β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
Type:
β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓, Warburg↓,
8255- LCA,    Antitumor and antimetastatic effects of licochalcone A in mouse models
- in-vivo, Colon, NA
COX2/PTGS2↓, iNOS↓, NF-kB↓, AP-1↓, AntiTum↑, β-catenin/ZEB1↓, OS↑, TumMeta↓, MMP9↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8197- LGE,    Citral induced apoptosis in MDA-MB-231 spheroid cells
- in-vitro, BC, MDA-MB-231
eff↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓,
8195- LGE,    In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity
- vitro+vivo, BC, 4T1
TumCD↑, Dose↝, TumVol↓, cl‑Casp3↑, β-catenin/ZEB1↑, ALDH↓, Wnt↓,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8392- LT,    Revisiting Luteolin Against the Mediators of Human Metastatic Colorectal Carcinoma: A Biomolecular Approach
- in-vitro, CRC, HCT15 - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1 - in-vitro, CRC, HT-29 - in-vitro, Nor, RWPE-1
selectivity↑, β-catenin/ZEB1↓, GSK‐3β↑, AKT1↓, PI3K↓, p50↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
1171- LT,    The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma
- in-vitro, CCA, NA
Wnt↓, TumCCA↑, Apoptosis↑, TumCMig↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4793- Lyco,    Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
- in-vitro, GC, AGS
antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
8499- MAG,    Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HCT116
β-catenin/ZEB1↓, TCF↓, TOPflash↓, cMyc↓, MMP7↓, UroPA↓, TumCI↓,
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,
8561- Matr,    Matrine triggers colon cancer cell apoptosis and G0/G1 cell cycle arrest via mediation of microRNA-22
- in-vitro, Colon, SW480 - in-vitro, CRC, SW-620
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, miR-22↑, Wnt↓, β-catenin/ZEB1↓, MEK↓, ERK↓,
8571- Matr,    Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling
- in-vitro, PC, Capan1
Dose↝, TumCP↓, Wnt↓, β-catenin/ZEB1↓, MMP14↓,
8572- Matr,    Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H460
Dose?, β-catenin/ZEB1↓, survivin↓, MMP↓, Casp9↑, Casp3↑,
8537- Matr,    Matrine restrains the development of colorectal cancer through regulating the AGRN/Wnt/β-catenin pathway
- vitro+vivo, CRC, NA
TumCG↓, AGRN↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓,
8536- Matr,    Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
- vitro+vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, angioG↓,
8529- Matr,    Matrine targets β-catenin and blocks the formation of β-catenin/TCF7L2 complex to promote ferroptosis and inhibit metastasis in triple-negative breast cancer
- in-vitro, BC, NA
β-catenin/ZEB1↓, Wnt↓, TCF7/TCF1↓, GPx4↝, Ferroptosis↑, EMT↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8747- MeSA,    Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers
- in-vitro, CRC, HT-29 - in-vitro, Laryn, FaDu - in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
β-catenin/ZEB1↓, ChemoSen↑,
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,
2240- MF,    Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathway
- in-vitro, Nor, C3H10T1/2
*Ca+2↑, *Diff↑, *BMD↑, *Wnt↑, *β-catenin/ZEB1↑, *eff↝,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
3478- MF,    One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study
- Trial, BC, NA - in-vitro, BC, MCF7 - in-vitro, Nor, C2C12
TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,
3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *5HT↑, *cFos↑, *Aβ↓, *memory↑, *BDNF↑, *Ach↑, *AChE↓, *cognitive↑, *BDNF↑, *NGF↑, *β-catenin/ZEB1↑, *p‑Akt↓, *mTOR↓, *MMP1↓, *MMP9↓, *MMP-10↓, *TIMP1↑, *TIMP2↑,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
8865- MOR,    Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells
- in-vitro, Liver, HepG2
Mst1↑, cl‑Casp3↑, YAP/TEAD↓, Apoptosis↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, TumCD↑,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
8959- mushLions,  BM,  L-Theanine,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
1797- NarG,    Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway
- in-vitro, BC, MDA-MB-231
TumCG↓, β-catenin/ZEB1↓, AntiTum↑, Apoptosis↑, TumCCA↑, P21↑, survivin↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27/CDKN1B↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,

Showing Research Papers: 151 to 200 of 256
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 256

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 2,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 6,   GPx4↝, 1,   GSH↓, 13,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 9,   HO-2↑, 1,   Iron↑, 2,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 6,   lipid-P↑, 5,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 9,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 13,   ROS↑, 74,   ROS⇅, 4,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 4,   SOD2↓, 2,   TAC?, 1,   TrxR↓, 3,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 3,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 5,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 2,   ALAT↝, 1,   AMACR↓, 1,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 19,   ATP↓, 4,   CAIX/CA9↓, 1,   ECAR↓, 1,   FAO↓, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   Glycolysis↓, 15,   GSK‐3β↓, 16,   GSK‐3β↑, 9,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 9,   HK1↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   lipoGen↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PKM2:PKM1↓, 2,   SCD1↓, 1,   SIRT1↓, 7,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 86,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 2,   aSmase↝, 1,   BAD↑, 2,   Bak↑, 4,   BAX↓, 2,   BAX↑, 38,   BAX↝, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 44,   Bcl-2↑, 4,   Bcl-2↝, 1,   Bcl-xL↓, 6,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   Casp↓, 1,   Casp↑, 15,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 48,   Casp3↝, 1,   cl‑Casp3↑, 13,   proCasp3↓, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 30,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 3,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 34,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 17,   FADD↑, 1,   Fas↓, 1,   Fas↑, 11,   FasL↑, 2,   Ferroptosis↑, 9,   HEY1↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 2,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 4,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 10,   p‑p38↑, 2,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↝, 1,   p‑Akt↓, 17,   AKT1↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   CREB↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   EphB4↓, 1,   ERK↓, 25,   ERK↑, 5,   p‑ERK↓, 7,   FGFR1↓, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 7,   JAK↓, 6,   JAK1↓, 3,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 9,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   Mst1↑, 1,   mTOR↓, 51,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   NRAS↓, 1,   p‑p42↓, 1,   p‑p42↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 62,   PI3K↝, 1,   p‑PI3K↓, 3,   PIAS-3↑, 1,   PKCδ↓, 4,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 8,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 49,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 6,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 41,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO4↑, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 2,   miR-205↑, 1,   miR-21↓, 6,   miR-210↓, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↑, 5,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 9,   other↓, 2,   other↑, 2,   other↝, 3,   PCAF↓, 1,   Shc↓, 1,   SOX2↓, 7,   SOX4↓, 3,   SOX4↑, 1,   SPP1↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 20,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 23,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 10,   LC3s↓, 1,   p62↓, 3,   p62↑, 2,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 17,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 19,   DNArepair↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 31,   P53↝, 1,   ac‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 26,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 12,   PCNA↑, 1,   SIRT6↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 19,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 2,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 58,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 4,   Ki-67↓, 11,   MAD↓, 1,   P21?, 1,   P21↑, 28,   P21↝, 1,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   Securin↓, 2,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 76,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 14,   CD24↓, 3,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   cFos↑, 1,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 49,   CSCs↑, 1,   Diff↑, 3,   EP2↓, 1,   EP4/PTGER4↓, 1,   FBXW7↝, 1,   Gli↓, 2,   Gli1↓, 9,   HH↓, 10,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 11,   Let-7↑, 2,   LRP6↓, 6,   p‑LRP6↓, 2,   mTORC1↓, 5,   Nanog↓, 9,   Nestin↓, 3,   NKD2↑, 2,   NOTCH↓, 17,   NOTCH⇅, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH2↓, 2,   NOTCH3↓, 3,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 8,   Smo↓, 5,   STAT1↓, 1,   p‑STAT1↓, 1,   TOPflash↓, 2,   TumCG↓, 40,   TumCP?, 1,   TumCP↓, 76,   TumCP↑, 1,   Wnt↓, 123,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 12,   AP-1↝, 2,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   Ca+2↝, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 45,   EMT↓, 70,   F-actin↓, 1,   FAK↓, 7,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 3,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB4↓, 1,   KRAS↓, 1,   LEF1↓, 5,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP14↓, 1,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 45,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 49,   MMPs↓, 18,   N-cadherin↓, 29,   N-cadherin↑, 1,   NCAM↓, 1,   NM23↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 3,   SMAD3↓, 2,   p‑SMAD3↓, 2,   Snail↓, 36,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 56,   TumCMig↓, 59,   TumCMig↑, 1,   TumMeta↓, 39,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 47,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 15,   ZEB2↑, 1,   β-catenin/ZEB1↓, 235,   β-catenin/ZEB1↑, 6,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   ECM/TCF↓, 1,   HIF-1↓, 2,   Hif1a↓, 25,   Hif1a↝, 1,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 47,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   CLDN1↓, 5,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 8,   MMP↓, 35,   MPT↑, 3,   NHE1↓, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 19,   CD44↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 12,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 3,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 6,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↝, 1,   IL8↓, 3,   Imm↑, 11,   Imm↝, 1,   Inflam↓, 16,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 79,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PGE2↓, 14,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TCF↓, 10,   TCF↑, 1,   TCF7/TCF1↓, 2,   TNF-α↓, 11,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 10,   AR↝, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 14,   BioAv↑, 13,   BioAv↝, 6,   BioEnh?, 1,   BioEnh↑, 3,   ChemoSen↑, 76,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↑, 3,   Dose↝, 17,   Dose∅, 4,   eff↓, 9,   eff↑, 27,   eff↝, 6,   GSTA1↑, 1,   Half-Life↓, 7,   Half-Life↝, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P450↓, 2,   P450↝, 1,   RadioS↑, 26,   selectivity↑, 27,   selectivity↝, 1,   Synergy↑, 43,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALB↑, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 10,   AR↝, 1,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 2,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 19,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 3,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   TBIL↓, 1,   TP53↑, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 7,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 14,   chemoPv↑, 14,   ChemoSideEff↓, 4,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 3,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↑, 3,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 7,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 8,   Sleep↑, 1,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 874

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 29,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 6,   GPx4↑, 2,   GSH↑, 7,   GSTs↑, 4,   H2O2↑, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 10,   i-Iron↓, 1,   lipid-P↓, 7,   MDA↓, 7,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 30,   ROS↑, 2,   mt-ROS↓, 1,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   GSK‐3β↓, 5,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 1,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Ferroptosis↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↑, 2,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   miR-34b-5p↓, 1,   other↝, 1,   RUNX2↑, 1,   TCF-4↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↑, 1,   Diff↑, 2,   FGF↑, 1,   Ki-67↑, 1,   TumCP↓, 1,   Wnt↓, 2,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 1,   EMT↓, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 3,   MUC1↑, 1,   OPN↑, 1,   Smad1↑, 1,   Smad7↑, 1,   STAC2↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 10,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   GLUT4↓, 1,   IBI↑, 2,   MMP↑, 1,   MUC19↓, 1,   MUC2↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 4,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 35,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 10,   p‑NF-kB↓, 1,   NLRP3↓, 2,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 6,   BDNF↑, 6,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 2,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 9,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   eff↑, 4,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   ALP↑, 1,   AST↓, 4,   BMD↑, 3,   CRP↓, 1,   IL6↓, 7,   IRes↑, 1,   LDH↓, 1,   LDH↑, 1,   OCN↑, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 7,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 4,   chemoP↑, 1,   chemoPv↑, 5,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 12,   Learn↑, 1,   memory↑, 11,   motorD↑, 1,   neuroP↑, 23,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 14,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 4,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 264

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Matrine
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Luteolin
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Ivermectin
5 Lycopene
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Kaempferol
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 phytic acid, Inositol hexakisphosphate
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 itraconazole
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Magnolol
2 Melatonin
2 Morin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Vitexin
1 lambertianic acid
1 methylseleninic acid
1 Magnetic Field Rotating
1 Zeolite
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
1 Orlistat
1 Phycocyanin
1 isoflavones
1 Rutin
1 buckwheat sprouts
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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