| Source: HalifaxProj(activate) |
| Type: |
| Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17. Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context. Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy. |
| 4900- | Sal, | Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications |
| - | Review, | BC, | NA |
| 5003- | Sal, | Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review |
| - | Review, | Var, | NA |
| 4904- | Sal, | CUR, | Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition |
| 4906- | Sal, | A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022) |
| - | Review, | BC, | NA |
| 4912- | Sal, | Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H460 | - | in-vitro, | Lung, | Calu-1 | - | in-vitro, | Lung, | H157 |
| 5124- | Sal, | Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance |
| - | in-vitro, | BC, | NA |
| 2445- | SFN, | Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | SkBr3 |
| 1455- | SFN, | Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Nor, | 1321N1 |
| 3298- | SIL, | Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells |
| - | in-vitro, | BC, | MCF-7 |
| 2410- | SIL, | Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF |
| - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | U251 | - | in-vivo, | NA, | NA |
| 2415- | SK, | Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways |
| - | in-vivo, | Arthritis, | NA |
| 2355- | SK, | Pharmacological properties and derivatives of shikonin-A review in recent years |
| - | Review, | Var, | NA |
| 2232- | SK, | Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis |
| - | in-vitro, | ESCC, | EC9706 |
| 2229- | SK, | Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways |
| - | in-vitro, | Melanoma, | A375 |
| 5101- | SK, | Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis |
| - | vitro+vivo, | CRC, | SW-620 | - | vitro+vivo, | CRC, | HCT116 |
| 4891- | Sper, | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 4894- | Sper, | Application of Spermidine in Cancer Research Models: Notes and Protocols |
| - | Review, | Var, | NA |
| 4895- | Sper, | Spermidine as a target for cancer therapy |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 4897- | Sper, | Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms |
| - | Review, | Var, | NA |
| 1018- | SSE, | Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo |
| - | vitro+vivo, | CRC, | HCT116 | - | vitro+vivo, | CRC, | SW480 |
| 5074- | SSE, | Application of Sodium Selenite in the Prevention and Treatment of Cancers |
| - | Review, | Var, | NA |
| 5110- | SSE, | Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells |
| - | in-vitro, | AML, | APL NB4 |
| 5105- | SSE, | Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells |
| - | in-vitro, | Pca, | LNCaP |
| 5086- | SSE, | Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells |
| - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | T98G | - | in-vitro, | GBM, | A172 |
| 2350- | UA, | Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | MDA-MB-231 |
| 5021- | UA, | Anticancer effect of ursolic acid via mitochondria-dependent pathways |
| - | Review, | Var, | NA |
| 4833- | Uro, | Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | IBD, | NA |
| 4837- | Uro, | Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review |
| - | Review, | Var, | NA |
| 4847- | Uro, | Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells |
| - | in-vitro, | CRC, | SW-620 |
| 4849- | Uro, | Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway |
| - | vitro+vivo, | GC, | NA |
| 1817- | VitK2, | Research progress on the anticancer effects of vitamin K2 |
| - | Review, | Var, | NA |
| 1824- | VitK2, | Vitamin K and its analogs: Potential avenues for prostate cancer management |
| - | Review, | Pca, | NA |
| 1816- | VitK2, | Role of Vitamin K in Selected Malignant Neoplasms in Women |
| - | Review, | Var, | NA |
| 1214- | VitK2, | Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells |
| - | in-vitro, | Bladder, | T24/HTB-9 | - | in-vitro, | Bladder, | J82 |
| 1837- | VitK3, | VitC, | Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death |
| - | in-vivo, | Pca, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:321 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid