TumCI Cancer Research Results

TumCI, Tumor Cell invasion: Click to Expand ⟱
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Tumor cell invasion is a critical process in cancer progression and metastasis, where cancer cells spread from the primary tumor to surrounding tissues and distant organs. This process involves several key steps and mechanisms:

1.Epithelial-Mesenchymal Transition (EMT): Many tumors originate from epithelial cells, which are typically organized in layers. During EMT, these cells lose their epithelial characteristics (such as cell-cell adhesion) and gain mesenchymal traits (such as increased motility). This transition is crucial for invasion.

2.Degradation of Extracellular Matrix (ECM): Tumor cells secrete enzymes, such as matrix metalloproteinases (MMPs), that degrade the ECM, allowing cancer cells to invade surrounding tissues. This degradation facilitates the movement of cancer cells through the tissue.

3.Cell Migration: Once the ECM is degraded, cancer cells can migrate. They often use various mechanisms, including amoeboid movement and mesenchymal migration, to move through the tissue. This migration is influenced by various signaling pathways and the tumor microenvironment.

4.Angiogenesis: As tumors grow, they require a blood supply to provide nutrients and oxygen. Tumor cells can stimulate the formation of new blood vessels (angiogenesis) through the release of growth factors like vascular endothelial growth factor (VEGF). This not only supports tumor growth but also provides a route for cancer cells to enter the bloodstream.

5.Invasion into Blood Vessels (Intravasation): Cancer cells can invade nearby blood vessels, allowing them to enter the circulatory system. This step is crucial for metastasis, as it enables cancer cells to travel to distant sites in the body.

6.Survival in Circulation: Once in the bloodstream, cancer cells must survive the immune response and the shear stress of blood flow. They can form clusters with platelets or other cells to evade detection.

7.Extravasation and Colonization: After traveling through the bloodstream, cancer cells can exit the circulation (extravasation) and invade new tissues. They may then establish secondary tumors (metastases) in distant organs.

8.Tumor Microenvironment: The surrounding microenvironment plays a significant role in tumor invasion. Factors such as immune cells, fibroblasts, and signaling molecules can either promote or inhibit invasion and metastasis.
Scientific Papers found: Click to Expand⟱
461- CUR,    Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-30a-5p↑, PCLAF↓, Bcl-2↓, Casp3↓, BAX↑, cl‑Casp3↑,
460- CUR,    Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, TCCSUP - in-vitro, Bladder, J82
miR-7641↓, p16↑, Apoptosis↑, TumCI↓,
476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
TumCMig↓, TumCI↓, Apoptosis↑, NEDD9↓, p‑Akt↓, p‑mTOR↓, PTEN↑, p73↑, β-TRCP↑,
456- CUR,    Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells
- vitro+vivo, GC, SGC-7901
miR-34a↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, Bcl-2↓, CDK4/6↓, cycD1/CCND1↓,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
158- CUR,    Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
MMP9↓, Matr↓, Inflam↓, antiOx↓, NF-kB↓, COX2/PTGS2↓, iNOS↓, TumCMig↓, TumCI↓,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, chemoPv↑,
181- CUR,    The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
- vitro+vivo, Pca, DU145
MMP2↓, MMP9↓, TumCP↓, TumCI↓,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
4656- CUR,  EGCG,    Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
CSCs↓, CD44↓, p‑STAT3↓, NF-kB↓, TumCI↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
4710- CUR,    Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, miR-206↑, p‑mTOR↓, p‑Akt↓,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
16- Cyc,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,
6245- Cyc,    Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
- vitro+vivo, PC, NA
HH↓, Snail↓, E-cadherin↑, EMT↓, TumCI↓, ChemoSen↑, TumMeta↓, ALDH↓, eff↑,
6246- Cyc,    Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
HH↓, TumCP↓, TumCCA↓, TumCI↓, NF-kB↓, MMP2↓, MMP9↓, ERα/ESR1↓, cycD1/CCND1↓,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
7451- CYN,    Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Apoptosis↑, TumCMig↓, TumCI↓, ERK↓, NF-kB↓, ROS↓, HO-1↑, NRF2↑, Bcl-2↓, NF-kB↓, other↝,
6255- Cyste,    Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity
- in-vitro, GBM, NA
MMPs↓, MMP2↓, MMP9↓, MMP14↓, TumCI↓, TumCMig↓, Dose↓,
6593- DAS,    Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors
- Review, Var, NA
TumCP↓, TumCI↓, TumMeta↓, Synergy↑, Src↓,
6590- DAS,    Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
- in-vitro, Pca, NA
Src↓, ABL1↓, BioAv↑, TumCG↓, Dose↓, TumCA↓, TumCMig↓, TumCI↓,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, Synergy↑, Synergy↑, other↝, RadioS↑, toxicity↓, Dose↝, Synergy↑, Synergy↑, Synergy↑, toxicity↝, eff↓,
6673- Deg,    Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion
- in-vitro, Var, NA
NF-kB↓, IKKα↓, TNFR 1↓, TumCP↓, TumCI↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
6664- DFE,    Anticancer Properties of Different Varieties of Date Palm (Phoenix dactylifera L.) Leaf Extracts in Human Tumor Cells: a Comparative Study
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓,
8843- DIM,    3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis
- in-vitro, NSCLC, NA
tumCV↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, EMT↓, Ferroptosis↑, Iron↑, ROS↑, MDA↑, GSH↓, AhR↓, NRF2↓, GPx4↓, MMP↓, eff↓,
8852- DIM,    3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, KYSE-30
AhR↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Vim↓, Slug↓, CLDN1↑, COX2/PTGS2↓, PGE2↓, ROCK1↓, ROCK1↓, EMT↓,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6326- DRE,  MT/VAE,    Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy
- in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, Apoptosis↑, MMP↓, TumCI↓, TumCMig↓, Synergy↑,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, Synergy↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, Synergy↑, CSCs↓, Dose↝, Half-Life↑,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
7220- EGb 761,    Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer
- vitro+vivo, GC, SGC-7901
TumCP↓, TumCMig↓, TumCI↓, p‑ERK↓, NF-kB↓, MMP2↓, eff↑, TumCG↓, TumMeta↓, Dose↝, TumVol↓,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, Var, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2/PTGS2↓, NOS2↓, ac‑H3↑, ac‑H4↑, Synergy↑,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
1072- EGCG,    Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways
- in-vitro, Thyroid, 8505C
EMT↓, TumCI↓, TumCMig↓, TGF-β↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓,
665- EGCG,    Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway
- in-vitro, Lung, H1299
AMPK↑, TumCP↓, TumCMig↓, TumCI↓,
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
- Review, Var, NA
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
688- EGCG,  GEM,    Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,

Showing Research Papers: 151 to 200 of 545
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 545

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 6,   ARE↓, 1,   Catalase↓, 3,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 13,   GSH↓, 27,   GSH↑, 2,   GSR↓, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 2,   HO-1↓, 5,   HO-1↑, 9,   Iron↑, 4,   i-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA?, 1,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 2,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 16,   NRF2↑, 15,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS↓, 19,   ROS↑, 146,   ROS⇅, 2,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 5,   SOD↑, 2,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↝, 1,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 3,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh∅, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   MFN2↓, 1,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 3,   ACADS/SCAD↓, 1,   ACC↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 25,   AMPK↝, 1,   p‑AMPK↑, 5,   ATP↓, 19,   CAIX/CA9↓, 1,   citrate↓, 1,   ECAR↓, 3,   ENO1↓, 1,   FABP4↑, 1,   FABP5/E-FABP↓, 1,   FAM↓, 1,   FASN↓, 6,   FDG↓, 1,   G6PD↓, 5,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 11,   GlutMet↓, 1,   Glycolysis↓, 34,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 17,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 11,   LDHA∅, 1,   LDL↓, 3,   lipidLev↓, 2,   lipoGen↓, 2,   NADPH↓, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 2,   PGM1↓, 1,   PIP3↑, 1,   PKM2↓, 19,   PKM2∅, 1,   Pyruv↓, 1,   R5P↝, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 5,   SIRT1↑, 4,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,   SREBP2↓, 2,   TCA↓, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 7,   Apoptosis↑, 233,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 2,   BAX↓, 1,   BAX↑, 84,   Bax:Bcl2↑, 14,   Bcl-2↓, 99,   Bcl-xL↓, 15,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 23,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   proCasp1↓, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 94,   cl‑Casp3↑, 24,   Casp7↑, 13,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 23,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 58,   p‑Casp9↑, 1,   cl‑Casp9↑, 8,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 47,   Cyt‑c↝, 1,   DR5↑, 10,   DR5∅, 1,   Endon↑, 1,   FADD↑, 3,   FADD∅, 1,   Fas↓, 2,   Fas↑, 11,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 22,   GSDMD↑, 2,   IAP1↓, 5,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 10,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   MOMP↓, 1,   MOMP↑, 3,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 2,   P2X7↓, 1,   p38↓, 6,   p38↑, 9,   p‑p38↓, 4,   p‑p38↑, 3,   p‑p38↝, 1,   Paraptosis↑, 1,   PDCD4↑, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP1↓, 1,   survivin↓, 38,   TNFR 1↓, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 9,   TUNEL↑, 1,   XIAP↓, 19,   YAP/TEAD↓, 6,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 122,   Akt↑, 5,   Akt↝, 1,   p‑Akt↓, 43,   p‑Akt↑, 1,   AKT1↓, 4,   AKT3↓, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 1,   p‑cMET↑, 2,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 7,   ERK↝, 2,   p‑ERK↓, 17,   p‑ERK↑, 1,   p‑ERK↝, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 10,   IKKα↝, 1,   p‑IKKα↓, 1,   IR↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 6,   JAK↝, 1,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 11,   p‑JAK2↓, 2,   p‑JAK3↓, 1,   JNK↓, 3,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 27,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MEK↓, 4,   p‑MEK↓, 2,   mTOR↓, 66,   mTOR↑, 4,   mTOR↝, 1,   p‑mTOR↓, 12,   mTORC2↓, 2,   mTORC2↑, 1,   NRAS↓, 1,   p42↑, 1,   P70S6K↓, 4,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PFKFB2↓, 1,   PI3K↓, 82,   PI3K↝, 1,   p‑PI3K↓, 13,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 8,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 22,   PTK2B / PYK2↓, 1,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 1,   SGK1↓, 1,   Sp1/3/4↓, 19,   Src↓, 4,   p‑Src↓, 1,   STAT↓, 6,   p‑STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 57,   STAT3↑, 3,   p‑STAT3↓, 10,   p‑STAT3↑, 2,   STAT5↓, 1,   STAT6↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 6,   cJun↑, 2,   p‑cJun↓, 1,   cMyc↓, 26,   DNMT1↓, 4,   DNMT1↑, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 11,   HDAC1↓, 4,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 2,   HMTs↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   Matr↓, 1,   METTL7A↑, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 3,   miR-145↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-194↑, 1,   miR-200b↑, 1,   miR-205↑, 2,   miR-206↑, 1,   miR-21↓, 8,   miR-223-3p↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-30a-5p↑, 1,   miR-340↓, 2,   miR-34a↓, 1,   miR-34a↑, 5,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-542↓, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-7641↓, 1,   miR-99↑, 1,   Myc↓, 1,   Myc↑, 1,   NDRG1↑, 1,   OCT4↓, 12,   other?, 1,   other↓, 2,   other↑, 3,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 2,   RASSF1A↑, 1,   sonoS↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 71,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 2,   ER Stress↑, 27,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   e-HSP70/HSPA5↓, 1,   HSP90↓, 13,   HSPs↓, 1,   IRE1↑, 3,   OTUB2↓, 1,   PDI↑, 1,   PERK↑, 9,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 4,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 42,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 33,   DNArepair↓, 5,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 50,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 3,   PARP↑, 9,   cl‑PARP↑, 42,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 21,   PCNA↑, 1,   POLD1↓, 1,   Telomerase↓, 5,   TOP1↓, 3,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2,   CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 20,   CDK2↑, 3,   CDK4↓, 25,   CDK4↑, 2,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 10,   CDK6↑, 2,   CDK6∅, 1,   CDK7↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 15,   cycD1/CCND1↓, 53,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 3,   cycE/CCNE↓, 14,   E2Fs↓, 2,   Ki-67↓, 31,   MAD↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 10,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TumCCA↓, 6,   TumCCA↑, 149,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 8,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP2↓, 1,   BMPs↑, 2,   CD133↓, 11,   CD133↑, 1,   CD24↓, 4,   CD34↓, 1,   cFos↓, 7,   p‑cFos↓, 1,   cMYB↓, 1,   CSCs↓, 38,   Diff↑, 5,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 13,   HH?, 1,   HH↓, 12,   IGF-1↓, 4,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 31,   Let-7↑, 1,   LRP6↓, 2,   p‑LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nestin↓, 3,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 5,   NOTCH1↝, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 6,   STAT1↓, 1,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 2,   TumCG?, 2,   TumCG↓, 108,   TumCG↑, 3,   TumCG∅, 1,   TumCP?, 1,   TumCP↓, 239,   TumCP↑, 5,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   WDR72↓, 1,   Wnt↓, 30,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   Ca+2↑, 20,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 2,   Cav1↓, 1,   p‑Cofilin↑, 2,   COL11A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 70,   EMT?, 1,   EMT↓, 124,   EMT↑, 4,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 14,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 7,   GLI2↓, 2,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 4,   ITGB3↓, 1,   ITGB4↓, 3,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 3,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP14↓, 2,   MMP16↓, 2,   MMP17↓, 1,   MMP2?, 1,   MMP2↓, 117,   MMP2↝, 1,   MMP3↓, 8,   MMP7↓, 11,   MMP9?, 1,   MMP9↓, 133,   MMP9↑, 1,   MMP9↝, 1,   MMPs↓, 32,   MTA1↓, 2,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 53,   NEDD9↓, 3,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   RECK↑, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 7,   Sharpin↓, 1,   Slug↓, 27,   Smad1↓, 2,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 9,   SMAD3↓, 8,   p‑SMAD3↓, 7,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail↓, 44,   Snail↑, 1,   T-cadherin↑, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 17,   TGF-β↑, 3,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 2,   TIMP2↑, 9,   TIMP3↑, 2,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 10,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 540,   TumCI↑, 7,   TumCMig?, 1,   TumCMig↓, 344,   TumCMig↑, 5,   TumMeta↓, 118,   TumMeta↑, 5,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 1,   uPA↓, 14,   uPAR↓, 2,   UroPA↓, 1,   Vim?, 1,   Vim↓, 58,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 17,   Zeb1↑, 1,   ZEB2↓, 3,   ZEB2↑, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↑, 2,   β-catenin/ZEB1↓, 53,   β-catenin/ZEB1↑, 2,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 96,   angioG↑, 2,   EGR1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 6,   Hif1a↓, 52,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 69,   VEGF↑, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 12,   GLUT1∅, 1,   GLUT3↓, 1,   GLUT3∅, 1,   MMP↓, 65,   MMP↑, 1,   MPT↑, 4,   OATPs↓, 1,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 13,   CD47↓, 1,   CD8+↑, 5,   p‑cDC2↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCR2↓, 1,   CXCR4↓, 11,   DR4↑, 7,   DR4∅, 1,   FOXP3↑, 1,   Gal-3↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 1,   IL12↓, 1,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL6↓, 26,   IL6↑, 1,   IL8↓, 8,   Imm↑, 11,   Imm↝, 2,   Inflam↓, 34,   Inflam↝, 2,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 114,   NF-kB↑, 6,   NF-kB↝, 2,   p‑NF-kB↓, 4,   p‑NF-kB↑, 1,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 3,   NLRP3↓, 5,   NLRP3↑, 2,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 2,   PGE2↓, 12,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 20,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↑, 1,   e-pH↑, 3,   i-pH↓, 1,   TAMS↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AhR↑, 2,   AR↓, 10,   ER-α36↓, 2,   ERα/ESR1↓, 1,   Estro↝, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 22,   BioAv↑, 23,   BioAv↝, 11,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 107,   CompStab↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose↓, 5,   Dose↑, 3,   Dose↝, 42,   Dose∅, 4,   eff↓, 20,   eff↑, 55,   eff↝, 3,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 7,   Half-Life↑, 2,   Half-Life↝, 7,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 1,   RadioS?, 1,   RadioS↑, 31,   selectivity↑, 62,   Synergy↑, 75,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   BMD↑, 2,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   CRP↓, 1,   DBIL↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 1,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 26,   IL6↑, 1,   LDH↓, 7,   LDH↑, 2,   Myc↓, 1,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 8,   PD-L1↑, 2,   PSA↓, 2,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 32,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 3,   AntiTum↓, 3,   AntiTum↑, 23,   cachexia↓, 1,   cardioP↑, 6,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 18,   chemoPv↑, 15,   ChemoSideEff↓, 3,   fatigue↓, 2,   FTO↓, 1,   FTO↑, 1,   hepatoP↓, 1,   hepatoP↑, 4,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 1,   OS↑, 11,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 5,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 8,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 1,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 19,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 25,   TumVol∅, 1,   TumW↓, 14,   TumW∅, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 3,   Sepsis↓, 2,  
Total Targets: 1048

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 49,   Catalase↑, 18,   Fenton↓, 1,   GPx↑, 13,   GPx1↑, 1,   GSH↑, 13,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 10,   Iron∅, 1,   Keap1↓, 2,   lipid-P↓, 17,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 22,   RNS↓, 3,   ROS↓, 44,   ROS↑, 1,   SOD↑, 16,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   HSP60/HSPD1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 2,   ATP↓, 1,   ATP↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 2,   HMG-CoA↓, 2,   LDL↓, 3,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 5,   Casp9↓, 3,   Cyt‑c↓, 1,   Fas↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 8,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 1,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   JAK2↑, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 2,   mTOR↓, 2,   mTOR↑, 2,   PI3K↑, 4,   PKCδ↓, 1,   PKCδ↑, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other↓, 2,   other↑, 1,   other↝, 4,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↝, 1,   EMT↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 2,   TumCI∅, 1,   TumCMig↓, 1,   TumCMig∅, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 5,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   MMP↑, 2,   MUC5AC↓, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 12,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL1β↓, 7,   IL4↓, 1,   IL4↑, 1,   IL6↓, 14,   Imm↓, 1,   Imm↑, 3,   Inflam?, 1,   Inflam↓, 55,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   NLRP3↓, 3,   PGE2↓, 5,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 14,   Treg lymp↝, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 1,   AChE↓, 4,   AChE↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 1,   ChAT↑, 1,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 20,   BioAv⇅, 1,   BioAv↝, 9,   BioEnh↑, 1,   CompStab↑, 1,   CompStab↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 5,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BMD↑, 2,   BP↓, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 14,   LDH↓, 2,   SpO2↑, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 6,   antiD↓, 1,   AntiDiabetic↑, 8,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 19,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↑, 17,   memory↑, 3,   neuroP?, 1,   neuroP↑, 32,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   radioP↑, 3,   RenoP↑, 6,   Risk↓, 1,   Stroke↓, 3,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 7,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 10,   GutMicro↑, 9,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 259

Scientific Paper Hit Count for: TumCI, Tumor Cell invasion
21 Curcumin
15 Resveratrol
14 Quercetin
13 Matrine
12 Honokiol
12 Magnolol
12 Shikonin
11 Berberine
11 Fisetin
10 Apigenin (mainly Parsley)
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
9 Thymoquinone
8 Melatonin
8 Eugenol
8 Garcinol
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Chlorogenic acid
7 Chrysin
7 Licochalcone A
7 Magnetic Fields
6 Metformin
6 Cinnamon
6 Dandelion Root
6 Emodin
6 Formononetin
6 Ginkgetin
6 Piperlongumine
5 Astragalus
5 Gemcitabine (Gemzar)
5 Ferulic acid
5 Hyperoside
5 Lycopene
5 Morin
5 Pterostilbene
4 Artemisinin
4 Baicalein
4 Carvacrol
4 Celastrol
4 Cyclopamine
4 Radiotherapy/Radiation
4 Gambogic Acid
4 Isoliquiritigenin
4 Juglone
4 Nimbolide
4 Phenethyl isothiocyanate
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Berbamine
3 Brucea javanica
3 brusatol
3 Capsaicin
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Centella asiatica / Gotu kola → asiaticoside
3 chaetocin
3 Zinc
3 Propolis -bee glue
3 Crocetin
3 Copper and Cu NanoParticles
3 Diindolylmethane
3 Evodiamine
3 Gallic acid
3 Paclitaxel/Taxol
3 Genistein (soy isoflavone)
3 Hydrogen Gas
3 Indole-3-carbinol
3 iodine
3 Magnetic Field Rotating
3 Bicarbonate(Sodium)
3 Piperine
3 Whole Body Vibration
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Aspirin
2 Astaxanthin
2 Beta-Caryophyllene
2 Boron
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Celecoxib
2 Hydroxycinnamic-acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dasatinib/Phyrago
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Ginkgolic acids
2 Ginkgolide B
2 5-fluorouracil
2 Graviola
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoflavones
2 isoorientin
2 isoquercitrin
2 itraconazole
2 Kaempferol
2 low dose naltrexone
2 Licorice
2 Linalool
2 Lutein
2 Modified Citrus Pectin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Cisplatin
2 salinomycin
2 Sulfasalazine
2 Selenite (Sodium)
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Butyrate
1 Carnosic acid
1 chitosan
1 Selenium NanoParticles
1 Chlorophyllin
1 Carvone
1 CUSP9
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetate
1 Date Fruit Extract
1 Mistletoe/Viscum album Extracts
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Galloflavin
1 Ginkgo biloba
1 Geraniol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Ivermectin
1 Isovitexin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 mebendazole
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 doxorubicin
1 immunotherapy
1 Magnesium
1 Methylsulfonylmethane
1 Noscapine
1 Oroxylin A
1 Oleuropein
1 Orlistat
1 Psoralidin
1 Docetaxel
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Usnic acid
1 Arsenic trioxide
1 Vitamin K2
1 VitK3,menadione
1 Vitexin
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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