TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1/ATG6↑, p62↓, MMP↓, ROS↑, TumAuto⇅, Synergy↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, Synergy↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
7056- GamB,    Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy
- in-vitro, RCC, 786-O
ER Stress↑, TumAuto↑, ROS↑, PrxI↓, Apoptosis↑, BID↑, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7267- Gink,    Neuroprotective Potential of Biflavone Ginkgetin: A Review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Aβ↓, *Inflam↓, *Dose↝, *cardioP↑, TumCCA↑, Apoptosis↑, TumAuto↑, STAT↓, *Stroke↓,
7265- Gink,    Ginkgetin targets GRP78 to induce dual pathways of ER stress and immune activation in osteosarcoma
- vitro+vivo, OS, NA
GRP78/BiP↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumAuto↑, PERK↑, eIF2α↑, ATF4↑, TumCG↓, TumMeta↓, Synergy↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7312- Gos,    A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
- vitro+vivo, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
eff↑, TumAuto↑, TumCG↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Apoptosis↑, eff↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
854- Gra,  AgNPs,    Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
- vitro+vivo, AML, THP1 - in-vitro, AML, AMJ13 - vitro+vivo, lymphoma, HBL
TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,
3787- H2,    Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis
- Review, AD, NA
*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
1627- HCA,  CRMs,  Sper,    Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
- Review, Var, NA
ChemoSen↑, Synergy↑, ACLY↓, LC3‑Ⅱ/LC3‑Ⅰ↑, TumAuto↑, other↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1441- HCQ,  Chemo,    Case report: stage 4 pancreatic cancer to remission using paricalcitol and hydroxychloroquine in addition to traditional chemotherapy
- Case Report, GBM, NA
TumAuto↓, Remission↑,
1439- HCQ,    Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine
- in-vitro, Melanoma, NA - in-vitro, CRC, HCT116
TumAuto↓, eff↓, other↓,
7505- HCQ,  GEM,  PacT,    A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients
- Trial, PC, NA
eff↑, TumAuto↓, Imm↑, CA19-9↓, OS↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7355- HibSad,    Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, ER-α36↓, BRCA1↓, Cav1↓, Proteasome↓, TumAuto↑, TumCMig↓, TumCI↓,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,
7344- Hne,    Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy
- in-vitro, Cerv, HeLa
tumCV↓, ROS↑, eff↓, TumAuto↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7547- HYP,    Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, TumAuto↑, ATG13↑,
7552- HYP,    Hyperoside exerts potent anticancer activity in skin cancer
- vitro+vivo, Melanoma, NA
AntiCan↑, *Inflam↓, *antiOx↑, PI3K↓, Akt↓, mTOR↓, TumCP↓, Apoptosis↑, TumAuto↑, chemoPv↑,
7775- IBC,    Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells
- vitro+vivo, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Necroptosis↑, TumAuto↑, Akt↓, BAX↑, cl‑Casp3↑, RIP3↑, p‑RIP3↑, MLKL↑, LC3‑Ⅱ/LC3‑Ⅰ↑, mtDam↑, ATP↓, ROS↑, TumCG↓,
8280- ISL,    ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
- vitro+vivo, HCC, SMMC-7721 cell
tumCV↓, TumCP↓, Apoptosis↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, TumCG↓, LC3II↑, cl‑Casp3↑, eff↑,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
9177- ITCs,  SFN,    Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
- Review, Var, NA
CSCs↓, GutMicro↑, Bacteria↓, TumCCA↑, Apoptosis↑, TumAuto↑, angioG↓, TumCI↓, TumMeta↓, NRF2↑, Glycolysis↓, Wnt↓, β-catenin/ZEB1↓, HH↓, NOTCH↓, NK cell↑, EMT↓, angioG↓, BioAv↓, BioAv↑, AntiBio↑, Bacteria↓, HK2↓, PDH↓, OXPHOS↓, AKT1↓, ACC1↓, FASN↓, ACC-α↓, ACLY↓, SREBP1/SREBF1↓, OCT4↓, Nanog↓, YAP/TEAD↓, miR-21↓, miR-29b↓, ALDH1A1↓, miR-140↑, CD44↓, BMI1↓, miR-200c↑, TumCG↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, α-SMA↓, Slug↓, Snail↓, Twist↓, DNAdam⇅, BioAv↓, ChemoSen↑,
2177- itraC,    Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression
- Study, Colon, NA - in-vitro, CRC, COLO205 - in-vitro, CRC, HCT116
OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, ChemoSen↑,
8011- itraC,    Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, SkBr3
MMP↓, Bcl-2↓, Casp3↑, TumAuto↑, LC3II↑, p62↓, HH↓, Shh↓, Gli1↓, Apoptosis↑, TumVol↓, eff↑, TumCCA↑,
7985- itraC,    Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking
- vitro+vivo, GBM, U87MG - vitro+vivo, GBM, C6
TumCP↓, TumAuto↑, SCP2↓, AKT1↓, mTOR↓, other↝,
8019- itraC,    Itraconazole Inhibits AKT/mTOR Signaling and Proliferation in Endometrial Cancer Cells
- in-vitro, Endo, AN3CA - in-vitro, Endo, HEC-1A - in-vitro, Endo, HEC-50B - in-vitro, Endo, SNG-II
*AntiFungal↑, TumCP↓, mTOR↓, LC3II↑, TumAuto↑, Akt↓,
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, AntiTum↑, ER Stress↑, TumAuto↑, ATF4↑, CHOP/DDIT3↝, TumCG↓, PERK↑, ROS↑, *toxicity↓, Ca+2↑,
8035- IVM,    Ivermectin and non-parasitic disorders: An update
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*AntiP↑, angioG↓, *AntiCan↓, mtDam↑, Apoptosis↑, necrosis↑, TumAuto↑, ROS↑, *neuroP↑, *Stroke↝, *cardioP↑,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8020- IVM,    Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
- vitro+vivo, BC, NA
AntiP↑, TumAuto↑, Akt↓, mTOR↓, PAK1↓, selectivity↑,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,

Showing Research Papers: 151 to 200 of 320
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 320

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↓, 1,   Catalase↓, 4,   Catalase↑, 5,   DJ-1↓, 1,   Fenton↑, 3,   GPx↓, 1,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 14,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 2,   H2O2↑, 8,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 3,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 7,   MDA↓, 2,   MDA↑, 5,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 4,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PrxII↓, 1,   ROS↓, 14,   ROS↑, 169,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TKT↓, 1,   TrxR↓, 2,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6,   FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 8,   compI↓, 4,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 27,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 5,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↝, 1,   PINK1↑, 5,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AApath↓, 1,   ACC↓, 1,   ACC-α↓, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 26,   p‑AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↝, 1,   CRM↑, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLS↑, 1,   glucose↓, 2,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK1↓, 1,   HK2↓, 15,   HK2↑, 1,   HMG-CoA↓, 3,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 4,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 10,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   SREBP1/SREBF1↓, 2,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 183,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 1,   BAX↓, 1,   BAX↑, 50,   Bax:Bcl2↑, 15,   Bcl-2↓, 57,   Bcl-2↑, 1,   Bcl-xL↓, 12,   Bcl-xL↑, 2,   BID↑, 2,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   BNIP3↝, 2,   Casp↑, 16,   cl‑Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp12↑, 2,   Casp3↓, 2,   Casp3↑, 62,   cl‑Casp3↑, 29,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   proCasp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↑, 1,   CellShr↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 41,   DR5↑, 9,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 20,   GRP58↓, 1,   IAP1↓, 4,   ICD↑, 2,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 5,   Necroptosis↑, 4,   necrosis↑, 8,   NOXA↑, 1,   oncosis↑, 2,   P2X7↓, 1,   p38↓, 4,   p38↑, 11,   p‑p38↑, 3,   Paraptosis↑, 2,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 20,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 18,   XIAP↓, 7,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 87,   Akt↑, 4,   p‑Akt↓, 21,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 3,   BCAP↓, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 13,   ERK↓, 17,   ERK↑, 3,   ERK↝, 2,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   GNAI1↓, 1,   HER2/EBBR2↓, 6,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 2,   JAK3↓, 1,   JNK↓, 3,   JNK↑, 18,   p‑JNK↑, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 14,   MAPK↑, 11,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   MEK↑, 1,   MKK4↓, 1,   mTOR↓, 75,   mTOR↑, 7,   mTOR∅, 1,   p‑mTOR↓, 13,   p‑mTOR↑, 1,   mTORC2↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 6,   P70S6K↑, 1,   p‑P70S6K↓, 1,   p‑P70S6K↑, 1,   PDE3B↓, 1,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 64,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3k/Akt/mTOR↓, 2,   PIK3CA↑, 1,   p‑PIK3R1↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 5,   Rictor↓, 1,   RIP1↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   STAT↓, 2,   STAT3↓, 19,   STAT3↑, 3,   STAT3↝, 2,   p‑STAT3↓, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 7,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 10,   cMyc↑, 2,   p‑cMyc↑, 1,   COMP↓, 1,   CREBBP↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   FOXO4↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC∅, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-199↓, 1,   miR-200c↑, 1,   miR-21↓, 4,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 2,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 4,   other↝, 17,   SOX2↓, 1,   SOX4↓, 2,   SUV39H↓, 1,   TFAP2A↓, 1,   TFE3↑, 2,   tumCV?, 1,   tumCV↓, 41,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 19,   CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 50,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 10,   HSP90↑, 1,   HSPs↑, 1,   IRE1↓, 1,   IRE1↑, 2,   p‑IRE1↑, 1,   PDI↑, 2,   PERK↑, 7,   Proteasome↓, 1,   UPR↑, 6,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 5,   ATG5↑, 17,   ATG5↝, 1,   ATG7↑, 7,   autoF↓, 2,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 49,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 2,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   CTSZ↓, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 14,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↓, 1,   LC3B-II↑, 11,   LC3I↓, 1,   LC3I↑, 2,   LC3II↑, 41,   LC3s↓, 1,   LC3s↑, 3,   LC3s↝, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 3,   MitoP↑, 3,   p62↓, 28,   p62↑, 11,   PARK2↑, 4,   RUBCN↓, 1,   TFEB↑, 1,   TumAuto?, 1,   TumAuto↓, 16,   TumAuto↑, 299,   TumAuto⇅, 2,   TumAuto↝, 3,   mt-TumAuto↑, 2,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↑, 1,   DNAdam↑, 31,   DNAdam⇅, 1,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 3,   P53↑, 45,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 10,   p‑PARP↑, 1,   cl‑PARP↑, 34,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   Telomerase↓, 4,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 6,   CDK2↑, 2,   CDK4↓, 6,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDKN1C/p57↓, 1,   p‑CHK1↑, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 18,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 11,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 8,   RB1↑, 1,   TumCCA↓, 3,   TumCCA↑, 96,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 3,   ALDH↓, 2,   ALDH1A1↓, 1,   BMI1↓, 3,   BMP2↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 24,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   Gli1↓, 2,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 3,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LGR5↓, 1,   mTORC1↓, 9,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 60,   TumCG↑, 1,   TumCG⇅, 1,   TumCP?, 1,   TumCP↓, 106,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 23,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AP-1↓, 2,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 19,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   COL1↓, 2,   COL2A1↓, 1,   COL4A3↓, 1,   COL9A3↓, 1,   E-cadherin↑, 14,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 5,   FAK↑, 1,   Fibronectin↓, 1,   GLI2↓, 1,   GP1BB↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 2,   LAMA5↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 5,   MMP9↓, 34,   MMP9:TIMP1↓, 1,   MMPs↓, 7,   MTA1↓, 1,   N-cadherin↓, 7,   NCAM↑, 1,   PAK1↓, 3,   PAK1↑, 1,   RECK↑, 1,   Rho↓, 1,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   Smad1↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 9,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 4,   TSC1↑, 1,   TumCA↓, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 49,   TumCMig↓, 42,   TumMeta↓, 37,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 6,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 3,   ZEB2↓, 1,   α-SMA↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50,   angioG↑, 2,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   NO↓, 2,   NO↑, 3,   TYMP/ECGF1↓, 1,   VCAM-1↓, 1,   VEGF↓, 30,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 72,   MMP↑, 1,   MPT↑, 5,   TRPM7↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD59↑, 1,   COX2/PTGS2↓, 25,   COX2/PTGS2↑, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 3,   DR4↑, 4,   FOXP3↑, 2,   Gal1↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 3,   IL17↓, 1,   IL1β↓, 6,   IL1β↑, 1,   IL2↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 14,   Imm↝, 3,   Inflam↓, 20,   Inflam↝, 1,   IRAK1↓, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 51,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 7,   PSA↓, 1,   RAGE↓, 2,   T-Cell↑, 1,   TCF↓, 1,   TCF↝, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 11,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   e-pH↑, 2,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 4,   CYP19↓, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 22,   BioAv↑, 19,   BioAv↝, 5,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 77,   CompStab?, 1,   CompStab↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 32,   Dose∅, 7,   eff↓, 46,   eff↑, 57,   eff↝, 5,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 3,   MDR1↓, 7,   P-gp/ABCB1↓, 12,   P-gp/ABCB1↝, 1,   P450↓, 1,   RadioS↑, 27,   selectivity↓, 1,   selectivity↑, 37,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 57,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 4,   AST↓, 2,   BRCA1↓, 1,   BRCA1↝, 1,   CA19-9↓, 1,   CEA↓, 1,   EGFR↓, 13,   EZH2↓, 2,   Ferritin↓, 6,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 13,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 2,   PD-L1↓, 4,   PSA↓, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 33,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 4,   CardioT↑, 1,   chemoP↑, 11,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 1,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 9,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 3,   TumVol↓, 21,   TumW↓, 13,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 896

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 7,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 3,   HO-1?, 1,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 8,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 11,   ROS↓, 29,   ROS↑, 1,   SOD↑, 10,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   mtDam↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   glucose↓, 2,   glucose↝, 1,   H2S↑, 1,   LDL↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   HOTAIR↑, 1,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 31,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NLRP3↓, 3,   NLRP3↑, 2,   PGE2↓, 2,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 4,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 5,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose⇅, 2,   Dose↝, 10,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   BP↓, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 9,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 8,   AntiTum↑, 4,   cardioP↑, 17,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 6,   cough?, 1,   hepatoP↑, 11,   memory↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 21,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 4,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 6,   Stroke↝, 1,   toxicity?, 1,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 11,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 178

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Ivermectin
6 Magnetic Fields
6 Baicalein
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Matrine
5 Melatonin
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 hydroxychloroquine
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 diet Short Term Fasting
3 Fisetin
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Sulforaphane (mainly Broccoli)
3 Isovitexin
3 Licorice
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Metformin
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Cranberry
2 Resveratrol
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Formononetin
2 Paclitaxel/Taxol
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Methyl Jasmonate
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Propolis -bee glue
2 Phycocyanin
2 Psoralidin
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Allyl isothiocyanate
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Ferulic acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Gemcitabine (Gemzar)
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 isoorientin
1 Isothiocyanates
1 Vitexin
1 Magnolol
1 mebendazole
1 immunotherapy
1 Magnetic Field Rotating
1 Magnesium
1 Morin
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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