↓, 1, LC3II↑, 4, p62↓, 2, p62↑, 1, PARK2↑, 1, RUBCN↓, 1, TumAuto↑, 14, ULK1/ATG1↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, BRCA1↑, 1, DNAdam↓, 1, DNAdam↑, 15, DNArepair↓, 1, hTERT/TERT↓, 3, MGMT↓, 1, p16↑, 1, P53↓, 2, P53↑, 49, P53↝, 1, p‑P53↓, 1, p‑P53↑, 1, PARP↓, 1, PARP↑, 9, cl‑PARP↑, 47, PARP1↑, 1, PCNA↓, 8, SIRT6↑, 1, Telomerase↓, 4, TOP1↓, 4, TOP2↓, 2, TRF2↓, 1, γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10, CDK2↓, 8, CDK4↓, 12, CDK6↓, 5, CDK8↓, 1, Chk2↓, 1, ChrCon↑, 1, Cyc↓, 3, Cyc↝, 1, cycA1/CCNA1↓, 5, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 15, cycD1/CCND1↓, 57, cycD1/CCND1↝, 1, CycD3↓, 1, cycE/CCNE↓, 4, cycE1↓, 1, GADD45A↑, 1, Ki-67↓, 7, P21↓, 4, P21↑, 35, P21↝, 1, p27/CDKN1B↓, 1, p27/CDKN1B↑, 14, pRB↓, 1, RB1↑, 1, p‑RB1↓, 1, TumCCA↓, 2, TumCCA↑, 72, TumCCA⇅, 1, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, BMI1↓, 1, CD24↓, 1, cFos↓, 2, CSCs↓, 5, Diff↑, 2, Gli1↓, 2, HH↓, 2, IGF-1↓, 4, IGF-2↓, 1, IGFBP3↑, 2, Ki-67↓, 7, Let-7↑, 1, mTORC1↓, 2, Nanog↓, 2, NOTCH↓, 5, NOTCH1↓, 1, NOTCH1↑, 1, NOTCH2↑, 1, PTCH1↓, 1, Shh↓, 2, Smo↓, 1, TumCG?, 1, TumCG↓, 38, TumCP?, 1, TumCP↓, 49, Wnt↓, 5, Wnt/(β-catenin)↓, 3, ZFX↓, 1,

Migration(tgid=13) ⓘ

AP-1↓, 4, AP-1↝, 1, AXL↓, 1, Ca+2↑, 8, Ca+2↝, 3, CAFs/TAFs↓, 1, cal2↑, 1, Cav1↓, 1, E-cadherin↑, 12, EMT↓, 18, EMT↑, 1, FAK↓, 6, p‑FAK↓, 1, Fibronectin↓, 1, GIT1↓, 1, ITGB1↓, 1, ITGB3↓, 1, LRP1↓, 1, MMP-10↓, 2, MMP1↓, 2, MMP13↓, 1, MMP16↓, 1, MMP2↓, 26, MMP2↝, 1, MMP3↓, 3, MMP7↓, 3, MMP9↓, 36, MMPs↓, 14, MTA1↓, 1, MUC4↓, 3, N-cadherin↓, 5, PDGF↓, 1, Rac1↓, 1, Rho↓, 1, ROCK1↓, 3, Slug↓, 2, SMAD3↓, 1, SMAD3↑, 1, Snail↓, 8, TET1↑, 1, TGF-β↓, 4, TIMP1↓, 1, TIMP1↑, 2, TIMP2↓, 2, TSC1↑, 1, TumCI?, 1, TumCI↓, 13, TumCI↑, 1, TumCMig↓, 11, TumMeta↓, 17, TumMeta↑, 2, Twist↓, 9, Tyro3↓, 1, uPA↓, 8, Vim↓, 12, Zeb1↓, 6, α-tubulin↓, 1, α-tubulin↑, 1, β-catenin/ZEB1↓, 7, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29, angioG↑, 1, CD31/PECAM-1↓, 5, Endoglin↑, 1, HIF-1↓, 1, Hif1a↓, 20, Hif1a↑, 1, NO↑, 2, VEGF↓, 43, VEGF↑, 1, VEGF↝, 1, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 3,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, CLDN1↓, 1, CTR1↑, 1, EPR↑, 1, GLUT1↓, 2, MMP?, 1, MMP↓, 40, MMP↑, 1, MPT↑, 2, NHE1↓, 1, SLC12A5↝, 1, TRPM7↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1, cDC2↓, 2, COX1↓, 1, COX2/PTGS2↓, 30, COX2/PTGS2↑, 1, COX2/PTGS2↝, 1, CXCR2↓, 1, CXCR4↓, 7, CXCR4↑, 1, DR4↑, 3, HCAR2↑, 1, ICAM-1↓, 6, IFN-γ↑, 1, IL1↓, 2, IL10↓, 2, IL1α↓, 1, IL1β↓, 4, IL2↓, 1, IL2↑, 1, IL6↓, 16, IL6↑, 1, IL6↝, 1, IL8↓, 2, Imm↑, 2, Inflam↓, 12, MCP1/CCL2↓, 1, MDSCs↓, 1, NAF1↓, 1, NF-kB↓, 65, NF-kB↝, 1, p‑NF-kB↓, 1, NLRP3↓, 1, NLRP3↑, 1, p50↓, 1, p65↓, 4, p‑p65↓, 2, ac‑p65↓, 1, ac‑p65↑, 2, PD-L1↓, 5, PGE1↓, 1, PGE2↓, 8, PSA↓, 3, PSA↝, 1, TLR4↓, 3, TNF-α↓, 14, TNF-α↝, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3, TRAF1↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1, AR↓, 5, AR↝, 1, PPARα↓, 1, PPARγ↓, 2, SXR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 9, BioAv↑, 12, BioAv↝, 1, BioEnh↑, 1, ChemoSen↑, 41, CompStab↑, 2, CompStab↝, 2, CYP1A1↓, 1, CYP1A2↓, 1, CYP3A4↓, 1, Dose?, 3, Dose↑, 1, Dose↝, 12, Dose∅, 1, eff↓, 25, eff↑, 22, Half-Life↓, 2, Half-Life↝, 2, Half-Life∅, 1, MDR1↓, 2, MRP1/ABCC1↝, 1, P-gp/ABCB1↓, 6, P450↓, 2, RadioS↑, 10, selectivity↑, 23, selectivity↝, 1, Synergy↑, 28,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 1, ALP↓, 1, AR↓, 5, AR↝, 1, ascitic↓, 1, BRAF↝, 1, BRCA1↑, 1, EGFR↓, 7, EGFR↝, 1, EZH2↓, 2, FOXM1↓, 2, HER2/EBBR2↓, 3, hTERT/TERT↓, 3, IL6↓, 16, IL6↑, 1, IL6↝, 1, LDH↓, 1, Maspin↑, 1, Myc↓, 2, PD-L1↓, 5, PSA↓, 3, PSA↝, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8, AntiTum↑, 6, cardioP↑, 3, chemoP↑, 8, chemoPv↑, 4, hepatoP↑, 8, neuroP↑, 3, Obesity↓, 1, OS↑, 1, QoL↑, 1, radioP↑, 3, RenoP↑, 3, Risk↓, 1, toxicity↓, 6, toxicity↝, 1, TumVol↓, 14, TumW↓, 7, Weight∅, 2,

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↝, 1,
Total Targets: 645

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 12, Catalase↑, 8, Fenton↓, 1, GPx↑, 4, GSH↑, 5, GSR↑, 1, GSTs↑, 3, HO-1↑, 2, lipid-P↓, 1, MDA↓, 2, MPO↓, 1, MPO↑, 1, NOX↓, 1, NOX4↓, 1, NQO1↑, 1, NRF2↑, 4, RNS↓, 3, ROS↓, 17, ROS∅, 1, SOD↓, 1, SOD↑, 8, SOD1↑, 1, SOD2↑, 1, TBARS↓, 1, VitE↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1, ALAT↓, 1, AMPK↑, 1, NAD↑, 1, NADPH↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3, BAD↓, 1, BAX↓, 1, BAX↑, 1, Bcl-2↑, 1, Bcl-xL↓, 1, Bcl-xL↑, 2, Casp3↓, 3, Casp9↓, 1, Cyt‑c↑, 1, iNOS↓, 2, p38↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1, p‑Akt↓, 1, p‑Akt↑, 1, p‑ERK↑, 1, IGF-1R↓, 1, JAK↓, 1, JAK2↑, 1, PDGFR-BB↓, 1, PI3K↑, 1, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, other↓, 2, other↝, 3, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1, HSP70/HSPA5↑, 1, UPR↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1, TumCP↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 1, AP-1↓, 1, Ca+2↓, 1, Ca+2↝, 1, cal2↓, 1, MMP2↓, 1, MMP9↓, 1, PAI-1/SERPINE1↓, 1, TumCI↓, 1, TumCMig↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1, NO↓, 2, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, GLUT1↑, 1, GLUT3↑, 1, MMP↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↑, 1, COX2/PTGS2↓, 4, FOXP3↑, 1, HMGB1↓, 2, IL10↑, 1, IL1β↓, 3, IL2↑, 1, IL4↑, 1, IL6↓, 4, IL8↓, 1, Imm↑, 1, Inflam↓, 13, Inflam↑, 1, M2 MC↑, 1, MCP1/CCL2↓, 1, NF-kB↓, 7, NLRP3↓, 1, PGE2↓, 2, TNF-α↓, 3, Treg lymp↝, 1, β-HEX↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8, BioAv↑, 2, BioAv↝, 2, BioAv∅, 1, Dose↓, 1, Dose↑, 1, Dose↝, 2, Dose∅, 1, eff↑, 3, GSTA1↑, 1, Half-Life↝, 2, Half-Life∅, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 2, BP↓, 1, BUN↓, 1, CRP↓, 1, IL6↓, 4, LDH↓, 1, SpO2↑, 1,

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 5, AntiArt↑, 2, AntiCan↑, 4, antiD↓, 1, AntiDiabetic↑, 2, antiPs↑, 1, AntiTum↑, 1, cardioP↑, 2, chemoP↑, 1, chemoPv↑, 1, hepatoP↓, 1, hepatoP↑, 2, memory↑, 2, neuroP?, 1, neuroP↑, 8, Obesity↓, 2, OS↑, 1, radioP↑, 3, RenoP↑, 1, Stress↓, 1, Stroke↓, 2, toxicity↓, 5, toxicity∅, 2, Weight↑, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3, AntiFungal↓, 1, AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 3, Bacteria↑, 1, Sepsis↓, 1,
Total Targets: 161

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL

14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
6 Gossypol/AT-101
6 Morin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
4 Sulforaphane (mainly Broccoli)
3 Cisplatin
3 Benzyl isothiocyanate
3 Boswellia (frankincense)
3 Fisetin
3 Gambogic Acid
3 Ginkgetin
3 Indole-3-carbinol
3 Phenethyl isothiocyanate
3 lambertianic acid
3 Luteolin
3 Mangiferin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Nimbolide
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Silver-NanoParticles
2 Paclitaxel/Taxol
2 Artemisinin
2 Berbamine
2 Beta-Caryophyllene
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 chaetocin
2 Cucurbitacin
2 Docetaxel
2 Ursolic acid
2 Ellagic acid
2 Garcinol
2 Honokiol
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Linalool
2 doxorubicin
2 Phenylbutyrate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Camptothecin
1 Anethole/trans-Anethole
1 Berberine
1 Betulinic acid
1 brusatol
1 Black turtle bean
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cranberry
1 Gemcitabine (Gemzar)
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 D-limonene
1 Emodin
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Formononetin
1 Isoliquiritigenin
1 Ginger/6-Shogaol/Gingerol
1 carboplatin
1 Chemotherapy
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Hyperthermia
1 Hyperoside
1 Isobavachalcone
1 Isothiocyanates
1 Allyl isothiocyanate
1 Juglone
1 Kaempferol
1 Licorice
1 Magnolol
1 mebendazole
1 Magnetic Fields
1 Moringin
1 Melatonin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Neem
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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