Vim Cancer Research Results

Vim, Vimentin: Click to Expand ⟱
Source:
Type:
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.

In many epithelial-derived tumors (carcinomas), elevated Vimentin expression is often observed in cancer cells that have undergone EMT. This upregulation is characteristic of a shift toward a mesenchymal state, which is associated with reduced cell–cell adhesion and increased motility. Vimentin expression is also noted in the tumor stroma, reflecting the presence and activation of mesenchymal cells such as cancer-associated fibroblasts (CAFs). This dual expression can contribute to the remodeling of the tumor microenvironment.
The degree of Vimentin expression may vary depending on the tumor type, grade, and stage. More aggressive and advanced tumors tend to show higher levels of Vimentin expression.

High Vimentin expression has been correlated with poor clinical outcomes in several cancers, including breast, colorectal, prostate, and lung cancers.
Elevated Vimentin levels are typically associated with higher tumor grade, increased invasiveness, enhanced metastatic potential, and a greater risk of recurrence.
As a component of the EMT signature, high Vimentin expression can serve as an indicator of a more aggressive tumor phenotype and is often associated with reduced overall survival.
- vimentin up-regulation is often used as a marker of EMT in cancer



Scientific Papers found: Click to Expand⟱
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3027- RosA,    Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway
- in-vitro, HCC, SMMC-7721 cell
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, TumCMig↓, MMPs↓, Vim↓,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp/ABCB1↓, ATP↓,
1132- RT,    Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
1137- Taur,    Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
- in-vitro, Pca, NA
N-cadherin↓, Twist↓, Zeb1↓, Snail↓, Vim↓, E-cadherin↑,
1138- TQ,    Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumMeta↓, EMT↓, E-cadherin↑, Vim↓, Slug↓, TGF-β↓, SMAD2↓, SMAD3↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
1139- UA,    Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells
- in-vitro, Lung, A549
TumMeta↓, AEG1↓, E-cadherin↑, N-cadherin↓, Vim↓, EMT↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4844- Uro,    Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,
1217- VitC,    High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
- in-vitro, BC, Bcap37 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, Vim↓, EMT↓,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,
4888- ZER,  5-FU,    Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts
- in-vitro, CRC, CT26
TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

Showing Research Papers: 151 to 183 of 183
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 183

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 4,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 1,   GPx4↓, 5,   GSH↓, 10,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   HO-1↓, 6,   HO-1↑, 6,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 5,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 9,   NRF2↑, 4,   p‑NRF2↓, 1,   PAO↑, 1,   ROS↓, 11,   ROS↑, 62,   ROS⇅, 4,   i-ROS↑, 1,   SOD↓, 10,   SOD↑, 4,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   Trx1↑, 1,   TrxR↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 2,   mitResp↓, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 8,   OCR↓, 2,   OXPHOS↓, 1,   PDH↓, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 13,   p‑AMPK↑, 1,   ATP↓, 3,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   FASN↓, 1,   GlutMet↓, 1,   Glycolysis↓, 7,   GSK‐3β↓, 8,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 3,   HK1↓, 1,   HK2↓, 8,   lactateProd↓, 1,   LDHA↓, 4,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 2,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 2,   SIRT1↓, 6,   SIRT1↑, 3,   SIRT2↓, 1,   SREBP1/SREBF1↓, 3,   SSAT↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 43,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 3,   BAX↓, 1,   BAX↑, 35,   Bax:Bcl2↑, 3,   Bcl-2↓, 40,   Bcl-2↑, 1,   Bcl-xL↓, 11,   BID↓, 1,   BID↑, 3,   BIM↑, 6,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   Casp3↓, 1,   Casp3↑, 40,   cl‑Casp3↑, 8,   Casp6↑, 1,   Casp7↑, 5,   cl‑Casp7↑, 1,   Casp8↑, 7,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 26,   cl‑Casp9↑, 3,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 26,   mt-Cyt‑c↓, 1,   Diablo↑, 6,   DR5↑, 10,   FADD↑, 2,   Fas?, 1,   Fas↑, 10,   FasL↑, 1,   Ferroptosis↑, 5,   HEY1↓, 1,   IAP1↓, 3,   iNOS↓, 8,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 11,   MDM2↓, 3,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 3,   p‑p38↓, 3,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 2,   survivin↓, 17,   survivin↝, 1,   TNFR 1↑, 2,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 2,   XIAP↓, 12,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 2,   p‑Akt↓, 19,   AKT1↓, 2,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 3,   p‑cMET↓, 1,   cSrc↓, 1,   EGFR↓, 16,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 9,   FGFR1↓, 2,   FGFR2↓, 1,   GRB2↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   p‑IGFR↓, 1,   IKKα↓, 4,   IKKα↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   p‑JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 1,   JNK↑, 3,   p‑JNK↓, 1,   p‑JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 10,   MAPK↑, 7,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 31,   mTOR↑, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   p42↑, 1,   p‑p42↓, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PI3K↓, 37,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 2,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKCδ↓, 2,   PTEN↓, 2,   PTEN↑, 13,   Raf↓, 1,   RAS↓, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 28,   p‑STAT3↓, 4,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 7,   p‑ATF4↝, 1,   cJun↓, 6,   cMyc↓, 21,   DNMT1↓, 4,   DNMT3A↓, 3,   DNMTs↓, 2,   EZH2↓, 5,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 3,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 6,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HES1↓, 2,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-126↑, 1,   miR-127-5p↑, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 2,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 3,   miR-210↓, 1,   miR-224↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-448↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 2,   NDRG1↑, 2,   OCT4↓, 12,   OCT4↑, 1,   other↓, 1,   other↑, 1,   other↝, 3,   PAX2↓, 1,   SOX2↓, 6,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 13,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↑, 13,   Erlin1↑, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 7,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 5,   p‑PERK↝, 1,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 8,   p62↓, 7,   PARK2↑, 1,   TumAuto↑, 14,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DFF45↑, 2,   DNAdam↑, 16,   DNAdam⇅, 1,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 29,   p53 Wildtype↑, 1,   PARP↑, 7,   cl‑PARP↑, 17,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 12,   POLD1↓, 1,   RAD51↓, 1,   Telomerase↓, 3,   TOP1↓, 3,   TOP2↓, 4,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 6,   CDK2↓, 15,   CDK2↑, 2,   CDK4↓, 18,   CDK4↑, 1,   CDK6↓, 10,   CDK6↑, 1,   CHK1↓, 3,   p‑CHK1↑, 1,   Chk2↓, 2,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 28,   cycE/CCNE↓, 7,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 11,   MAD↓, 1,   MKI67↑, 1,   P21↓, 1,   P21↑, 21,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 7,   pRB↓, 1,   pRB↑, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 2,   TAp63α↑, 1,   TumCCA↓, 2,   TumCCA↑, 48,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 3,   AXIN1↓, 1,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 3,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 1,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 28,   CSCs↑, 1,   CSCsMark↓, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 2,   IGFBP3↑, 1,   JAG1↓, 1,   Ki-67↓, 11,   Let-7↓, 1,   Let-7↑, 3,   LRP6↓, 3,   p‑LRP6↓, 2,   mTORC1↓, 1,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 1,   NKD2↑, 1,   NOTCH↓, 10,   NOTCH1↓, 8,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Piezo1↑, 1,   Pirin↓, 1,   SFRP5↑, 1,   Shh↓, 4,   Smo↓, 2,   p‑STAT1↓, 2,   TOPflash↓, 1,   TumCG↓, 28,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 53,   TumCP↑, 3,   tyrosinase↓, 1,   Wnt↓, 27,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 9,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   CDH1↑, 2,   COL1↓, 5,   COL1A1↓, 3,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 17,   E-cadherin↑, 116,   EMT↓, 113,   EMT↑, 2,   F-actin↑, 1,   FAK↓, 5,   Fibronectin↓, 16,   Fibronectin↑, 1,   ITGA5↓, 1,   ITGA5↑, 3,   ITGB1↓, 2,   ITGB1↑, 3,   ITGB3↓, 1,   LAMA5↑, 3,   LEF1↓, 2,   MALAT1↓, 2,   MET↓, 2,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 1,   MMP1:TIMP1↑, 1,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 57,   MMP3↓, 6,   MMP7↓, 6,   MMP9↓, 65,   pro‑MMP9↓, 1,   MMPs↓, 8,   MTA1↓, 1,   N-cadherin↓, 76,   N-cadherin↑, 2,   p44↑, 1,   p‑p44↓, 1,   PDGF↓, 2,   PIR↓, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 5,   Sharpin↓, 1,   Slug↓, 37,   Smad1↓, 2,   SMAD2↓, 5,   p‑SMAD2↓, 6,   SMAD3↓, 5,   p‑SMAD3↓, 5,   Snail↓, 68,   Snail↑, 5,   TET1↑, 2,   TGF-β↓, 14,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 2,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 3,   TumCI?, 2,   TumCI↓, 66,   TumCMig?, 1,   TumCMig↓, 65,   TumCMig↑, 1,   TumMeta↓, 38,   TumMeta↑, 1,   Twist↓, 24,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 11,   uPAR↓, 1,   Vim?, 1,   Vim↓, 168,   Vim↑, 7,   Zeb1↓, 24,   Zeb1↑, 4,   ZEB2↓, 3,   ZEB2↑, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 52,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 2,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 24,   NO↓, 2,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 37,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 1,   GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 32,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,   OCLN↑, 1,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 9,   CD44↑, 1,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 27,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 8,   DR4↑, 1,   FOXP3↓, 1,   HMGB1↓, 3,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 3,   IL10↓, 4,   IL12↓, 2,   IL12↑, 1,   IL18↓, 1,   IL1β↓, 8,   IL2↓, 1,   IL2↑, 3,   IL4↑, 1,   IL6↓, 19,   IL8↓, 5,   Imm↑, 3,   Inflam↓, 5,   IRAK1↓, 1,   LIF↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 48,   NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 3,   p50↓, 2,   p65↓, 5,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 10,   PSA↓, 3,   RAGE↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↓, 4,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AR↓, 4,   ER-α36↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 2,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 7,   BioAv↝, 3,   ChemoSen↑, 44,   ChemoSen⇅, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   Dose↑, 2,   Dose↝, 10,   Dose∅, 4,   DrugR↓, 1,   eff↓, 4,   eff↑, 18,   eff↝, 3,   eff∅, 1,   GSTA1↓, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 3,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 7,   P450↓, 2,   RadioS↑, 16,   selectivity↑, 13,   Synergy?, 1,   Synergy↑, 41,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 4,   AST↓, 1,   AST↝, 1,   BRCA1↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 16,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 5,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 19,   LDH↓, 3,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 3,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   antiD↑, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 7,   cachexia↓, 3,   cardioP↑, 5,   chemoP?, 1,   chemoP↑, 10,   chemoPv↑, 4,   ChemoSideEff↓, 3,   hepatoP↑, 3,   neuroP↑, 2,   OS↑, 4,   Pin1↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 4,   toxicity?, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 5,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 774

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 17,   Catalase↓, 1,   Catalase↑, 11,   DPPH↓, 1,   GPx↓, 1,   GPx↑, 9,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 6,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 7,   MDA↓, 6,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 13,   Prx↓, 1,   Prx↑, 1,   ROS↓, 26,   SOD↑, 13,   SOD2↑, 1,   TAC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 2,   ATP↑, 1,   LDHA↑, 1,   NAD↑, 1,   PKM2↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3?, 1,   Casp3↓, 3,   Casp9↓, 1,   iNOS↓, 3,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IκB?, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↑, 2,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   HOTAIR↑, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↓, 1,   COL1↓, 3,   COL3A1↓, 1,   E-cadherin↑, 6,   EMT↓, 5,   F-actin↓, 1,   Fibronectin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Smad7↑, 2,   Snail↓, 1,   Snail↑, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↓, 9,   Vim↑, 1,   α-SMA↓, 7,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   MMP↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 6,   IL5↓, 1,   IL6↓, 6,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 16,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 3,   PGE2↓, 3,   RAGE↓, 1,   SOCS-3↓, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   BDNF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 1,   BioAv↝, 1,   eff↑, 2,   Half-Life↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 3,   BUN↓, 1,   creat↓, 2,   CRP↓, 1,   IL6↓, 6,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 3,   AntiArt↑, 1,   AntiCan↑, 2,   AntiTum↑, 3,   cardioP↑, 3,   CardioT↓, 1,   chemoP↑, 2,   cognitive↑, 3,   hepatoP↑, 7,   Learn↑, 1,   memory↑, 4,   Mucositis↓, 1,   neuroP↑, 8,   PDE4↓, 1,   RenoP↑, 1,   Stroke↓, 1,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 161

Scientific Paper Hit Count for: Vim, Vimentin
12 Curcumin
9 Luteolin
8 Quercetin
7 Ashwagandha(Withaferin A)
6 Fisetin
6 Resveratrol
5 EGCG (Epigallocatechin Gallate)
5 Matrine
4 Astragalus
4 Baicalein
4 Pterostilbene
4 Rosmarinic acid
3 Benzyl isothiocyanate
3 Boron
3 Propolis -bee glue
3 5-fluorouracil
3 Diindolylmethane
3 Honokiol
3 Silymarin (Milk Thistle) silibinin
3 Thymoquinone
3 Urolithin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalin
2 Berberine
2 Caffeic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Emodin
2 Garcinol
2 Grapeseed extract
2 HydroxyTyrosol
2 Isorhamnetin
2 Sulforaphane (mainly Broccoli)
2 Juglone
2 Melatonin
2 Ursolic acid
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 2-DeoxyGlucose
1 Allyl isothiocyanate
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 Aspirin
1 Betulinic acid
1 Boswellia (frankincense)
1 Butyrate
1 Carvacrol
1 Carnosine
1 Cannabidiol
1 Chlorogenic acid
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Gemcitabine (Gemzar)
1 Eugenol
1 Ferulic acid
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Cisplatin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgetin
1 Proanthocyanidins
1 Hydrogen Gas
1 Chemotherapy
1 Hydroxycinnamic-acid
1 phytic acid, Inositol hexakisphosphate
1 Inositol
1 capecitabine
1 Isoliquiritigenin
1 Isothiocyanates
1 L-Theanine
1 Licorice
1 Magnolol
1 Metformin
1 Magnetic Fields
1 Mangiferin
1 Morin
1 Naringin
1 Oroxylin-A
1 Oleuropein
1 Phenethyl isothiocyanate
1 Phycocyanin
1 Piperine
1 Piperlongumine
1 Plumbagin
1 Rutin
1 salinomycin
1 α-Santalol/Sandalwood oil
1 Selenate
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Taurine
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:336  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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