TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
509- MF,    Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields
- Review, NA, NA
Ca+2↑, TumAuto↑, Apoptosis↑, angioG↓, ROS↑,
227- MFrot,  MF,    Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway
- in-vivo, Lung, A549 - in-vitro, Lung, A549
TumCG↓, miR-486↑, BCAP↓, Apoptosis↑, ROS↑, TumAuto↑, LC3II↑, ATG5↑, Beclin-1↑, p62↑, TumCP↓,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,
1801- NarG,    A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations
- Review, Var, NA
AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, eff↑, BioEnh↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1↓, p62↑, PI3K↓, chemoPv↑,
4976- Nimb,    Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition
- vitro+vivo, PC, NA
ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1↑, other↝, other↝,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
4946- PEITC,    Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,
4921- PEITC,    The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, HDAC↓, Risk↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
5214- PI,    Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW48 - in-vitro, CRC, SW-620
TumCP↓, TumAuto↑, Akt↓, mTOR↓, ROS↑,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27↑, P53↑, Casp9↑, Casp3↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
4967- PSO,    Psoralidin's Anti-Cancer Mechanisms: A Technical Guide
- Review, Var, NA
NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,
1993- PTL,    Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer
- in-vitro, Cerv, HeLa
tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,
4704- PTS,  Cisplatin,    Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS
- in-vitro, Bladder, NA
PI3K↓, mTOR↓, P70S6K↓, MEK↑, ERK↑, ChemoSen↑, TumAuto↑,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
63- QC,    Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
- in-vitro, Pca, NA
RAGE↓, PI3K↓, mTOR↓, Akt↓, Apoptosis↑, TumAuto↑, ChemoSen↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, NA, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4912- Sal,    Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157
CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP↑, AKT1↓, mTOR↓,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
6447- SAO,    Autophagy Induction by α-Santalol in Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
p‑Akt↓, p‑mTOR↓, TumAuto↑,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF-7
LC3II↑, Beclin-1↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,
5101- SK,    Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
- vitro+vivo, CRC, SW-620 - vitro+vivo, CRC, HCT116
Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2229- SK,    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
- in-vitro, Melanoma, A375
Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1↑, ROS↑, eff↓,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
4894- Sper,    Application of Spermidine in Cancer Research Models: Notes and Protocols
- Review, Var, NA
TumAuto↑, AntiTum↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,
4897- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA
Inflam↓, TumAuto↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Bcl-2↓,
1018- SSE,    Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW480
TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1↑, p62↓, ROS↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,

Showing Research Papers: 151 to 200 of 214
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 214

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   Ferroptosis↑, 2,   GPx4↓, 1,   GSH↓, 6,   H2O2↑, 3,   Iron↑, 3,   lipid-P↑, 1,   MDA↑, 1,   NAF1↓, 1,   NRF2↑, 1,   OXPHOS↓, 2,   OXPHOS↝, 1,   ROS↑, 36,   mt-ROS↑, 2,   SIRT3↑, 1,   SOD↓, 1,   TrxR1↓, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 9,   CDC2↓, 1,   EGF↓, 1,   ETC↓, 1,   MEK↓, 1,   MEK↑, 1,   MKK4↓, 1,   MMP↓, 14,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 4,   OCR↓, 3,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMP↑, 1,   AMPK↑, 3,   BCAP↓, 1,   cMyc↓, 1,   CRM↑, 1,   CYP3A4↓, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 8,   HK2↓, 4,   lactateProd↓, 3,   LDH↓, 4,   LDHA↓, 1,   PFK↓, 1,   PFKP↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 7,  

Cell Death ⓘ

Akt↓, 13,   p‑Akt↓, 2,   Apoptosis?, 2,   Apoptosis↑, 28,   ATF2↓, 1,   BAD↑, 1,   BAX↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 12,   Bcl-xL↓, 2,   BID↑, 1,   BMP2↓, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 10,   cl‑Casp3↑, 5,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 6,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 2,   GRP58↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   iNOS↑, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   Myc↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   p27↑, 3,   p38↓, 1,   p38↑, 2,   p‑p38↑, 1,   RIP1↓, 1,   survivin↓, 2,   Telomerase↓, 2,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 4,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 4,   p‑eIF2α↑, 1,   ER Stress↑, 7,   IRE1↓, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   ATG5↑, 3,   autoF↓, 1,   Beclin-1↓, 1,   Beclin-1↑, 7,   BNIP3?, 1,   BNIP3↝, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3I↑, 1,   LC3II↑, 6,   LC3s↑, 1,   lysosome↓, 1,   p62↓, 3,   p62↑, 2,   TFEB↑, 1,   TumAuto↓, 1,   TumAuto↑, 50,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   DNArepair↑, 1,   DNMT1↓, 1,   P53↑, 8,   p‑P53↑, 1,   cl‑PARP↑, 4,   cl‑PARP↝, 1,   TP53↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   P21↓, 1,   P21↑, 6,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CSCs↓, 9,   CSCsMark↓, 1,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,   EMT↓, 5,   ERK↓, 2,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 2,   Gli1↓, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   mTOR↓, 11,   mTOR↑, 1,   p‑mTOR↓, 1,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 10,   PTCH1↓, 1,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   Src↓, 1,   STAT3↓, 3,   TumCG↓, 5,   TumCG⇅, 1,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↑, 2,   CD31↓, 1,   F-actin↓, 1,   FAK↓, 2,   GLI2↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   Ki-67↓, 1,   LAMP1?, 1,   miR-486↑, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 4,   RAGE↓, 1,   RIP3↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 6,   TumCP↓, 16,   TumMeta↓, 4,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 2,   eNOS↑, 1,   Hif1a↓, 4,   NO↑, 1,   PDI↑, 1,   VEGF↓, 6,  

Barriers & Transport ⓘ

GLUT1↓, 3,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CTSZ↓, 1,   Gal1↑, 1,   IL10↓, 3,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 4,   NF-kB↓, 6,   NF-kB↑, 2,   NK cell↑, 1,   p65↓, 1,   TLR4↓, 2,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

e-pH↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 3,   BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 10,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 1,   Dose∅, 3,   eff↓, 9,   eff↑, 16,   eff↝, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 2,   Ferritin↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 4,   Myc↓, 1,   RAGE↓, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↑, 3,   cardioP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 1,   OS↑, 3,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 276

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   GPx1↑, 1,   ROS↓, 3,   ROS↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 1,   IL17↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   Dose⇅, 1,   Dose↝, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   RenoP↑, 1,   toxicity↝, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 35

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Baicalein
6 EGCG (Epigallocatechin Gallate)
5 Celastrol
5 Eugenol
5 Gambogic Acid
5 Spermidine
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 diet Short Term Fasting
3 hydroxychloroquine
3 Luteolin
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Ashwagandha(Withaferin A)
2 Boron
2 Chrysin
2 Resveratrol
2 Dichloroacetate
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 HydroxyCitric Acid
2 Honokiol
2 itraconazole
2 Nimbolide
2 Propolis -bee glue
2 Psoralidin
2 Sulforaphane (mainly Broccoli)
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Metformin
1 Bufalin/Huachansu
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Graviola
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 immunotherapy
1 Magnetic Field Rotating
1 Mushroom Chaga
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Phenylbutyrate
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 Cisplatin
1 α-Santalol/Sandalwood oil
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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